Abstract:
:Activation of host innate immune responses was studied in severe acute respiratory syndrome coronavirus (SCV)-infected human A549 lung epithelial cells, macrophages, and dendritic cells (DCs). In all cell types, SCV-specific subgenomic mRNAs were seen, whereas no expression of SCV proteins was found. No induction of cytokine genes (alpha interferon [IFN-alpha], IFN-beta, interleukin-28A/B [IL-28A/B], IL-29, tumor necrosis factor alpha, CCL5, or CXCL10) or IFN-alpha/beta-induced MxA gene was seen in SCV-infected A549 cells, macrophages, or DCs. SCV also failed to induce DC maturation (CD86 expression) or enhance major histocompatibility complex class II expression. Our data strongly suggest that SCV fails to activate host cell cytokine gene expression in human macrophages and DCs.
journal_name
J Viroljournal_title
Journal of virologyauthors
Ziegler T,Matikainen S,Rönkkö E,Osterlund P,Sillanpää M,Sirén J,Fagerlund R,Immonen M,Melén K,Julkunen Idoi
10.1128/JVI.79.21.13800-13805.2005subject
Has Abstractpub_date
2005-11-01 00:00:00pages
13800-5issue
21eissn
0022-538Xissn
1098-5514pii
79/21/13800journal_volume
79pub_type
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doi:10.1128/JVI.67.6.3134-3141.1993
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pub_type: 杂志文章
doi:10.1128/JVI.71.6.4564-4570.1997
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pub_type: 杂志文章
doi:10.1128/JVI.66.4.2057-2066.1992
更新日期:1992-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.75.20.9585-9595.2001
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1977-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.12.6263-6269.1990
更新日期:1990-12-01 00:00:00
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pub_type: 杂志文章
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