Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro.

abstract：:The involvement of two bacteriophage T4 gene products in the initiation of T4 tail tube and sheath polymerization on mature baseplates has been studied by radioautography of acrylamide gels of various partially completed tail structures. The products of genes 48 and 54 (P48[the nomenclature P48 refers to the protein p...

journal_title：Journal of virology

authors： Berget PB,Warner HR

更新日期：1975-12-01 00:00:00

abstract：:Polymorphic basic residues near the C terminus of the prion protein (PrP) in humans and sheep appear to protect against prion disease. In heterozygotes, inhibition of prion formation appears to be dominant negative and has been simulated in cultured cells persistently infected with scrapie prions. The results of nucle...

journal_title：Journal of virology

authors： Zulianello L,Kaneko K,Scott M,Erpel S,Han D,Cohen FE,Prusiner SB

更新日期：2000-05-01 00:00:00

abstract：:The zinc finger antiviral protein (ZAP) is a recently isolated host antiviral factor. It specifically inhibits the replication of Moloney murine leukemia virus (MLV) and Sindbis virus (SIN) by preventing the accumulation of viral RNA in the cytoplasm. For this report, we mapped the viral sequences that are sensitive t...

journal_title：Journal of virology

authors： Guo X,Carroll JW,Macdonald MR,Goff SP,Gao G

更新日期：2004-12-01 00:00:00

abstract：:The enhancer of human papillomavirus type 16 (HPV-16) is considered to be specific for epithelial cells, in particular for cervical carcinoma-derived cell lines. We reexamined this hypothesis with the complete enhancer as well as nonoverlapping subclones and found all clones to be active in epithelial cell lines deriv...

journal_title：Journal of virology

authors： Chong T,Apt D,Gloss B,Isa M,Bernard HU

更新日期：1991-11-01 00:00:00

abstract：:The UL11 tegument protein of herpes simplex virus plays a critical role in the secondary envelopment; however, the mechanistic details remain elusive. Here, we report a new function of UL11 in the budding process in which it directs efficient acquisition of glycoprotein E (gE) via a direct interaction. In vitro bindin...

journal_title：Journal of virology

authors： Han J,Chadha P,Meckes DG Jr,Baird NL,Wills JW

更新日期：2011-09-01 00:00:00

abstract：:Isoelectrofocusing of nonionic-detergent-disrupted flaviviruses separated the envelope glycoprotein of 53,000 to 58,000 daltons and the nucleocapsid protein of 14,000 daltons. The envelope protein and nucleocapsid protein were isolated at isoelectric points of pI 7.8 and 10.3, respectively. The antigenic determinants ...

journal_title：Journal of virology

authors： Trent DW

更新日期：1977-06-01 00:00:00

abstract：:HIV-1 buds as an immature, noninfectious virion. Proteolysis of its main structural component, Gag, is required for morphological maturation and infectivity and leads to release of four functional domains and the spacer peptides SP1 and SP2. The N-terminal cleavages of Gag and the separation of SP1 from CA are all ess...

journal_title：Journal of virology

authors： de Marco A,Heuser AM,Glass B,Kräusslich HG,Müller B,Briggs JA

更新日期：2012-12-01 00:00:00

abstract：:Phage 2 adsorbed to Pseudomonas aeruginosa strain BI in 5 mM Tris buffer, providing that cations like Na(+), Mg(2+), or Ca(2+) were present. Adsorption was observed over a broad pH range, reaching a maximum level around pH 7.5, which coincided with the pH required for maximal activity of the phage 2-associated slime p...

journal_title：Journal of virology

authors： Reese JF,Dimitracopoulos G,Bartell PF

更新日期：1974-01-01 00:00:00

abstract：:The major immediate-early (MIE) gene of human cytomegalovirus (HCMV) produces multiple mRNAs through differential splicing and polyadenylation. Reverse transcriptase PCR was used to characterize transcripts from exons 1, 2, 3, and 4 (immediate-early 1 [IE1]). The expected IE72 and IE19 mRNAs were detected, as well as ...

journal_title：Journal of virology

authors： Awasthi S,Isler JA,Alwine JC

更新日期：2004-08-01 00:00:00

abstract：:The ORF3 protein of hepatitis E virus (HEV) is a multifunctional protein important for virus replication. The ORF3 proteins from human, swine, and avian strains of HEV contain a conserved PXXP amino acid motif, resembling either Src homology 3 (SH3) cell signaling interaction motifs or "late domains" involved in host ...

journal_title：Journal of virology

authors： Kenney SP,Pudupakam RS,Huang YW,Pierson FW,LeRoith T,Meng XJ

更新日期：2012-05-01 00:00:00

abstract：:Knowledge of the mechanisms of virus dissemination in acute measles is cursory, but cells of the monocyte/macrophage (MM) lineage appear to be early targets. We characterized the dissemination of the Edmonston B vaccine strain of measles virus (MV-Ed) in peripheral blood mononuclear cells (PBMC) of two mouse strains e...

journal_title：Journal of virology

authors： Roscic-Mrkic B,Schwendener RA,Odermatt B,Zuniga A,Pavlovic J,Billeter MA,Cattaneo R

更新日期：2001-04-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) mutations that confer escape from cytotoxic T-lymphocyte (CTL) recognition can sometimes result in lower viral fitness. These mutations can then revert upon transmission to a new host in the absence of CTL-mediated immune selection pressure restricted by the HLA alleles of t...

journal_title：Journal of virology

authors： Rousseau CM,Daniels MG,Carlson JM,Kadie C,Crawford H,Prendergast A,Matthews P,Payne R,Rolland M,Raugi DN,Maust BS,Learn GH,Nickle DC,Coovadia H,Ndung'u T,Frahm N,Brander C,Walker BD,Goulder PJ,Bhattacharya T,Hecke

更新日期：2008-07-01 00:00:00

abstract：:Despite being able to use the Bonzo coreceptor as efficiently as CCR5 in transfected cells, pediatric human immunodeficiency virus type 1 isolate P6 was unable to replicate in peripheral blood mononuclear cells (PBMC) lacking the CCR5 receptor. Furthermore, its replication in wild-type PBMC was completely inhibited by...

journal_title：Journal of virology

authors： Zhang YJ,Moore JP

更新日期：1999-04-01 00:00:00

abstract：:A virulent porcine epidemic diarrhea virus (PEDV) strain, DR13, was obtained from suckling pigs suspected of having porcine epidemic diarrhea in 1999 in Korea, and its attenuated counterpart was derived from virulent strain DR13 by serial propagation in Vero cells. This report describes the first complete genome seque...

journal_title：Journal of virology

authors： Park SJ,Kim HK,Song DS,An DJ,Park BK

更新日期：2012-05-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a prevalent pathogen that establishes lifelong infection in the host. Virus persistence is aided by extensive manipulation of the host immune system, particularly cytokine and chemokine signaling pathways. The HCMV UL111A gene encodes cmvIL-10, an ortholog of human interleukin-10 that h...

journal_title：Journal of virology

authors： Tu CC,Arnolds KL,O'Connor CM,Spencer JV

更新日期：2018-02-12 00:00:00

abstract：:The nef gene contributes to the replication of primate lentiviruses by altering the trafficking of cellular proteins involved in adaptive immunity (class I and II major histocompatibility complex [MHC]) and viral transmission (CD4 and DC-SIGN). A conserved acidic leucine-based sequence (E(160)xxxLL) within human immun...

journal_title：Journal of virology

authors： Coleman SH,Madrid R,Van Damme N,Mitchell RS,Bouchet J,Servant C,Pillai S,Benichou S,Guatelli JC

更新日期：2006-02-01 00:00:00

abstract：:In Escherichia coli B infected with phage T4 with mutations in gene 55 the shut-off of synthesis of two early enzymes was found to be delayed 10 to 15 min as compared to wild-type T4 infection. The kinetics of early enzyme formation was very similar to that obtained after DNA-negative mutant infection. The transcripti...

journal_title：Journal of virology

authors： Bolund C

更新日期：1973-07-01 00:00:00

abstract：UNLABELLED:Little is known about the antiviral response in mollusks. As in other invertebrates, the interferon signaling pathways have not been identified, and in fact, there is a debate about whether invertebrates possess antiviral immunity similar to that of vertebrates. In marine bivalves, due to their filtering act...

journal_title：Journal of virology

authors： Novoa B,Romero A,Álvarez ÁL,Moreira R,Pereiro P,Costa MM,Dios S,Estepa A,Parra F,Figueras A

更新日期：2016-08-12 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) nonstructural protein 3A plays important roles in virus replication, virulence, and host range. In other picornaviruses, homodimerization of 3A has been shown to be relevant for its biological activity. In this work, FMDV 3A homodimerization was evidenced by an in situ protein fluor...

journal_title：Journal of virology

authors： González-Magaldi M,Postigo R,de la Torre BG,Vieira YA,Rodríguez-Pulido M,López-Viñas E,Gómez-Puertas P,Andreu D,Kremer L,Rosas MF,Sobrino F

更新日期：2012-10-01 00:00:00

abstract：:In coliphage 186, 22 essential genes were defined by complementation studies with amber mutants. Eighteen genes were associated with phage morphogenesis: 11 with phage tail formation, and 7 with phage head formation. The remaining four genes are discussed in the accompanying paper (S. M. Hocking and J. B. Egan, J. Vir...

journal_title：Journal of virology

authors： Hocking SM,Egan JB

更新日期：1982-12-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) Vif recruits a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 enzymes (APOBEC3C-H) and PP2A phosphatase regulators (PPP2R5A to PPP2R5E). While APOBEC3 antagonism is the canonical function of HIV-1 Vif, this viral accessory protein is also known to trigger G2/...

journal_title：Journal of virology

authors： Salamango DJ,McCann JL,Demir Ö,Becker JT,Wang J,Lingappa JR,Temiz NA,Brown WL,Amaro RE,Harris RS

更新日期：2020-10-14 00:00:00

abstract：:MicroRNAs (miRNAs) represent a conserved class of small noncoding RNAs that are found in all higher eukaryotes as well as some DNA viruses. miRNAs are 20 to 25 nucleotides in length and have important regulatory functions in biological processes such as embryonic development, cell differentiation, hormone secretion, a...

journal_title：Journal of virology

authors： Zhu JY,Pfuhl T,Motsch N,Barth S,Nicholls J,Grässer F,Meister G

更新日期：2009-04-01 00:00:00

abstract：UNLABELLED:A hallmark of Ebola virus (EBOV) infection is the formation of viral inclusions in the cytoplasm of infected cells. These viral inclusions contain the EBOV nucleocapsids and are sites of viral replication and nucleocapsid maturation. Although there is growing evidence that viral inclusions create a protected...

journal_title：Journal of virology

authors： Nelson EV,Schmidt KM,Deflubé LR,Doğanay S,Banadyga L,Olejnik J,Hume AJ,Ryabchikova E,Ebihara H,Kedersha N,Ha T,Mühlberger E

更新日期：2016-07-27 00:00:00

abstract：:We have constructed new murine leukemia virus (MLV)-based vectors (TIN vectors) which, following integration, contain human immunodeficiency virus (HIV) type 1 U3 and R sequences in place of the MLV U3 and R regions. This provides, for the first time, single transcriptional unit retroviral vectors under the control of...

journal_title：Journal of virology

authors： Cannon PM,Kim N,Kingsman SM,Kingsman AJ

更新日期：1996-11-01 00:00:00

abstract：:Most retroviral packaging cell lines were established by a helper virus plasmid cotransfected with a separate plasmid encoding a selection marker. Since this selection marker coexisted in trans with the helper virus sequence, helper virus gene expression could be inactivated by host DNA methylation despite selection f...

journal_title：Journal of virology

authors： Young WB,Link CJ Jr

更新日期：2000-06-01 00:00:00

abstract：:Infection of macaque monkeys with simian immunodeficiency virus (SIV) is probably the best animal model currently available for studying acquired immunodeficiency syndrome. In this report, we describe three infectious molecular clones of SIVmac and one of human immunodeficiency virus type 2 (HIV-2) and their use in th...

journal_title：Journal of virology

authors： Naidu YM,Kestler HW 3rd,Li Y,Butler CV,Silva DP,Schmidt DK,Troup CD,Sehgal PK,Sonigo P,Daniel MD

更新日期：1988-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) contains two membrane-associated envelope glycoproteins, E1 and E2, which assemble as a heterodimer in the endoplasmic reticulum (ER). In this study, predictive algorithms and genetic analyses of deletion mutants and glycosylation site variants of the E1 glycoprotein were used to suggest that t...

journal_title：Journal of virology

authors： Nakai K,Okamoto T,Kimura-Someya T,Ishii K,Lim CK,Tani H,Matsuo E,Abe T,Mori Y,Suzuki T,Miyamura T,Nunberg JH,Moriishi K,Matsuura Y

更新日期：2006-11-01 00:00:00

abstract：:Molluscum contagiosum virus (MCV), a member of the human poxvirus family, encodes the MC159 protein that inhibits Fas-, tumor necrosis factor (TNF)-, and TNF-related apoptosis-inducing ligant (TRAIL)-induced apoptosis. We used site-directed mutagenesis to change charged or hydrophobic amino acid residues to alanines t...

journal_title：Journal of virology

authors： Garvey TL,Bertin J,Siegel RM,Wang GH,Lenardo MJ,Cohen JI

更新日期：2002-01-01 00:00:00

abstract：:This study reports the identification and initial characterization of the precursors, modified forms, and oligomers of bovine herpesvirus 1 (BHV-1) gI and gE proteins with polyvalent rabbit serum specific for gI or gE. Our experiments used the Colorado strain of BHV-1 and mutant viruses with insertions of the Escheric...

journal_title：Journal of virology

authors： Whitbeck JC,Knapp AC,Enquist LW,Lawrence WC,Bello LJ

更新日期：1996-11-01 00:00:00

abstract：:Human immunodeficiency virus type 2 (HIV-2) strains vary widely in their abilities to grow in Old World monkey (OWM) cells such as those of cynomolgus monkeys (CM). We evaluated eight HIV-2 isolates for their sensitivities to CM TRIM5alpha, an anti-HIV factor in OWM cells. We found that different HIV-2 isolates showed...

journal_title：Journal of virology

authors： Song H,Nakayama EE,Yokoyama M,Sato H,Levy JA,Shioda T

更新日期：2007-07-01 00:00:00