Relative replication fitness of a high-level 3'-azido-3'-deoxythymidine-resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr-->Gly) at codon 69.

abstract：:Adenovirus gene therapy is a promising tool in the clinical treatment of many genetic and acquired diseases. However, it has also caused pathogenic effects in organs such as the liver. The redox-sensitive transcription factors AP-1 and NF-kappaB have been implicated in these effects. To study the mechanisms of adenovi...

journal_title：Journal of virology

authors： Zhang HJ,Drake VJ,Xu L,Hu J,Domann FE,Oberley LW,Kregel KC

更新日期：2002-01-01 00:00:00

abstract：:Human metapneumovirus (hMPV) is a leading cause of viral lower respiratory tract infection in children. The sole target of neutralizing antibodies targeting hMPV is the fusion (F) protein, a class I viral fusion protein mediating virus-cell membrane fusion. There have been several monoclonal antibodies (mAbs) isolated...

journal_title：Journal of virology

authors： Bar-Peled Y,Diaz D,Pena-Briseno A,Murray J,Huang J,Tripp RA,Mousa JJ

更新日期：2019-09-12 00:00:00

abstract：:The ability of HIV-1 to establish a latent infection presents a barrier to curing HIV. The best-studied reservoir of latent virus in vivo is resting memory CD4(+) T cells, but it has recently been shown that CD34(+) hematopoietic progenitor cells (HPCs) can also become latently infected by HIV-1 in vitro and in vivo. ...

journal_title：Journal of virology

authors： McNamara LA,Ganesh JA,Collins KL

更新日期：2012-09-01 00:00:00

abstract：:LA3382 is a temperature-sensitive replication-defective mutant of Rous sarcoma virus that contains four active mutations. In this study we performed experiments to determine the biochemical defect that blocks the synthesis of infections virus late in the replication cycle. At the nonpermissive temperature (41 degrees ...

journal_title：Journal of virology

authors： Hardwick JM,Hunter E

更新日期：1981-12-01 00:00:00

abstract：:Transcriptional stimulatory properties of virus-encoded transactivators appear to be critical for viral gene expression and may be linked to cellular transformation in certain cases. Recently, the simian virus 40 (SV40) 17-kDa small-t antigen was shown to stimulate transcription of polymerase II and III genes in trans...

journal_title：Journal of virology

authors： Rajan P,Dhamankar V,Rundell K,Thimmapaya B

更新日期：1991-12-01 00:00:00

abstract：:We have tested triple and quadruple combinations of human monoclonal antibodies (MAbs), which are directed against various epitopes on human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins, and a high-titer anti-HIV-1 human immunoglobulin (HIVIG) preparation for their abilities to neutralize a chimeric si...

journal_title：Journal of virology

authors： Li A,Katinger H,Posner MR,Cavacini L,Zolla-Pazner S,Gorny MK,Sodroski J,Chou TC,Baba TW,Ruprecht RM

更新日期：1998-04-01 00:00:00

abstract：:Since parvoviruses apparently do not possess a DNA polymerase activity, one or more of the host cell DNA polymerases must be responsible for replicating the single-stranded DNA genome. We have focused on determining which polymerase, alpha, beta, or gamma (pol alpha, pol beta, or pol gamma, respectively), is responsib...

journal_title：Journal of virology

authors： Robertson AT,Stout ER,Bates RC

更新日期：1984-03-01 00:00:00

abstract：:The smallpox vaccine is the prototypic vaccine, yet the viral targets critical for vaccine-mediated protection remain unclear in humans. We have produced protein microarrays of a near-complete vaccinia proteome and used them to determine the major antigen specificities of the human humoral immune response to the small...

journal_title：Journal of virology

authors： Davies DH,McCausland MM,Valdez C,Huynh D,Hernandez JE,Mu Y,Hirst S,Villarreal L,Felgner PL,Crotty S

更新日期：2005-09-01 00:00:00

abstract：:S-Adenosylhomocysteine was found to have no effect on Epstein-Barr virus-induced transformation of B-lymphocytes and to stimulate viral capsid antigen expression only slightly in the FF41-1 cell line. In contrast, the S-adenosylhomocysteine analogs sinefungin and S-isobutyladenosine inhibited Epstein-Barr virus transf...

journal_title：Journal of virology

authors： Long WK,Fronko GE,Lindemeyer RG,Wu B,Henderson EE

更新日期：1987-01-01 00:00:00

abstract：UNLABELLED:Nonhuman primates (NHPs) are a historically important source of zoonotic viruses and are a gold-standard model for research on many human pathogens. However, with the exception of simian immunodeficiency virus (SIV) (family Retroviridae), the blood-borne viruses harbored by these animals in the wild remain i...

journal_title：Journal of virology

authors： Bailey AL,Lauck M,Ghai RR,Nelson CW,Heimbruch K,Hughes AL,Goldberg TL,Kuhn JH,Jasinska AJ,Freimer NB,Apetrei C,O'Connor DH

更新日期：2016-07-11 00:00:00

abstract：:Mounting evidence suggests that human immunodeficiency virus type 1 (HIV-1) Gag-specific T helper cells contribute to effective antiviral control, but their functional characteristics and the precise epitopes targeted by this response remain to be defined. In this study, we generated CD4(+) T-cell clones specific for ...

journal_title：Journal of virology

authors： Norris PJ,Sumaroka M,Brander C,Moffett HF,Boswell SL,Nguyen T,Sykulev Y,Walker BD,Rosenberg ES

更新日期：2001-10-01 00:00:00

abstract：:Natural killer (NK) cells serve as a crucial first-line defense against tumors and virus-infected cells. We previously showed that lysis of influenza virus (IV)-infected cells is mediated by the interaction between the NK receptor, NKp46, and the IV hemagglutinin (HA) type 1 expressed by the infected cells. This inter...

journal_title：Journal of virology

authors： Mendelson M,Tekoah Y,Zilka A,Gershoni-Yahalom O,Gazit R,Achdout H,Bovin NV,Meningher T,Mandelboim M,Mandelboim O,David A,Porgador A

更新日期：2010-04-01 00:00:00

abstract：:The release of Bluetongue virus (BTV) and other members of the Orbivirus genus from infected host cells occurs predominantly by cell lysis, and in some cases, by budding from the plasma membrane. Two nonstructural proteins, NS3 and NS3A, have been implicated in this process. Here we show that both proteins bind to hum...

journal_title：Journal of virology

authors： Wirblich C,Bhattacharya B,Roy P

更新日期：2006-01-01 00:00:00

abstract：:The mechanism by which bovine herpesvirus 1 (BHV-1) predisposes cattle to bacterial pneumonia was investigated by using an in vitro system to demonstrate immunosuppression. At a multiplicity of infection of 0.001, live or inactivated BHV-1 induced a 50% inhibition of the proliferative response of peripheral blood mono...

journal_title：Journal of virology

authors： Hutchings DL,Campos M,Qualtiere L,Babiuk LA

更新日期：1990-09-01 00:00:00

abstract：:Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of nanobodies (Nbs) to target lentiv...

journal_title：Journal of virology

authors： Goyvaerts C,Dingemans J,De Groeve K,Heirman C,Van Gulck E,Vanham G,De Baetselier P,Thielemans K,Raes G,Breckpot K

更新日期：2013-10-01 00:00:00

abstract：:Incorporation of the vaccinia virus A36R protein into the outer membrane of intracellular enveloped virions (IEV) is dependent on expression of the A33R protein. Possible interactions of the 200-amino-acid cytoplasmic domain of the A36R protein with itself or with the cytoplasmic domain of the A33R, A34R, B5R, or F12L...

journal_title：Journal of virology

authors： Ward BM,Weisberg AS,Moss B

更新日期：2003-04-01 00:00:00

abstract：:Japanese encephalitis virus (JEV) is a mosquito-borne pathogenic flavivirus responsible for acute viral encephalitis in humans. The cellular entry of JEV is poorly characterized in terms of molecular requirements and pathways. Here we present a systematic study of the internalization mechanism of JEV in fibroblasts an...

journal_title：Journal of virology

authors： Kalia M,Khasa R,Sharma M,Nain M,Vrati S

更新日期：2013-01-01 00:00:00

abstract：:Fcgamma receptor (FcgammaR)-mediated entry of infectious dengue virus immune complexes into monocytes/macrophages is hypothesized to be a key event in the pathogenesis of complicated dengue fever. FcgammaRIA (CD64) and FcgammaRIIA (CD32), which predominate on the surface of such dengue virus-permissive cells, were com...

journal_title：Journal of virology

authors： Rodrigo WW,Jin X,Blackley SD,Rose RC,Schlesinger JJ

更新日期：2006-10-01 00:00:00

abstract：:We have selected neutralization escape mutants by using a monoclonal antibody (nt-MAb) against a sequential epitope between amino acids 93 through 104 (neutralization antigenic site I) of poliovirus type 1 Mahoney. The majority of mutants were also resistant against five strain-specific nt-MAbs which recognized confor...

journal_title：Journal of virology

authors： Wiegers K,Uhlig H,Dernick R

更新日期：1988-05-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is the most common opportunistic infection in immunosuppressed individuals, such as transplant recipients or people living with HIV/AIDS, and congenital CMV is the leading viral cause of developmental disabilities in infants. Due to the highly species-specific nature of CMV, animal mode...

journal_title：Journal of virology

authors： Marsh AK,Willer DO,Ambagala AP,Dzamba M,Chan JK,Pilon R,Fournier J,Sandstrom P,Brudno M,MacDonald KS

更新日期：2011-12-01 00:00:00

abstract：:Macrophage adherence, an important regulatory signal, has the potential to affect human immunodeficiency virus (HIV) production either directly or by priming monocytes to respond to other activating signals. We have investigated the role of adherence as an activator of HIV-1 transcription and release. The effects of a...

journal_title：Journal of virology

authors： Shattock RJ,Friedland JS,Griffin GE

更新日期：1993-06-01 00:00:00

abstract：:We have demonstrated that a liposomal array of well-ordered trimers enhances B cell activation, germinal center formation, and the elicitation of tier-2 autologous neutralizing antibodies. Previously, we coupled well-ordered cleavage-independent NFL trimers via their C-terminal polyhistidine tails to nickel lipids int...

journal_title：Journal of virology

authors： Bale S,Goebrecht G,Stano A,Wilson R,Ota T,Tran K,Ingale J,Zwick MB,Wyatt RT

更新日期：2017-07-27 00:00:00

abstract：:10A1 murine leukemia virus can enter cells by using either of two different cell surface phosphate transport proteins, the gibbon ape leukemia virus receptor Glvr-1 (Pit-1) or the amphotropic retrovirus receptor Ram-1 (Pit-2). Glvr-1 and Ram-1 are widely expressed in different tissues, but the relative amounts of each...

journal_title：Journal of virology

authors： Miller AD,Chen F

更新日期：1996-08-01 00:00:00

abstract：:Synthetic peptides of increasing length and corresponding in sequence to the C-terminal end of the HA1 molecule of influenza virus were constructed and examined for their immunogenic and antigenic properties. Peptides containing at least the four C-terminal amino acids, when coupled to keyhole limpet hemocyanin, were ...

journal_title：Journal of virology

authors： Tang XL,Tregear GW,White DO,Jackson DC

更新日期：1988-12-01 00:00:00

abstract：:Knowledge of the mechanisms of virus dissemination in acute measles is cursory, but cells of the monocyte/macrophage (MM) lineage appear to be early targets. We characterized the dissemination of the Edmonston B vaccine strain of measles virus (MV-Ed) in peripheral blood mononuclear cells (PBMC) of two mouse strains e...

journal_title：Journal of virology

authors： Roscic-Mrkic B,Schwendener RA,Odermatt B,Zuniga A,Pavlovic J,Billeter MA,Cattaneo R

更新日期：2001-04-01 00:00:00

abstract：:We determined the capacity of microcapsules formed by the combination of sodium alginate, an aqueous anionic polymer, and spermine hydrochloride, an aqueous cationic amine, to enhance protection against rotavirus challenge in mice. Adult BALB/c mice were orally inoculated with either free or microencapsulated rotaviru...

journal_title：Journal of virology

authors： Moser CA,Speaker TJ,Offit PA

更新日期：1998-05-01 00:00:00

abstract：:The cytotoxic T-lymphocyte (CTL) response to lymphocytic choriomeningitis virus infection determines the outcome of infection. Here we show that this response in BALB/c mice (H-2d), when analyzed both at the primary CTL level and using CTL clones, is predominantly monospecific. The vast majority of CTL have a common s...

journal_title：Journal of virology

authors： Whitton JL,Tishon A,Lewicki H,Gebhard J,Cook T,Salvato M,Joly E,Oldstone MB

更新日期：1989-10-01 00:00:00

abstract：:Antiviral effects were characterized for two oligodeoxyribonucleoside methylphosphonates synthesized in an antisense (3'-TCTTAACC-5') or a sense (5'-AGAATTGG-3') orientation, based on the RNA sequence of the first splice acceptor site of the tat-3 gene of human immunodeficiency virus (HIV) (5'...AGAAUUGG...3'). The de...

journal_title：Journal of virology

authors： Zaia JA,Rossi JJ,Murakawa GJ,Spallone PA,Stephens DA,Kaplan BE,Eritja R,Wallace RB,Cantin EM

更新日期：1988-10-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) possesses low pathogenic potential in an immunocompetent host. In the immunosuppressed host, however, a wide spectrum of infection outcomes, ranging from asymptomatic to life threatening, can follow either primary or nonprimary infection. The variability in the manifestations of HCMV infec...

journal_title：Journal of virology

authors： Sequar G,Britt WJ,Lakeman FD,Lockridge KM,Tarara RP,Canfield DR,Zhou SS,Gardner MB,Barry PA

更新日期：2002-08-01 00:00:00

abstract：:Historically, the adenoviral E3 region was found to be nonessential for viral replication in vitro. In addition, adenoviruses whose genome was more than approximately 105% the size of the native genome were inefficiently packaged. These profound observations were used experimentally to insert transgenes into the adeno...

journal_title：Journal of virology

authors： Zhu M,Bristol JA,Xie Y,Mina M,Ji H,Forry-Schaudies S,Ennist DL

更新日期：2005-05-01 00:00:00