Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence.

Abstract:

:Transcriptional activation of the human T-cell leukemia virus type I (HTLV-I) long terminal repeat (LTR) by viral protein p40x requires a 21-base-pair (bp) sequence which is repeated three times within the LTR. This sequence contains a core octanucleotide (TGACGTCT) which has been attributed to be a cyclic-AMP (cAMP)-responsive element. We demonstrate here that the HTLV-I LTR can be specifically stimulated by cAMP regulators and have identified four proteins in HeLa cells that bind to the HTLV-I 21-bp sequence. We correlated the in vitro binding and transcriptional activity of one of these cellular factors (Mr, 180,000) to the trans-activation of the HTLV-I LTR by p40x. Point mutations were generated within the cAMP octanucleotide of the HTLV-I 21-bp sequence that simultaneously abolished biological responsiveness to trans-activation by p40x and to stimulation by cAMP. We found that these mutations also eliminated the binding of the 180-kilodalton HeLa factor to the HTLV-I 21-bp element. In the absence of a demonstrable DNA-binding property for p40x, we hypothesize that cellular proteins are involved, possibly through signal transduction pathways, in its trans-activation of responsive promoters.

journal_name

J Virol

journal_title

Journal of virology

authors

Jeang KT,Boros I,Brady J,Radonovich M,Khoury G

doi

10.1128/JVI.62.12.4499-4509.1988

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

4499-509

issue

12

eissn

0022-538X

issn

1098-5514

journal_volume

62

pub_type

杂志文章
  • Transcriptional activities of mammalian genomes at sites of recombination with foreign DNA.

    abstract::The nucleotide sequences of several sites of recombination between adenovirus DNA and hamster, mouse, or human cell DNAs were determined. These sites of recombination had been cloned from adenovirus type 2 (Ad2)- or type 12 (Ad12)-transformed cells, from Ad12-induced tumor cells, or from a symmetric recombinant betwee...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.61.2.344-353.1987

    authors: Schulz M,Freisem-Rabien U,Jessberger R,Doerfler W

    更新日期:1987-02-01 00:00:00

  • Contrasting effects from a single major histocompatibility complex class II molecule (H-2E) in recovery from Friend virus leukemia.

    abstract::Resistance to erythroleukemia induced by infection with the Friend virus complex (FV) has been mapped to several genes residing both within and outside the murine major histocompatibility complex (MHC). MHC genes located in the A, D, and Qa/Tla regions of the murine H-2 complex have been shown to affect disease resist...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.68.8.4921-4926.1994

    authors: Perry LL,Miyazawa M,Hasenkrug K,Wehrly K,David CS,Chesebro B

    更新日期:1994-08-01 00:00:00

  • A cell-free replication system for human polyomavirus JC DNA.

    abstract::The human polyomavirus JC virus (JCV) establishes persistent infections in most individuals and is the etiologic agent of progressive multifocal leukoencephalopathy. In this report, we describe the establishment of a soluble cell-free system that is capable of replicating exogenous plasmid DNA containing the JCV origi...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.71.10.7421-7428.1997

    authors: Nesper J,Smith RW,Kautz AR,Sock E,Wegner M,Grummt F,Nasheuer HP

    更新日期:1997-10-01 00:00:00

  • Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg.

    abstract::The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a complementary minus strand. This process is initiated by the covalent attachment of UMP to the terminal protein VPg, yielding VPgpU and VPgpUpU. We have previously shown that these products can be made in vitro in a reaction th...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.74.22.10359-10370.2000

    authors: Paul AV,Rieder E,Kim DW,van Boom JH,Wimmer E

    更新日期:2000-11-01 00:00:00

  • Transcription factor Sp1 mediates cell-specific trans-activation of the human cytomegalovirus DNA polymerase gene promoter by immediate-early protein IE86 in glioblastoma U373MG cells.

    abstract::Human cytomegalovirus (HCMV) gene expression is highly cell and tissue specific. Cell factor-mediated regulatory interactions are involved in regulating the restricted expression of the HCMV major immediate-early (IE) gene (J. F. Baskar, P. P. Smith, G. Nilaver, R. A. Jupp, S. Hoffmann, N. J. Peffer, D. J. Tenney, A. ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.72.1.236-244.1998

    authors: Wu J,O'Neill J,Barbosa MS

    更新日期:1998-01-01 00:00:00

  • Three-dimensional structure of a protozoal double-stranded RNA virus that infects the enteric pathogen Giardia lamblia.

    abstract:UNLABELLED:Giardia lamblia virus (GLV) is a small, nonenveloped, nonsegmented double-stranded RNA (dsRNA) virus infecting Giardia lamblia, the most common protozoan pathogen of the human intestine and a major agent of waterborne diarrheal disease worldwide. GLV (genus Giardiavirus) is a member of family Totiviridae, al...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02745-14

    authors: Janssen ME,Takagi Y,Parent KN,Cardone G,Nibert ML,Baker TS

    更新日期:2015-01-15 00:00:00

  • Rotavirus genome segment 4 determines viral replication phenotype in cultured liver cells (HepG2).

    abstract::One-step growth determinations were performed with five strains of rotavirus in HepG2, a cell line derived from human liver. Three virus strains (SA11-C13, SA11-C14, and RRV) replicated in HepG2 cells and attained yields 10- to 100-fold above input titers. Two virus strains (B223 and SA11-4F) failed to replicate above...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.64.3.1044-1049.1990

    authors: Ramig RF,Galle KL

    更新日期:1990-03-01 00:00:00

  • Identification, characterization, and sequence analysis of a cDNA encoding a phosphoprotein of human herpesvirus 6.

    abstract::Human herpesvirus 6 (HHV-6)-specific monoclonal antibody (Mab) 9A5D12 reacted with the nucleus of HHV-6 strain GS-infected cells and immunoprecipitated a phosphorylated polypeptide with an approximate size of 41 kDa, designated HHV-6 P41. A 110-kDa polypeptide was also immunoprecipitated by the MAb. These polypeptides...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.65.6.2884-2894.1991

    authors: Chang CK,Balachandran N

    更新日期:1991-06-01 00:00:00

  • HIV-1 Gag associates with specific uropod-directed microdomains in a manner dependent on its MA highly basic region.

    abstract::In polarized T cells, HIV-1 Gag localizes to a rear-end protrusion known as the uropod in a multimerization-dependent manner. Gag-laden uropods participate in formation of virological synapses, intercellular contact structures that play a key role in cell-to-cell HIV-1 transmission. Our previous observations suggest t...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00040-13

    authors: Llewellyn GN,Grover JR,Olety B,Ono A

    更新日期:2013-06-01 00:00:00

  • In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor.

    abstract::ABT-378, a new human immunodeficiency virus type 1 (HIV-1) protease inhibitor which is significantly more active than ritonavir in cell culture, is currently under investigation for the treatment of AIDS. Development of viral resistance to ABT-378 in vitro was studied by serial passage of HIV-1 (pNL4-3) in MT-4 cells....

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.72.9.7532-7541.1998

    authors: Carrillo A,Stewart KD,Sham HL,Norbeck DW,Kohlbrenner WE,Leonard JM,Kempf DJ,Molla A

    更新日期:1998-09-01 00:00:00

  • Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis.

    abstract::Infection with the murine coronavirus strain JHM decreases cell surface expression of major histocompatibility complex class I antigens. Northern blots showed that JHM virus infection rapidly reduced the level of actin mRNA, whereas the levels of major histocompatibility complex class I and tubulin mRNAs were reduced ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.68.10.6815-6819.1994

    authors: Kyuwa S,Cohen M,Nelson G,Tahara SM,Stohlman SA

    更新日期:1994-10-01 00:00:00

  • Relative replication fitness of a high-level 3'-azido-3'-deoxythymidine-resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr-->Gly) at codon 69.

    abstract::The combination of an amino acid deletion at codon 67 (delta 67) and Thr-to-Gly change at codon 69 (T69G) in the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) is associated with high-level resistance to multiple RT inhibitors. To determine the relative contributions of the delta 67 and T69G...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.74.23.10958-10964.2000

    authors: Imamichi T,Berg SC,Imamichi H,Lopez JC,Metcalf JA,Falloon J,Lane HC

    更新日期:2000-12-01 00:00:00

  • The ATR signaling pathway is disabled during infection with the parvovirus minute virus of mice.

    abstract:UNLABELLED:The ATR kinase has essential functions in maintenance of genome integrity in response to replication stress. ATR is recruited to RPA-coated single-stranded DNA at DNA damage sites via its interacting partner, ATRIP, which binds to the large subunit of RPA. ATR activation typically leads to activation of the ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01412-14

    authors: Adeyemi RO,Pintel DJ

    更新日期:2014-09-01 00:00:00

  • Identification of a gp41 core-binding molecule with homologous sequence of human TNNI3K-like protein as a novel human immunodeficiency virus type 1 entry inhibitor.

    abstract::Human immunodeficiency virus type 1 (HIV-1) gp41 plays a critical role in the viral fusion process, and its N- and C-terminal heptad repeat domains serve as important targets for developing anti-HIV-1 drugs, like T-20 (generic name, enfuvirtide; brand name, Fuzeon). Here, we conducted a yeast two-hybrid screening on a...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00644-10

    authors: Zhu Y,Lu L,Xu L,Yang H,Jiang S,Chen YH

    更新日期:2010-09-01 00:00:00

  • Naive T-cell depletion related to infection by X4 human immunodeficiency virus type 1 in poor immunological responders to highly active antiretroviral therapy.

    abstract::The reasons for poor CD4+ T-cell recovery in some human immunodeficiency virus (HIV)-infected subjects despite effective highly active antiretroviral therapy (HAART) remain unclear. We recently reported that CXCR4-using (X4) HIV-1 could be gradually selected in cellular reservoirs during sustained HAART. Because of th...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00965-06

    authors: Delobel P,Nugeyre MT,Cazabat M,Sandres-Sauné K,Pasquier C,Cuzin L,Marchou B,Massip P,Cheynier R,Barré-Sinoussi F,Izopet J,Israël N

    更新日期:2006-10-01 00:00:00

  • Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins.

    abstract::The cytoplasmic domains of the transmembrane (TM) envelope proteins (TM-CDs) of most retroviruses have a Tyr-based motif, YXXO, in their membrane-proximal regions. This signal is involved in the trafficking and endocytosis of membrane receptors via clathrin-associated AP-1 and AP-2 adaptor complexes. We have used CD8-...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.73.2.1350-1361.1999

    authors: Berlioz-Torrent C,Shacklett BL,Erdtmann L,Delamarre L,Bouchaert I,Sonigo P,Dokhelar MC,Benarous R

    更新日期:1999-02-01 00:00:00

  • An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: downregulated immune activation and improved T cell-dependent vaccine responses.

    abstract::Chronic HIV infection is characterized by chronic immune activation and dysfunctional T cells with elevated intracellular cyclic AMP (cAMP), which inhibits the T cell activation capability. cAMP may be induced by prostaglandin E(2) following lipopolysaccharide (LPS)-induced upregulation of cyclooxygenase type 2 (COX-2...

    journal_title:Journal of virology

    pub_type: 杂志文章,随机对照试验

    doi:10.1128/JVI.00073-11

    authors: Pettersen FO,Torheim EA,Dahm AE,Aaberge IS,Lind A,Holm M,Aandahl EM,Sandset PM,Taskén K,Kvale D

    更新日期:2011-07-01 00:00:00

  • CTCF-dependent chromatin boundary element between the latency-associated transcript and ICP0 promoters in the herpes simplex virus type 1 genome.

    abstract::Cells latently infected with herpes simplex virus (HSV) contain nucleosomal DNA similar to that of host cell chromatin. Recent studies have demonstrated that histones in the latency-associated transcript (LAT) promoter and intron regions contain histone modifications permissive for transcription. However, those histon...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.02447-06

    authors: Chen Q,Lin L,Smith S,Huang J,Berger SL,Zhou J

    更新日期:2007-05-01 00:00:00

  • B-lymphoma induction by reticuloendotheliosis virus: characterization of a mutated chicken syncytial virus provirus involved in c-myc activation.

    abstract::Nondefective reticuloendotheliosis virus induces chicken bursal lymphoma in a manner similar to that of avian leukosis virus. The provirus integrates in the c-myc locus and uses a promoter insertion mechanism to activate c-myc expression. We cloned a provirus involved in c-myc activation from a B lymphoma. Detailed st...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.61.7.2084-2090.1987

    authors: Swift RA,Boerkoel C,Ridgway A,Fujita DJ,Dodgson JB,Kung HJ

    更新日期:1987-07-01 00:00:00

  • Porcine teschoviruses comprise at least eleven distinct serotypes: molecular and evolutionary aspects.

    abstract::Nucleotide sequencing and phylogenetic analysis of 10 recognized prototype strains of the porcine enterovirus (PEV) cytopathic effect (CPE) group I reveals a close relationship of the viral genomes to the previously sequenced strain F65, supporting the concept of a reclassification of this virus group into a new picor...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.75.4.1620-1631.2001

    authors: Zell R,Dauber M,Krumbholz A,Henke A,Birch-Hirschfeld E,Stelzner A,Prager D,Wurm R

    更新日期:2001-02-01 00:00:00

  • Analysis of simian virus 40-induced transformation of hamster kidney tissue in vitro. 8. Induction of infectious simian virus 40 from virogenie transformed hamster cells by amino acid deprivation or cycloheximide treatment.

    abstract::Clones of virogenic simian virus 40 (SV40)-transformed hamster kidney cells were exposed to medium deficient in the essential amino acids leucine, arginine, or methionine. Infectious virus was induced after deprivation periods of from 24 to 32 hr. The highest yields of infectious SV40 were obtained from cultures depri...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.9.3.448-453.1972

    authors: Kaplan JC,Wilbert SM,Black PH

    更新日期:1972-03-01 00:00:00

  • Expression and function of chemokine receptors on human thymocytes: implications for infection by human immunodeficiency virus type 1.

    abstract::The presence or absence of the receptor CD4 and the coreceptors CCR5 and CXCR4 restrict the cell tropism of human immunodeficiency virus type 1 (HIV-1). Despite the importance of thymic infection by HIV-1, conflicting reports regarding the expression of HIV-1 coreceptors on human thymocytes have not been resolved. We ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.75.18.8752-8760.2001

    authors: Taylor JR Jr,Kimbrell KC,Scoggins R,Delaney M,Wu L,Camerini D

    更新日期:2001-09-01 00:00:00

  • Properties of Corynebacterium acnes bacteriophage and description of an interference phenomenon.

    abstract::Nine virulent bacteriophages of the anaerobe Corynebacterium (Propionibacterium) acnes, the P-a series, are DNA phages, with long, curved nonretractile tails (130 nm) without tail plates or fibers. They have isometric heads (420 by 460 nm), and are placed in Bradley's group B-1. There is permanent plaque suppression a...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.14.5.1268-1273.1974

    authors: Zierdt CH

    更新日期:1974-11-01 00:00:00

  • Evolutionary relationships and systematics of the alphaviruses.

    abstract::Partial E1 envelope glycoprotein gene sequences and complete structural polyprotein sequences were used to compare divergence and construct phylogenetic trees for the genus Alphavirus. Tree topologies indicated that the mosquito-borne alphaviruses could have arisen in either the Old or the New World, with at least two...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.75.21.10118-10131.2001

    authors: Powers AM,Brault AC,Shirako Y,Strauss EG,Kang W,Strauss JH,Weaver SC

    更新日期:2001-11-01 00:00:00

  • Monomeric APOBEC3G is catalytically active and has antiviral activity.

    abstract::APOBEC3G (APO3G) is a cytidine deaminase that restricts replication of vif-defective human immunodeficiency virus type 1 (HIV-1). Like other members of the cellular deaminase family, APO3G has the propensity to form homo-multimers. In the current study, we investigated the functional determinants for multimerization o...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.80.10.4673-4682.2006

    authors: Opi S,Takeuchi H,Kao S,Khan MA,Miyagi E,Goila-Gaur R,Iwatani Y,Levin JG,Strebel K

    更新日期:2006-05-01 00:00:00

  • Insertion mutation of the int-1 and int-2 loci by mouse mammary tumor virus in premalignant and malignant neoplasms from the GR mouse strain.

    abstract::Mouse mammary tumor virus (MMTV)-induced mammary adenocarcinomas can develop from several different premalignant precursors common in GR mice. Insertion mutagenesis of the mammary protooncogenes int-1 and int-2 was studied in this multistep system by analyzing samples from various stages of neoplastic development for ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.64.4.1794-1802.1990

    authors: Morris DW,Barry PA,Bradshaw HD Jr,Cardiff RD

    更新日期:1990-04-01 00:00:00

  • Characterization of T-even bacteriophage substructures. I. Tail fibers and tail tubes.

    abstract::T-even bacteriophages were grown and purified in bulk quantities. The protein coats were disrupted into their component substructures by treatment with 67% dimethyl sulfoxide (DMSO). Tail fibers and tubes were purified on glycerol-CsCl-D(2)O gradients and examined with respect to sedimentation properties, subunit mole...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.6.4.534-544.1970

    authors: Cummings DJ,Kusy AR,Chapman VA,DeLong SS,Stone KR

    更新日期:1970-10-01 00:00:00

  • Resolving the assembly state of herpes simplex virus during axon transport by live-cell imaging.

    abstract::Neurotropic herpesviruses depend on long-distance axon transport for the initial establishment of latency in peripheral ganglia (retrograde transport) and for viral spread in axons to exposed body surfaces following reactivation (anterograde transport). Images of neurons infected with herpes simplex virus type 1 (HSV-...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01296-10

    authors: Antinone SE,Zaichick SV,Smith GA

    更新日期:2010-12-01 00:00:00

  • Differences in determinants required for complex formation and transactivation in related VP16 proteins.

    abstract::VP16-H is an essential structural protein of herpes simplex virus type 1 (HSV-1) and is also a potent activator of virus immediate-early (IE) gene expression. Current models of functional determinants within VP16-H indicate that it consists of two domains, an N-terminal domain involved in recruiting VP16-H to a multic...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.74.21.10112-10121.2000

    authors: Grapes M,O'Hare P

    更新日期:2000-11-01 00:00:00

  • Early events in parvovirus replication: lack of integration by minute virus of mice into host cell DNA.

    abstract::Viral DNA sequences were not detected in high-molecular-weight host DNA until well after the onset of viral DNA replication. ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.30.1.397-399.1979

    authors: Richards RG,Armentrout RW

    更新日期:1979-04-01 00:00:00