Targeting of human antigen-presenting cell subsets.

Abstract:

:Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of nanobodies (Nbs) to target lentivectors specifically to human lymph node-resident myeloid dendritic cells, demonstrating that Nbs represent a powerful tool to redirect lentivectors to human antigen-presenting cell subsets.

journal_name

J Virol

journal_title

Journal of virology

authors

Goyvaerts C,Dingemans J,De Groeve K,Heirman C,Van Gulck E,Vanham G,De Baetselier P,Thielemans K,Raes G,Breckpot K

doi

10.1128/JVI.01498-13

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

11304-8

issue

20

eissn

0022-538X

issn

1098-5514

pii

JVI.01498-13

journal_volume

87

pub_type

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