Hepatitis C virus envelope proteins bind lactoferrin.

abstract：:We have previously shown that expression of the adenovirus E1A 12S or 13S products in NIH 3T3 fibroblasts induces susceptibility to the cytotoxic actions of tumor necrosis factor alpha (TNF alpha). A large number of studies have mapped the multiple biological functions of the 12S and 13S products to three highly conse...

journal_title：Journal of virology

authors： Ames RS,Holskin B,Mitcho M,Shalloway D,Chen MJ

更新日期：1990-09-01 00:00:00

abstract：:We used the mammalian reoviruses to determine the molecular basis of the clearance of a virus from the bloodstream by specific organs. Reovirus serotypes 1 (T1) and 3 (T3) were radiolabeled with [35S]methionine or 125I, and the viruses were injected intravenously into weanling rats. The distribution of radioactivity w...

journal_title：Journal of virology

authors： Verdin EM,Lynn SP,Fields BN,Maratos-Flier E

更新日期：1988-02-01 00:00:00

abstract：:Rubella virus is an enveloped positive-strand RNA virus of the family TOGAVIRIDAE: Virions are composed of three structural proteins: a capsid and two membrane-spanning glycoproteins, E2 and E1. During virus assembly, the capsid interacts with genomic RNA to form nucleocapsids. In the present study, we have investigat...

journal_title：Journal of virology

authors： Law LM,Everitt JC,Beatch MD,Holmes CF,Hobman TC

更新日期：2003-02-01 00:00:00

abstract：:The rarely identified influenza A viruses of the H15 hemagglutinin subtype have been isolated exclusively in Australia. Here we report the isolation of an H15N4 influenza A virus (A/teal/Chany/7119/2008) in Western Siberia, Russia. Phylogenetic analysis demonstrated that the internal genes of the A/teal/Chany/7119/200...

journal_title：Journal of virology

authors： Sivay MV,Baranovich T,Marchenko VY,Sharshov KA,Govorkova EA,Shestopalov AM,Webby RJ

更新日期：2013-03-01 00:00:00

abstract：:BALB/c mice sensitized to herpes simplex virus type 1 (HSV-1) develop a vigorous delayed-type hypersensitivity (DTH) response upon intradermal virus antigen challenge. Although CD4(+) T cells are a key mediator of this response, neutrophils are the most abundant cells at the antigen challenge site both initially and a...

journal_title：Journal of virology

authors： Tumpey TM,Fenton R,Molesworth-Kenyon S,Oakes JE,Lausch RN

更新日期：2002-08-01 00:00:00

abstract：:Vaccinia virus, the basis of the smallpox vaccine, is one of the largest viruses to replicate in humans. We have used in situ atomic force microscopy (AFM) to directly visualize fully hydrated, intact intracellular mature vaccinia virus (IMV) virions and chemical and enzymatic treatment products thereof. The latter in...

journal_title：Journal of virology

authors： Malkin AJ,McPherson A,Gershon PD

更新日期：2003-06-01 00:00:00

abstract：:Polyomavirus small t antigen was purified from genetically engineered Escherichia coli and used as the immunogen for the production of polyclonal and monoclonal antibodies. A new series of plasmids for increased expression of polyomavirus T antigens or a T antigen-beta-galactosidase fusion protein was constructed by r...

journal_title：Journal of virology

authors： Pallas DC,Schley C,Mahoney M,Harlow E,Schaffhausen BS,Roberts TM

更新日期：1986-12-01 00:00:00

abstract：:Cells that express glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) resist infection by HSV-1 and HSV-2 because of interference with viral penetration. The results presented here show that both HSV-1 and HSV-2 gD can mediate interference and that various HSV-1 and HSV-2 strains differ in sensitivity to this ...

journal_title：Journal of virology

authors： Dean HJ,Warner MS,Terhune SS,Johnson RM,Spear PG

更新日期：1995-08-01 00:00:00

abstract：:We have found that the burst size of bacteriophage T7 was decreased in two Escherichia coli temperature-sensitive gyrase mutants incubated at the restrictive temperature. This reduction in burst size indicates that gyrase may be required for T7 growth. ...

journal_title：Journal of virology

authors： Steck TR,Drlica K

更新日期：1985-01-01 00:00:00

abstract：:Sindbis virus nonstructural polyproteins and their cleavage products are believed to be essential components of viral RNA replication and transcription complexes. Although numerous studies have investigated the effect of mutations in nsP1-, nsP2-, and nsP4-coding regions on Sindbis virus-specific RNA synthesis, relati...

journal_title：Journal of virology

authors： LaStarza MW,Lemm JA,Rice CM

更新日期：1994-09-01 00:00:00

abstract：:Viral infectivity factor (Vif) is one of the human immunodeficiency virus (HIV) accessory proteins and is conserved in the primate lentivirus group. This protein is essential for viral replication in vivo and for productive infection of nonpermissive cells, such as peripheral blood mononuclear cells (PBMC). Vif counte...

journal_title：Journal of virology

authors： Ribeiro AC,Maia e Silva A,Santa-Marta M,Pombo A,Moniz-Pereira J,Goncalves J,Barahona I

更新日期：2005-01-01 00:00:00

abstract：:In previous reports it was demonstrated that the Nipah virus V and W proteins have interferon (IFN) antagonist activity due to their ability to block signaling from the IFN-alpha/beta receptor (J. J. Rodriguez, J. P. Parisien, and C. M. Horvath, J. Virol. 76:11476-11483, 2002; M. S. Park et al., J. Virol. 77:1501-1511...

journal_title：Journal of virology

authors： Shaw ML,García-Sastre A,Palese P,Basler CF

更新日期：2004-06-01 00:00:00

abstract：:Immune activation is a major characteristic of human immunodeficiency virus type 1 (HIV-1) infection and a strong prognostic factor for HIV-1 disease progression. The underlying mechanisms leading to immune activation in viremic HIV-1 infection, however, are not fully understood. Here we show that, following the initi...

journal_title：Journal of virology

authors： Meier A,Alter G,Frahm N,Sidhu H,Li B,Bagchi A,Teigen N,Streeck H,Stellbrink HJ,Hellman J,van Lunzen J,Altfeld M

更新日期：2007-08-01 00:00:00

abstract：:Neurons of the sensory ganglia are the major site of varicella-zoster virus (VZV) latency and may undergo productive infection during reactivation. Although the VZV glycoprotein E/glycoprotein I (gE/gI) complex is known to be critical for neurovirulence, few studies have assessed the roles of these proteins during inf...

journal_title：Journal of virology

authors： Christensen J,Steain M,Slobedman B,Abendroth A

更新日期：2013-12-01 00:00:00

abstract：:The 5'-terminal nucleotide sequence from positions 50 to 130 of vesicular stomatitis virus RNA was determined indirectly by using a defective interfering particle RNA which contains covalently linked genomic minus and antigenomic plus sense RNAs. The last 18 nucleotides of the L gene coding for in the viral polymerase...

journal_title：Journal of virology

authors： Schubert M,Keene JD,Herman RC,Lazzarini RA

更新日期：1980-05-01 00:00:00

abstract：:Immunogenic regions of the gp41 transmembrane protein of human immunodeficiency virus type 1 (HIV-1) were previously mapped by examining polyclonal sera from HIV-infected patients and rodent polyclonal and monoclonal antibodies (MAbs) to peptides of gp41. To define the epitopes within these regions to which infected h...

journal_title：Journal of virology

authors： Xu JY,Gorny MK,Palker T,Karwowska S,Zolla-Pazner S

更新日期：1991-09-01 00:00:00

abstract：:Pestiviruses prevent alpha/beta interferon (IFN-alpha/beta) production by promoting proteasomal degradation of interferon regulatory factor 3 (IRF3) by means of the viral N(pro) nonstructural protein. N(pro) is also an autoprotease, and its amino-terminal coding sequence is involved in translation initiation. We previ...

journal_title：Journal of virology

authors： Ruggli N,Summerfield A,Fiebach AR,Guzylack-Piriou L,Bauhofer O,Lamm CG,Waltersperger S,Matsuno K,Liu L,Gerber M,Choi KH,Hofmann MA,Sakoda Y,Tratschin JD

更新日期：2009-01-01 00:00:00

abstract：UNLABELLED:The cytomegaloviruses (CMVs) are among the most genetically complex mammalian viruses, with viral genomes that often exceed 230 kbp. Manipulation of cytomegalovirus genomes is largely performed using infectious bacterial artificial chromosomes (BACs), which necessitates the maintenance of the viral genome in...

journal_title：Journal of virology

authors： Bierle CJ,Anderholm KM,Wang JB,McVoy MA,Schleiss MR

更新日期：2016-07-11 00:00:00

abstract：UNLABELLED:In vitro, infection of polarized human intestinal epithelial cells by coxsackievirus B3 (CVB3) depends on virus interaction with decay-accelerating factor (DAF), a receptor expressed on the apical cell surface. Although mice are highly susceptible to CVB3 infection when virus is delivered by intraperitoneal ...

journal_title：Journal of virology

authors： Pan J,Zhang L,Odenwald MA,Shen L,Turner JR,Bergelson JM

更新日期：2015-04-01 00:00:00

abstract：:The Middle East respiratory syndrome coronavirus (MERS-CoV) nonstructural protein 16 (nsp16) is an S-adenosyl-l-methionine (SAM)-dependent 2'-O-methyltransferase (2'-O-MTase) that is thought to methylate the ribose 2'-OH of the first transcribed nucleotide (N1) of viral RNA cap structures. This 2'-O-MTase activity is ...

journal_title：Journal of virology

authors： Aouadi W,Blanjoie A,Vasseur JJ,Debart F,Canard B,Decroly E

更新日期：2017-02-14 00:00:00

abstract：:Genetic conflicts between retroviruses and their receptors result in the evolution of novel host entry restrictions and novel virus envelopes, and such variants can influence trans-species transmission. We screened rodents and other mammals for sequence variation in the Xpr1 receptor for the mouse xenotropic or polytr...

journal_title：Journal of virology

authors： Yan Y,Liu Q,Wollenberg K,Martin C,Buckler-White A,Kozak CA

更新日期：2010-11-01 00:00:00

abstract：:Complement, part of the innate immune system, acts to remove pathogens and unwanted host material. Complement is known to function in all tissues, including the central nervous system (CNS). In this study, we demonstrated the importance of the complement system within the CNS in the development of behavioral seizures ...

journal_title：Journal of virology

authors： Libbey JE,Kirkman NJ,Wilcox KS,White HS,Fujinami RS

更新日期：2010-07-01 00:00:00

abstract：:Recombinant adeno-associated virus (rAAV) vectors have been shown to be useful for efficient gene delivery to a variety of dividing and nondividing cells. Mechanisms responsible for the long-term, persistent expression of the rAAV transgene are not well understood. In this study we investigated the kinetics of rAAV-me...

journal_title：Journal of virology

authors： Malik AK,Monahan PE,Allen DL,Chen BG,Samulski RJ,Kurachi K

更新日期：2000-04-01 00:00:00

abstract：:The administration of cyclophosphamide (50 to 100 mg/kg) at 48 to 72 h before removal of murine lung or spleen mononuclear cells for culture rendered DBA/2 mice incapable of generating an effective cytotoxic T-lymphocyte response to influenza A virus-infected cells. The cytotoxic T-lymphocyte precursor frequency to in...

journal_title：Journal of virology

authors： Merluzzi VJ,Welte K,Mertelsmann RH,Souza L,Boone T,Last-Barney K

更新日期：1984-07-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) remains latent throughout the life of the carrier, with cells containing the provirus and viral gene expression efficiently down-regulated. On a molecular level, exactly how viruses are down-regulated in vivo remains unresolved. We described here the possibility that down-re...

journal_title：Journal of virology

authors： Saiga A,Orita S,Minoura-Tada N,Maeda M,Aono Y,Asakawa M,Nakahara K,Kubota R,Osame M,Igarashi H

更新日期：1997-06-01 00:00:00

abstract：:Bovine bone marrow-derived macrophages infected with the cytopathic biotype of bovine viral diarrhea virus released an antiviral activity into the supernatant which was tentatively characterized as type I interferon because of its physicochemical properties. Such supernatants primed both infected and uninfected macrop...

journal_title：Journal of virology

authors： Adler B,Adler H,Pfister H,Jungi TW,Peterhans E

更新日期：1997-04-01 00:00:00

abstract：:In some type C retroviruses, translation of the pol gene appears to require translational suppression of the proximal gag amber codon. To identify the region of the viral nucleic acid responsible for synthesis of the pol gene products, a 300-base-pair DNA fragment containing the stop codon from a type C murine virus (...

journal_title：Journal of virology

authors： Panganiban AT

更新日期：1988-10-01 00:00:00

abstract：:The recent advent of genome sequences as the only source available to classify many newly discovered viruses challenges the development of virus taxonomy by expert virologists who traditionally rely on extensive virus characterization. In this proof-of-principle study, we address this issue by presenting a computation...

journal_title：Journal of virology

authors： Lauber C,Gorbalenya AE

更新日期：2012-04-01 00:00:00

abstract：UNLABELLED:Molluscum contagiosum virus (MOCV), the only circulating human-specific poxvirus, has a worldwide distribution and causes benign skin lesions that may persist for months in young children and severe infections in immunosuppressed adults. Studies of MOCV are restricted by the lack of an efficient animal model...

journal_title：Journal of virology

authors： Mendez-Rios JD,Yang Z,Erlandson KJ,Cohen JI,Martens CA,Bruno DP,Porcella SF,Moss B

更新日期：2016-04-14 00:00:00

abstract：:The entire measles virus (MV) hemagglutinin (HA)-coding region was reconstructed from cloned cDNAs and used as part of a hybrid transcription unit to replace a region of the adenovirus type 5 genome corresponding to the entire E1a transcription unit and most of the E1b transcription unit. The resulting recombinant vir...

journal_title：Journal of virology

authors： Alkhatib G,Briedis DJ

更新日期：1988-08-01 00:00:00