Identification of P48 and P54 as components of bacteriophage T4 baseplates.

abstract：:Egress of wrapped virus (WV) to the cell periphery following vaccinia virus (VACV) replication is dependent on interactions with the microtubule motor complex kinesin-1 and is mediated by the viral envelope protein A36. Here we report that ectromelia virus (ECTV), a related orthopoxvirus and the causative agent of mou...

journal_title：Journal of virology

authors： Lynn H,Horsington J,Ter LK,Han S,Chew YL,Diefenbach RJ,Way M,Chaudhri G,Karupiah G,Newsome TP

更新日期：2012-07-01 00:00:00

abstract：:Both the RNase H domain of Moloney murine leukemia virus (Mo-MLV) reverse transcriptase (RT) and Escherichia coli RNase H possess a positively charged alpha-helix (C helix) and a loop that are not present in the RNase H domains of human immunodeficiency virus (HIV) RT or avian sarcoma virus RT. Although a mutant Mo-ML...

journal_title：Journal of virology

authors： Lim D,Orlova M,Goff SP

更新日期：2002-08-01 00:00:00

abstract：:Co-infection of neonatal BALB/c mice with Friend virus (FV) complex (containing defective spleen focus-forming virus [SFFV] and endogenous N-tropic leukemia-inducing helper virus [LLV-F]) and B-tropic Tennant leukemia virus (TenLV) resulted in the inhibition of LLV-F by the Fv-1(b) gene and recovery of a TenLV pseudot...

journal_title：Journal of virology

authors： Eckner RJ

更新日期：1973-09-01 00:00:00

abstract：:We analyzed the CD4+ T-lymphocyte responses to dengue, West Nile, and yellow fever viruses 4 months after immunization of a volunteer with an experimental live-attenuated dengue virus type 1 vaccine (DEN-1 45AZ5). We examined bulk culture proliferation to noninfectious antigens, determined the precursor frequency of s...

journal_title：Journal of virology

authors： Green S,Kurane I,Edelman R,Tacket CO,Eckels KH,Vaughn DW,Hoke CH Jr,Ennis FA

更新日期：1993-10-01 00:00:00

abstract：:Virus entry into host cells is a complex process that is largely regulated by access to specific cellular receptors. Human adenoviruses (HAdVs) and many other viruses use cell adhesion molecules such as the coxsackievirus and adenovirus receptor (CAR) for attachment to and entry into target cells. These molecules are ...

journal_title：Journal of virology

authors： Persson BD,Lenman A,Frängsmyr L,Schmid M,Ahlm C,Plückthun A,Jenssen H,Arnberg N

更新日期：2020-07-01 00:00:00

abstract：:Cell extracts from murine A9 or human HeLa cells containing wild-type copies the NS1 polypeptide of minute virus of mice (MVM), produced from a recombinant vaccinia virus, can support the resolution of viral 3' termini from palindromic junction fragments of dimeric, replicative-form MVM DNA. Resolution resulted in the...

journal_title：Journal of virology

authors： Cotmore SF,Nüesch JP,Tattersall P

更新日期：1993-03-01 00:00:00

abstract：:West Nile virus (WNV) is a human pathogen that can cause neurological disorders, including meningoencephalitis. Experiments with mice and mammalian cell cultures revealed that WNV exhibited resistance to the innate immune program induced by alpha interferon (IFN-alpha). We have investigated the nature of this inhibiti...

journal_title：Journal of virology

authors： Guo JT,Hayashi J,Seeger C

更新日期：2005-02-01 00:00:00

abstract：:Many viruses induce type I interferon responses by activating cytoplasmic RNA sensors, including the RIG-I-like receptors (RLRs). Although two members of the RLR family, RIG-I and MDA5, have been implicated in host control of virus infection, the relative role of each RLR in restricting pathogenesis in vivo remains un...

journal_title：Journal of virology

authors： Lazear HM,Pinto AK,Ramos HJ,Vick SC,Shrestha B,Suthar MS,Gale M Jr,Diamond MS

更新日期：2013-11-01 00:00:00

abstract：:Hepatitis C virus (HCV) remains a significant threat to the general health of the world's population, and there is a pressing need for the development of new treatments and preventative vaccines. Here, we describe the generation of retrovirus-based pseudoparticles (HCVpp) incorporating a panel of full-length E1E2 clon...

journal_title：Journal of virology

authors： Owsianka A,Tarr AW,Juttla VS,Lavillette D,Bartosch B,Cosset FL,Ball JK,Patel AH

更新日期：2005-09-01 00:00:00

abstract：:Norovirus immunity is poorly understood as the limited data available on protection after infection are often contradictory. In contrast to the more prominent GII noroviruses, GI norovirus infections are less frequent in outbreaks. The GI noroviruses display very complex patterns of heterotypic immune responses follow...

journal_title：Journal of virology

authors： Lindesmith LC,Donaldson E,Leon J,Moe CL,Frelinger JA,Johnston RE,Weber DJ,Baric RS

更新日期：2010-02-01 00:00:00

abstract：:Polymorphic basic residues near the C terminus of the prion protein (PrP) in humans and sheep appear to protect against prion disease. In heterozygotes, inhibition of prion formation appears to be dominant negative and has been simulated in cultured cells persistently infected with scrapie prions. The results of nucle...

journal_title：Journal of virology

authors： Zulianello L,Kaneko K,Scott M,Erpel S,Han D,Cohen FE,Prusiner SB

更新日期：2000-05-01 00:00:00

abstract：:The antiviral effects of nitric oxide (NO) on Japanese encephalitis virus (JEV), a member of the family Flaviviridae, were investigated in this study. In vitro, inhibition of replication of JEV in gamma interferon-activated RAW 264.7 murine macrophages was correlated to cellular NO production. When cocultured with inf...

journal_title：Journal of virology

authors： Lin YL,Huang YL,Ma SH,Yeh CT,Chiou SY,Chen LK,Liao CL

更新日期：1997-07-01 00:00:00

abstract：:Human influenza viruses are more efficiently isolated by inoculating patient samples into the amniotic rather than the allantoic cavity of embryonated chicken eggs. This type of cultivation selects virus variants with mutations around the hemagglutinin (HA) receptor binding site. To understand the molecular basis of t...

journal_title：Journal of virology

authors： Ito T,Suzuki Y,Takada A,Kawamoto A,Otsuki K,Masuda H,Yamada M,Suzuki T,Kida H,Kawaoka Y

更新日期：1997-04-01 00:00:00

abstract：:Persistent hepatitis B virus (HBV) infection is characterized by a weak and narrowly focused CD8+ T-cell response to HBV that is thought to reflect the induction of central and/or peripheral tolerance to HBV proteins in neonatal and adult onset infections, respectively. Immunotherapeutic strategies that overcome toler...

journal_title：Journal of virology

authors： Kakimi K,Isogawa M,Chung J,Sette A,Chisari FV

更新日期：2002-09-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) integrase protein (IN) catalyzes two reactions required to integrate HIV DNA into the human genome: 3' processing of the viral DNA ends and integration. IN has three domains, the N-terminal zinc-binding domain, the catalytic core, and the C-terminal SH3 domain. Previously, it was...

journal_title：Journal of virology

authors： van den Ent FM,Vos A,Plasterk RH

更新日期：1999-04-01 00:00:00

abstract：:We investigated the use of infectious cDNA for the production of poliovirus type 1-type 3 recombinants. One such recombinant virus was produced, but a second construct involving the transfer of part of the capsid protein region was not infectious. Our results suggest that the approach may prove valuable but that not a...

journal_title：Journal of virology

authors： Stanway G,Hughes PJ,Westrop GD,Evans DM,Dunn G,Minor PD,Schild GC,Almond JW

更新日期：1986-03-01 00:00:00

abstract：:A large percentage of the repetitive elements in mammalian genomes are retroelements, which have been moved primarily by LINE-1 retrotransposons and endogenous retroviruses. Although LINE-1 elements have remained active throughout the mammalian radiation, specific groups of endogenous retroviruses generally remain act...

journal_title：Journal of virology

authors： Cantrell MA,Ederer MM,Erickson IK,Swier VJ,Baker RJ,Wichman HA

更新日期：2005-12-01 00:00:00

abstract：:A 4,500-bp BamHI fragment, located within the HindIII A segment of the vaccinia virus genome, was found to contain eight potential coding regions for polypeptides of 78 to 346 amino acids. The open reading frames with 133, 346, and 125 codons were homologous to profilin (an actin-binding protein), 3-beta-hydroxysteroi...

journal_title：Journal of virology

authors： Blasco R,Cole NB,Moss B

更新日期：1991-09-01 00:00:00

abstract：:To study the function of the varicella-zoster virus (VZV) gB cytoplasmic domain during viral infection, we produced a VZV recombinant virus that expresses a truncated form of gB lacking the C-terminal 36 amino acids of its cytoplasmic domain (VZV gB-36). VZV gB-36 replicates in noncomplementing cells and grows at a ra...

journal_title：Journal of virology

authors： Heineman TC,Hall SL

更新日期：2002-01-01 00:00:00

abstract：:Poliovirus (PV) modifies membrane-trafficking machinery in host cells for its viral RNA replication. To date, ARF1, ACBD3, BIG1/BIG2, GBF1, RTN3, and PI4KB have been identified as host factors of enterovirus (EV), including PV, involved in membrane traffic. In this study, we performed small interfering RNA (siRNA) scr...

journal_title：Journal of virology

authors： Arita M,Wakita T,Shimizu H

更新日期：2012-05-01 00:00:00

abstract：:Inhibition of RNA synthesis of the LH strain of type 3 poliovirus at the restrictive temperature occurs concurrently with the breakdown of noncapsid virus-specific peptide 2. This finding, along with other reported data (B.D. Korant, In Proteases and Biological Control, p. 621-644, 1975), suggests that noncapsid virus...

journal_title：Journal of virology

authors： Bowles SA,Tershak DR

更新日期：1978-08-01 00:00:00

abstract：:Current human immunodeficiency virus type 1 (HIV-1) envelope vaccine candidates elicit high antibody binding titers with neutralizing activity against T-cell line-adapted but not primary HIV-1 isolates. Serum antibodies from these human vaccine recipients were also found to be preferentially directed to linear epitope...

journal_title：Journal of virology

authors： VanCott TC,Mascola JR,Kaminski RW,Kalyanaraman V,Hallberg PL,Burnett PR,Ulrich JT,Rechtman DJ,Birx DL

更新日期：1997-06-01 00:00:00

abstract：:Retinoid (vitamin A) is an essential diet constituent that governs a broad range of biological processes. Its biologically active metabolite, all-trans retinoic acid (ATRA), exhibits a potent antiviral property by enhancing both innate and adaptive antiviral immunity against a variety of viral pathogens, such as, but ...

journal_title：Journal of virology

authors： Bang BR,Li M,Tsai KN,Aoyagi H,Lee SA,Machida K,Aizaki H,Jung JU,Ou JJ,Saito T

更新日期：2019-04-03 00:00:00

abstract：UNLABELLED:Modified vaccinia virus Ankara (MVA) serves as a versatile platform in vaccine development. This highly attenuated orthopoxvirus, which cannot replicate in mammalian cells, triggers strong innate immune responses, including cell migration. Previously, we have shown that induction of chemokine (C-C motif) lig...

journal_title：Journal of virology

authors： Price PJ,Luckow B,Torres-Domínguez LE,Brandmüller C,Zorn J,Kirschning CJ,Sutter G,Lehmann MH

更新日期：2014-09-01 00:00:00

abstract：:As viruses are reliant upon their host cell to serve as proper environments for their replication, many have evolved mechanisms to alter intracellular conditions to suit their own needs. For example, human cytomegalovirus induces quiescent cells to enter the cell cycle and then arrests them in late G(1), before they e...

journal_title：Journal of virology

authors： Kalejta RF,Shenk T

更新日期：2003-03-01 00:00:00

abstract：:Recently, recombinant baculoviruses have been used to show that expression of six herpes simplex virus type 1 genes results in the formation of capsid-like particles. We have applied cryoelectron microscopy and three-dimensional image reconstruction to establish their structural authenticity to a resolution of approxi...

journal_title：Journal of virology

authors： Trus BL,Homa FL,Booy FP,Newcomb WW,Thomsen DR,Cheng N,Brown JC,Steven AC

更新日期：1995-11-01 00:00:00

abstract：:Combined Southern blot hybridization analyses of DNA digests of several clinical strains of Streptococcus pneumoniae have revealed the presence of a gene (hblR), or part of it, similar to the hbl7 gene coding for the cell wall lytic enzyme of the temperate HB-746 phage. The results confirmed that the genome of HB-746,...

journal_title：Journal of virology

authors： Romero A,Lopez R,Garcia P

更新日期：1992-05-01 00:00:00

abstract：:Kilham rat virus (KRV) was grown in a rat nephroma cell line and was purified by two isopycnic centrifugations in cesium chloride. The virus contains single-stranded deoxyribonucleic acid (DNA) with a molecular weight of approximately 1.6 x 10(6). The DNA was extracted from the virion by both phenol extraction and by ...

journal_title：Journal of virology

authors： Salzman LA,White WL,Kakefuda T

更新日期：1971-06-01 00:00:00

abstract：:A panel of 28 insertion mutants of the human immunodeficiency virus type 1 (HIV-1) Gag precursor (Pr55Gag) was constructed by linker-insertion mutagenesis and expressed in recombinant baculovirus-infected insect cells. One set of 14 mutants carried the normal N-myristylation signal; the other set constituted their non...

journal_title：Journal of virology

authors： Chazal N,Carrière C,Gay B,Boulanger P

更新日期：1994-01-01 00:00:00

abstract：:The efficiency of processing of polyoma viral RNA and of its export from nucleus to cytoplasm was measured in primary mouse kidney cells by comparing the initial rates of incorporation of [3H]uridine into cytoplasmic and nuclear viral RNA. Appropriate methods of cell fractionation were chosen to maximize yields of cyt...

journal_title：Journal of virology

authors： Acheson NH

更新日期：1981-02-01 00:00:00