Abstract:
:Varicella-zoster virus (VZV) is a highly species-specific herpesvirus that targets sensory ganglionic neurons. This species specificity has limited the study of many aspects of VZV pathogenesis, including neuronal infection. We report development of a highly efficient neuroblastoma cell model to study productive VZV infection of neuronal cells. We show that differentiation of SH-SY5Y neuroblastoma cells yields a homogenous population of neuron-like cells that are permissive to the full VZV replicative cycle. These cells supported productive infection by both laboratory and clinical VZV isolates, including the live varicella vaccine. This model may enable rapid identification of genetic determinants facilitating VZV neurotropism.
journal_name
J Viroljournal_title
Journal of virologyauthors
Christensen J,Steain M,Slobedman B,Abendroth Adoi
10.1128/JVI.00515-11subject
Has Abstractpub_date
2011-08-01 00:00:00pages
8436-42issue
16eissn
0022-538Xissn
1098-5514pii
JVI.00515-11journal_volume
85pub_type
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