cis-Acting inhibitory elements within the pol-env region of human T-cell leukemia virus type 1 possibly involved in viral persistence.

abstract：:All presently available replication-competent proviral clones of human immunodeficiency virus type 1 (HIV-1) are derived from cell culture-amplified virus. Since tissue culture is highly selective for viral strains with an in vitro growth advantage, such clones may not be representative of the biologically relevant vi...

journal_title：Journal of virology

authors： Li Y,Kappes JC,Conway JA,Price RW,Shaw GM,Hahn BH

更新日期：1991-08-01 00:00:00

abstract：:The cellular transcription factors Sp1 and NF-kappaB were upregulated shortly after the binding of purified live or UV-inactivated human cytomegalovirus (HCMV) to the cell surface. The rapid time frame of transcription factor induction is similar to that seen in other systems in which cellular factors are induced foll...

journal_title：Journal of virology

authors： Yurochko AD,Hwang ES,Rasmussen L,Keay S,Pereira L,Huang ES

更新日期：1997-07-01 00:00:00

abstract：:Retroviral capsid assembly can occur by either of two distinct morphogenic processes: in type C viruses, the capsid assembles and buds at the plasma membrane, while in type B and D viruses, the capsid assembles within the cytoplasm and is then transported to the plasma membrane for budding. We have previously reported...

journal_title：Journal of virology

authors： Choi G,Park S,Choi B,Hong S,Lee J,Hunter E,Rhee SS

更新日期：1999-07-01 00:00:00

abstract：:Mutants (N(-)nin) of bacteriophage lambda in which the N gene product is not required for growth on wild-type Escherichia coli do not plate on recA bacterial mutants. Secondary mutants, selected for growth on recA, lie within the immunity region to the right of gene cI and appear identical to the cro mutants of Eisen ...

journal_title：Journal of virology

authors： Court D,Campbell A

更新日期：1972-06-01 00:00:00

abstract：:Chronic infections with viruses such as hepatitis B virus, hepatitis C virus, and HIV constitute a major global public health problem. Studies of chronic viral infections in humans and mice show that persistent antigenic stimulation induces dysregulation of T cell responses; virus-specific T cells either undergo clona...

journal_title：Journal of virology

authors： Sullivan JA,Kim EH,Plisch EH,Suresh M

更新日期：2012-09-01 00:00:00

abstract：:Epstein-Barr virus (EBV) infection leads to lifelong viral persistence through its latency in B cells. EBV-specific T cells control reactivations and prevent the development of EBV-associated malignancies in most healthy carriers, but infection can sometimes cause chronic disease and malignant transformation. Epstein-...

journal_title：Journal of virology

authors： Leskowitz RM,Zhou XY,Villinger F,Fogg MH,Kaur A,Lieberman PM,Wang F,Ertl HC

更新日期：2013-08-01 00:00:00

abstract：:It has become evident that naturally occurring CD25(+) regulatory T cells (T(reg) cells) not only influence self-antigen specific immune response but also dampen foreign antigen specific immunity. This report extends our previous findings by demonstrating that immunity to certain herpes simplex virus (HSV) vaccines is...

journal_title：Journal of virology

authors： Toka FN,Suvas S,Rouse BT

更新日期：2004-12-01 00:00:00

abstract：:Analyses of the breadth and specificity of virus-specific CD8(+) T cell responses associated with control of HIV have largely relied on measurement of cytokine secretion by effector T cells. These have resulted in the identification of HIV elite controllers with low or absent responses in which non-T-cell mechanisms o...

journal_title：Journal of virology

authors： Ndhlovu ZM,Proudfoot J,Cesa K,Alvino DM,McMullen A,Vine S,Stampouloglou E,Piechocka-Trocha A,Walker BD,Pereyra F

更新日期：2012-06-01 00:00:00

abstract：:A number of herpes simplex virus (HSV) glycoproteins are found in oligomeric states: glycoprotein E (gE)-gI and gH-gL form heterodimers, and both gB and gC have been detected as homodimers. We have further explored the organization of glycoproteins in the virion envelope by using both purified virions to quantitate gl...

journal_title：Journal of virology

authors： Handler CG,Eisenberg RJ,Cohen GH

更新日期：1996-09-01 00:00:00

abstract：:Waterfowl are the natural reservoir of all influenza A viruses, which are usually nonpathogenic in wild aquatic birds. However, in late 2002, outbreaks of highly pathogenic H5N1 influenza virus caused deaths among wild migratory birds and resident waterfowl, including ducks, in two Hong Kong parks. In February 2003, a...

journal_title：Journal of virology

authors： Sturm-Ramirez KM,Ellis T,Bousfield B,Bissett L,Dyrting K,Rehg JE,Poon L,Guan Y,Peiris M,Webster RG

更新日期：2004-05-01 00:00:00

abstract：:Distinct functional CD8+ T-cell populations have been observed during human immunodeficiency virus (HIV) infection. One of these functions is the inhibition of viral replication by a noncytotoxic mechanism, which was shown to be mediated by the CD8+CD28+ subpopulation. On the other hand, CD8+ T cells exert an HIV-spec...

journal_title：Journal of virology

authors： Fiorentino S,Dalod M,Olive D,Guillet JG,Gomard E

更新日期：1996-03-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) to human immunodeficiency virus type 1 were produced. Two antibodies reacted with the 17-kilodalton core protein (p17) of the virus and with its polyprotein precursor. To various degrees, each MAb neutralized infection by the cell-free virus. With a series of sequential overlapping hexapep...

journal_title：Journal of virology

authors： Papsidero LD,Sheu M,Ruscetti FW

更新日期：1989-01-01 00:00:00

abstract：:A number of positive-strand RNA viruses, such as hepatitis C virus (HCV) and poliovirus, use double-membrane vesicles (DMVs) as replication sites. However, the role of cellular proteins in DMV formation during virus replication is poorly understood. HCV NS4B protein induces the formation of a "membranous web" structur...

journal_title：Journal of virology

authors： Kong L,Aoyagi H,Yang Z,Ouyang T,Matsuda M,Fujimoto A,Watashi K,Suzuki R,Arita M,Yamagoe S,Dohmae N,Suzuki T,Suzuki T,Muramatsu M,Wakita T,Aizaki H

更新日期：2020-01-06 00:00:00

abstract：:We previously reported that a mutant Rous sarcoma virus (RSV) with an alternate polypurine tract (PPT), DuckHepBFlipPPT, had unexpectedly high titers and that the PPT was miscleaved primarily at one position following a GA dinucleotide by the RNase H of reverse transcriptase (RT). This miscleavage resulted in a portio...

journal_title：Journal of virology

authors： Chang KW,Oh J,Alvord WG,Hughes SH

更新日期：2008-09-01 00:00:00

abstract：:The effect of rifampin on the replication of vaccinia DNA was studied in mouse L cells by a cytochemical techinque and by alkaline sucrose sedimentation analysis of newly synthesized viral DNA molecules. By the use of a fluorescent DNA-binding compound (Hoechst 33258), the sequential appearance, size, and location of ...

journal_title：Journal of virology

authors： Esteban M

更新日期：1977-02-01 00:00:00

abstract：:Binding of human immunodeficiency virus type 1 (HIV-1) to CD4 receptors induces multiple cellular signaling pathways, including the MEK/ERK cascade. While the interaction of X4 HIV-1 with CXCR4 does not seem to activate this pathway, viruses using CCR5 for entry efficiently activate MEK/ERK kinases (W. Popik, J. E. He...

journal_title：Journal of virology

authors： Popik W,Pitha PM

更新日期：2000-03-01 00:00:00

abstract：:Herpesvirus nucleocapsids traverse the nuclear envelope into the cytoplasm in a process called nuclear egress that includes disruption of the nuclear lamina. In several herpesviruses, a key player in nuclear egress is a complex of two proteins, whose homologs in human cytomegalovirus (HCMV) are UL50 and UL53. However,...

journal_title：Journal of virology

authors： Sharma M,Kamil JP,Coughlin M,Reim NI,Coen DM

更新日期：2014-01-01 00:00:00

abstract：:Influenza B virus (IBV) is considered a major human pathogen, responsible for seasonal epidemics of acute respiratory illness. Two antigenically distinct IBV hemagglutinin (HA) lineages cocirculate worldwide with little cross-reactivity. Live attenuated influenza virus (LAIV) vaccines have been shown to provide better...

journal_title：Journal of virology

authors： Santos JJS,Finch C,Sutton T,Obadan A,Aguirre I,Wan Z,Lopez D,Geiger G,Gonzalez-Reiche AS,Ferreri L,Perez DR

更新日期：2017-05-26 00:00:00

abstract：:Human cytomegalovirus (HCMV) has emerged as a clinically opportunistic pathogen that targets multiple types of ocular cells and tissues, including the iris region of the uveal tract during anterior uveitis. In this report, we used primary cultures of human iris stroma (HIS) cells derived from human eye donors to inves...

journal_title：Journal of virology

authors： Baldwin J,Maus E,Zanotti B,Volin MV,Tandon R,Shukla D,Tiwari V

更新日期：2015-05-01 00:00:00

abstract：:We reported previously that the movement protein (MP) of tomato mosaic tobamovirus is phosphorylated, and we proposed that MP phosphorylation is important for viral pathogenesis. Experimental data indicated that phosphorylation enhances the stability of MP in vivo and enables the protein to assume the correct intracel...

journal_title：Journal of virology

authors： Kawakami S,Hori K,Hosokawa D,Okada Y,Watanabe Y

更新日期：2003-01-01 00:00:00

abstract：:The family Asfarviridae contains only a single virus species, African swine fever virus (ASFV). ASFV is a viral agent with significant economic impact due to its devastating effects on populations of domesticated pigs during outbreaks but has not been reported to infect humans. We report here the discovery of novel vi...

journal_title：Journal of virology

authors： Loh J,Zhao G,Presti RM,Holtz LR,Finkbeiner SR,Droit L,Villasana Z,Todd C,Pipas JM,Calgua B,Girones R,Wang D,Virgin HW

更新日期：2009-12-01 00:00:00

abstract：:Poliovirus (PV) modifies membrane-trafficking machinery in host cells for its viral RNA replication. To date, ARF1, ACBD3, BIG1/BIG2, GBF1, RTN3, and PI4KB have been identified as host factors of enterovirus (EV), including PV, involved in membrane traffic. In this study, we performed small interfering RNA (siRNA) scr...

journal_title：Journal of virology

authors： Arita M,Wakita T,Shimizu H

更新日期：2012-05-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) uses a variety of chemokine receptors as coreceptors for virus entry, and the ability of the virus to be neutralized by antibody may depend on which coreceptors are used. In particular, laboratory-adapted variants of the virus that use CXCR4 as a coreceptor are highly sensit...

journal_title：Journal of virology

authors： Montefiori DC,Collman RG,Fouts TR,Zhou JY,Bilska M,Hoxie JA,Moore JP,Bolognesi DP

更新日期：1998-03-01 00:00:00

abstract：:We report here that sex hormones modulate susceptibility to a sexually transmitted viral agent, herpes simplex virus type 2 (HSV-2), in a mouse model. Ovariectomized mice were administered either saline (control), estradiol (E(2)), progesterone (P(4)), or a combination of both estradiol and progesterone (E+P) and infe...

journal_title：Journal of virology

authors： Gillgrass AE,Fernandez SA,Rosenthal KL,Kaushic C

更新日期：2005-03-01 00:00:00

abstract：:The 5'-terminal nucleotide sequence from positions 50 to 130 of vesicular stomatitis virus RNA was determined indirectly by using a defective interfering particle RNA which contains covalently linked genomic minus and antigenomic plus sense RNAs. The last 18 nucleotides of the L gene coding for in the viral polymerase...

journal_title：Journal of virology

authors： Schubert M,Keene JD,Herman RC,Lazzarini RA

更新日期：1980-05-01 00:00:00

abstract：:The 5' untranslated region (UTR) of hepatitis C virus (HCV), which is composed of four domains (I, II, III, and IV) and a pseudoknot, is essential for translation and viral replication. Equine nonprimate hepacivirus (EHcV) harbors a 5' UTR consisting of a large 5'-terminal domain (I); three additional domains (I', II,...

journal_title：Journal of virology

authors： Tanaka T,Otoguro T,Yamashita A,Kasai H,Fukuhara T,Matsuura Y,Moriishi K

更新日期：2018-03-14 00:00:00

abstract：:The viral genes UL128, UL130, and UL131A have been identified as major determinants of endothelial cell (EC) tropism of human cytomegalovirus (HCMV), with deletion of either gene causing a null phenotype. We hypothesized that a functional scanning of these genes by minor genetic modifications would allow for the gener...

journal_title：Journal of virology

authors： Schuessler A,Sampaio KL,Sinzger C

更新日期：2008-11-01 00:00:00

abstract：:We previously demonstrated that chimeric porcine parvovirus-like particles (PPV:VLP) carrying heterologous epitopes, when injected intraperitoneally into mice without adjuvant, activate strong CD4(+) and CD8(+) T-cell responses specific for the foreign epitopes. In the present study, we investigated the immunogenicity...

journal_title：Journal of virology

authors： Sedlik C,Dridi A,Deriaud E,Saron MF,Rueda P,Sarraseca J,Casal JI,Leclerc C

更新日期：1999-04-01 00:00:00

abstract：:The synthesis of minus-strand RNA was studied in cell cultures infected with the heat-resistant strain of Sindbis virus and with temperature-sensitive (ts) belonging to complementation groups A, B, F, and G, all of which exhibited an RNA-negative (RNA-) phenotype when infection was initiated and maintained at 39 degre...

journal_title：Journal of virology

authors： Sawicki DL,Sawicki SG,Keränen S,Kääriäinen L

更新日期：1981-08-01 00:00:00

abstract：:Mammalian reoviruses are internalized into cells by receptor-mediated endocytosis. Within the endocytic compartment, the viral outer capsid undergoes acid-dependent proteolysis resulting in removal of the sigma3 protein and proteolytic cleavage of the mu1/mu1C protein. Ammonium chloride (AC) is a weak base that blocks...

journal_title：Journal of virology

authors： Clark KM,Wetzel JD,Gu Y,Ebert DH,McAbee SA,Stoneman EK,Baer GS,Zhu Y,Wilson GJ,Prasad BV,Dermody TS

更新日期：2006-01-01 00:00:00