Abstract:
:Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of nanobodies (Nbs) to target lentivectors specifically to human lymph node-resident myeloid dendritic cells, demonstrating that Nbs represent a powerful tool to redirect lentivectors to human antigen-presenting cell subsets.
journal_name
J Viroljournal_title
Journal of virologyauthors
Goyvaerts C,Dingemans J,De Groeve K,Heirman C,Van Gulck E,Vanham G,De Baetselier P,Thielemans K,Raes G,Breckpot Kdoi
10.1128/JVI.01498-13subject
Has Abstractpub_date
2013-10-01 00:00:00pages
11304-8issue
20eissn
0022-538Xissn
1098-5514pii
JVI.01498-13journal_volume
87pub_type
杂志文章abstract::MC159 is a viral FLIP (FLICE inhibitory protein) encoded by the molluscum contagiosum virus (MCV) enabling MCV to evade antiviral immunity and to establish persistent infections in humans. Here, we show that MC159 contains a functional SH3 binding motif, which mediates avid and selective binding to SH3BP4, a signaling...
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
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abstract::Therapeutic suppression of human immunodeficiency virus type 1 (HIV-1) replication may help elucidate interactions between the host cellular immune responses and HIV-1 infection. We performed a detailed longitudinal evaluation of two subjects before and after the start of highly active antiretroviral therapy (HAART). ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.8.6721-6728.1999
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journal_title:Journal of virology
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journal_title:Journal of virology
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pub_type: 杂志文章
doi:10.1128/JVI.14.5.1310-1313.1974
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
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abstract::HBI is a recombinant avian retrovirus with novel pathogenic properties that was derived from the myc-containing virus MC29. In contrast to MC29, which causes endotheliomas in chickens, HBI induces lymphoid tumors. The results of molecular cloning and nucleotide sequencing of HBI reported here show that the virus conta...
journal_title:Journal of virology
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doi:10.1128/JVI.63.2.892-900.1989
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.23.11935-11938.2001
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journal_title:Journal of virology
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journal_title:Journal of virology
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.16.2.237-240.1975
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.11.3528-3535.1987
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.12.9855-9858.1997
更新日期:1997-12-01 00:00:00