Abstract:
:Therapeutic suppression of human immunodeficiency virus type 1 (HIV-1) replication may help elucidate interactions between the host cellular immune responses and HIV-1 infection. We performed a detailed longitudinal evaluation of two subjects before and after the start of highly active antiretroviral therapy (HAART). Both subjects had evidence of in vivo-activated and memory cytotoxic T-lymphocyte precursor (CTLp) activity against multiple HIV-1 gene products. After the start of therapy, both subjects had declines in the levels of in vivo-activated HIV-1-specific CTLs and had immediate increases in circulating HIV-1-specific CTL memory cells. With continued therapy, and continued suppression of viral load, levels of memory CTLps declined. HLA A*0201 peptide tetramer staining demonstrated that declining levels of in vivo-activated CTL activity were associated with a decrease in the expression of the CD38(+) activation marker. Transient increases in viral load during continued therapy were associated with increases in the levels of virus-specific CTLps in both individuals. The results were confirmed by measuring CTL responses to discrete optimal epitopes. These studies illustrate the dynamic equilibrium between the host immune response and levels of viral antigen burden and suggest that efforts to augment HIV-1-specific immune responses in subjects on HAART may decrease the incidence of virologic relapse.
journal_name
J Viroljournal_title
Journal of virologyauthors
Kalams SA,Goulder PJ,Shea AK,Jones NG,Trocha AK,Ogg GS,Walker BDdoi
10.1128/JVI.73.8.6721-6728.1999subject
Has Abstractpub_date
1999-08-01 00:00:00pages
6721-8issue
8eissn
0022-538Xissn
1098-5514journal_volume
73pub_type
杂志文章abstract::Two mutant strains (vi12 and vi13) of herpes simplex virus that contain insertion mutations in the sequences that encode the DNA-binding domain of viral regulatory protein ICP4 were generated. Both mutations disrupted specific DNA binding and resulted in transcriptionally inactive molecules; however, the ability of th...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.1.299-307.1991
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abstract::A chimeric porcine circovirus (PCV1-2) with the capsid gene of pathogenic PCV2 cloned into the genomic backbone of nonpathogenic PCV1 is attenuated in pigs but elicits protective immunity against PCV2. In this study, short epitope tags were inserted into the C terminus of the capsid protein of the chimeric PCV1-2 vacc...
journal_title:Journal of virology
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doi:10.1128/JVI.02294-10
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.11.6682-6688.1993
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.19.9068-9076.2001
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.10.6653-6657.1996
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.7.4283-4290.1996
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doi:10.1128/JVI.02171-06
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.7.3192-3198.1990
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.36.2.622-626.1980
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.67.9.5279-5288.1993
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02658-13
更新日期:2013-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.21.13800-13805.2005
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.2.1013-1018.1991
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
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journal_title:Journal of virology
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.3.5.506-512.1969
更新日期:1969-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.21.10112-10121.2000
更新日期:2000-11-01 00:00:00
abstract:UNLABELLED:Modified vaccinia virus Ankara (MVA) serves as a versatile platform in vaccine development. This highly attenuated orthopoxvirus, which cannot replicate in mammalian cells, triggers strong innate immune responses, including cell migration. Previously, we have shown that induction of chemokine (C-C motif) lig...
journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
abstract::The E1A gene of highly oncogenic type 12 adenovirus (Ad12) possesses a segment unique to this serotype and comprising 60 base pairs contiguous with and separating conserved regions 2 and 3 in the gene. A similar but slightly longer segment is also present in the E1A gene of highly oncogenic simian adenovirus type 7 (D...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.2.877-887.1994
更新日期:1994-02-01 00:00:00