A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase promotes the generation of defective interfering RNAs.

abstract：:Persistent infection with hepatitis C virus (HCV) is a major cause of chronic liver diseases. The aim of this study was to identify host cell factor(s) participating in the HCV replication complex (RC) and to clarify the regulatory mechanisms of viral genome replication dependent on the host-derived factor(s) identifi...

journal_title：Journal of virology

authors： Hara H,Aizaki H,Matsuda M,Shinkai-Ouchi F,Inoue Y,Murakami K,Shoji I,Kawakami H,Matsuura Y,Lai MM,Miyamura T,Wakita T,Suzuki T

更新日期：2009-05-01 00:00:00

abstract：:In this study, we characterized the viral determinants of coreceptor usage in relation to susceptibility to antibody-mediated neutralization or enhancement of infectivity by using chimeras of three highly related human immunodeficiency virus type 1 (HIV-1) isolates of different phenotypes. We found that the V3 region ...

journal_title：Journal of virology

authors： Guillon C,Schutten M,Boers PH,Gruters RA,Osterhaus AD

更新日期：2002-03-01 00:00:00

abstract：:Polyacrylamide gel electrophoretic analysis of purified preparations of human and calf diarrhea viruses indicated eight polypeptide components, or possibly nine in the case of the calf diarrhea virus. Thermal denaturation and analytical studies of the calf diarrhea virus genome showed it to consist of 11 double-strand...

journal_title：Journal of virology

authors： Rodger SM,Schnagl RD,Holmes IH

更新日期：1975-11-01 00:00:00

abstract：:Recombinant viruses were constructed to have an Escherichia coli replicon containing a mutagenesis marker, the supF gene, integrated within the thymidine kinase locus (tk) of herpes simplex virus type 1. These viruses expressed either wild-type or mutant DNA polymerase (Pol) and were tested in a mutagenesis assay for ...

journal_title：Journal of virology

authors： Hwang YT,Liu BY,Hwang CB

更新日期：2002-04-01 00:00:00

abstract：:The wild-type strain of vesicular stomatitis virus (VSV) contains in its complete virion (VSV-1, B particles) a minus strand RNA. The principle defective particle of the wild-type strain (VSV-111, T particles) contains a shorter minus strand, homologous to part of the VSV-1 genome. Neither virion contains any detectab...

journal_title：Journal of virology

authors： Roy P,Repik P,Hefti E,Bishop DH

更新日期：1973-06-01 00:00:00

abstract：:The gastrointestinal tract is constantly exposed to a variety of potentially invasive bacteria and viruses. The first line of defense of the host against these pathogens is the intestinal mucosal surface, which consists of epithelial cells, intraepithelial lymphocytes (IELs), mucus, and secretory immunoglobulins. Litt...

journal_title：Journal of virology

authors： Offit PA,Dudzik KI

更新日期：1989-08-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) are important for the control of virus replication during respiratory infections. For human metapneumovirus (hMPV), an H-2(d)-restricted CTL epitope in the M2-2 protein has been described. In this study, we screened the hMPV F, G, N, M, M2-1, and M2-2 proteins using three independent alg...

journal_title：Journal of virology

authors： Melendi GA,Zavala F,Buchholz UJ,Boivin G,Collins PL,Kleeberger SR,Polack FP

更新日期：2007-10-01 00:00:00

abstract：:The development of neoplasia frequently involves inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways and disruption of cell cycle checkpoints that monitor the integrity of replication and cell division. The human papillomavirus type 16 (HPV-16) oncoproteins, E6 and E7, have been shown to bind p53...

journal_title：Journal of virology

authors： Martin LG,Demers GW,Galloway DA

更新日期：1998-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) often causes a persistent infection associated with hypergammaglobulinemia, high levels of antiviral antibody and circulating immune complexes, and immune complex disease. We previously reported that only a limited neutralizing activity to vesicular stomatitis virus or HCV pseudotype is generat...

journal_title：Journal of virology

authors： Meyer K,Ait-Goughoulte M,Keck ZY,Foung S,Ray R

更新日期：2008-03-01 00:00:00

abstract：:Mitochondrial DNA synthesis in adenovirus type 2-infected HeLa cells was measured at various times from 0 to 24 h postinfection. Although viral infection effectively turned off host chromosomal DNA synthesis, mitochondrial DNA synthesis was not inhibited. These findings indicate a dissociation between the regulation o...

journal_title：Journal of virology

authors： Fisher PB,Horwitz MS

更新日期：1977-05-01 00:00:00

abstract：:Here, we report that specific manipulations of the cellular response to virus infection can cause prevention of apoptosis and consequent establishment of persistent infection. Infection of several human cell lines with Sendai virus (SeV) or human parainfluenza virus 3, two prototypic paramyxoviruses, caused slow apopt...

journal_title：Journal of virology

authors： Peters K,Chattopadhyay S,Sen GC

更新日期：2008-04-01 00:00:00

abstract：:A monoclonal antibody, MAb vpg15, inhibits feline immunodeficiency virus (FIV) infection in tissue culture. The antibody is directed to a determinant of the feline cell surface marker, CD9, implying that CD9 may serve as a viral receptor or coreceptor in this system. In cells expressing CD9, MAb vpg15 markedly delayed...

journal_title：Journal of virology

authors： de Parseval A,Lerner DL,Borrow P,Willett BJ,Elder JH

更新日期：1997-08-01 00:00:00

abstract：:We determined the sequence of the gene for the virion transactivator protein Vmw65 of herpes simplex virus type 2 (HSV-2), strain 333. An analysis of the coding sequence revealed an overall high degree of primary sequence conservation (86%) relative to the HSV-1 protein, although the carboxy-terminal region which enco...

journal_title：Journal of virology

authors： Greaves RF,O'Hare P

更新日期：1991-12-01 00:00:00

abstract：:Replicase gene expression by the human coronavirus 229E involves the synthesis of two large polyproteins, pp1a and pp1ab. Experimental evidence suggests that these precursor molecules are subject to extensive proteolytic processing. In this study, we show that a chymotrypsin-like enzyme, the virus-encoded 3C-like prot...

journal_title：Journal of virology

authors： Ziebuhr J,Siddell SG

更新日期：1999-01-01 00:00:00

abstract：:The Duplan strain of murine leukemia virus induces murine AIDS in C57BL/6 mice. When spleen cells from C57BL/6 mice infected with the virus were transplanted into nude mice, subcutaneous solid tumors at the transplanted sites were formed and splenomegaly and lymphadenopathy were induced. These transplantable cells wer...

journal_title：Journal of virology

authors： Kubo Y,Nakagawa Y,Kakimi K,Matsui H,Iwashiro M,Kuribayashi K,Masuda T,Hiai H,Hirama T,Yanagawa S

更新日期：1992-09-01 00:00:00

abstract：:The human immunodeficiency virus Tat protein is essential for virus replication and is a candidate vaccine antigen. Macaques immunized with Tat or chemically modified Tat toxoid having the same clade B sequence developed strong antibody responses. We compared these antisera for their abilities to recognize diverse Tat...

journal_title：Journal of virology

authors： Tikhonov I,Ruckwardt TJ,Hatfield GS,Pauza CD

更新日期：2003-03-01 00:00:00

abstract：:An mRNA-ribonucleoprotein particle (mRNP) was found in vesicular stomatitis virus (VSV)-infected Chinese hamster ovary cells. The particle was present 3 and 4.5 h after infection but was barely discernible at 2 h. The mRNP (buoyant density, 1.56 g/cm3), which cosedimented with viral nucleocapsid in a sucrose density g...

journal_title：Journal of virology

authors： Rosen CA,Ennis HL,Cohen PS

更新日期：1982-12-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infections in sub-Saharan Africa represent about 56% of global infections. Study of active-site mutations (the V82A single mutation and the V82F I84V double mutation) in the less-studied South African HIV type 1 subtype C (C-SA) protease indicated that neither mutation had a signific...

journal_title：Journal of virology

authors： Mosebi S,Morris L,Dirr HW,Sayed Y

更新日期：2008-11-01 00:00:00

abstract：:High-risk human papillomaviruses (HPVs), including HPV-16 and HPV-18, are the causative agents of cervical carcinomas and are linked to several other tumors of the anogenital and oropharyngeal regions. The majority of HPV-induced tumors contain integrated copies of the normally episomal HPV genome that invariably reta...

journal_title：Journal of virology

authors： Kennedy EM,Kornepati AV,Goldstein M,Bogerd HP,Poling BC,Whisnant AW,Kastan MB,Cullen BR

更新日期：2014-10-01 00:00:00

abstract：:The discovery that hepatitis B virus (HBV) integrates into host chromosomes raises the question of whether such viral DNA integration correlates directly with the activation of specific oncogenes or the inactivation of anti-oncogenes. To obtain insight into this problem, we randomly collected HBV integrant samples fro...

journal_title：Journal of virology

authors： Tokino T,Matsubara K

更新日期：1991-12-01 00:00:00

abstract：:The human papillomavirus type 11 (HPV-11) L1 major capsid protein can be trypsinized to generate recombinant capsomeres that retain HPV genotype-restricted capsid antigenicity (M. Li, T. P. Cripe, P. A. Estes, M. K. Lyon, R. C. Rose, and R. L. Garcea, J. Virol. 71:2988-2995, 1997). In the present study, HPV-11 virion-...

journal_title：Journal of virology

authors： Rose RC,White WI,Li M,Suzich JA,Lane C,Garcea RL

更新日期：1998-07-01 00:00:00

abstract：:To clarify hematological abnormalities following infection with human immunodeficiency virus (HIV), we examined the hematopoietic capability of bone marrow by using cynomolgus monkeys infected with pathogenic simian/human immunodeficiency virus (SHIV) strain C2/1, an animal model of HIV infection. The relationship bet...

journal_title：Journal of virology

authors： Yamakami K,Honda M,Takei M,Ami Y,Kitamura N,Nishinarita S,Sawada S,Horie T

更新日期：2004-10-01 00:00:00

abstract：:Antibody-dependent enhancement of flavivirus infection, which except for dengue virus is without clear proof in vivo, is still under debate. Recently, postexposure immunoglobulin prophylaxis against tick-borne encephalitis virus, a flavivirus, was claimed to possibly have worsened the outcome of infection due to antib...

journal_title：Journal of virology

authors： Kreil TR,Eibl MM

更新日期：1997-04-01 00:00:00

abstract：:The temporal regulation of DNA replication is thought to be important for chromosome organization and genome stability. We show here that Epstein-Barr virus (EBV) genomes replicate in mid- to late S phase and that agents that accelerate replication timing of EBV reduce viral genome stability. Hydroxyurea (HU) treatmen...

journal_title：Journal of virology

authors： Zhou J,Snyder AR,Lieberman PM

更新日期：2009-03-01 00:00:00

abstract：:Barley stripe mosaic virus (BSMV) encodes three movement proteins in an overlapping triple gene block (TGB), but little is known about the physical interactions of these proteins. We have characterized a ribonucleoprotein (RNP) complex consisting of the TGB1 protein and plus-sense BSMV RNAs from infected barley plants...

journal_title：Journal of virology

authors： Lim HS,Bragg JN,Ganesan U,Lawrence DM,Yu J,Isogai M,Hammond J,Jackson AO

更新日期：2008-05-01 00:00:00

abstract：:Fluorosulfonylbenzoyl 5'-adenosine (FSBA) bound to one site in simian virus 40 large T antigen (T) and covalently modified greater than 95% of the molecules in a complete reaction. This analog for ATP specifically cross-links to the Mg-phosphate pocket in ATP-binding sites. Cyanogen bromide cleavage and tryptic digest...

journal_title：Journal of virology

authors： Bradley MK

更新日期：1990-10-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) displays both interstrain and intrastrain genetic variability. Virus populations with extensive microheterogeneity have been defined as swarms or quasispecies. Many of the genomes within HIV-1 swarms appear to be defective in one or more genes required for viral replication....

journal_title：Journal of virology

authors： Lori F,Hall L,Lusso P,Popovic M,Markham P,Franchini G,Reitz MS Jr

更新日期：1992-09-01 00:00:00

abstract：:The genome of a human papillomavirus (HPV) found in a patient with Bowen's disease of the skin was molecularly cloned. Blot hybridization experiments, performed under stringent conditions, revealed no cross-hybridization between this HPV DNA and the other known HPV DNAs, showing that this HPV represents a new type, te...

journal_title：Journal of virology

authors： Kawashima M,Jablonska S,Favre M,Obalek S,Croissant O,Orth G

更新日期：1986-02-01 00:00:00

abstract：:The pathogenic parvovirus B19 (B19V) has an extreme tropism for human erythroid progenitor cells. In vitro, only a few erythroid leukemic cell lines (JK-1 and KU812Ep6) or megakaryoblastoid cell lines (UT7/Epo and UT7/Epo-S1) with erythroid characteristics support B19V replication, but these cells are only semipermiss...

journal_title：Journal of virology

authors： Wong S,Zhi N,Filippone C,Keyvanfar K,Kajigaya S,Brown KE,Young NS

更新日期：2008-03-01 00:00:00

abstract：:We have developed idiotype-anti-idiotype monoclonal antibodies that provide evidence for rabies virus binding to the acetylcholine receptor (AChR). Hybridoma cell lines 7.12 and 7.25 resulted after fusion of NS-1 myeloma cells with spleen cells from a BALB/c mouse immunized with rabies virus strain CVS. Antibody 7.12 ...

journal_title：Journal of virology

authors： Hanham CA,Zhao F,Tignor GH

更新日期：1993-01-01 00:00:00