Abstract:
:West Nile virus (WNV) is a human pathogen that can cause neurological disorders, including meningoencephalitis. Experiments with mice and mammalian cell cultures revealed that WNV exhibited resistance to the innate immune program induced by alpha interferon (IFN-alpha). We have investigated the nature of this inhibition and have found that WNV replication inhibited the activation of many known IFN-inducible genes, because it prevented the phosphorylation and activation of the Janus kinases JAK1 and Tyk2. As a consequence, activation of the transcription factors STAT1 and STAT2 did not occur in WNV-infected cells. Moreover, we demonstrated that the viral nonstructural proteins are responsible for this effect. Thus, our results provided an explanation for the observed resistance of WNV to IFN-alpha in cells of vertebrate origin.
journal_name
J Viroljournal_title
Journal of virologyauthors
Guo JT,Hayashi J,Seeger Cdoi
10.1128/JVI.79.3.1343-1350.2005subject
Has Abstractpub_date
2005-02-01 00:00:00pages
1343-50issue
3eissn
0022-538Xissn
1098-5514pii
79/3/1343journal_volume
79pub_type
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