Abstract:
:Serological surveys have revealed that 30 to 50% of wild-caught African green monkeys have antibodies reactive to simian immunodeficiency virus (SIV), a retrovirus related to human immunodeficiency virus (HIV). Although the nucleotide sequence of one SIVagm isolate, Tyo1, was recently reported, the extent of genetic variability among SIVagm isolates remains to be determined. Restriction endonuclease mapping of infectious molecular clones of two SIVagm isolates (266 and 385), described in this note, revealed conservation of only 4 of 39 sites across the genome. Partial sequence analysis of the molecular clones revealed only 80% amino acid sequence conservation in the pol gene. Although the three Kenyan SIVagm isolates, Tyo1, 385, and 266, are more closely related to each other than to other primate lentiviruses, genetic variation among these three isolates is much greater than that observed previously among individual HIV type 1 (HIV-1), HIV-2, or SIVmac isolates. Less variability among HIV-1 and HIV-2 isolates could be explained by recent entry into the human population. The extensive genetic variation in these Kenyan SIVagm isolates should prompt continued examination of SIVagm variability from dispersed geographic regions; SIVagm strains much more closely related to HIV-1, HIV-2, or SIVmac which would be reasonable candidates for recent cross-species transmission may be found.
journal_name
J Viroljournal_title
Journal of virologyauthors
Li Y,Naidu YM,Daniel MD,Desrosiers RCdoi
10.1128/JVI.63.4.1800-1802.1989subject
Has Abstractpub_date
1989-04-01 00:00:00pages
1800-2issue
4eissn
0022-538Xissn
1098-5514journal_volume
63pub_type
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journal_title:Journal of virology
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doi:10.1128/JVI.64.9.4549-4552.1990
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.3.1408-1413.1991
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doi:10.1128/JVI.2.7.657-662.1968
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1974-10-01 00:00:00
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.7.4565-4571.1994
更新日期:1994-07-01 00:00:00
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journal_title:Journal of virology
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pub_type: 杂志文章
doi:10.1128/JVI.72.9.7255-7262.1998
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.9.2929-2933.1987
更新日期:1987-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.23.2.250-262.1977
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.12.7877-7887.1995
更新日期:1995-12-01 00:00:00
abstract::Genotype 1 hepatitis E viruses (HEVs) are restricted to primate hosts, whereas genotype 3 HEVs predominantly infect swine, in addition to primates. In order to identify possible determinants of the host range, infectious recombinant viruses and chimeras of a genotype 1 isolate and a genotype 3 isolate were compared fo...
journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2004-11-01 00:00:00