The single-stranded DNA genome of novel archaeal virus halorubrum pleomorphic virus 1 is enclosed in the envelope decorated with glycoprotein spikes.

abstract：:On the basis of the conservation of neuraminidase (N) active-site residues in influenza virus N and paramyxovirus hemagglutinin-neuraminidase (HN), it has been suggested that the three-dimensional (3D) structures of the globular heads of the two proteins are broadly similar. In this study, details of this structural s...

journal_title：Journal of virology

authors： Langedijk JP,Daus FJ,van Oirschot JT

更新日期：1997-08-01 00:00:00

abstract：UNLABELLED:Despite the nutritional and health benefits of breast milk, breast milk can serve as a vector for mother-to-child HIV transmission. Most HIV-infected infants acquire HIV through breastfeeding. Paradoxically, most infants breastfed by HIV-positive women do not become infected. This is potentially attributed t...

journal_title：Journal of virology

authors： Wahl A,Baker C,Spagnuolo RA,Stamper LW,Fouda GG,Permar SR,Hinde K,Kuhn L,Bode L,Aldrovandi GM,Garcia JV

更新日期：2015-11-01 00:00:00

abstract：:The coding capacity of human cytomegalovirus (HCMV) for glycoproteins by far exceeds that of other herpesviruses. Few of these proteins have been characterized so far. We have investigated the gene product of reading frame UL132. The putative protein product of UL132 is a glycoprotein with a theoretical mass of 29.8 k...

journal_title：Journal of virology

authors： Spaderna S,Kropff B,Ködel Y,Shen S,Coley S,Lu S,Britt W,Mach M

更新日期：2005-09-01 00:00:00

abstract：:The helicase-like 1a and polymerase-like 2a proteins of brome mosaic virus (BMV) are required for viral RNA replication in vivo, are present in membrane-bound viral RNA polymerase extracts, and share conservation with the many other members of the alphavirus-like superfamily. To better understand BMV RNA replication a...

journal_title：Journal of virology

authors： Restrepo-Hartwig MA,Ahlquist P

更新日期：1996-12-01 00:00:00

abstract：:The 2009 pandemic influenza H1N1 (H1N1pdm) virus was generated by reassortment of swine influenza viruses of different lineages. This was the first influenza pandemic to emerge in over 4 decades and the first to occur after the realization that influenza pandemics arise from influenza viruses of animals. In order to u...

journal_title：Journal of virology

authors： Chan RW,Kang SS,Yen HL,Li AC,Tang LL,Yu WC,Yuen KM,Chan IW,Wong DD,Lai WW,Kwong DL,Sihoe AD,Poon LL,Guan Y,Nicholls JM,Peiris JS,Chan MC

更新日期：2011-11-01 00:00:00

abstract：:The phosphoprotein pp65 (ppUL83) of human cytomegalovirus (HCMV) is abundantly synthesized during lytic infection in cultured fibroblasts. As a major constituent of extracellular particles, it gains entry to infected cells immediately after adsorption and subsequently translocates to the cell nucleus. This efficient t...

journal_title：Journal of virology

authors： Schmolke S,Kern HF,Drescher P,Jahn G,Plachter B

更新日期：1995-10-01 00:00:00

abstract：:Canine parvovirus type 2 (CPV-2) is a severe enteric pathogen of dogs, causing high mortality in unvaccinated dogs. After emerging, CPV-2 spread rapidly worldwide. However, there is now some evidence to suggest that international transmission appears to be more restricted. In order to investigate the transmission and ...

journal_title：Journal of virology

authors： Clegg SR,Coyne KP,Parker J,Dawson S,Godsall SA,Pinchbeck G,Cripps PJ,Gaskell RM,Radford AD

更新日期：2011-08-01 00:00:00

abstract：:Many replication events are involved in the influenza A virus life cycle, and they are accomplished by different virus proteins with specific functions. However, because the size of the influenza virus genome is limited, the virus uses different mechanisms to express multiple viral proteins from a single gene segment....

journal_title：Journal of virology

authors： Muramoto Y,Noda T,Kawakami E,Akkina R,Kawaoka Y

更新日期：2013-03-01 00:00:00

abstract：:CD4C/HIV(nef) transgenic (Tg) mice express Nef in CD4+ T cells and in the cells of the macrophage/monocyte/dendritic lineage, and they develop an AIDS-like disease similar to human AIDS. In these mice, Nef is constitutively expressed throughout life. To rule out the contribution of any developmental defects caused by ...

journal_title：Journal of virology

authors： Rahim MM,Chrobak P,Hu C,Hanna Z,Jolicoeur P

更新日期：2009-11-01 00:00:00

abstract：UNLABELLED:Virus-like particles (VLPs) built on the Newcastle disease virus (NDV) core proteins, NP and M, and containing two chimeric proteins, F/F and H/G, composed of respiratory syncytial virus (RSV) fusion protein (F) and glycoprotein (G) ectodomains fused to the transmembrane and cytoplasmic domains of the NDV F ...

journal_title：Journal of virology

authors： McGinnes Cullen L,Schmidt MR,Kenward SA,Woodland RT,Morrison TG

更新日期：2015-07-01 00:00:00

abstract：:The herpesvirus tegument is a layer of viral and cellular proteins located between the capsid and envelope of the virion. The VP1/2 tegument protein is critical for the propagation of all herpesviruses examined. Using an infectious clone of the alphaherpesvirus pseudorabies virus, we have made a collection of truncati...

journal_title：Journal of virology

authors： Lee JI,Luxton GW,Smith GA

更新日期：2006-12-01 00:00:00

abstract：:We have analyzed the production of tumor necrosis factor alpha (TNF-alpha) induced by in vitro infection with African swine fever (ASF) virus (ASFV) and the systemic and local release of this inflammatory cytokine upon in vivo infection. An early increase in TNF-alpha mRNA expression was detected in ASFV-infected alve...

journal_title：Journal of virology

authors： Gómez del Moral M,Ortuño E,Fernández-Zapatero P,Alonso F,Alonso C,Ezquerra A,Domínguez J

更新日期：1999-03-01 00:00:00

abstract：:We previously demonstrated that the adeno-associated virus (AAV) Rep68 and Rep78 proteins are able to nick the AAV origin of DNA replication at the terminal resolution site (trs) in an ATP-dependent manner. Using four types of modified or mutant substrates, we now have investigated the substrate requirements of Rep68 ...

journal_title：Journal of virology

authors： Snyder RO,Im DS,Ni T,Xiao X,Samulski RJ,Muzyczka N

更新日期：1993-10-01 00:00:00

abstract：:The activation of the human polyomavirus BK causes polyomavirus-associated nephropathy in immunocompromised humans. Studies of the virus have been restricted since the virus DNA replication is species specific. Cell-based and cell-free DNA replication systems, including the BK virus (BKV) monopolymerase DNA replicatio...

journal_title：Journal of virology

authors： Tikhanovich I,Nasheuer HP

更新日期：2010-07-01 00:00:00

abstract：:We investigated the integration sites, infectivities, and expression of Rous-associated virus-0 (Rav-0) DNAs in exogenously infected turkey and chicken cells. Restriction endonuclease analyses of the DNAs of RAV-0-infected cells indicated that unique integration sites of RAV-0 DNA were detectable in clones of RAV-0-in...

journal_title：Journal of virology

authors： Jenkins NA,Cooper GM

更新日期：1980-12-01 00:00:00

abstract：:Human respiratory syncytial virus (HRSV) is the leading cause of serious pediatric acute respiratory tract infections, and a better understanding is needed of the host response to HRSV and its attenuated vaccine derivatives. It has been shown previously that HRSV nonstructural proteins 1 and 2 (NS1 and NS2) inhibit th...

journal_title：Journal of virology

authors： Spann KM,Tran KC,Collins PL

更新日期：2005-05-01 00:00:00

abstract：:Monoclonal antibody vpg15 detects a 24-kDa cell surface protein on feline cells permissive for infection with feline immunodeficiency virus (FIV). The antibody blocks infection of FIV-susceptible cells, and expression of the vpg15 marker is decreased in FIV-infected cells in vitro. These results suggest that the antib...

journal_title：Journal of virology

authors： Hosie MJ,Willett BJ,Dunsford TH,Jarrett O,Neil JC

更新日期：1993-03-01 00:00:00

abstract：:Under natural conditions and in some experimental models, rabies virus infection of the central nervous system causes relatively mild histopathological changes, without prominent evidence of neuronal death despite its lethality. In this study, the effects of rabies virus infection on the structure of neurons were inve...

journal_title：Journal of virology

authors： Scott CA,Rossiter JP,Andrew RD,Jackson AC

更新日期：2008-01-01 00:00:00

abstract：:A map of bacteriophage lambda was constructed, including accurate positions for all 41 cut sites made by 12 different restriction enzymes. Over 100 fragments from single, multiple, and partial enzyme digestions were measured versus standards that were calibrated with respect to DNA molecules of known sequence. The dat...

journal_title：Journal of virology

authors： Daniels DL,de Wet JR,Blattner FR

更新日期：1980-01-01 00:00:00

abstract：:The effect of bacteriophage SPO1 infection of Bacillus subtilis and a deoxyribonucleic acid (DNA) polymerase-deficient (pol(-)) mutant of this microorganism on the synthesis of DNA has been examined. Soon after infection, the incorporation of deoxyribonucleoside triphosphates into acid-insoluble material by cell lysat...

journal_title：Journal of virology

authors： Yehle CO,Ganesan AT

更新日期：1972-02-01 00:00:00

abstract：:Arenaviruses are rodent-borne viruses with a bisegmented RNA genome. A genetically unique arenavirus, Lujo virus, was recently discovered as the causal agent of a nosocomial outbreak of acute febrile illness with hemorrhagic manifestations in Zambia and South Africa. The outbreak had a case fatality rate of 80%. A rev...

journal_title：Journal of virology

authors： Bergeron É,Chakrabarti AK,Bird BH,Dodd KA,McMullan LK,Spiropoulou CF,Nichol ST,Albariño CG

更新日期：2012-10-01 00:00:00

abstract：:In an attempt to identify the molecules involved in the pathogenesis of prion diseases, we performed cDNA subtraction on the brain tissues of mice affected with an experimental prion disease and the unaffected control. The genes identified as being upregulated in the prion-affected brain tissue included those encoding...

journal_title：Journal of virology

authors： Kopacek J,Sakaguchi S,Shigematsu K,Nishida N,Atarashi R,Nakaoke R,Moriuchi R,Niwa M,Katamine S

更新日期：2000-01-01 00:00:00

abstract：UNLABELLED:The gastrointestinal mucosa is the primary site where human immunodeficiency virus type 1 (HIV-1) invades, amplifies, and becomes persistently established, and cell-to-cell transmission of HIV-1 plays a pivotal role in mucosal viral dissemination. Mast cells are widely distributed in the gastrointestinal tra...

journal_title：Journal of virology

authors： Jiang AP,Jiang JF,Wei JF,Guo MG,Qin Y,Guo QQ,Ma L,Liu BC,Wang X,Veazey RS,Ding YB,Wang JH

更新日期：2015-12-30 00:00:00

abstract：:The murine polyomavirus (Py) enters mouse fibroblasts and kidney epithelial cells via an endocytic pathway that is caveola-independent (as well as clathrin-independent). In contrast, uptake of simian virus 40 into the same cells is dependent on caveola. Following the initial uptake of Py, both microtubules and microfi...

journal_title：Journal of virology

authors： Gilbert JM,Goldberg IG,Benjamin TL

更新日期：2003-02-01 00:00:00

abstract：:In a study of the evolution and distribution of avian retroviruses, we found avian sarcoma and leukosis virus (ASLV) gag genes in 26 species of galliform birds from North America, Central America, eastern Europe, Asia, and Africa. Nineteen of the 26 host species from whom ASLVs were sequenced were not previously known...

journal_title：Journal of virology

authors： Dimcheff DE,Drovetski SV,Krishnan M,Mindell DP

更新日期：2000-05-01 00:00:00

abstract：:Productive replication of human immunodeficiency virus type 1 (HIV-1) occurs efficiently only in humans. The posttranscriptional stages of the HIV-1 life cycle proceed poorly in mouse cells, with a resulting defect in viral assembly and release. Previous work has shown that the presence of human chromosome 2 increases...

journal_title：Journal of virology

authors： Elinav H,Wu Y,Coskun A,Hryckiewicz K,Kemler I,Hu Y,Rogers H,Hao B,Ben Mamoun C,Poeschla E,Sutton R

更新日期：2012-11-01 00:00:00

abstract：:Antigens derived from host cells are detectable in the envelope of human immunodeficiency virus type 1 (HIV-1) and result in a distinctive viral phenotype reflecting that of the host cell. An immunomagnetic capture assay targeting discriminatory host proteins was developed to differentiate between HIV-1 derived from m...

journal_title：Journal of virology

authors： Lawn SD,Roberts BD,Griffin GE,Folks TM,Butera ST

更新日期：2000-01-01 00:00:00

abstract：:A soluble polymerase-template complex prepared from poliovirus-infected cells was found to incorporate radioactive UTP into trichloroacetic acid-insoluble RNA linearly for 8 h in the presence of ATP and Mg2+. Radioactive CTP or GTP was not incorporated under identical conditions. Nearest-neighbor analysis of the in vi...

journal_title：Journal of virology

authors： Yin FH

更新日期：1977-01-01 00:00:00

abstract：:Infection of quiescent cells by human cytomegalovirus (HCMV) elicits severe cell cycle deregulation, resulting in a G(1)/S arrest, which can be partly attributed to the inactivation of the anaphase-promoting complex (APC). As we previously reported, the premature phosphorylation of its coactivator Cdh1 and/or the diss...

journal_title：Journal of virology

authors： Tran K,Kamil JP,Coen DM,Spector DH

更新日期：2010-10-01 00:00:00

abstract：:Herpesvirus nucleocapsids are translocated from their assembly site in the nucleus to the cytosol by acquisition of a primary envelope at the inner nuclear membrane which subsequently fuses with the outer nuclear membrane. This transport through the nuclear envelope requires homologs of the conserved herpesviral pUL31...

journal_title：Journal of virology

authors： Grimm KS,Klupp BG,Granzow H,Müller FM,Fuchs W,Mettenleiter TC

更新日期：2012-06-01 00:00:00