Molecular characterization of proteolytic processing of the Gag proteins of human spumavirus.

abstract：:We have studied the unintegrated infectious DNA of Harvey sarcoma virus (Ha-SV) and Moloney leukemia virus (Mo-MuLV). The source of infectious viral DNA was the Hirt supernatant fraction from cells acutely infected with Ha-SV and Mo-MuLV. To obtain a direct quantitative assay for infectious viral DNA, recipient mouse ...

journal_title：Journal of virology

authors： Lowy DR,Rands E,Scolnick EM

更新日期：1978-05-01 00:00:00

abstract：:Pancreatic islets from DBA/2 mice infected with the D variant of encephalomyocarditis (EMC-D) virus revealed lymphocytic infiltration with moderate to severe destruction of pancreatic beta cells. Our previous studies showed that the major population of infiltrating cells at the early stages of infection is macrophages...

journal_title：Journal of virology

authors： Hirasawa K,Jun HS,Maeda K,Kawaguchi Y,Itagaki S,Mikami T,Baek HS,Doi K,Yoon JW

更新日期：1997-05-01 00:00:00

abstract：:The possible addition of extra sequences to simian virus 40 (SV40) DNA was analyzed by electron microscopy in two different cell systems, productively infected monkey cells and activated heterokaryons on monkey and transformed mouse 3T3 cells. We found that the closed circular DNA fraction, extracted from monkey cells...

journal_title：Journal of virology

authors： Yoshike K,Defendi V

更新日期：1977-08-01 00:00:00

abstract：:In this study we report the complete sequence and genome organization of the serotype I feline coronavirus (FCoV) strain Black. Furthermore, a reverse genetic system was established for this FCoV strain by cloning a full-length cDNA copy into vaccinia virus. This clone served as basis for the generation of recombinant...

journal_title：Journal of virology

authors： Tekes G,Hofmann-Lehmann R,Stallkamp I,Thiel V,Thiel HJ

更新日期：2008-02-01 00:00:00

abstract：:Polyomaviruses are small nonenveloped particles with a circular double-stranded genome, approximately 5 kbp in size. The mammalian polyomaviruses mainly cause persistent subclinical infections in their natural nonimmunocompromised hosts. In contrast, the polyomaviruses of birds--avian polyomavirus (APV) and goose hemo...

journal_title：Journal of virology

authors： Johne R,Wittig W,Fernández-de-Luco D,Höfle U,Müller H

更新日期：2006-04-01 00:00:00

abstract：:Epstein-Barr Virus (EBV) generates a variety of viral microRNAs (miRNAs) by processing the BHRF1 and BamHI A rightward (BART) transcripts. BART miRNAs are expressed in all cells latently infected with EBV, but the functions of most BART miRNAs remain unknown. The results of a cell proliferation assay revealed that miR...

journal_title：Journal of virology

authors： Choi H,Lee H,Kim SR,Gho YS,Lee SK

更新日期：2013-07-01 00:00:00

abstract：:Many complex viruses use an assembly pathway in which their genome is packaged into an empty procapsid which subsequently matures into its final expanded form. We utilized Pseudomonas phage 6, a well-established virus assembly model, to probe the plasticity of the procapsid maturation pathway. The 6 packaging nucleosi...

journal_title：Journal of virology

authors： Sun X,Pirttimaa MJ,Bamford DH,Poranen MM

更新日期：2013-12-01 00:00:00

abstract：:Viral infection triggers host innate immune responses through cellular sensor molecules which activate multiple signaling cascades that induce the production of interferons (IFN) and other cytokines. The recent identification of mammalian cytoplasmic viral RNA sensors, such as retinoic acid-inducible gene I (RIG-I)-li...

journal_title：Journal of virology

authors： Biacchesi S,LeBerre M,Lamoureux A,Louise Y,Lauret E,Boudinot P,Brémont M

更新日期：2009-08-01 00:00:00

abstract：:Y-box binding protein YB-1 is a member of a family of DNA and RNA binding proteins which have been shown to affect gene expression at both the transcriptional and translational levels. We have previously shown that YB-1 modulates transcription from the promoters of the ubiquitous human polyomavirus JC virus (JCV). Her...

journal_title：Journal of virology

authors： Safak M,Gallia GL,Ansari SA,Khalili K

更新日期：1999-12-01 00:00:00

abstract：:The coronavirus nucleocapsid (N) protein is a structural protein that forms a ribonucleoprotein complex with genomic RNA. In addition to its structural role, it has been described as an RNA-binding protein that might be involved in coronavirus RNA synthesis. Here, we report a reverse genetic approach to elucidate the ...

journal_title：Journal of virology

authors： Schelle B,Karl N,Ludewig B,Siddell SG,Thiel V

更新日期：2005-06-01 00:00:00

abstract：:Only a few archaeal viruses have been subjected to detailed structural analyses. Major obstacles have been the extreme conditions such as high salinity or temperature needed for the propagation of these viruses. In addition, unusual morphotypes of many archaeal viruses have made it difficult to obtain further informat...

journal_title：Journal of virology

authors： Pietilä MK,Laurinavicius S,Sund J,Roine E,Bamford DH

更新日期：2010-01-01 00:00:00

abstract：:The cytopathic effect (CPE) seen with some subgroups of avian sarcoma and leukosis virus (ASLV) is associated with viral Env activation of the death-promoting activity of TVB (a tumor necrosis factor receptor-related receptor that is most closely related to mammalian TNF-related apoptosis-inducing ligand [TRAIL] recep...

journal_title：Journal of virology

authors： Klucking S,Collins AS,Young JA

更新日期：2005-07-01 00:00:00

abstract：:At least four members of the integrin family of receptors, alphaVbeta1, alphaVbeta3, alphaVbeta6, and alphaVbeta8, have been identified as receptors for foot-and-mouth disease virus (FMDV) in vitro. Our investigators have recently shown that the efficiency of receptor usage appears to be related to the viral serotype ...

journal_title：Journal of virology

authors： Duque H,LaRocco M,Golde WT,Baxt B

更新日期：2004-09-01 00:00:00

abstract：:Three monkeypox virus (MPV) antibody-secreting murine monoclones were characterized as being of the immunoglobulin G1 isotype, gave a 4+ reaction in the indirect fluorescent-antibody test, gave a positive reaction in the enzyme immunoassay, and did not neutralize MPV. These monoclonal antibodies were determined by the...

journal_title：Journal of virology

authors： Roumillat LF,Patton JL,Davis ML

更新日期：1984-10-01 00:00:00

abstract：:The small and middle T (tumor) antigens of polyomavirus have been shown previously to associate with the 36-kDa catalytic subunit and the 63-kDa regulatory subunit of protein phosphatase type 2A, apparently substituting for a normal third 55-kDa regulatory subunit (D.C. Pallas, L.K. Shahrik, B.L. Martin, S. Jaspers, T...

journal_title：Journal of virology

authors： Pallas DC,Weller W,Jaspers S,Miller TB,Lane WS,Roberts TM

更新日期：1992-02-01 00:00:00

abstract：:Modification of proteins by ubiquitin is essential for numerous cellular processes. The RING-H2 finger motif has been implicated in ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Four proteins, WSSV199, WSSV222, WSSV249, and WSSV403, from white spot syndrome virus (WSSV) contain the RING-H2 motif. Here we...

journal_title：Journal of virology

authors： Wang Z,Chua HK,Gusti AA,He F,Fenner B,Manopo I,Wang H,Kwang J

更新日期：2005-07-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infects human cells by binding to surface CD4 molecules and directly fusing with the cell membrane. Although mouse cells expressing human CD4 bind HIV, they do not become infected, apparently because of a block in membrane fusion. To study this problem, we constructed a recombinant v...

journal_title：Journal of virology

authors： Ashorn PA,Berger EA,Moss B

更新日期：1990-05-01 00:00:00

abstract：:Dengue virus (DENV) is an important human pathogen, especially in the tropical and subtropical parts of the world, causing considerable morbidity and mortality. DENV replication occurs in the cytoplasm; however, a high proportion of nonstructural protein 5 (NS5), containing methyltransferase (MTase) and RNA-dependent ...

journal_title：Journal of virology

authors： Kumar A,Bühler S,Selisko B,Davidson A,Mulder K,Canard B,Miller S,Bartenschlager R

更新日期：2013-04-01 00:00:00

abstract：:The Sindbis virus minimal subgenomic mRNA promoter (spanning positions -19 to +5 relative to the subgenomic mRNA start site) is approximately three- to sixfold less active than the fully active -98 to +14 promoter region. We identified two elements flanking the -19 to +5 region which increase its transcription to leve...

journal_title：Journal of virology

authors： Wielgosz MM,Raju R,Huang HV

更新日期：2001-04-01 00:00:00

abstract：:The expression strategy of parvoviruses of the Densovirus genus has as yet not been reported. Clones were obtained from the densonucleosis virus of Galleria mellonella (GmDNV) that yielded infectious virus upon transfection into LD652 cells. Its genome was found to be the longest (6,039 nucleotides [nt]), with the lar...

journal_title：Journal of virology

authors： Tijssen P,Li Y,El-Far M,Szelei J,Letarte M,Zádori Z

更新日期：2003-10-01 00:00:00

abstract：:Pseudomonas aeruginosa myovirus KZ has a 270-kb genome within a T=27 icosahedral capsid that contains a large, unusual, and structurally well-defined protein cylindrical inner body (IB) spanning its interior. Proteolysis forms a pivotal stage in KZ head and IB morphogenesis, with the protease gp175 cleaving at least 1...

journal_title：Journal of virology

authors： Thomas JA,Black LW

更新日期：2013-08-01 00:00:00

abstract：:Replication of all positive-strand RNA viruses is intimately associated with membranes. Here we utilize electron tomography and other methods to investigate the remodeling of membranes in poliovirus-infected cells. We found that the viral replication structures previously described as "vesicles" are in fact convoluted...

journal_title：Journal of virology

authors： Belov GA,Nair V,Hansen BT,Hoyt FH,Fischer ER,Ehrenfeld E

更新日期：2012-01-01 00:00:00

abstract：:A major difference between vaccine and wild-type strains of measles virus (MV) in vitro is the wider cell specificity of vaccine strains, resulting from the receptor usage of the hemagglutinin (H) protein. Wild-type H proteins recognize the signaling lymphocyte activation molecule (SLAM) (CD150), which is expressed on...

journal_title：Journal of virology

authors： Takeuchi K,Nagata N,Kato SI,Ami Y,Suzaki Y,Suzuki T,Sato Y,Tsunetsugu-Yokota Y,Mori K,Van Nguyen N,Kimura H,Nagata K

更新日期：2012-03-01 00:00:00

abstract：:The coding capacity of human cytomegalovirus (HCMV) for glycoproteins by far exceeds that of other herpesviruses. Few of these proteins have been characterized so far. We have investigated the gene product of reading frame UL132. The putative protein product of UL132 is a glycoprotein with a theoretical mass of 29.8 k...

journal_title：Journal of virology

authors： Spaderna S,Kropff B,Ködel Y,Shen S,Coley S,Lu S,Britt W,Mach M

更新日期：2005-09-01 00:00:00

abstract：:Reovirus attachment protein σ1 engages glycan receptors and junctional adhesion molecule-A (JAM-A) and is thought to undergo a conformational change during the proteolytic disassembly of virions to infectious subvirion particles (ISVPs) that accompanies cell entry. The σ1 protein is also the primary target of neutrali...

journal_title：Journal of virology

authors： Dietrich MH,Ogden KM,Katen SP,Reiss K,Sutherland DM,Carnahan RH,Goff M,Cooper T,Dermody TS,Stehle T

更新日期：2017-01-31 00:00:00

abstract：:Infection by viruses depends on a balance between capsid stability and dynamics. This study investigated biologically and biotechnologically relevant aspects of the relationship in foot-and-mouth disease virus (FMDV) between capsid structure and thermostability and between thermostability and infectivity. In the FMDV ...

journal_title：Journal of virology

authors： López-Argüello S,Rincón V,Rodríguez-Huete A,Martínez-Salas E,Belsham GJ,Valbuena A,Mateu MG

更新日期：2019-05-01 00:00:00

abstract：:The assembly of human cytomegalovirus (HCMV) is thought to be similar to that which has been proposed for alphaherpesviruses and involve envelopment of tegumented subviral particles at the nuclear membrane followed by export from the cell by a poorly defined pathway. However, several studies have shown that at least t...

journal_title：Journal of virology

authors： Sanchez V,Greis KD,Sztul E,Britt WJ

更新日期：2000-01-01 00:00:00

abstract：:Certain murine leukemia viruses (MLVs) can induce progressive noninflammatory spongiform neurodegeneration similar to that caused by prions. The primary MLV determinants responsible have been mapped to within the env gene; however, it has remained unclear how env mediates disease, whether non-Env viral components are ...

journal_title：Journal of virology

authors： Li Y,Cardona SM,Traister RS,Lynch WP

更新日期：2011-03-01 00:00:00

abstract：:EBNA2 transcriptional activation and regulated EBNALP coactivation are critical for Epstein-Barr virus-infected primary B-lymphocyte growth transformation. EBNALP coactivation requires the EBNA2 acidic activation domain (E2AD); EBNALP can bind to E2AD. EBNALP has now been found to bind less well to EBNA2 amino acids 1...

journal_title：Journal of virology

authors： Peng CW,Zhao B,Kieff E

更新日期：2004-10-01 00:00:00

abstract：:Chikungunya virus (CHIKV), a mosquito-borne alphavirus, has traditionally circulated in Africa and Asia, causing human febrile illness accompanied by severe, chronic joint pain. In Africa, epidemic emergence of CHIKV involves the transition from an enzootic, sylvatic cycle involving arboreal mosquito vectors and nonhu...

journal_title：Journal of virology

authors： Volk SM,Chen R,Tsetsarkin KA,Adams AP,Garcia TI,Sall AA,Nasar F,Schuh AJ,Holmes EC,Higgs S,Maharaj PD,Brault AC,Weaver SC

更新日期：2010-07-01 00:00:00