CD4+ and CD8+ T-cell responses to latent antigen EBNA-1 and lytic antigen BZLF-1 during persistent lymphocryptovirus infection of rhesus macaques.

abstract：:We molecularly cloned JC polyomavirus DNAs from urine samples of eight nonimmunosuppressed patients and two healthy individuals. The cloned viral DNAs all contained an archetypal regulatory sequence from which various regulatory sequences of JC polyomavirus isolates derived from patients with progressive multifocal le...

journal_title：Journal of virology

authors： Yogo Y,Kitamura T,Sugimoto C,Ueki T,Aso Y,Hara K,Taguchi F

更新日期：1990-06-01 00:00:00

abstract：:Rous sarcoma virus (RSV), a simple retrovirus, needs to export unspliced viral RNA from the nucleus to the cytoplasm, circumventing the host cell restriction on cytoplasmic expression of intron-containing RNA. The cytoplasmic accumulation of full-length viral RNA is promoted by two cis-acting direct repeat (DR) elemen...

journal_title：Journal of virology

authors： Paca RE,Ogert RA,Hibbert CS,Izaurralde E,Beemon KL

更新日期：2000-10-01 00:00:00

abstract：:Latency-associated transcript (LAT) promoter deletion mutants of herpes simplex virus type 1 have a reduced capacity to reactivate following adrenergic induction in the rabbit eye model. We have mapped a reactivation phenotype within LAT and describe the construction of recombinants in which poly(A) addition sites hav...

journal_title：Journal of virology

authors： Bloom DC,Hill JM,Devi-Rao G,Wagner EK,Feldman LT,Stevens JG

更新日期：1996-04-01 00:00:00

abstract：:Cottontail rabbit papillomavirus induces strictly epithelial tumors in both cottontail and domestic rabbits. A high proportion of the initial benign papillomas progress within 8 to 14 months to invasive carcinomas. With the help of mRNA-specific riboprobes for E6, E7, E1, E2, L1 and L2, we investigated by in situ hybr...

journal_title：Journal of virology

authors： Zeltner R,Borenstein LA,Wettstein FO,Iftner T

更新日期：1994-06-01 00:00:00

abstract：:In mammalian cells, alphavirus replication complexes are anchored to the plasma membrane. This interaction with lipid bilayers is mediated through the viral methyl/guanylyltransferase nsP1 and reinforced by palmitoylation of cysteine residue(s) in the C-terminal region of this protein. Lipid content of membranes suppo...

journal_title：Journal of virology

authors： Bakhache W,Neyret A,Bernard E,Merits A,Briant L

更新日期：2020-05-04 00:00:00

abstract：:Influenza A virus NS2 protein, also called nuclear export protein (NEP), is crucial for the nuclear export of viral ribonucleoproteins. However, the molecular mechanisms of NEP mediation in this process remain incompletely understood. A leucine-rich nuclear export signal (NES2) in NEP, located at the predicted N2 heli...

journal_title：Journal of virology

authors： Huang S,Chen J,Chen Q,Wang H,Yao Y,Chen J,Chen Z

更新日期：2013-01-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is an essential regulatory protein that localizes to the nuclei of infected cells. The strong nuclear localization signal (NLS) of ICP27 was identified recently and shown to reside in the amino-terminal portion of the polypeptide from residues 110 t...

journal_title：Journal of virology

authors： Hibbard MK,Sandri-Goldin RM

更新日期：1995-08-01 00:00:00

abstract：:Integrins mediate cell adhesion and motility on the extracellular matrix, yet they also promote viral attachment and/or entry. Evidence is presented that adenovirus internalization by alpha(v) integrins requires activation of phosphoinositide-3-OH kinase (PI3K), whereas alpha(v) integrin-mediated cell motility depends...

journal_title：Journal of virology

authors： Li E,Stupack D,Klemke R,Cheresh DA,Nemerow GR

更新日期：1998-03-01 00:00:00

abstract：:A retrovirus vector has been developed that selects for instances in which the provirus integrates in close proximity to cellular promoters. Coding sequences for a selectable marker (histidinol dehydrogenase) were inserted into the 3' long terminal repeat (LTR) of an enhancerless Molony murine leukemia virus. Although...

journal_title：Journal of virology

authors： von Melchner H,Ruley HE

更新日期：1989-08-01 00:00:00

abstract：UNLABELLED:Identification and characterization of CD8(+) T cells effectively controlling HIV-1 variants are necessary for the development of AIDS vaccines and for studies of AIDS pathogenesis, although such CD8(+) T cells have been only partially identified. In this study, we sought to identify CD8(+) T cells controlli...

journal_title：Journal of virology

authors： Murakoshi H,Akahoshi T,Koyanagi M,Chikata T,Naruto T,Maruyama R,Tamura Y,Ishizuka N,Gatanaga H,Oka S,Takiguchi M

更新日期：2015-05-01 00:00:00

abstract：:The polycistronic P/C mRNA of Sendai virus is translated under cell-free conditions into five proteins (P, C', C, Y1, and Y2) from overlapping reading frames. In this study, we showed that in addition to the P, C', and C proteins, Y1 and Y2 were expressed by six different Sendai virus strains in infected cells. The Y ...

journal_title：Journal of virology

authors： Dillon PJ,Gupta KC

更新日期：1989-02-01 00:00:00

abstract：:Panicum mosaic virus (PMV) is a recently molecularly characterized RNA virus with the unique feature of supporting the replication of two subviral RNAs in a few species of the family Gramineae. The subviral agents include a satellite RNA (satRNA) that is devoid of a coding region and the unrelated satellite panicum mo...

journal_title：Journal of virology

authors： Qiu W,Scholthof KB

更新日期：2001-06-01 00:00:00

abstract：:Bluetongue virus (BTV), a member of the Reoviridae family, is an insect-borne animal pathogen. Virus release from infected cells is predominantly by cell lysis, but some BTV particles are also released from the plasma membrane. The nonstructural protein NS3 has been implicated in this process. Using alternate initiato...

journal_title：Journal of virology

authors： Celma CC,Roy P

更新日期：2011-05-01 00:00:00

abstract：:A large percentage of the repetitive elements in mammalian genomes are retroelements, which have been moved primarily by LINE-1 retrotransposons and endogenous retroviruses. Although LINE-1 elements have remained active throughout the mammalian radiation, specific groups of endogenous retroviruses generally remain act...

journal_title：Journal of virology

authors： Cantrell MA,Ederer MM,Erickson IK,Swier VJ,Baker RJ,Wichman HA

更新日期：2005-12-01 00:00:00

abstract：:Four mutants of the virulent Mahoney strain of poliovirus were generated by introducing mutations in nucleotides (nt) 128 to 134 of the genome, a region that contains a part of the stem-loop II (SLII) structure located within the internal ribosomal entry site (IRES; nt 120 to 590) (K. Shiroki, T. Ishii, T. Aoki, Y. Ot...

journal_title：Journal of virology

authors： Ishii T,Shiroki K,Hong DH,Aoki T,Ohta Y,Abe S,Hashizume S,Nomoto A

更新日期：1998-03-01 00:00:00

abstract：:Rinderpest virus is a morbillivirus and is the causative agent of a widespread and important disease of cattle. The viral genome is a single strand of RNA in the negative sense. We have constructed plasmids containing cDNA copies of the 5' and 3' termini of the virus separated by a reporter gene and have shown that an...

journal_title：Journal of virology

authors： Baron MD,Barrett T

更新日期：1997-02-01 00:00:00

abstract：:Gene transfer to differentiated airway epithelia with existing viral vectors is very inefficient when they are applied to the apical surface. This largely reflects the polarized distribution of receptors on the basolateral surface. To identify new receptor-ligand interactions that might be used to redirect vectors to ...

journal_title：Journal of virology

authors： Wang G,Deering C,Macke M,Shao J,Burns R,Blau DM,Holmes KV,Davidson BL,Perlman S,McCray PB Jr

更新日期：2000-10-01 00:00:00

abstract：UNLABELLED:Noroviruses are the leading cause of acute gastroenteritis outbreaks worldwide. The majority of norovirus outbreaks are caused by genogroup II.4 (GII.4). Novel GII.4 strains emerge every 2 to 4 years and replace older variants as the dominant norovirus. Novel variants emerge through a combination of recombin...

journal_title：Journal of virology

authors： Vega E,Donaldson E,Huynh J,Barclay L,Lopman B,Baric R,Chen LF,Vinjé J

更新日期：2014-12-01 00:00:00

abstract：:Jaagsiekte sheep retrovirus (JSRV) is the causative agent of a transmissible lung cancer of sheep known as ovine pulmonary carcinoma. Recently, we have found that the expression of the JSRV envelope (Env) is sufficient to transform mouse NIH 3T3 cells in classical transformation assays. To further investigate the mech...

journal_title：Journal of virology

authors： Palmarini M,Maeda N,Murgia C,De-Fraja C,Hofacre A,Fan H

更新日期：2001-11-01 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus (KSHV) is an emerging pathogen and is the causative infectious agent of Kaposi sarcoma and two malignancies of B cell origin. To date, there is no licensed KSHV vaccine. Development of an effective vaccine against KSHV continues to be limited by a poor understanding of how the vir...

journal_title：Journal of virology

authors： Muniraju M,Mutsvunguma LZ,Foley J,Escalante GM,Rodriguez E,Nabiee R,Totonchy J,Mulama DH,Nyagol J,Wussow F,Barasa AK,Brehm M,Ogembo JG

更新日期：2019-07-30 00:00:00

abstract：:The Vpr protein, encoded by the human immunodeficiency virus type 1 (HIV-1) genome, is one of the nonstructural proteins packaged in large amounts into viral particles. We have previously reported that Vpr associates with the DNA repair enzyme uracil DNA glycosylase (UDG). In this study, we extended these observations...

journal_title：Journal of virology

authors： Willetts KE,Rey F,Agostini I,Navarro JM,Baudat Y,Vigne R,Sire J

更新日期：1999-02-01 00:00:00

abstract：:Inoculation of the leafhopper cell line AC-20 with wound tumor virus resulted in a productive noncytopathic infection with no detectable alteration of cellular protein synthesis. Virus-specific polypeptide synthesis, detectable by 8 h postinoculation, increased in a linear fashion, reaching a peak (approximately 10 to...

journal_title：Journal of virology

authors： Peterson AJ,Nuss DL

更新日期：1985-11-01 00:00:00

abstract：:Monoclonal antibodies (MAb) reactive with the glycoprotein of vesicular stomatitis virus (VSV) serotypes Indiana (VSV-Ind) and New Jersey (VSV-NJ) were used to protect mice against lethal infection. MAb which reacted with a number of distinct epitopes and which could neutralize the virus in vitro could also protect ag...

journal_title：Journal of virology

authors： Lefrancois L

更新日期：1984-07-01 00:00:00

abstract：:The genetic diversity among globally circulating human immunodeficiency virus type 1 (HIV-1) strains is a serious challenge for HIV-1 vaccine design. We have generated a synthetic group M consensus env gene (CON6) for induction of cross-subtype immune responses and report here a comparative study of T-cell responses t...

journal_title：Journal of virology

authors： Weaver EA,Lu Z,Camacho ZT,Moukdar F,Liao HX,Ma BJ,Muldoon M,Theiler J,Nabel GJ,Letvin NL,Korber BT,Hahn BH,Haynes BF,Gao F

更新日期：2006-07-01 00:00:00

abstract：:The genome of a canine parvovirus isolate strain (CPV-N) was cloned, and the DNA sequence was determined. The entire genome, including ends, was 5,323 nucleotides in length. The terminal repeat at the 3' end of the genome shared similar structural characteristics but limited homology with the rodent parvoviruses. The ...

journal_title：Journal of virology

authors： Reed AP,Jones EV,Miller TJ

更新日期：1988-01-01 00:00:00

abstract：:The initial aim of this study was to combine attributes of adeno-associated virus (AAV) and adenovirus (Ad) gene therapy vectors to generate an Ad-AAV hybrid vector allowing efficient site-specific integration with Ad vectors. In executing our experimental strategy, we found that, in addition to the known incompatibil...

journal_title：Journal of virology

authors： Philpott NJ,Giraud-Wali C,Dupuis C,Gomos J,Hamilton H,Berns KI,Falck-Pedersen E

更新日期：2002-06-01 00:00:00

abstract：:Rubella virus is an enveloped positive-strand RNA virus of the family TOGAVIRIDAE: Virions are composed of three structural proteins: a capsid and two membrane-spanning glycoproteins, E2 and E1. During virus assembly, the capsid interacts with genomic RNA to form nucleocapsids. In the present study, we have investigat...

journal_title：Journal of virology

authors： Law LM,Everitt JC,Beatch MD,Holmes CF,Hobman TC

更新日期：2003-02-01 00:00:00

abstract：UNLABELLED:Following retrovirus entry, the viral capsid (CA) disassembles into its component capsid proteins. The rate of this uncoating process, which is regulated by CA-CA interactions and by the association of the capsid with host cell factors like cyclophilin A (CypA), can influence the efficiency of reverse transc...

journal_title：Journal of virology

authors： Tipper C,Sodroski JG

更新日期：2014-09-01 00:00:00

abstract：:West Nile virus (WNV) is a human pathogen that can cause neurological disorders, including meningoencephalitis. Experiments with mice and mammalian cell cultures revealed that WNV exhibited resistance to the innate immune program induced by alpha interferon (IFN-alpha). We have investigated the nature of this inhibiti...

journal_title：Journal of virology

authors： Guo JT,Hayashi J,Seeger C

更新日期：2005-02-01 00:00:00

abstract：:In some retroviruses, such as Rous sarcoma virus and prototype foamy virus, Gag proteins are known to shuttle between the nucleus and the cytoplasm and are implicated in nuclear export of the viral genomic unspliced RNA (gRNA) for subsequent encapsidation. A similar function has been proposed for human immunodeficienc...

journal_title：Journal of virology

authors： Grewe B,Hoffmann B,Ohs I,Blissenbach M,Brandt S,Tippler B,Grunwald T,Uberla K

更新日期：2012-03-01 00:00:00