Abstract:
:Despite successful antiretroviral therapy (ART), low-level viremia (LLV) may be intermittently detected in most HIV-infected patients. Longitudinal blood plasma and resting CD4(+) T cells were obtained from two patients on suppressive ART to investigate the source of LLV. Single-genome sequencing of HIV-1 env from LLV plasma was performed, and the sequences were compared to sequences recovered from limiting-dilution outgrowth assays of resting CD4(+) T cells. The circulating LLV virus clone was identical to virus recovered from outgrowth assays from pools of millions of resting CD4(+) T cells. Understanding the sources of LLV requires evaluation of all possible reservoirs of persistent HIV infection.
journal_name
J Viroljournal_title
Journal of virologyauthors
Anderson JA,Archin NM,Ince W,Parker D,Wiegand A,Coffin JM,Kuruc J,Eron J,Swanstrom R,Margolis DMdoi
10.1128/JVI.00284-11subject
Has Abstractpub_date
2011-05-01 00:00:00pages
5220-3issue
10eissn
0022-538Xissn
1098-5514pii
JVI.00284-11journal_volume
85pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.71.4.3307-3311.1997
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.11.6376-6379.1991
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00745-18
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pub_type: 杂志文章
doi:10.1128/JVI.63.4.1800-1802.1989
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.06791-11
更新日期:2012-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01470-20
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.10.5184-5193.2004
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.17.7834-7841.2000
更新日期:2000-09-01 00:00:00
abstract::Capsids of polyomaviruses--small, nonenveloped DNA viruses--consist of the major structural protein VP1 and the minor structural proteins VP2 and VP3. The contributions of the individual capsid proteins to functions of the viral particle, such as DNA encapsidation, cell receptor attachment, entry, and uncoating, are s...
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pub_type: 杂志文章
doi:10.1128/JVI.70.11.7517-7526.1996
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