Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections.

abstract：:Marek's disease virus DNA appears to be wound around a central structure connecting the two inner poles of the capsid. Based on electron micrographs of Marek's disease virions, a diagram of spatial configuration of virus DNA is presented. This diagram may explain the pleomorphic character of the herpesvirus core obser...

journal_title：Journal of virology

authors： Nazerian K

更新日期：1974-05-01 00:00:00

abstract：:The DNAs of the five nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid viruses contain overlapping segments of the early region of wild-type SV40 DNA. The complementary DNA strands of these five viruses have been separated with synthetic polyribonucleotides in isopycnic cesium chloride gradients. The relat...

journal_title：Journal of virology

authors： Patch CT,Lewis AM Jr,Levine AS

更新日期：1974-03-01 00:00:00

abstract：:A variant form of splicing of RNA crossing the Epstein-Barr virus (EBV) BZLF1 gene was observed in the late productive cycle of EBV. This splice omits the middle exon of BZLF1 and joins the outer two exons of BZLF1 in frame, but the shortened form of BZLF1 protein (Z delta) could not be detected in natural EBV infecti...

journal_title：Journal of virology

authors： Lau R,Packham G,Farrell PJ

更新日期：1992-10-01 00:00:00

abstract：:A tumorigenic line of mouse cells transformed by the nononcogenic murine K papovavirus was established and characterized. Tumor-bearing animals produced antibody specific for K virus-transformed cells; the K virus T antiserum did not react with polyomavirus-transformed cells. Immunoprecipitation of the T antigen in th...

journal_title：Journal of virology

authors： Kanda T,Takemoto KK

更新日期：1984-06-01 00:00:00

abstract：:The architecture of a retroviral genome presents some unusual features for transcriptional regulation because of duplication of the transcriptional control sequences in the 5' and 3' long terminal repeats (LTRs). We have studied the transcriptional activity of the 5' and 3' LTRs of human immunodeficiency virus type 1 ...

journal_title：Journal of virology

authors： Klaver B,Berkhout B

更新日期：1994-06-01 00:00:00

abstract：:The polypeptides of three paramyxoviruses (simian virus 5, Newcastle disease virus, and Sendai virus) were separated by polyacrylamide gel electrophoresis. Glycoproteins were identified by the use of radioactive glucosamine as a carbohydrate precursor. The protein patterns reveal similarities among the three viruses. ...

journal_title：Journal of virology

authors： Mountcastle WE,Compans RW,Choppin PW

更新日期：1971-01-01 00:00:00

abstract：:NF-kappaB signaling is critical to the survival and transformation of cells infected by the human gammaherpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. Here we have examined how elimination of the NF-kappaB transcription factor p50 from mice affects the life cycle of murine gammaherpesviru...

journal_title：Journal of virology

authors： Krug LT,Collins CM,Gargano LM,Speck SH

更新日期：2009-05-01 00:00:00

abstract：:Among the five serine incorporator (SERINC) family members, SERINC5 (Ser5) was reported to strongly inhibit HIV-1 replication, which is counteracted by Nef. Ser5 produces 5 alternatively spliced isoforms: Ser5-001 has 10 putative transmembrane domains, whereas Ser5-004, -005, -008a, and -008b do not have the last one....

journal_title：Journal of virology

authors： Zhang X,Zhou T,Yang J,Lin Y,Shi J,Zhang X,Frabutt DA,Zeng X,Li S,Venta PJ,Zheng YH

更新日期：2017-04-28 00:00:00

abstract：:Two defective RNAs (designated D RNA 3 alpha and D RNA 3 beta) were found to be associated with the Fny strain of cucumber mosaic cucumovirus but not with the Sny strain after serial passages in a tobacco host. The D RNAs were derived from RNA 3 by single, in-frame deletions within the 3a open reading frame. A full-le...

journal_title：Journal of virology

authors： Graves MV,Roossinck MJ

更新日期：1995-08-01 00:00:00

abstract：:A closed circular, double-stranded infectious DNA of Moloney leukemia virus has been described previously. The present report characterizes a second type of infectious, unintegrated viral DNA which is linear, largely double stranded, and of mass comparable to that of the closed circular viral DNA. The linear form is o...

journal_title：Journal of virology

authors： Smotkin D,Yoshimura FK,Weinberg RA

更新日期：1976-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) chronic infection is characterized by low-level or undetectable cellular immune responses against HCV antigens. HCV proteins have been shown to affect various intracellular events and modulate immune responses, although the precise mechanisms used to mediate these effects are not fully understo...

journal_title：Journal of virology

authors： Saito K,Ait-Goughoulte M,Truscott SM,Meyer K,Blazevic A,Abate G,Ray RB,Hoft DF,Ray R

更新日期：2008-04-01 00:00:00

abstract：:Serological surveys have revealed that 30 to 50% of wild-caught African green monkeys have antibodies reactive to simian immunodeficiency virus (SIV), a retrovirus related to human immunodeficiency virus (HIV). Although the nucleotide sequence of one SIVagm isolate, Tyo1, was recently reported, the extent of genetic v...

journal_title：Journal of virology

authors： Li Y,Naidu YM,Daniel MD,Desrosiers RC

更新日期：1989-04-01 00:00:00

abstract：:Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRC-CH31, from two clonal lineages of memory B cells with distinct specificit...

journal_title：Journal of virology

authors： Bonsignori M,Montefiori DC,Wu X,Chen X,Hwang KK,Tsao CY,Kozink DM,Parks RJ,Tomaras GD,Crump JA,Kapiga SH,Sam NE,Kwong PD,Kepler TB,Liao HX,Mascola JR,Haynes BF

更新日期：2012-04-01 00:00:00

abstract：:Herpes simplex virus (HSV) is an important human pathogen with a high worldwide seroprevalence. HSV enters epithelial cells, the primary site of infection, by a low-pH pathway. HSV glycoprotein B (gB) undergoes low pH-induced conformational changes, which are thought to drive membrane fusion. When neutralized back to ...

journal_title：Journal of virology

authors： Weed DJ,Dollery SJ,Komala Sari T,Nicola AV

更新日期：2018-08-16 00:00:00

abstract：:The infection of a bacterium by a phage starts with attachment to a receptor molecule on the host cell surface by the phage. Since receptor-phage interactions are crucial to successful infections, they are major determinants of phage host range and, by extension, of the broader effects that phages have on bacterial co...

journal_title：Journal of virology

authors： de Jonge PA,Smit Sibinga DJC,Boright OA,Costa AR,Nobrega FL,Brouns SJJ,Dutilh BE

更新日期：2020-11-09 00:00:00

abstract：:Monoclonal antibodies (MAb) reactive with the glycoprotein of vesicular stomatitis virus (VSV) serotypes Indiana (VSV-Ind) and New Jersey (VSV-NJ) were used to protect mice against lethal infection. MAb which reacted with a number of distinct epitopes and which could neutralize the virus in vitro could also protect ag...

journal_title：Journal of virology

authors： Lefrancois L

更新日期：1984-07-01 00:00:00

abstract：:Adenovirus type 35 (Ad35) is a group B adenovirus that has been isolated primarily from patients with acquired immunodeficiency syndrome and other immunodeficiency disorders. We have studied the interaction of this unique adenovirus with the immune system by analyzing Ad35 early viral proteins in infected HeLa cells. ...

journal_title：Journal of virology

authors： Flomenberg PR,Chen M,Horwitz MS

更新日期：1987-12-01 00:00:00

abstract：:Whole-body bioimaging was used to study dissemination of vaccinia virus (VACV) in normal and in immune deficient (nu(-)/nu(-)) mice protected from lethality by postchallenge administration of ST-246. Total fluxes were recorded in the liver, spleen, lungs, and nasal cavities of live mice after intranasal infection with...

journal_title：Journal of virology

authors： Zaitseva M,Shotwell E,Scott J,Cruz S,King LR,Manischewitz J,Diaz CG,Jordan RA,Grosenbach DW,Golding H

更新日期：2013-05-01 00:00:00

abstract：:Recent studies using radiolabeled rotavirus lysates have demonstrated a 35-kilodalton viral protein that binds specifically to the surface of MA104 cells (N. Fukuhara, O. Yoshie, S. Kitakoa, and T. Konno, J. Virol. 62:2209-2218, 1988; M. Sabara, J. Gilchrist, G.R. Hudson, and L.A. Babiuk, J. Virol. 53:58-66, 1985). Th...

journal_title：Journal of virology

authors： Bass DM,Mackow ER,Greenberg HB

更新日期：1990-01-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) protein is a transcriptional regulator of viral and cellular genes that is essential for EBV-mediated immortalization of B lymphocytes in vitro. EBNA-3C can inhibit transcription through an association with the cellular DNA-binding protein Jkappa, a function sh...

journal_title：Journal of virology

authors： Zhao B,Sample CE

更新日期：2000-06-01 00:00:00

abstract：:Persistent infection with oncogenic human papillomaviruses (HPVs) causes cervical cancer, accompanied by the accumulation of somatic mutations into the host genome. There are concomitant genetic changes in the HPV genome during viral infection; however, their relevance to cervical carcinogenesis is poorly understood. ...

journal_title：Journal of virology

authors： Hirose Y,Onuki M,Tenjimbayashi Y,Mori S,Ishii Y,Takeuchi T,Tasaka N,Satoh T,Morisada T,Iwata T,Miyamoto S,Matsumoto K,Sekizawa A,Kukimoto I

更新日期：2018-05-29 00:00:00

abstract：UNLABELLED:While a clear understanding of the events leading to successful establishment of host-specific viral populations and productive infection in the central nervous system (CNS) has not yet been reached, the simian immunodeficiency virus (SIV)-infected rhesus macaque provides a powerful model for the study of hu...

journal_title：Journal of virology

authors： Lamers SL,Nolan DJ,Rife BD,Fogel GB,McGrath MS,Burdo TH,Autissier P,Williams KC,Goodenow MM,Salemi M

更新日期：2015-08-01 00:00:00

abstract：:Further advances are required in understanding protection from AIDS by T-cell immunity. We analyzed a set of multigenic simian/human immunodeficiency virus (SHIV) DNA and fowlpox virus priming and boosting vaccines for immunogenicity and protective efficacy in outbred pigtail macaques. The number of vaccinations requi...

journal_title：Journal of virology

authors： Dale CJ,De Rose R,Stratov I,Chea S,Montefiori DC,Thomson S,Ramshaw IA,Coupar BE,Boyle DB,Law M,Kent SJ

更新日期：2004-12-01 00:00:00

abstract：:Viral infectivity factor (Vif) is one of the human immunodeficiency virus (HIV) accessory proteins and is conserved in the primate lentivirus group. This protein is essential for viral replication in vivo and for productive infection of nonpermissive cells, such as peripheral blood mononuclear cells (PBMC). Vif counte...

journal_title：Journal of virology

authors： Ribeiro AC,Maia e Silva A,Santa-Marta M,Pombo A,Moniz-Pereira J,Goncalves J,Barahona I

更新日期：2005-01-01 00:00:00

abstract：:A gene encoding a polypeptide with homology to mammalian vascular endothelial growth factors (VEGFs) has been discovered in the genome of orf virus (OV), a parapoxvirus that affects sheep and goats and, occasionally, humans. The gene is transcribed abundantly early in infection and is found immediately outside the inv...

journal_title：Journal of virology

authors： Lyttle DJ,Fraser KM,Fleming SB,Mercer AA,Robinson AJ

更新日期：1994-01-01 00:00:00

abstract：:We report a Sendai virus (SeV) vector system for expression of major histocompatibility complex (MHC) class I/peptide complexes. We cloned the extracellular domain of a human MHC class I heavy chain, HLA-A*2402, and human beta-2 microglobulin (beta2m) fused with HLA-A*2402-restricted human immunodeficiency virus type ...

journal_title：Journal of virology

authors： Kawana-Tachikawa A,Tomizawa M,Nunoya J,Shioda T,Kato A,Nakayama EE,Nakamura T,Nagai Y,Iwamoto A

更新日期：2002-12-01 00:00:00

abstract：:Among the numerous immunological abnormalities observed in chronically human immunodeficiency virus (HIV)-infected individuals, perturbations in memory CD4 T cells are thought to contribute specifically to disease pathogenesis. Among these, functional imbalances in the frequencies of T regulatory cells (Tregs) and int...

journal_title：Journal of virology

authors： Lai SH,Starke CE,Flynn JK,Vinton CL,Ortiz AM,Mudd JC,Brenchley JM

更新日期：2019-04-17 00:00:00

abstract：:Coronaviruses generally have a narrow host range, infecting one or just a few species. Using targeted RNA recombination, we constructed a mutant of the coronavirus mouse hepatitis virus (MHV) in which the ectodomain of the spike glycoprotein (S) was replaced with the highly divergent ectodomain of the S protein of fel...

journal_title：Journal of virology

authors： Kuo L,Godeke GJ,Raamsman MJ,Masters PS,Rottier PJ

更新日期：2000-02-01 00:00:00

abstract：:A nucleotide phosphohydrolase is firmly associated with a purified polyhedral cytoplasmic deoxyvirus, frog virus 3. This adenosine triphosphatase is distinguishable from known mammalian cell adenosine triphosphatases and from adenosine triphosphatase of an unrelated cytoplasmic replicating virus grown in the same host...

journal_title：Journal of virology

authors： Vilagines R,McAuslan BR

更新日期：1971-05-01 00:00:00

abstract：:Rubella virus is an enveloped positive-strand RNA virus of the family TOGAVIRIDAE: Virions are composed of three structural proteins: a capsid and two membrane-spanning glycoproteins, E2 and E1. During virus assembly, the capsid interacts with genomic RNA to form nucleocapsids. In the present study, we have investigat...

journal_title：Journal of virology

authors： Law LM,Everitt JC,Beatch MD,Holmes CF,Hobman TC

更新日期：2003-02-01 00:00:00