Inhibition of human immunodeficiency virus by using an oligonucleoside methylphosphonate targeted to the tat-3 gene.

abstract：:Interspecies transmission of the transmissible spongiform encephalopathies (TSEs), or prion diseases, can result in the adaptation and selection of TSE strains with an expanded host range and increased virulence such as in the case of bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease. To investiga...

journal_title：Journal of virology

authors： Bartz JC,Bessen RA,McKenzie D,Marsh RF,Aiken JM

更新日期：2000-06-01 00:00:00

abstract：:Defining a macrophage-tropic phenotype for HIV-1 to assess a role in pathogenesis is complicated by the fact that HIV-1 isolates vary continuously in their ability to enter monocyte-derived macrophages (MDMs) in vitro, and MDMs vary in their ability to support HIV-1 entry. To overcome these limitations, we identified ...

journal_title：Journal of virology

authors： Joseph SB,Arrildt KT,Swanstrom AE,Schnell G,Lee B,Hoxie JA,Swanstrom R

更新日期：2014-02-01 00:00:00

abstract：:We isolated a simian virus 40 mutant, dl2194, which carried deletions in both early genes. One deletion removed 234 base pairs in the 54/59 region within the small-t-antigen coding sequence and the large-T-antigen gene intron. The second deletion removed 57 base pairs at the C terminus of the large-T-antigen coding se...

journal_title：Journal of virology

authors： Feunteun J,Carmichael G,Nicolas JC,Kress M

更新日期：1981-12-01 00:00:00

abstract：:Covalently closed circular molecules of viral DNA synthesized in virus-infected cells are composed mainly of monomers sedimenting at 22 to 27S in neutral sucrose gradients. These monomers are detected by annealing with complementary DNA or transfection assay. However, 11% of the infectious circles sediment faster than...

journal_title：Journal of virology

authors： Goubin G,Hill M

更新日期：1979-02-01 00:00:00

abstract：:Previous studies have suggested that the U(L)17 gene of herpes simplex virus type 1 (HSV-1) is essential for virus replication. In this study, viral mutants incorporating either a lacZ expression cassette in place of 1,490 bp of the 2,109-bp U(L)17 open reading frame [HSV-1(deltaU(L)17)] or a DNA oligomer containing a...

journal_title：Journal of virology

authors： Salmon B,Cunningham C,Davison AJ,Harris WJ,Baines JD

更新日期：1998-05-01 00:00:00

abstract：:Avian influenza virus (AIV) surveillance in Antarctica during 2013 revealed the prevalence of evolutionarily distinct influenza viruses of the H11N2 subtype in Adélie penguins. Here we present results from the continued surveillance of AIV on the Antarctic Peninsula during 2014 and 2015. In addition to the continued d...

journal_title：Journal of virology

authors： Hurt AC,Su YCF,Aban M,Peck H,Lau H,Baas C,Deng YM,Spirason N,Ellström P,Hernandez J,Olsen B,Barr IG,Vijaykrishna D,Gonzalez-Acuna D

更新日期：2016-10-14 00:00:00

abstract：:When short pulses of [(3)H]uracil were administered to Bacillus subtilis infected with phage 2C, the main species of labeled RNA was a 10S component that hybridized chiefly, but not exclusively, with the heavy strand of 2C DNA. After long pulses, most of the radioactivity was found in the 23S, 16S, and 5S rRNA's, whic...

journal_title：Journal of virology

authors： Cocito C

更新日期：1974-12-01 00:00:00

abstract：:Lipoxins are host anti-inflammatory molecules that play a vital role in restoring tissue homeostasis. The efficacy of lipoxins and their analog epilipoxins in treating inflammation and its associated diseases has been well documented. Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL) are two well-known inflamm...

journal_title：Journal of virology

authors： Chandrasekharan JA,Huang XM,Hwang AC,Sharma-Walia N

更新日期：2016-11-28 00:00:00

abstract：:Feline leukemia viruses (FeLVs) belonging to interference subgroup C induce fatal anemia resembling human pure red cell aplasia (PRCA). Subgroup A FeLVs, although closely related genetically to FeLVs of subgroup C, do not induce PRCA. The determinants for PRCA induction by a molecularly cloned prototype subgroup C vir...

journal_title：Journal of virology

authors： Dean GA,Groshek PM,Mullins JI,Hoover EA

更新日期：1992-09-01 00:00:00

abstract：:In polarized epithelial cells, the vesicular stomatitis virus glycoprotein is segregated to the basolateral plasma membrane, where budding of the virus takes place. We have generated recombinant viruses expressing mutant glycoproteins without the basolateral-membrane-targeting signal in the cytoplasmic domain. Though ...

journal_title：Journal of virology

authors： Zimmer G,Zimmer KP,Trotz I,Herrler G

更新日期：2002-04-01 00:00:00

abstract：:Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immuniz...

journal_title：Journal of virology

authors： Lewis AJ,Whitton JL,Hatalski CG,Weissenböck H,Lipkin WI

更新日期：1999-03-01 00:00:00

abstract：:Nucleic acids from an unidentified virus from ringed seals (Phoca hispida) were amplified using sequence-independent PCR, subcloned, and then sequenced. The full genome of a novel RNA virus was derived, identifying the first sequence-confirmed picornavirus in a marine mammal. The phylogenetic position of the tentative...

journal_title：Journal of virology

authors： Kapoor A,Victoria J,Simmonds P,Wang C,Shafer RW,Nims R,Nielsen O,Delwart E

更新日期：2008-01-01 00:00:00

abstract：:Noninfectious spikeless particles have been obtained from vesicular stomatitis virus (VSV, Indiana serotype) by bromelain or Pronase treatment. They lack the viral glycoprotein (G) but contain all the other viral components (RNA, lipid, and other structural proteins). Triton-solubilized VSV-Indiana glycoprotein prepar...

journal_title：Journal of virology

authors： Bishop DH,Repik P,Obijeski JF,Moore NF,Wagner RR

更新日期：1975-07-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) requires that its genome be reverse transcribed into double-stranded DNA for productive infection of cells. This process requires not only reverse transcriptase but also the nucleocapsid protein (NC), which functions as a nucleic acid chaperone. Reverse transcription general...

journal_title：Journal of virology

authors： Thomas JA,Bosche WJ,Shatzer TL,Johnson DG,Gorelick RJ

更新日期：2008-10-01 00:00:00

abstract：:Flavopiridol, roscovitine, and other inhibitors of Cyclin-Dependent Kinases (CDK) inhibit the replication of a variety of viruses in vitro while proving nontoxic in human clinical trials of their effects against cancer. Consequently, these and other Pharmacological CDK inhibitors (PCIs) have been proposed as potential...

journal_title：Journal of virology

authors： Diwan P,Lacasse JJ,Schang LM

更新日期：2004-09-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) of macaques isolate SIVmac239 is highly resistant to neutralization by polyclonal antisera or monoclonal antibodies, a property that it shares with most primary isolates of human immunodeficiency virus type 1 (HIV-1). This resistance is important for the ability of the virus to pers...

journal_title：Journal of virology

authors： Johnson WE,Sanford H,Schwall L,Burton DR,Parren PW,Robinson JE,Desrosiers RC

更新日期：2003-09-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is a highly species-specific herpesvirus that targets sensory ganglionic neurons. This species specificity has limited the study of many aspects of VZV pathogenesis, including neuronal infection. We report development of a highly efficient neuroblastoma cell model to study productive VZV i...

journal_title：Journal of virology

authors： Christensen J,Steain M,Slobedman B,Abendroth A

更新日期：2011-08-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV/human herpesvirus 8 [HHV-8]) is a gamma-2-herpesvirus responsible for Kaposi's sarcoma as well as primary effusion lymphoma (PEL). KSHV is a lymphotropic virus that has pirated many mammalian genes involved in inflammation, cell cycle control, and angiogenesis. Among these...

journal_title：Journal of virology

authors： Cannon M,Philpott NJ,Cesarman E

更新日期：2003-01-01 00:00:00

abstract：:When mouse L cells are infected for 22 hr with vesicular stomatitis virus (VSV), a ribonucleic acid-containing enveloped virus, greater than 70% of the major histocompatibility antigen (H-2), is no longer detectable by the method of inhibition of immune cytolysis. Infected cells prelabeled with (14)C-glucosamine also ...

journal_title：Journal of virology

authors： Hecht TT,Summers DF

更新日期：1972-10-01 00:00:00

abstract：UNLABELLED:Multiple cellular pathways are regulated by small ubiquitin-like modifier (SUMO) modification, including ubiquitin-mediated proteolysis, signal transduction, innate immunity, and antiviral defense. In the study described in this report, we investigated the effects of SUMO on the replication of two members of...

journal_title：Journal of virology

authors： Maarifi G,Hannoun Z,Geoffroy MC,El Asmi F,Zarrouk K,Nisole S,Blondel D,Chelbi-Alix MK

更新日期：2016-06-24 00:00:00

abstract：:The Moloney murine leukemia virus (MuLV) is a highly leukemogenic virus. To map the leukemogenic potential of Moloney MuLV, we constructed chimeric viral DNA genomes in vitro between parental cloned infectious viral DNA from Moloney and amphotropic 4070-A MuLVs. Infectious chimeric MuLVs were recovered by microinjecti...

journal_title：Journal of virology

authors： DesGroseillers L,Jolicoeur P

更新日期：1984-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) uses tonsils as the portal of entry to establish persistent infection. EBV is found in various B-cell subsets in tonsils but exclusively in memory B cells in peripheral blood. The in vitro susceptibilities of B-cell subsets to EBV infection have been studied solely qualitatively. In this work,...

journal_title：Journal of virology

authors： Dorner M,Zucol F,Berger C,Byland R,Melroe GT,Bernasconi M,Speck RF,Nadal D

更新日期：2008-05-01 00:00:00

abstract：:Despite successful antiretroviral therapy (ART), low-level viremia (LLV) may be intermittently detected in most HIV-infected patients. Longitudinal blood plasma and resting CD4(+) T cells were obtained from two patients on suppressive ART to investigate the source of LLV. Single-genome sequencing of HIV-1 env from LLV...

journal_title：Journal of virology

authors： Anderson JA,Archin NM,Ince W,Parker D,Wiegand A,Coffin JM,Kuruc J,Eron J,Swanstrom R,Margolis DM

更新日期：2011-05-01 00:00:00

abstract：:Restriction factors are intrinsic cellular defense proteins that have evolved to block microbial infections. Retroviruses such as HIV-1 are restricted by TRIM5 proteins, which recognize the viral capsid shell that surrounds, organizes, and protects the viral genome. TRIM5α uses a SPRY domain to bind capsids with low i...

journal_title：Journal of virology

authors： Wagner JM,Christensen DE,Bhattacharya A,Dawidziak DM,Roganowicz MD,Wan Y,Pumroy RA,Demeler B,Ivanov DN,Ganser-Pornillos BK,Sundquist WI,Pornillos O

更新日期：2018-01-30 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV68 [also known as gammaHV-68]) is distinguished by its ability to replicate to high titers in cultured cells, making it an excellent candidate for studying gammaherpesvirus virion composition. Extracellular MHV68 virions were isolated, and abundant virion-associated proteins were identif...

journal_title：Journal of virology

authors： Bortz E,Whitelegge JP,Jia Q,Zhou ZH,Stewart JP,Wu TT,Sun R

更新日期：2003-12-01 00:00:00

abstract：:To identify the domains of Vpr that are involved nuclear localization, we transfected HeLa cells with a panel of expression vectors that encode mutant Vpr protein with deletions or substitutions within putative domains. Immunofluorescence staining of transfected cells revealed that wild-type Vpr was localized predomin...

journal_title：Journal of virology

authors： Kamata M,Aida Y

更新日期：2000-08-01 00:00:00

abstract：:Previous studies have demonstrated that the genetic determinants of simian immunodeficiency virus (SIV) neurovirulence map to the env and nef genes. Recent studies from our laboratory demonstrated that SIV replication in primary rhesus macaque astrocyte cultures is dependent upon the nef gene. Here, we demonstrate tha...

journal_title：Journal of virology

authors： Overholser ED,Babas T,Zink MC,Barber SA,Clements JE

更新日期：2005-04-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) possesses low pathogenic potential in an immunocompetent host. In the immunosuppressed host, however, a wide spectrum of infection outcomes, ranging from asymptomatic to life threatening, can follow either primary or nonprimary infection. The variability in the manifestations of HCMV infec...

journal_title：Journal of virology

authors： Sequar G,Britt WJ,Lakeman FD,Lockridge KM,Tarara RP,Canfield DR,Zhou SS,Gardner MB,Barry PA

更新日期：2002-08-01 00:00:00

abstract：:The Cp promoter of Epstein-Barr virus (EBV) directs most transcription of the EBNA genes in lymphoblastoid cell lines. The functions of two control regions in the Cp promoter have been studied by construction of recombinant EBV strains containing specific mutations in these elements. Mutation of the RBP-Jk (CBF1) bind...

journal_title：Journal of virology

authors： Evans TJ,Farrell PJ,Swaminathan S

更新日期：1996-03-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) immediate-early 2 (IE2) transactivator has previously been shown to form intranuclear, dot-like accumulations in association with subnuclear structures known as promyelocytic leukemia protein (PML) nuclear bodies or ND10. We recently observed that IE2 can form dot-like structures even ...

journal_title：Journal of virology

authors： Sourvinos G,Tavalai N,Berndt A,Spandidos DA,Stamminger T

更新日期：2007-09-01 00:00:00