Effects of anti-E2 monoclonal antibody on sindbis virus replication in AT3 cells expressing bcl-2.

abstract：:Activation of microglia and astroglia is seen in many neurodegenerative diseases including prion diseases. Activated glial cells produce cytokines as a protective response against certain pathogens and as part of the host inflammatory response to brain damage. In addition, cytokines might also exacerbate tissue damage...

journal_title：Journal of virology

authors： Tribouillard-Tanvier D,Striebel JF,Peterson KE,Chesebro B

更新日期：2009-11-01 00:00:00

abstract：:Transgenic mice expressing the simian virus 40 large T antigen (TAg) in enterocytes develop intestinal hyperplasia that progresses to dysplasia with age. This induction requires TAg action on the retinoblastoma (Rb) family of tumor suppressors and is independent of the p53 pathway. In cell culture systems, the inactiv...

journal_title：Journal of virology

authors： Rathi AV,Sáenz Robles MT,Pipas JM

更新日期：2007-09-01 00:00:00

abstract：:The Roseobacter clade has been recognized as one of the abundant bacterial lineages in marine environments, which makes the characterization of bacteriophages infecting members of the clade important. Here we report the complete genome sequence of bacteriophage P12053L, which infects Celeribacter sp. strain IMCC12053,...

journal_title：Journal of virology

authors： Kang I,Jang H,Oh HM,Cho JC

更新日期：2012-08-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) mutants with codon insertions and deletions in IE-0, the gene encoding ICP0, were constructed. The HSV-1 deletion mutant dl1403 (N. D. Stow and E. C. Stow, J. Gen. Virol. 67:2571-2585, 1986) and an IE-0:lacZ transplacement vector isolated in this study were used to facilitate the co...

journal_title：Journal of virology

authors： Chen J,Silverstein S

更新日期：1992-05-01 00:00:00

abstract：:We have selected neutralization escape mutants by using a monoclonal antibody (nt-MAb) against a sequential epitope between amino acids 93 through 104 (neutralization antigenic site I) of poliovirus type 1 Mahoney. The majority of mutants were also resistant against five strain-specific nt-MAbs which recognized confor...

journal_title：Journal of virology

authors： Wiegers K,Uhlig H,Dernick R

更新日期：1988-05-01 00:00:00

abstract：:HB-3, a temperate bacteriophage of Streptococcus pneumoniae, synthesizes its own murein hydrolase activity when multiplying on cultures of pneumococcus. The enzyme (HBL) was purified and biochemically characterized as an N-acetylmuramoyl-L-alanine amidase of 36,000 daltons, and a 2.1-kilobase DraI fragment containing ...

journal_title：Journal of virology

authors： Romero A,Lopez R,Garcia P

更新日期：1990-01-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is a highly species-specific herpesvirus that targets sensory ganglionic neurons. This species specificity has limited the study of many aspects of VZV pathogenesis, including neuronal infection. We report development of a highly efficient neuroblastoma cell model to study productive VZV i...

journal_title：Journal of virology

authors： Christensen J,Steain M,Slobedman B,Abendroth A

更新日期：2011-08-01 00:00:00

abstract：UNLABELLED:Little is known about the antiviral response in mollusks. As in other invertebrates, the interferon signaling pathways have not been identified, and in fact, there is a debate about whether invertebrates possess antiviral immunity similar to that of vertebrates. In marine bivalves, due to their filtering act...

journal_title：Journal of virology

authors： Novoa B,Romero A,Álvarez ÁL,Moreira R,Pereiro P,Costa MM,Dios S,Estepa A,Parra F,Figueras A

更新日期：2016-08-12 00:00:00

abstract：:The temperature-sensitive defects of virus mutants isolated from L cells persistently infected with Newcastle disease virus (NDV) were analyzed. Genetic grouping of the mutants by complementation tests was attempted by using several different methods, including yield analysis, RNA synthesis, and heterozygote formation...

journal_title：Journal of virology

authors： Preble OT,Youngner JS

更新日期：1973-09-01 00:00:00

abstract：:On the basis of the conservation of neuraminidase (N) active-site residues in influenza virus N and paramyxovirus hemagglutinin-neuraminidase (HN), it has been suggested that the three-dimensional (3D) structures of the globular heads of the two proteins are broadly similar. In this study, details of this structural s...

journal_title：Journal of virology

authors： Langedijk JP,Daus FJ,van Oirschot JT

更新日期：1997-08-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) alpha protein ICP27 regulates the transition between the delayed-early and late phases of the viral infection. Previous genetic analyses have suggested that the important functional domains of ICP27 map to its carboxyl-terminal half. One striking feature of the primary sequence ...

journal_title：Journal of virology

authors： Rice SA,Lam V,Knipe DM

更新日期：1993-04-01 00:00:00

abstract：UNLABELLED:Although the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) epidemic was controlled by nonvaccine measures, coronaviruses remain a major threat to human health. The design of optimal coronavirus vaccines therefore remains a priority. Such vaccines present major challenges: coronavirus im...

journal_title：Journal of virology

authors： Honda-Okubo Y,Barnard D,Ong CH,Peng BH,Tseng CT,Petrovsky N

更新日期：2015-03-01 00:00:00

abstract：:Hepatitis B virus (HBV) is an enveloped DNA virus that presumably buds at intracellular membranes of infected cells. HBV budding involves two endocytic host proteins, the ubiquitin-interacting adaptor gamma 2-adaptin and the Nedd4 ubiquitin ligase. Here, we demonstrate that HBV release also requires the cellular machi...

journal_title：Journal of virology

authors： Lambert C,Döring T,Prange R

更新日期：2007-09-01 00:00:00

abstract：:To identify retroviral antigenic determinants recognized by CD4+ T helper cells during tumor rejection, we established four noncytolytic, helper-type, CD4+ T-cell clones by limiting dilution cultures of mixed lymphocyte-tumor cultures from mice immune to a Friend virus-induced tumor, FBL-3. Among these, three T helper...

journal_title：Journal of virology

authors： Iwashiro M,Kondo T,Shimizu T,Yamagishi H,Takahashi K,Matsubayashi Y,Masuda T,Otaka A,Fujii N,Ishimoto A

更新日期：1993-08-01 00:00:00

abstract：:Targeted vectors will be necessary for many gene therapy applications. To target retroviruses to melanomas, we fused a single-chain variable fragment antibody (scFv) directed against the surface glycoprotein high-molecular-weight melanoma-associated antigen (HMW-MAA) to the amphotropic murine leukemia virus envelope. ...

journal_title：Journal of virology

authors： Martin F,Neil S,Kupsch J,Maurice M,Cosset F,Collins M

更新日期：1999-08-01 00:00:00

abstract：:Unlike RNA viruses, most DNA viruses replicate their genomes with high-fidelity polymerases that rarely make base substitution errors. Nevertheless, experimental evolution studies have revealed rapid acquisition of adaptive mutations during serial passage of attenuated vaccinia virus (VACV). One way in which adaptatio...

journal_title：Journal of virology

authors： Senkevich TG,Zhivkoplias EK,Weisberg AS,Moss B

更新日期：2020-08-31 00:00:00

abstract：:Exosomes are small vesicles secreted from cells that participate in intercellular communication events. Accumulating evidence demonstrates that host exosome pathways are hijacked by viruses and that virally modified exosomes contribute to virus spread and immune evasion. In the case of tumor viruses, recent findings s...

journal_title：Journal of virology

authors： Meckes DG Jr

更新日期：2015-05-01 00:00:00

abstract：:A variant form of splicing of RNA crossing the Epstein-Barr virus (EBV) BZLF1 gene was observed in the late productive cycle of EBV. This splice omits the middle exon of BZLF1 and joins the outer two exons of BZLF1 in frame, but the shortened form of BZLF1 protein (Z delta) could not be detected in natural EBV infecti...

journal_title：Journal of virology

authors： Lau R,Packham G,Farrell PJ

更新日期：1992-10-01 00:00:00

abstract：:The configuration of latent varicella-zoster virus (VZV) DNA was analyzed by PCR. Template DNA for both internal and terminal VZV primers was present in a 1:1 ratio in ganglionic DNA, compared with a 15:1 ratio in DNA extracted from VZV virions, indicating that the VZV genomic termini are adjacent in latently infected...

journal_title：Journal of virology

authors： Clarke P,Beer T,Cohrs R,Gilden DH

更新日期：1995-12-01 00:00:00

abstract：:Expression of the human ADA cDNA encoded by the Moloney murine leukemia virus spliced RNA form is enhanced by intron-contained sequences. The presence of sequences corresponding to the viral gag gene in a Moloney murine leukemia virus-based vector results in the generation of 10- to 40-fold higher titers of virus. ...

journal_title：Journal of virology

authors： Armentano D,Yu SF,Kantoff PW,von Ruden T,Anderson WF,Gilboa E

更新日期：1987-05-01 00:00:00

abstract：:We showed previously that retrovirus vector particles can encapsidate RNAs without retroviral cis-acting sequences, that such RNAs are reverse transcribed in infected target cells, and that the cDNA copies are inserted into the host genome resulting in cDNA genes (R. Dornburg and H. M. Temin, Mol. Cell. Biol. 8:2328-2...

journal_title：Journal of virology

authors： Dornburg R,Temin HM

更新日期：1990-02-01 00:00:00

abstract：:The effectiveness and potential immunosuppressive effects of anti-inflammatory glucocorticoids in the lungs of severe acute respiratory syndrome (SARS) patients are undefined. We treated porcine respiratory coronavirus (PRCV)-infected conventional pigs with the corticosteroid dexamethasone (DEX) as a model for SARS. I...

journal_title：Journal of virology

authors： Zhang X,Alekseev K,Jung K,Vlasova A,Hadya N,Saif LJ

更新日期：2008-05-01 00:00:00

abstract：:In less than 3 months after the first cases of swine origin 2009 influenza A (H1N1) virus infections were reported from Mexico, WHO declared a pandemic. The pandemic virus is antigenically distinct from seasonal influenza viruses, and the majority of human population lacks immunity against this virus. We have studied ...

journal_title：Journal of virology

authors： Osterlund P,Pirhonen J,Ikonen N,Rönkkö E,Strengell M,Mäkelä SM,Broman M,Hamming OJ,Hartmann R,Ziegler T,Julkunen I

更新日期：2010-02-01 00:00:00

abstract：:Diseases of the nasopharyngeal epithelium due to Epstein-Barr virus (EBV) infection typically occur in chronic virus carriers with preexisting virus-specific antibodies. In vitro studies have shown that EBV-specific immunoglobulin A (IgA) promotes infection of human epithelial cells, otherwise refractory to EBV, via t...

journal_title：Journal of virology

authors： Gan YJ,Chodosh J,Morgan A,Sixbey JW

更新日期：1997-01-01 00:00:00

abstract：UNLABELLED:While a clear understanding of the events leading to successful establishment of host-specific viral populations and productive infection in the central nervous system (CNS) has not yet been reached, the simian immunodeficiency virus (SIV)-infected rhesus macaque provides a powerful model for the study of hu...

journal_title：Journal of virology

authors： Lamers SL,Nolan DJ,Rife BD,Fogel GB,McGrath MS,Burdo TH,Autissier P,Williams KC,Goodenow MM,Salemi M

更新日期：2015-08-01 00:00:00

abstract：:Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a gammaherpesvirus of mice, is transmitted sexually. We show that this depends on the major virion envelope glycoprotein gp150. gp...

journal_title：Journal of virology

authors： Zeippen C,Javaux J,Xiao X,Ledecq M,Mast J,Farnir F,Vanderplasschen A,Stevenson P,Gillet L

更新日期：2017-06-09 00:00:00

abstract：:Infection of mouse L-cell spinner cultures by vesicular stomatitis virus (VSV) effected the selective translation of viral mRNA by 4h after viral adsorption. Cell-free systems prepared from mock- and VSV-infected cells reflected this phenomenon; protein synthesis was reduced in the virus-infected cell lysate by approx...

journal_title：Journal of virology

authors： Centrella M,Lucas-Lenard J

更新日期：1982-03-01 00:00:00

abstract：:Herpes simplex virus (HSV) glycoprotein B (gB) is an integral part of the multicomponent fusion system required for virus entry and cell-cell fusion. Here we investigated the mechanism of viral neutralization by the monoclonal antibody (MAb) 2c, which specifically recognizes the gB of HSV type 1 (HSV-1) and HSV-2. Bin...

journal_title：Journal of virology

authors： Krawczyk A,Krauss J,Eis-Hübinger AM,Däumer MP,Schwarzenbacher R,Dittmer U,Schneweis KE,Jäger D,Roggendorf M,Arndt MA

更新日期：2011-02-01 00:00:00

abstract：:Spanins are bacteriophage lysis proteins responsible for disruption of the outer membrane, the final step of Gram-negative host lysis. The absence of spanins results in a terminal phenotype of fragile spherical cells. The phage T1 employs a unimolecular spanin gp11 that has an N-terminal lipoylation signal and a C-ter...

journal_title：Journal of virology

authors： Kongari R,Snowden J,Berry JD,Young R

更新日期：2018-10-29 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection of the human thymus results in depletion of CD4-bearing thymocytes. This depletion is initially manifested in the immature CD4+/CD8+ thymocyte subset. To determine cellular factors involved in HIV infection in the thymus, we examined the expression of the recently ...

journal_title：Journal of virology

authors： Kitchen SG,Zack JA

更新日期：1997-09-01 00:00:00