Abstract:
:Antisera produced in mice recognize primarily type-specific antigenic determinants on both the major core protein, p30, and the major envelope proteins, gp70 and p15(E), of the endogenous leukemia viruses (MuLV) of BALB/c mice. Three different mouse sera were investigated in detail. (i) Antisera prepared in C57BL/6 mice against the AKR leukemia K36 reacted with the gp70, p15(E), and p30 proteins of MuLV. Certain pools of the C57BL/6 anti-AKR K36 serum contained antibodies which serologically distinguished the p30 proteins of N-ecotropic, B-ecotropic, and xenotropic BALB/c MuLV. (ii) Antisera prepared in BALB/c mice against the BALB/c sarcoma 1315 contained antibodies that reacted with a type-specific antigen of the 1315 MuLV gp70 that is not found on other BALB/c MuLV. (iii) The normal sera of multiparous BALB/c mice contained antibodies that reacted with gp70 and p15(E) proteins of ecotropic MuLV. Sera from some of these mice contained antibodies that serologically distinguished the gp70 of N-ecotropic and B-ecotropic BALB/c viruses. These results emphasize the utility of mouse antisera in the serological typing of MuLV. Furthermore, the antigenic differences observed in the p30 and gp70 proteins should be of particular use in the future analysis of recombinant BALB/c MuLV.
journal_name
J Viroljournal_title
Journal of virologyauthors
Brown JP,Boiocchi M,Nowinski RCdoi
10.1128/JVI.32.1.345-349.1979subject
Has Abstractpub_date
1979-10-01 00:00:00pages
345-9issue
1eissn
0022-538Xissn
1098-5514journal_volume
32pub_type
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.11.6900-6909.1994
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.8.5300-5305.1994
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pub_type: 杂志文章
doi:10.1128/JVI.68.7.4117-4125.1994
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.66.11.6813-6818.1992
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journal_title:Journal of virology
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.8.4914-4923.1995
更新日期:1995-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.10.5636-5640.1991
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pub_type: 杂志文章
doi:10.1128/JVI.37.2.628-635.1981
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pub_type: 杂志文章
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更新日期:2007-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1997-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.2.756-763.1995
更新日期:1995-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1979-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.5.3175-3182.1994
更新日期:1994-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.9.4759-4768.1991
更新日期:1991-09-01 00:00:00