Rotavirus SA11 genome segment 11 protein is a nonstructural phosphoprotein.

abstract：:By marker rescue with cloned herpes simplex virus 2 DNA fragments, we have mapped the temperature-sensitive mutations of a series of herpes simplex virus 2 mutants to a region of the herpes simplex virus 2 genome that lies within or near the coding sequences for the major DNA-binding protein, ICP8. In cells infected w...

journal_title：Journal of virology

authors： Spang AE,Godowski PJ,Knipe DM

更新日期：1983-01-01 00:00:00

abstract：:Immunogenic regions of the gp41 transmembrane protein of human immunodeficiency virus type 1 (HIV-1) were previously mapped by examining polyclonal sera from HIV-infected patients and rodent polyclonal and monoclonal antibodies (MAbs) to peptides of gp41. To define the epitopes within these regions to which infected h...

journal_title：Journal of virology

authors： Xu JY,Gorny MK,Palker T,Karwowska S,Zolla-Pazner S

更新日期：1991-09-01 00:00:00

abstract：UNLABELLED:The RNA genome of respiratory syncytial virus (RSV) is constitutively encapsidated by the viral nucleoprotein N, thus forming a helical nucleocapsid. Polymerization of N along the genomic and antigenomic RNAs is concomitant to replication and requires the preservation of an unassembled monomeric nucleoprotei...

journal_title：Journal of virology

authors： Galloux M,Gabiane G,Sourimant J,Richard CA,England P,Moudjou M,Aumont-Nicaise M,Fix J,Rameix-Welti MA,Eléouët JF

更新日期：2015-04-01 00:00:00

abstract：:We have studied initiation and regulation of early transcription of simian virus (SV40) DNA in vitro by eucaryotic RNA polymerase II, using both a crude HeLa cell extract and a partially purified calf thymus polymerase supplemented with a HeLa cell S100 fraction. Analysis of initiation sites by primer-directed cDNA sy...

journal_title：Journal of virology

authors： Lebowitz P,Ghosh PK

更新日期：1982-02-01 00:00:00

abstract：:Two mutant strains (vi12 and vi13) of herpes simplex virus that contain insertion mutations in the sequences that encode the DNA-binding domain of viral regulatory protein ICP4 were generated. Both mutations disrupted specific DNA binding and resulted in transcriptionally inactive molecules; however, the ability of th...

journal_title：Journal of virology

authors： Shepard AA,DeLuca NA

更新日期：1991-01-01 00:00:00

abstract：:The functions of the two rotavirus glycoproteins were investigated by using tunicamycin and a variant of SA11 rotavirus having nonglycosylated VP7. Results showed that glycosylation of VP7 is not required for normal viral morphogenesis and infectivity and suggested that the nonstructural glycoprotein is involved in as...

journal_title：Journal of virology

authors： Petrie BL,Estes MK,Graham DY

更新日期：1983-04-01 00:00:00

abstract：:Circoviruses are small, nonenveloped icosahedral animal viruses characterized by circular single-stranded DNA genomes. Their genomes are the smallest possessed by animal viruses. Infections with circoviruses, which can lead to economically important diseases, frequently result in virus-induced damage to lymphoid tissu...

journal_title：Journal of virology

authors： Crowther RA,Berriman JA,Curran WL,Allan GM,Todd D

更新日期：2003-12-01 00:00:00

abstract：:The mucosal adjuvant effect of synthetic double-stranded RNA polyriboinosinic polyribocytidylic acid [poly(I:C)] against influenza virus was examined under intranasal coadministration with inactivated hemagglutinin (HA) vaccine in BALB/c mice and was shown to have a protective effect against both nasal-restricted infe...

journal_title：Journal of virology

authors： Ichinohe T,Watanabe I,Ito S,Fujii H,Moriyama M,Tamura S,Takahashi H,Sawa H,Chiba J,Kurata T,Sata T,Hasegawa H

更新日期：2005-03-01 00:00:00

abstract：:Strong determinants of the host range of influenza A viruses have been identified on the polymerase complex formed by the PB1, PB2, and PA subunits and on the nucleoprotein (NP). In the present study, molecular mechanisms that may involve these four core proteins and contribute to the restriction of avian influenza vi...

journal_title：Journal of virology

authors： Rameix-Welti MA,Tomoiu A,Dos Santos Afonso E,van der Werf S,Naffakh N

更新日期：2009-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) has two envelope proteins, E1 and E2, which form a heterooligomer. During dissection of interacting regions of HCV E1 and E2, we found the presence of an interfering compound or compounds in skim milk. Here we report that human as well as bovine lactoferrin, a multifunctional immunomodulator, b...

journal_title：Journal of virology

authors： Yi M,Kaneko S,Yu DY,Murakami S

更新日期：1997-08-01 00:00:00

abstract：:Three tegument proteins of human cytomegalovirus (HCMV), ppUL82 (pp71), pUL69, and ppUL83 (pp65), were examined for the ability to stimulate the production of infectious virus from human diploid fibroblasts transfected with viral DNA. Although viral DNA alone had a low intrinsic infectivity of 3 to 8 plaques/microg of...

journal_title：Journal of virology

authors： Baldick CJ Jr,Marchini A,Patterson CE,Shenk T

更新日期：1997-06-01 00:00:00

abstract：:The Kilham strain of polyomavirus (KV) infects vascular endothelial cells in vivo (J. E. Greenlee, Infect. Immun. 26:705-713, 1979), but no permissive cell type for growth of the virus in vitro has been identified. The failure of KV DNA to replicate in mouse fibroblast cells after transfection suggested that viral gen...

journal_title：Journal of virology

authors： Zhang S,Magnusson G

更新日期：2001-11-01 00:00:00

abstract：:The goal of an effective AIDS vaccine is to generate immunity that will prevent human immunodeficiency virus 1 (HIV-1) acquisition. Despite limited progress toward this goal, renewed optimism has followed the recent success of the RV144 vaccine trial in Thailand. However, the lack of complete protection in this trial ...

journal_title：Journal of virology

authors： Yamamoto T,Johnson MJ,Price DA,Wolinsky DI,Almeida JR,Petrovas C,Nason M,Yeh WW,Shen L,Roederer M,Rao SS,McDermott AB,Lefebvre F,Nabel GJ,Haddad EK,Letvin NL,Douek DC,Koup RA

更新日期：2012-05-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) alpha protein ICP27 regulates the transition between the delayed-early and late phases of the viral infection. Previous genetic analyses have suggested that the important functional domains of ICP27 map to its carboxyl-terminal half. One striking feature of the primary sequence ...

journal_title：Journal of virology

authors： Rice SA,Lam V,Knipe DM

更新日期：1993-04-01 00:00:00

abstract：UNLABELLED:HIV-1-specific CD8 T cells can influence HIV-1 disease progression during untreated HIV-1 infection, but the functional and phenotypic properties of HIV-1-specific CD8 T cells in individuals treated with suppressive antiretroviral therapy remain less well understood. Here we show that a subgroup of HIV-1-spe...

journal_title：Journal of virology

authors： Vigano S,Negron J,Ouyang Z,Rosenberg ES,Walker BD,Lichterfeld M,Yu XG

更新日期：2015-08-01 00:00:00

abstract：:Hepatitis delta virus (HDV) contains two types of hepatitis delta antigens (HDAg) in the virion. The small form (S-HDAg) is required for HDV RNA replication, whereas the large form (L-HDAg) potently inhibits it by a dominant-negative inhibitory mechanism. The sequential appearance of these two forms in the infected ce...

journal_title：Journal of virology

authors： Modahl LE,Lai MM

更新日期：2000-08-01 00:00:00

abstract：:Poliovirus replicase- and host factor-catalyzed copying of 3'-terminal polyadenylic acid [poly(A)] of poliovirion RNA was studied. Host factor-stimulated synthesis of polyuridylic acid [poly(U)] by the replicase required ATP in addition to UTP. ATP was not required for the oligouridylic acid-primed copying of 3'-termi...

journal_title：Journal of virology

authors： Morrow CD,Hocko J,Navab M,Dasgupta A

更新日期：1984-05-01 00:00:00

abstract：:Two foot-and-mouth disease virus (FMDV) genome sequences have been determined for isolates collected from recent field outbreaks in North Africa (Egypt) and the Middle East (Palestinian Autonomous Territories). These data represent the first examples of complete genomic sequences for the FMDV SAT 2 topotype VII, which...

journal_title：Journal of virology

authors： Valdazo-González B,Knowles NJ,Hammond J,King DP

更新日期：2012-08-01 00:00:00

abstract：:Hepatitis B viruses (HBVs) replicate by reverse transcription of an RNA intermediate. Packaging of this RNA pregenome into nucleocapsids and replication initiation depend crucially on the interaction of the reverse transcriptase, P protein, with the cis-acting, 5' end-proximal encapsidation signal epsilon. The overall...

journal_title：Journal of virology

authors： Beck J,Nassal M

更新日期：1997-07-01 00:00:00

abstract：:We have investigated the mechanism of duck hepatitis B virus (DHBV) entry into susceptible primary duck hepatocytes (PDHs), using mutants of carboxypeptidase D (gp180), a transmembrane protein shown to act as the primary cellular receptor for avian hepatitis B virus uptake. The variant proteins were abundantly produce...

journal_title：Journal of virology

authors： Breiner KM,Schaller H

更新日期：2000-03-01 00:00:00

abstract：:West Nile virus has spread rapidly across the United States, and there is currently no approved human vaccine or therapy to prevent or treat disease. Passive immunization with antibodies against the envelope protein represents a promising means to provide short-term prophylaxis and treatment for West Nile virus infect...

journal_title：Journal of virology

authors： Gould LH,Sui J,Foellmer H,Oliphant T,Wang T,Ledizet M,Murakami A,Noonan K,Lambeth C,Kar K,Anderson JF,de Silva AM,Diamond MS,Koski RA,Marasco WA,Fikrig E

更新日期：2005-12-01 00:00:00

abstract：UNLABELLED:T-cell immunoglobulin and mucin domain 1 (TIM-1) and other TIM family members were recently identified as phosphatidylserine (PtdSer)-mediated virus entry-enhancing receptors (PVEERs). These proteins enhance entry of Ebola virus (EBOV) and other viruses by binding PtdSer on the viral envelope, concentrating ...

journal_title：Journal of virology

authors： Moller-Tank S,Albritton LM,Rennert PD,Maury W

更新日期：2014-06-01 00:00:00

abstract：:The role of the cell nucleus in the development of African swine fever virus in Vero cells has been studied. No viral growth could be detected in enucleated cells under conditions that allow normal development of Sindbis virus. Furthermore, African swine fever virus DNA synthesis was inhibited more than 95% after infe...

journal_title：Journal of virology

authors： Ortin J,Vińuela E

更新日期：1977-03-01 00:00:00

abstract：:Human immunodeficiency virus infection in humans and simian immunodeficiency virus (SIV) infection in rhesus macaques (RM) leads to a generalized loss of immune responses involving perturbations in T-cell receptor (TCR) signaling. In contrast, naturally SIV-infected sooty mangabeys (SM) remain asymptomatic and retain ...

journal_title：Journal of virology

authors： Bostik P,Wu P,Dodd GL,Villinger F,Mayne AE,Bostik V,Grimm BD,Robinson D,Kung HJ,Ansari AA

更新日期：2001-12-01 00:00:00

abstract：:Rotavirus is the leading global cause of diarrheal mortality for unvaccinated children under 5 years of age. The outer capsid of rotavirus virions consists of VP7 and VP4 proteins, which determine viral G and P types, respectively, and are primary targets of neutralizing antibodies. Successful vaccination depends upon...

journal_title：Journal of virology

authors： Ogden KM,Tan Y,Akopov A,Stewart LS,McHenry R,Fonnesbeck CJ,Piya B,Carter MH,Fedorova NB,Halpin RA,Shilts MH,Edwards KM,Payne DC,Esona MD,Mijatovic-Rustempasic S,Chappell JD,Patton JT,Halasa NB,Das SR

更新日期：2018-12-10 00:00:00

abstract：:Paramyxoviruses such as human parainfluenza viruses that bear inserts encoding protective antigens of heterologous viruses can induce an effective immunity against the heterologous viruses in experimental animals. However, vectors based on common human pathogens would be expected to be restricted in replication in the...

journal_title：Journal of virology

authors： Bukreyev A,Huang Z,Yang L,Elankumaran S,St Claire M,Murphy BR,Samal SK,Collins PL

更新日期：2005-11-01 00:00:00

abstract：:Several independent cell lines transformed by simian virus 40 carry a species of viral RNA of 900,000 to 1,000,000 daltons. A viral RNA species of similar size is found early in the lytic cycle. Late in the viral lytic cycle, two prominent viral RNA species of about 600,000 and 900,000 daltons are seen. The larger lat...

journal_title：Journal of virology

authors： Weinberg RA,Ben-Ishai Z,Newbold JE

更新日期：1974-06-01 00:00:00

abstract：:Nonglucosylated and fragmented T4 DNA shows a gene-specific variation in transformation efficiency. ...

journal_title：Journal of virology

authors： McNicol LA

更新日期：1973-08-01 00:00:00

abstract：:Rous sarcoma virus (RSV), a simple retrovirus, needs to export unspliced viral RNA from the nucleus to the cytoplasm, circumventing the host cell restriction on cytoplasmic expression of intron-containing RNA. The cytoplasmic accumulation of full-length viral RNA is promoted by two cis-acting direct repeat (DR) elemen...

journal_title：Journal of virology

authors： Paca RE,Ogert RA,Hibbert CS,Izaurralde E,Beemon KL

更新日期：2000-10-01 00:00:00

abstract：:The cocultivation of a lung cell line from the Southeast Asian mouse Mus cervicolor with cells from heterologous species has resulted in the isolation of two new distinct type C viruses. Both viruses are endogenous to M. cervicolor and are present in multiple copies in the cellular DNA of these mice. One of the viruse...

journal_title：Journal of virology

authors： Benveniste RE,Callahan R,Sherr CJ,Chapman V,Todaro GJ

更新日期：1977-03-01 00:00:00