Comparison of the genetic recombination rates of human immunodeficiency virus type 1 in macrophages and T cells.

abstract：:Herpes simplex virus 1 (HSV-1) is a common human pathogen that causes lifelong latent infection of sensory neurons. Non-nucleoside inhibitors that can limit HSV-1 recurrence are particularly useful in treating immunocompromised individuals or cases of emerging acyclovir-resistant strains of herpesvirus. We report that...

journal_title：Journal of virology

authors： Lin LT,Chen TY,Chung CY,Noyce RS,Grindley TB,McCormick C,Lin TC,Wang GH,Lin CC,Richardson CD

更新日期：2011-05-01 00:00:00

abstract：:The U(L)17 protein (pU(L)17) of herpes simplex virus 1 (HSV-1) likely associates with the surfaces of DNA-containing capsids in a heterodimer with pU(L)25. pU(L)17 is also associated with viral light particles that lack capsid proteins, suggesting its presence in the tegument of the HSV-1 virion. To help determine how...

journal_title：Journal of virology

authors： Scholtes LD,Yang K,Li LX,Baines JD

更新日期：2010-08-01 00:00:00

abstract：:UR2 is a newly characterized avian sarcoma virus whose genome contains a unique sequence that is not related to the sequences of other avian sarcoma virus transforming genes thus far identified. This unique sequence, termed ros, is fused to part of the viral gag gene. The product of the fused gag-ros gene of UR2 is a ...

journal_title：Journal of virology

authors： Feldman RA,Wang LH,Hanafusa H,Balduzzi PC

更新日期：1982-04-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) tat protein functions at a much lower level in rodent cells than in human cells. This species-specific difference in trans activation appears to be due to the lack of a functional homolog of a human cofactor for tat in rodent cells. Using HIV-1 long terminal repeat-drive...

journal_title：Journal of virology

authors： Newstein M,Stanbridge EJ,Casey G,Shank PR

更新日期：1990-09-01 00:00:00

abstract：:Three polyadenylated RNAs, 9, 7.3, and 3.5 kilobases long, of a human endogenous retrovirus, ERV3, are abundant in human placental chorion, representing about 0.03 to 0.05% of the total mRNA. We characterized the structure of these mRNAs by Northern blot and S1 nuclease mapping analyses. We found that all three RNAs w...

journal_title：Journal of virology

authors： Kato N,Pfeifer-Ohlsson S,Kato M,Larsson E,Rydnert J,Ohlsson R,Cohen M

更新日期：1987-07-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) capsid is a T=16 icosahedral shell that forms in the nuclei of infected cells. Capsid assembly also occurs in vitro in reaction mixtures created from insect cell extracts containing recombinant baculovirus-expressed HSV-1 capsid proteins. During capsid formation, the major capsi...

journal_title：Journal of virology

authors： Spencer JV,Newcomb WW,Thomsen DR,Homa FL,Brown JC

更新日期：1998-05-01 00:00:00

abstract：:One unique feature of the shrimp white spot syndrome virus (WSSV) genome is the presence of a giant open reading frame (ORF) of 18,234 nucleotides that encodes a long polypeptide of 6,077 amino acids with a hitherto unknown function. In the present study, by applying proteomic methodology to analyze the sodium dodecyl...

journal_title：Journal of virology

authors： Leu JH,Tsai JM,Wang HC,Wang AH,Wang CH,Kou GH,Lo CF

更新日期：2005-01-01 00:00:00

abstract：:ICP0 is a transcriptional activating protein required for the efficient replication and reactivation of latent herpes simplex virus 1 (HSV-1). Multiple regions of ICP0 contribute its activity, the most prominent of which appears to be the RING finger, which confers E3 ubiquitin ligase activity. A region in the C termi...

journal_title：Journal of virology

authors： Ferenczy MW,Ranayhossaini DJ,Deluca NA

更新日期：2011-05-01 00:00:00

abstract：:The final assembly of rotavirus particles takes place in the endoplasmic reticulum (ER). In this work, we evaluated by RNA interference the relevance to rotavirus assembly and infectivity of grp78, protein disulfide isomerase (PDI), grp94, calnexin, calreticulin, and ERp57, members of the two ER folding systems descri...

journal_title：Journal of virology

authors： Maruri-Avidal L,López S,Arias CF

更新日期：2008-06-01 00:00:00

abstract：:BALB/c mice treated with pristane and Abelson virus have been used as an animal model system for the rapid induction of plasmacytomas. Myelomonocytic tumors with helper Moloney murine leukemia virus clonally inserted into the c-myb locus were observed in about 10% of pristane-primed BALB/c mice infected with Abelson v...

journal_title：Journal of virology

authors： Shen-Ong GL,Wolff L

更新日期：1987-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular carcinoma. An important player in subverting the host response to HCV in...

journal_title：Journal of virology

authors： Çevik RE,Cesarec M,Da Silva Filipe A,Licastro D,McLauchlan J,Marcello A

更新日期：2017-08-24 00:00:00

abstract：:Herpes simplex virus (HSV) strains HSV type 1 (HSV-1) KOS and HSV-2 186 are representative of delayed and early shutoff strains, respectively, with regard to their ability to inhibit protein synthesis in Friend erythroleukemia cells. When these cells were simultaneously infected with HSV-1 KOS and HSV-2 186, HSV-1 KOS...

journal_title：Journal of virology

authors： Hill TM,Sadler JR,Betz JL

更新日期：1985-10-01 00:00:00

abstract：UNLABELLED:The encephalitic response to viral infection requires local chemokine production and the ensuing recruitment of immune and inflammatory leukocytes. Accordingly, chemokine receptors present themselves as plausible therapeutic targets for drugs aimed at limiting encephalitic responses. However, it remains uncl...

journal_title：Journal of virology

authors： Michlmayr D,McKimmie CS,Pingen M,Haxton B,Mansfield K,Johnson N,Fooks AR,Graham GJ

更新日期：2014-09-01 00:00:00

abstract：:An R638A mutation of the polymerase acidic protein (PA) subunit of the RNA polymerase of influenza A/WSN/33 virus results in severe attenuation of viral growth in cell culture by promoting the synthesis of defective interfering RNAs. We propose that R638A is an "elongation" mutant that destabilizes PA-RNA template int...

journal_title：Journal of virology

authors： Fodor E,Mingay LJ,Crow M,Deng T,Brownlee GG

更新日期：2003-04-01 00:00:00

abstract：UNLABELLED:The potency and breadth of the recently isolated neutralizing human monoclonal antibodies to HIV-1 have stimulated interest in their use to prevent or to treat HIV-1 infection. Due to the antigenically diverse nature of the HIV-1 envelope (Env), no single antibody is highly active against all viral strains. ...

journal_title：Journal of virology

authors： Asokan M,Rudicell RS,Louder M,McKee K,O'Dell S,Stewart-Jones G,Wang K,Xu L,Chen X,Choe M,Chuang G,Georgiev IS,Joyce MG,Kirys T,Ko S,Pegu A,Shi W,Todd JP,Yang Z,Bailer RT,Rao S,Kwong PD,Nabel GJ,Mascola JR

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:Herpes simplex virus 1 (HSV-1) glycoprotein B (gB)-specific CD8(+) T cells protect mice from herpes infection and disease. However, whether and which HSV-1 gB-specific CD8(+) T cells play a key role in the "natural" protection seen in HSV-1-seropositive healthy asymptomatic (ASYMP) individuals (who have neve...

journal_title：Journal of virology

authors： Khan AA,Srivastava R,Spencer D,Garg S,Fremgen D,Vahed H,Lopes PP,Pham TT,Hewett C,Kuang J,Ong N,Huang L,Scarfone VM,Nesburn AB,Wechsler SL,BenMohamed L

更新日期：2015-04-01 00:00:00

abstract：:Synthetic peptides of increasing length and corresponding in sequence to the C-terminal end of the HA1 molecule of influenza virus were constructed and examined for their immunogenic and antigenic properties. Peptides containing at least the four C-terminal amino acids, when coupled to keyhole limpet hemocyanin, were ...

journal_title：Journal of virology

authors： Tang XL,Tregear GW,White DO,Jackson DC

更新日期：1988-12-01 00:00:00

abstract：:Hpt-13 is a Chinese hamster cell line deficient in hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) and sensitive to a medium containing 10(-4) M hypoxanthine, 5.5 X 10(-6) M aminopterin, and 10(-4) M thymidine. In this cell line there is a high incidence of cells resistant to this selective medium after an incubat...

journal_title：Journal of virology

authors： Marengo C,Mbikay M,Weber J,Thirion JP

更新日期：1981-04-01 00:00:00

abstract：:Oligonucleotide-directed mutagenesis was used to construct a nonsense mutation in open reading frame (ORF) E2 of bovine papillomavirus DNA. A single base substitution mutation was constructed which converted a TAC codon into a TAG amber stop codon at a position in the ORF that did not overlap with any other viral ORFs...

journal_title：Journal of virology

authors： DiMaio D

更新日期：1986-02-01 00:00:00

abstract：:We previously reported that a recombinant pantothenate auxotroph of Mycobacterium bovis BCG expressing human immunodeficiency virus type 1 (HIV-1) subtype C Gag (rBCGpan-Gag) efficiently primes the mouse immune system for a boost with a recombinant modified vaccinia virus Ankara (rMVA) vaccine. In this study, we furth...

journal_title：Journal of virology

authors： Chege GK,Burgers WA,Stutz H,Meyers AE,Chapman R,Kiravu A,Bunjun R,Shephard EG,Jacobs WR Jr,Rybicki EP,Williamson AL

更新日期：2013-05-01 00:00:00

abstract：:An in vitro system is described for the assembly of herpes simplex virus type 1 (HSV-1) procapsids beginning with three purified components, the major capsid protein (VP5), the triplexes (VP19C plus VP23), and a hybrid scaffolding protein. Each component was purified from insect cells expressing the relevant protein(s...

journal_title：Journal of virology

authors： Newcomb WW,Homa FL,Thomsen DR,Trus BL,Cheng N,Steven A,Booy F,Brown JC

更新日期：1999-05-01 00:00:00

abstract：:Heat shock protein 70 (Hsp70) is incorporated within the membrane of primate lentiviral virions. Here we demonstrate that Hsp70 is also incorporated into oncoretroviral virions and that it remains associated with membrane-stripped human immunodeficiency virus type 1 (HIV-1) virion cores. To determine if Hsp70 promotes...

journal_title：Journal of virology

authors： Gurer C,Höglund A,Höglund S,Luban J

更新日期：2005-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) nonstructural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRp) that acts as a key player in the HCV replication complex. Understanding the interplay between the viral and cellular components of the HCV replication complex could provide new insight for prevention of the progression of...

journal_title：Journal of virology

authors： Huang JT,Tseng CP,Liao MH,Lu SC,Yeh WZ,Sakamoto N,Chen CM,Cheng JC

更新日期：2013-05-01 00:00:00

abstract：:Epstein-Barr virus (EBV) can be reactivated from latency into the lytic cycle by many stimuli believed to operate by different mechanisms. Cell lines containing EBV differ in their responses to inducing stimuli, yet all stimuli require de novo protein synthesis (44). A crucial step preliminary to identifying these pro...

journal_title：Journal of virology

authors： Countryman J,Gradoville L,Bhaduri-McIntosh S,Ye J,Heston L,Himmelfarb S,Shedd D,Miller G

更新日期：2009-10-01 00:00:00

abstract：:The genetic evolution of human immunodeficiency virus type 1 (HIV-1) in the brain is distinct from that in lymphoid tissues, indicating tissue-specific compartmentalization of the virus. Few primary HIV-1 envelope glycoproteins (Envs) from uncultured brain tissues have been biologically well characterized. In this stu...

journal_title：Journal of virology

authors： Ohagen A,Devitt A,Kunstman KJ,Gorry PR,Rose PP,Korber B,Taylor J,Levy R,Murphy RL,Wolinsky SM,Gabuzda D

更新日期：2003-11-01 00:00:00

abstract：:It has been shown that not all but most of the avian influenza viruses replicate in the upper respiratory tract of pigs (H. Kida et al., J. Gen. Virol. 75:2183-2188, 1994). It was shown that A/chicken/Yamaguchi/7/2004 (H5N1) [Ck/Yamaguchi/04 (H5N1)] did not replicate in pigs (N. Isoda et al., Arch. Virol. 151:1267-127...

journal_title：Journal of virology

authors： Manzoor R,Sakoda Y,Nomura N,Tsuda Y,Ozaki H,Okamatsu M,Kida H

更新日期：2009-02-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent for KS tumors, multicentric Castleman's disease, and primary effusion lymphomas. Like other herpesvirus capsids, the KSHV capsid is an icosahedral structure composed of six proteins. The capsid shell is made up of the major capsid protein, two tripl...

journal_title：Journal of virology

authors： Perkins EM,Anacker D,Davis A,Sankar V,Ambinder RF,Desai P

更新日期：2008-07-01 00:00:00

abstract：:Analysis of the pronase-derived glycopeptides of isolated mumps virus glycoproteins revealed the presence of both complex and high-mannose-type oligosaccharides on the HN and F1 glycoproteins, whereas only high-mannose-type glycopeptides were detected on F2. Endoglycosidase F, a newly described glycosidase that cleave...

journal_title：Journal of virology

authors： Herrler G,Compans RW

更新日期：1983-08-01 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1) enhances the growth of T lymphocytes, allowing the generation of T-lymphocyte cell lines. This report describes a limiting-dilution assay system which uses low input numbers of HTLV-1-producing cells for generation of T-lymphocyte cultures. The HTLV-1 transformants gener...

journal_title：Journal of virology

authors： Persaud D,Muñoz JL,Tarsis SL,Parks ES,Parks WP

更新日期：1995-10-01 00:00:00

abstract：:Deoxyribonucleoside triphosphates are incorporated into T4 DNA in infected cells treated with toluene. Under the proper conditions the incorporation is controlled by the known T4 DNA polymerase and proceeds by a semiconservative mechanism. Both strands of the phage DNA are replicated into a high molecular weight proge...

journal_title：Journal of virology

authors： Miller RC Jr,Taylor DM,MacKay K,Smith HW

更新日期：1973-12-01 00:00:00