A monoclonal antibody which blocks infection with feline immunodeficiency virus identifies a possible non-CD4 receptor.

abstract：:The murine polyomavirus (Py) enters mouse fibroblasts and kidney epithelial cells via an endocytic pathway that is caveola-independent (as well as clathrin-independent). In contrast, uptake of simian virus 40 into the same cells is dependent on caveola. Following the initial uptake of Py, both microtubules and microfi...

journal_title：Journal of virology

authors： Gilbert JM,Goldberg IG,Benjamin TL

更新日期：2003-02-01 00:00:00

abstract：:Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (p...

journal_title：Journal of virology

authors： Van Poucke S,Doedt J,Baumann J,Qiu Y,Matrosovich T,Klenk HD,Van Reeth K,Matrosovich M

更新日期：2015-12-01 00:00:00

abstract：:RIG-I is a major cytoplasmic sensor of viral pathogen-associated molecular pattern (PAMP) RNA and induces type I interferon (IFN) production upon viral infection. A double-stranded RNA (dsRNA)-binding protein, PACT, plays an important role in potentiating RIG-I function. We have shown previously that arenaviral nucleo...

journal_title：Journal of virology

authors： Shao J,Huang Q,Liu X,Di D,Liang Y,Ly H

更新日期：2018-06-13 00:00:00

abstract：:Protein synthesis in adenovirus-infected cells is regulated during the late phase of infection. The rate of initiation is maintained by a small viral RNA, virus-associated (VA) RNAI, which prevents the phosphorylation of eukaryotic initiation factor eIF-2 by a double-stranded RNA-activated protein kinase, DAI. On the ...

journal_title：Journal of virology

authors： Pe'ery T,Mellits KH,Mathews MB

更新日期：1993-06-01 00:00:00

abstract：:Techniques are described for the growth and rapid purification of the avian coronavirus infectious bronchitis virus (IBV). Purified IBV has a sedimentation coefficient of 320S and a buoyant density of 1.22 g/ml in sucrose-deuterium oxide equilibrium gradients. IBV RNA extracted by proteinase K in the presence of sodiu...

journal_title：Journal of virology

authors： Lomniczi B,Kennedy I

更新日期：1977-10-01 00:00:00

abstract：:Western equine encephalitis virus (WEEV; Togaviridae, Alphavirus) is an enveloped RNA virus that is typically transmitted to vertebrate hosts by infected mosquitoes. WEEV is an important cause of viral encephalitis in humans and horses in the Americas, and infection results in a range of disease, from mild flu-like il...

journal_title：Journal of virology

authors： Sherman MB,Weaver SC

更新日期：2010-10-01 00:00:00

abstract：:An E1-E3-deleted recombinant adenovirus vector expressing the hybrid protein TetR-KRAB has been produced. In this virus, AdTG9562, the E2 transcription is regulated by TetR-KRAB and tetO sequences inserted in cis. In the absence of tetracycline, a strong reduction in E2A gene expression, viral DNA replication, and lat...

journal_title：Journal of virology

authors： Rittner K,Schultz H,Pavirani A,Mehtali M

更新日期：1997-04-01 00:00:00

abstract：:Neonatal infection of most mouse strains with lymphocytic choriomeningitis virus (LCMV) leads to a life-long persistent infection characterized by high virus loads in the central nervous system (CNS) in the absence of inflammation and tissue destruction. These mice, however, exhibit impaired learning and memory. The o...

journal_title：Journal of virology

authors： Kunz S,Rojek JM,Roberts AJ,McGavern DB,Oldstone MB,de la Torre JC

更新日期：2006-09-01 00:00:00

abstract：:Three amber mutations were introduced proximal to the syn3 locus of the herpes simplex virus type 1 glycoprotein B (gB) gene specifying gB derivatives lacking the carboxy-terminal 28, 49, or 64 amino acids. A complementation system that utilized gBs expressed in COS cells to complement gB-null virus K delta T was esta...

journal_title：Journal of virology

authors： Baghian A,Huang L,Newman S,Jayachandra S,Kousoulas KG

更新日期：1993-04-01 00:00:00

abstract：:Influenza viral complementary RNA (cRNA), i.e., viral mRNA was radioactive when purified from the cytoplasmic fraction of cordycepin-treated canine kidney cells that were incubated with [methyl-3H]methionine during infection. Approximately 55 to 60% of the methyl-3H radioactivity was in internal N6-methyladenosine, a ...

journal_title：Journal of virology

authors： Krug RM,Morgan MA,Shatkin AJ

更新日期：1976-10-01 00:00:00

abstract：:A large number of polyoma virus-transformed cells of rat, mouse, and hamster origin were examined for presence of T-antigen species. The results showed that all lines of cells contained middle and small T antigens, but not all contained a full-sized large T antigen, in some cell lines large T antigen was absent, where...

journal_title：Journal of virology

authors： Ito Y,Spurr N,Griffin BE

更新日期：1980-07-01 00:00:00

abstract：:The recent yellow fever virus (YFV) epidemic in Brazil in 2017 and Zika virus (ZIKV) epidemic in 2015 serve to remind us of the importance of flaviviruses as emerging human pathogens. With the current global flavivirus threat, there is an urgent need for antivirals and vaccines to curb the spread of these viruses. How...

journal_title：Journal of virology

authors： Miorin L,Laurent-Rolle M,Pisanelli G,Co PH,Albrecht RA,García-Sastre A,Morrison J

更新日期：2019-06-28 00:00:00

abstract：:Viruses with spindle-shaped virions are abundant in diverse environments. Over the years, such viruses have been isolated from a wide range of archaeal hosts. Evolutionary relationships between them remained enigmatic, however. Here, using structural proteins as markers, we define familial ties among these "dark horse...

journal_title：Journal of virology

authors： Krupovic M,Quemin ER,Bamford DH,Forterre P,Prangishvili D

更新日期：2014-02-01 00:00:00

abstract：:We performed live cell visualization assays to directly assess the interaction between competing adeno-associated virus (AAV) and herpes simplex virus type 1 (HSV-1) DNA replication. Our studies reveal the formation of separate AAV and HSV-1 replication compartments and the inhibition of HSV-1 replication compartment ...

journal_title：Journal of virology

authors： Glauser DL,Strasser R,Laimbacher AS,Saydam O,Clément N,Linden RM,Ackermann M,Fraefel C

更新日期：2007-05-01 00:00:00

abstract：UNLABELLED:Giardia lamblia virus (GLV) is a small, nonenveloped, nonsegmented double-stranded RNA (dsRNA) virus infecting Giardia lamblia, the most common protozoan pathogen of the human intestine and a major agent of waterborne diarrheal disease worldwide. GLV (genus Giardiavirus) is a member of family Totiviridae, al...

journal_title：Journal of virology

authors： Janssen ME,Takagi Y,Parent KN,Cardone G,Nibert ML,Baker TS

更新日期：2015-01-15 00:00:00

abstract：:Gene therapy is proposed as a novel therapeutic strategy for treating glioblastoma multiforme (GBM), a devastating brain cancer. In the clinic, antivector immune responses pose formidable challenges. Herein we demonstrate that high-capacity adenovirus vectors (HC-Ads) carrying the conditional cytotoxic gene herpes sim...

journal_title：Journal of virology

authors： King GD,Muhammad AK,Xiong W,Kroeger KM,Puntel M,Larocque D,Palmer D,Ng P,Lowenstein PR,Castro MG

更新日期：2008-05-01 00:00:00

abstract：:In order to elucidate the molecular mechanisms of action of the tat-responsive sequence, mutational analysis of the tat-responsive sequence was carried out. The most critical region comprised nucleotides +18 to +44 and included the 3-nucleotide bulge at positions +23 to +25, the loop sequence, and an intact stem. In a...

journal_title：Journal of virology

authors： Roy S,Parkin NT,Rosen C,Itovitch J,Sonenberg N

更新日期：1990-03-01 00:00:00

abstract：:Individuals infected with the human immunodeficiency virus (HIV) experience a marked loss of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the depletion of these cells are not yet understood. In this study, we observed that CD4+ T lymphocytes from HIV type 1 (HIV-1)-infected and uninfec...

journal_title：Journal of virology

authors： Heinkelein M,Sopper S,Jassoy C

更新日期：1995-11-01 00:00:00

abstract：:Antisera produced in mice recognize primarily type-specific antigenic determinants on both the major core protein, p30, and the major envelope proteins, gp70 and p15(E), of the endogenous leukemia viruses (MuLV) of BALB/c mice. Three different mouse sera were investigated in detail. (i) Antisera prepared in C57BL/6 mi...

journal_title：Journal of virology

authors： Brown JP,Boiocchi M,Nowinski RC

更新日期：1979-10-01 00:00:00

abstract：:Functional defects in cytotoxic CD8(+) T cell responses arise in chronic human viral infections, but the mechanisms involved are not well understood. In mice, CD4 cell-mediated interleukin-21 (IL-21) production is necessary for the maintenance of CD8(+) T cell function and control of persistent viral infections. To in...

journal_title：Journal of virology

authors： Chevalier MF,Jülg B,Pyo A,Flanders M,Ranasinghe S,Soghoian DZ,Kwon DS,Rychert J,Lian J,Muller MI,Cutler S,McAndrew E,Jessen H,Pereyra F,Rosenberg ES,Altfeld M,Walker BD,Streeck H

更新日期：2011-01-01 00:00:00

abstract：:Polyomavirus large T antigen has an N-terminal domain of approximately 260 amino acids which can immortalize primary cells but lacks sequences known to be required for DNA binding and replication. Treatment of full-length large T with either V8 protease or chymotrypsin yields an N-terminal fragment of 36 to 40 kDa and...

journal_title：Journal of virology

authors： Holman PS,Gjoerup OV,Davin T,Schaffhausen BS

更新日期：1994-02-01 00:00:00

abstract：:The herpes simplex virus 1 (HSV-1) infected-cell protein 0 (ICP0) has the characteristics of a promiscuous transactivator of genes introduced into cells by infection or transfection. To identify cellular proteins interacting with ICP0, we used a domain of exon II of ICP0 that is known to be crucial for regulatory func...

journal_title：Journal of virology

authors： Kawaguchi Y,Van Sant C,Roizman B

更新日期：1997-10-01 00:00:00

abstract：:Simian virus 40 large T antigen (large T) in the early and the late phases of infection differs significantly in its sequence-specific DNA-binding and ATPase activities, indicating that different large-T populations participate in virus-specific events at various stages of the infectious cycle. To further characterize...

journal_title：Journal of virology

authors： Schirmbeck R,Deppert W

更新日期：1989-05-01 00:00:00

abstract：:Cellular and viral factors participate in the replication cycle of rotavirus. We report that the guanine nucleotide exchange factor GBF1, which activates the small GTPase Arf1 to induce COPI transport processes, is required for rotavirus replication since knocking down GBF1 expression by RNA interference or inhibiting...

journal_title：Journal of virology

authors： Martínez JL,Arnoldi F,Schraner EM,Eichwald C,Silva-Ayala D,Lee E,Sztul E,Burrone ÓR,López S,Arias CF

更新日期：2019-09-12 00:00:00

abstract：:Envelope glycoprotein E1 (gp51 to gp54) is the most antigenic protein of hog cholera virus or classical swine fever virus (CSFV). Four antigenic domains, A to D, have been mapped on E1 with a panel of monoclonal antibodies (MAbs) raised against CSFV strain Brescia. The boundaries of these domains have been established...

journal_title：Journal of virology

authors： van Rijn PA,Miedema GK,Wensvoort G,van Gennip HG,Moormann RJ

更新日期：1994-06-01 00:00:00

abstract：:Ebola virus is the etiologic agent of a lethal hemorrhagic fever in humans and nonhuman primates with mortality rates of up to 90%. Previous studies with Zaire Ebola virus (ZEBOV), mouse-adapted virus (MA-ZEBOV), and mutant viruses (ZEBOV-NP(ma), ZEBOV-VP24(ma), and ZEBOV-NP/VP24(ma)) allowed us to identify the mutati...

journal_title：Journal of virology

authors： Cilloniz C,Ebihara H,Ni C,Neumann G,Korth MJ,Kelly SM,Kawaoka Y,Feldmann H,Katze MG

更新日期：2011-09-01 00:00:00

abstract：:The dengue type 4 virus (DEN4) genome contains a 384-nucleotide (nt) 3' noncoding sequence in which the last 81 nt, predicted to form a secondary structure, are thought to be essential for virus replication. Immediately upstream of the secondary structure, short RNA sequences that are conserved among mosquito-borne fl...

journal_title：Journal of virology

authors： Men R,Bray M,Clark D,Chanock RM,Lai CJ

更新日期：1996-06-01 00:00:00

abstract：:Genomic variation and related evolutionary dynamics of human respiratory syncytial virus (RSV), a common causative agent of severe lower respiratory tract infections, may affect its transmission behavior. RSV evolutionary patterns are likely to be influenced by a precarious interplay between selection favoring variant...

journal_title：Journal of virology

authors： Tan L,Coenjaerts FE,Houspie L,Viveen MC,van Bleek GM,Wiertz EJ,Martin DP,Lemey P

更新日期：2013-07-01 00:00:00

abstract：:Identifying protease cleavage sites contributes to our understanding of their specificity and biochemical properties and can help in designing specific inhibitors. One route to this end is the generation and screening of random libraries of cleavage sites. Both synthetic and phage-displayed libraries have been extensi...

journal_title：Journal of virology

authors： Pacini L,Vitelli A,Filocamo G,Bartholomew L,Brunetti M,Tramontano A,Steinkühler C,Migliaccio G

更新日期：2000-11-01 00:00:00

abstract：:Molluscs, comprising one of the most successful phyla, lack clear evidence of adaptive immunity and yet thrive in the oceans, which are rich in viruses. There are thought to be nearly 120,000 species of Mollusca, most living in marine habitats. Despite the extraordinary abundance of viruses in oceans, molluscs often h...

journal_title：Journal of virology

authors： Dang VT,Benkendorff K,Green T,Speck P

更新日期：2015-08-01 00:00:00