Abstract:
:Open reading frame 24 (ORF24) of murine gammaherpesvirus 68 (MHV-68) is conserved among beta- and gammaherpesviruses; however, its function in viral replication has not been defined. Using MHV-68 as a model, we have identified ORF24 as being essential for viral replication. An ORF24-null virus was generated and shown to be defective in late gene expression. Expression of early genes, as well as viral genome replication, was not affected. Furthermore, the defect in late gene expression was likely due to a deficiency in transcription. Thus, we have identified an MHV-68 protein, ORF24, that is essential for the expression of viral late proteins yet dispensable for viral DNA replication.
journal_name
J Viroljournal_title
Journal of virologyauthors
Wong E,Wu TT,Reyes N,Deng H,Sun Rdoi
10.1128/JVI.02726-06subject
Has Abstractpub_date
2007-06-01 00:00:00pages
6761-4issue
12eissn
0022-538Xissn
1098-5514pii
JVI.02726-06journal_volume
81pub_type
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1987-12-01 00:00:00