Abstract:
:Here, we report that specific manipulations of the cellular response to virus infection can cause prevention of apoptosis and consequent establishment of persistent infection. Infection of several human cell lines with Sendai virus (SeV) or human parainfluenza virus 3, two prototypic paramyxoviruses, caused slow apoptosis, which was markedly accelerated upon blocking the action of phosphatidylinositol 3-kinases (PI3 kinases) in the infected cells. The observed apoptosis required viral gene expression and the action of the caspase 8 pathway. Although virus infection activated PI3 kinase, as indicated by AKT activation, its blockage did not inhibit JNK activation or IRF-3 activation. The action of neither the Jak-STAT pathway nor the NF-kappaB pathway was required for apoptosis. In contrast, IRF-3 activation was essential, although induction of the proapototic protein TRAIL by IRF-3 was not required. When IRF-3 was absent or its activation by the RIG-I pathway was blocked, SeV established persistent infection, as documented by viral protein production and infectious virus production. Introduction of IRF-3 in the persistently infected cells restored the cells' ability to undergo apoptosis. These results demonstrated that in our model system, IRF-3 controlled the fate of the SeV-infected cells by promoting apoptosis and preventing persistence.
journal_name
J Viroljournal_title
Journal of virologyauthors
Peters K,Chattopadhyay S,Sen GCdoi
10.1128/JVI.02536-07subject
Has Abstractpub_date
2008-04-01 00:00:00pages
3500-8issue
7eissn
0022-538Xissn
1098-5514pii
JVI.02536-07journal_volume
82pub_type
杂志文章abstract::Bovine spongiform encephalopathy (BSE) is a fatal, transmissible, neurodegenerative disease of cattle. BSE can be transmitted experimentally between cattle through the oral route, and in this study, brain tissue samples from animals at different time points postinoculation were analyzed for changes in gene expression....
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00352-09
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.4.1381-1387.1988
更新日期:1988-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.63.9.3661-3668.1989
更新日期:1989-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.01396-16
更新日期:2016-10-28 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.79.14.8960-8968.2005
更新日期:2005-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.3.1101-1113.2000
更新日期:2000-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.11.9604-9608.1999
更新日期:1999-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.9.6757-6764.1997
更新日期:1997-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.71.9.6677-6682.1997
更新日期:1997-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.03241-13
更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.65.9.4874-4881.1991
更新日期:1991-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.8.4021-4024.1990
更新日期:1990-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 临床试验,杂志文章
doi:10.1128/JVI.70.5.2950-2956.1996
更新日期:1996-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.19.9367-9377.2001
更新日期:2001-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.9.6850-6862.1997
更新日期:1997-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.10.5749-5753.1993
更新日期:1993-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.00438-12
更新日期:2012-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.17.9136-9146.2003
更新日期:2003-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2009-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.3.1602-1611.1996
更新日期:1996-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.16.8360-8373.2002
更新日期:2002-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.9.6582-6592.1997
更新日期:1997-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.18.8582-8588.2000
更新日期:2000-09-01 00:00:00
abstract::The core gene of hepatitis B virus contains two in-phase AUG codons which may both be used in the viral life cycle. By in vitro translation of transcripts produced in vitro, we investigated the corresponding core gene products and their counterparts in vivo. Depending on the location of the 5' end of the transcripts, ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.10.3109-3113.1987
更新日期:1987-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.24.13039-13048.2002
更新日期:2002-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.58.3.743-747.1986
更新日期:1986-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00101-16
更新日期:2016-03-28 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00