Coordinate regulation of replication and virus assembly by the large envelope protein of an avian hepadnavirus.

abstract：:There is a high degree of intraisolate sequence heterogeneity in the tax gene of human T-cell leukemia virus type I (HTLV-I), although the sequence variation between patients is small compared with that of human immunodeficiency virus type 1. In the present study, we investigated whether naturally occurring amino acid...

journal_title：Journal of virology

authors： Niewiesk S,Daenke S,Parker CE,Taylor G,Weber J,Nightingale S,Bangham CR

更新日期：1995-04-01 00:00:00

abstract：:Hemagglutination (HA) by the mammalian reoviruses is mediated by interactions between the viral sigma 1 protein and sialoglycoproteins on the erythrocyte surface. Three serotype 3 (T3) reovirus strains were identified that do not agglutinate either bovine or type O human erythrocytes (HA negative): T3 clone 43 (T3C43)...

journal_title：Journal of virology

authors： Dermody TS,Nibert ML,Bassel-Duby R,Fields BN

更新日期：1990-10-01 00:00:00

abstract：:Fatal infection with the highly pathogenic Lassa virus (LASV) is characterized by extensive viral dissemination, indicating broad tissue tropism. The major cellular receptor for LASV is the highly conserved extracellular matrix receptor dystroglycan (DG). Binding of LASV depends on DG's tissue-specific posttranslation...

journal_title：Journal of virology

authors： Fedeli C,Torriani G,Galan-Navarro C,Moraz ML,Moreno H,Gerold G,Kunz S

更新日期：2018-02-12 00:00:00

abstract：:By superinfection of human immunodeficiency virus type 2 (HIV-2) strain HIV-2ben-infected macaques with simian immunodeficiency virus (SIV) strain SIVmac, we investigated the mutual influences of an apathogenic and a pathogenic virus in vivo. Four rhesus and two cynomolgus monkeys were infected with HIV-2ben in 1988 a...

journal_title：Journal of virology

authors： Petry H,Dittmer U,Stahl-Hennig C,Coulibaly C,Makoschey B,Fuchs D,Wachter H,Tolle T,Morys-Wortmann C,Kaup FJ

更新日期：1995-03-01 00:00:00

abstract：:Retroviral Gag proteins direct the assembly and release of virus particles from the plasma membrane. The budding machinery consists of three small domains, the M (membrane-binding), I (interaction), and L (late or "pinching-off") domains. In addition, Gag proteins contain sequences that control particle size. For Rous...

journal_title：Journal of virology

authors： Krishna NK,Wills JW

更新日期：2001-07-01 00:00:00

abstract：:Walleye dermal sarcoma virus (WDSV) is a complex retrovirus associated with dermal sarcomas in walleye fish. A WDSV accessory gene encodes a cyclin homolog or retroviral cyclin (rv-cyclin). WDSV rv-cyclin was found to be associated with transcription complexes and to affect transcription in a cell-type and promoter-de...

journal_title：Journal of virology

authors： Rovnak J,Quackenbush SL

更新日期：2006-12-01 00:00:00

abstract：:Heterozygous replicative form molecules of bacteriophage phiX174 deoxyribonucleic acid (DNA) have been constructed in vitro. These are composed of viral strands extracted from purified preparations of phage bearing ts mutations and complementary strands of either half length or full length synthesized with purified DN...

journal_title：Journal of virology

authors： Merriam V,Dumas LB,Sinsheimer RL

更新日期：1971-05-01 00:00:00

abstract：:The herpes simplex virus (HSV) capsid is released into the cytoplasm after fusion of viral and host membranes, whereupon dynein-dependent trafficking along microtubules targets it to the nuclear envelope. Binding of the capsid to the nuclear pore complex (NPC) is mediated by the capsid protein pUL25 and the capsid-tet...

journal_title：Journal of virology

authors： Huffman JB,Daniel GR,Falck-Pedersen E,Huet A,Smith GA,Conway JF,Homa FL

更新日期：2017-07-12 00:00:00

abstract：:We have previously shown that the nonconserved carboxy-terminal exon of the adenovirus type 2 E1A-289R protein contains two interchangeable sequence elements, auxiliary region (AR) 1 and AR2, that are required for efficient CR3-mediated transcriptional activation of the viral E4 promoter (M. Bondesson, C. Svensson, S....

journal_title：Journal of virology

authors： Ström AC,Ohlsson P,Akusjärvi G

更新日期：1998-07-01 00:00:00

abstract：:Accurate and sensitive quantitation of infectious human immunodeficiency virus (HIV) has been difficult to achieve. In this report, a quantitative focal immunoassay (FIA) for HIV was developed using human HeLa cells rendered susceptible to HIV infection by introduction of the CD4 gene via a retrovirus vector. Infected...

journal_title：Journal of virology

authors： Chesebro B,Wehrly K

更新日期：1988-10-01 00:00:00

abstract：:In cell-free systems, 2-5A [ppp(A2'p)nA, n = 2 to greater than or equal to 4] activates a latent endoribonuclease, the 2-5A-dependent RNase, which cleaves rRNA in intact ribosomes into discrete and characteristic products (D. H. Wreschner et al., Nucleic Acids Res. 9:1571-1581, 1981). Here we present Northern blots wh...

journal_title：Journal of virology

authors： Silverman RH,Skehel JJ,James TC,Wreschner DH,Kerr IM

更新日期：1983-06-01 00:00:00

abstract：:PM2 DNA was prepared with different superhelical densities (sigma) in order to examine the relationship betweenn supercoiling and the occurrence of a region(s) of unpaired bases in this DNA. A previous study showed that CH3HgOH reacts with native superhelical PM2 DNA more rapidly than the nicked form II. This evaluati...

journal_title：Journal of virology

authors： Woodworth-Gutai M,Lebowitz J

更新日期：1976-04-01 00:00:00

abstract：:Kinetic analysis showed that the Ki values and the Ki/Km ratios for mutated, recombinant M184V human immunodeficiency virus type 1 reverse transcriptase (RT) for (-)2'-dideoxy-3'-thiacytidine triphosphate (3TCTP) were 35-fold higher than the equivalent values for wild-type RT but only about twice as high as the equiva...

journal_title：Journal of virology

authors： Quan Y,Gu Z,Li X,Li Z,Morrow CD,Wainberg MA

更新日期：1996-08-01 00:00:00

abstract：:The basis for the switch from CCR5 to CXCR4 coreceptor usage seen in approximately 50% of human immunodeficiency virus type 1 (HIV-1) subtype B-infected individuals as disease advances is not well understood. Among the reasons proposed are target cell limitation and better immune recognition of the CXCR4 (X4)-tropic c...

journal_title：Journal of virology

authors： Ho SH,Tasca S,Shek L,Li A,Gettie A,Blanchard J,Boden D,Cheng-Mayer C

更新日期：2007-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) RNA genome replicates within the ribonucleoprotein (RNP) complex in the modified membranous structures extended from endoplasmic reticulum. A proteomic analysis of HCV RNP complexes revealed the association of oxysterol binding protein (OSBP) as one of the components of these complexes. OSBP in...

journal_title：Journal of virology

authors： Amako Y,Sarkeshik A,Hotta H,Yates J 3rd,Siddiqui A

更新日期：2009-09-01 00:00:00

abstract：:Heron hepatitis B virus (HHBV) is an avian hepadnavirus that is closely related to duck hepatitis B virus (DHBV). To learn more about the mechanism of hepadnavirus replication, we characterized a clone of HHBV that contains a substitution of DHBV sequence from nucleotide coordinates 403 to 1364. This clone, named HDE1...

journal_title：Journal of virology

authors： Mueller-Hill K,Loeb DD

更新日期：1996-12-01 00:00:00

abstract：:The core gene of hepatitis B virus contains two in-phase AUG codons which may both be used in the viral life cycle. By in vitro translation of transcripts produced in vitro, we investigated the corresponding core gene products and their counterparts in vivo. Depending on the location of the 5' end of the transcripts, ...

journal_title：Journal of virology

authors： Weimer T,Salfeld J,Will H

更新日期：1987-10-01 00:00:00

abstract：:Open reading frame 24 (ORF24) of murine gammaherpesvirus 68 (MHV-68) is conserved among beta- and gammaherpesviruses; however, its function in viral replication has not been defined. Using MHV-68 as a model, we have identified ORF24 as being essential for viral replication. An ORF24-null virus was generated and shown ...

journal_title：Journal of virology

authors： Wong E,Wu TT,Reyes N,Deng H,Sun R

更新日期：2007-06-01 00:00:00

abstract：:Inhibitors of hemagglutination by type A2 influenza virus and a recently isolated strain of type B influenza virus were separated by sucrose density gradient centrifugation and agarose gel filtration from horse serum. Using selected reagents, it was demonstrated that the active substituent on the horse serum inhibitor...

journal_title：Journal of virology

authors： Levinson B,Pepper D,Belyavin G

更新日期：1969-05-01 00:00:00

abstract：:The 2009 pandemic influenza H1N1 (H1N1pdm) virus was generated by reassortment of swine influenza viruses of different lineages. This was the first influenza pandemic to emerge in over 4 decades and the first to occur after the realization that influenza pandemics arise from influenza viruses of animals. In order to u...

journal_title：Journal of virology

authors： Chan RW,Kang SS,Yen HL,Li AC,Tang LL,Yu WC,Yuen KM,Chan IW,Wong DD,Lai WW,Kwong DL,Sihoe AD,Poon LL,Guan Y,Nicholls JM,Peiris JS,Chan MC

更新日期：2011-11-01 00:00:00

abstract：:We have examined the relative ability of Sendai virus M (matrix) protein to associate with membranes containing viral glycoproteins at three distinct stages of the exocytic pathway prior to cell surface appearance. By the use of selective low-temperature incubations or the ionophore monensin, the transport of newly sy...

journal_title：Journal of virology

authors： Sanderson CM,McQueen NL,Nayak DP

更新日期：1993-02-01 00:00:00

abstract：:In this study, we examined the ability of the hepatitis B virus (HBV) precore, envelope, and X gene products to modulate HBV replication in the livers of transgenic mice that replicate the virus. Hepatic HBV replication was not affected by overexpression of the envelope or X gene products when these animals were cross...

journal_title：Journal of virology

authors： Guidotti LG,Matzke B,Pasquinelli C,Shoenberger JM,Rogler CE,Chisari FV

更新日期：1996-10-01 00:00:00

abstract：:A hallmark of infection with herpes simplex virus type 1 (HSV-1) is the establishment of latency in ganglia of the infected individual. During the life of the latently infected individual, the virus can occasionally reactivate, travel back to the eye, and cause recurrent disease. Indeed, a major cause of corneal scarr...

journal_title：Journal of virology

authors： Mott KR,Bresee CJ,Allen SJ,BenMohamed L,Wechsler SL,Ghiasi H

更新日期：2009-03-01 00:00:00

abstract：:Five human recombinant Fab fragments (Fabs) specific for measles virus (MV) proteins were isolated from three antibody phage display libraries generated from RNAs derived from bone marrow or splenic lymphocytes from three MV-immune individuals. All Fabs reacted in an enzyme-linked immunosorbent assay with MV antigens....

journal_title：Journal of virology

authors： de Carvalho Nicacio C,Williamson RA,Parren PW,Lundkvist A,Burton DR,Björling E

更新日期：2002-01-01 00:00:00

abstract：:Influenza viruses unable to express NS1 protein (delNS1) replicate poorly and induce large amounts of interferon (IFN). They are therefore considered candidate viruses for live-attenuated influenza vaccines. Their attenuated replication is generally assumed to result from the inability to counter the antiviral host re...

journal_title：Journal of virology

authors： van Wielink R,Harmsen MM,Martens DE,Peeters BP,Wijffels RH,Moormann RJ

更新日期：2012-11-01 00:00:00

abstract：:Activated microglia and astroglia are known to be involved in a variety of neurodegenerative diseases, including prion diseases. In the present experiments, we studied activation of astroglia and microglia after intraocular scrapie infection in transgenic mice expressing prion protein (PrP) in multiple cell types (tg7...

journal_title：Journal of virology

authors： Kercher L,Favara C,Striebel JF,LaCasse R,Chesebro B

更新日期：2007-10-01 00:00:00

abstract：:The genome of varicella-zoster virus (VZV) is a linear, double-stranded molecule of DNA composed of a long (L) region covalently linked to a short (S) region. The S region is capable of inverting relative to a fixed orientation of the L region, giving rise to two equimolar populations. We have investigated other forms...

journal_title：Journal of virology

authors： Kinchington PR,Reinhold WC,Casey TA,Straus SE,Hay J,Ruyechan WT

更新日期：1985-10-01 00:00:00

abstract：:The mechanisms involved in the emergence of virulent mammalian viruses were investigated in the adult immunodeficient SCID mouse infected by the attenuated prototype strain of the parvovirus Minute Virus of Mice (MVMp). Cloned MVMp intravenously inoculated in mice consistently evolved during weeks of subclinical infec...

journal_title：Journal of virology

authors： Rubio MP,López-Bueno A,Almendral JM

更新日期：2005-09-01 00:00:00

abstract：:Enveloped viruses often require cleavage of a surface glycoprotein by a cellular endoprotease such as furin for infectivity and virulence. Previously, we showed that Ebola virus glycoprotein does not require the furin cleavage motif for virus replication in cell culture. Here, we show that there are no appreciable dif...

journal_title：Journal of virology

authors： Neumann G,Geisbert TW,Ebihara H,Geisbert JB,Daddario-DiCaprio KM,Feldmann H,Kawaoka Y

更新日期：2007-03-01 00:00:00

abstract：:Epstein-Barr virus (EBV) in vivo is known to establish persistent infection in resting, circulating memory B cells and to productively replicate in plasma cells. Until now, the molecular mechanism of how EBV switches from latency to lytic replication in vivo was not known. Here, we report that the plasma cell differen...

journal_title：Journal of virology

authors： Sun CC,Thorley-Lawson DA

更新日期：2007-12-01 00:00:00