Abstract:
:A tumorigenic line of mouse cells transformed by the nononcogenic murine K papovavirus was established and characterized. Tumor-bearing animals produced antibody specific for K virus-transformed cells; the K virus T antiserum did not react with polyomavirus-transformed cells. Immunoprecipitation of the T antigen in the transformed cells revealed large T antigen (molecular weight 84,000). About 10 to 15 copies of K virus DNA were found to be integrated in the cellular DNA.
journal_name
J Viroljournal_title
Journal of virologyauthors
Kanda T,Takemoto KKdoi
10.1128/JVI.50.3.954-956.1984subject
Has Abstractpub_date
1984-06-01 00:00:00pages
954-6issue
3eissn
0022-538Xissn
1098-5514journal_volume
50pub_type
杂志文章abstract::The route of internalization of the pestivirus bovine viral diarrhea virus (BVDV) was studied by using different chemical and biophysical inhibitors of endocytosis. Expression of the dominant-negative mutant Dyn(K44A) of the GTPase dynamin in MDBK cells, as well as the treatment of the cells with chlorpromazine and be...
journal_title:Journal of virology
pub_type: 杂志文章
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abstract::Cytolytic T-lymphocyte (CTL) activity specific for respiratory syncytial (RS) virus was investigated after intranasal infection of mice with RS virus, after intraperitoneal infection of mice with a recombinant vaccinia virus expressing the F glycoprotein, and after intramuscular vaccination of mice with Formalin-inact...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.9.4232-4241.1990
更新日期:1990-09-01 00:00:00
abstract::The minor glycoproteins from hepatitis B surface antigen, GP33 and GP36, contain at their carboxy-terminal part the sequence of the major protein P24. They have 55 additional amino acids at the amino-terminal part which are coded by the pre-S region of the viral DNA. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.46.2.626-628.1983
更新日期:1983-05-01 00:00:00
abstract::To gain further insight on the function of the herpes simplex virus type 1 (HSV-1) packaging signal (a sequence), we constructed a recombinant virus containing a unique a sequence, which was flanked by two loxP sites in parallel orientation. The phenotype of this recombinant, named HSV-1 LaL, was studied in cell lines...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.18.8402-8412.2000
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abstract::In less than 3 months after the first cases of swine origin 2009 influenza A (H1N1) virus infections were reported from Mexico, WHO declared a pandemic. The pandemic virus is antigenically distinct from seasonal influenza viruses, and the majority of human population lacks immunity against this virus. We have studied ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01619-09
更新日期:2010-02-01 00:00:00
abstract::Influenza viruses unable to express NS1 protein (delNS1) replicate poorly and induce large amounts of interferon (IFN). They are therefore considered candidate viruses for live-attenuated influenza vaccines. Their attenuated replication is generally assumed to result from the inability to counter the antiviral host re...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01725-12
更新日期:2012-11-01 00:00:00
abstract::Mus dunni endogenous virus (MDEV) is activated from cells of the Asian wild mouse M. dunni (also known as Mus terricolor) in response to treatment with either 5-iodo-2'-deoxyuridine or hydrocortisone. MDEV represents a new murine retrovirus interference group and thus appears to use a different receptor for entry into...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.6.4663-4670.1997
更新日期:1997-06-01 00:00:00
abstract::The DNAs of the five nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid viruses contain overlapping segments of the early region of wild-type SV40 DNA. The complementary DNA strands of these five viruses have been separated with synthetic polyribonucleotides in isopycnic cesium chloride gradients. The relat...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.13.3.677-689.1974
更新日期:1974-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
abstract::Herpes simplex virus 1 replication initiates angiogenesis and inflammation in the cornea. This can result in herpetic stromal keratitis (HSK), which is a leading cause of infection-induced corneal blindness. Host cellular factors mediate the progression of HSK, but little is known about these cellular factors and thei...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00505-12
更新日期:2012-08-01 00:00:00
abstract::Friend murine leukemia virus (F-MuLV) is a replication-competent, ecotropic, NB-tropic retrovirus which produces a rapidly fatal erythroleukemia in susceptible strains of mice. We previously molecularly cloned the entire F-MuLV genome. Transfection of this cloned DNA into NIH 3T3 mouse fibroblasts produces a virus wit...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.46.3.718-725.1983
更新日期:1983-06-01 00:00:00
abstract::Regulatory T (T(R)) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4(+) CD25(+) human T(R) cells suppress virus-specific T-cell responses. Depletion of T(R) cells from peripheral blood mononuclear cells enhances T-cell responses ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.5.2454-2459.2004
更新日期:2004-03-01 00:00:00
abstract::Mounting evidence suggests that human immunodeficiency virus type 1 (HIV-1) Gag-specific T helper cells contribute to effective antiviral control, but their functional characteristics and the precise epitopes targeted by this response remain to be defined. In this study, we generated CD4(+) T-cell clones specific for ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.20.9771-9779.2001
更新日期:2001-10-01 00:00:00
abstract::Bluetongue virus (BTV), an insect-vectored emerging pathogen of both wild ruminants and livestock, has had a severe economic impact in agriculture in many parts of the world. The investigation of BTV replication and pathogenesis has been hampered by the lack of a reverse genetics system. Recovery of infectious BTV is ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00808-08
更新日期:2008-09-01 00:00:00
abstract::In the course of our studies on oxidative stress as a component of pathological processes in humans, we showed that microintrusion into cells with microcapillary and ultramicroelectrochemical detection could mimic many types of mechanical intrusion leading to an instant (0.1 s) and high (some femtomoles) burst release...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.2.1447-1452.1999
更新日期:1999-02-01 00:00:00
abstract::Sequences which encode Epstein-Barr virus (EBV) RNA in nasopharyngeal carcinoma (NPC) tissue have been identified. We utilized human biopsy material directly as well as NPC grown in nude mice. Total RNA was extracted from the tumor material and separated into polyadenylated and nonpolyadenylated fractions by oligodeox...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.48.3.580-590.1983
更新日期:1983-12-01 00:00:00
abstract::Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been implicated in the pathogenesis of Kaposi's sarcoma. KSHV encodes K-bZIP (open reading frame K8), a protein that belongs to the basic region-leucine zipper (bZIP) family of transcription factors. Here we show that K-bZIP associates with ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.24.11977-11982.2000
更新日期:2000-12-01 00:00:00
abstract::The M2-2 protein of respiratory syncytial virus (RSV) is involved in regulation of viral RNA transcription and replication. Encoded by the next-to-last gene of RSV, the M2-2 open reading frame (ORF) overlaps with the upstream M2-1 ORF, suggesting that the production of the M2-2 protein might be tightly regulated durin...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.22.13943-13952.2005
更新日期:2005-11-01 00:00:00
abstract::Attempts to elicit broadly neutralizing antibody responses by human immunodeficiency virus type 1 (HIV-1) vaccine antigens have been met with limited success. To better understand the requirements for cross-neutralization of HIV-1, we have characterized the neutralizing antibody specificities present in the sera of th...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02749-06
更新日期:2007-06-01 00:00:00
abstract::Many complex viruses use an assembly pathway in which their genome is packaged into an empty procapsid which subsequently matures into its final expanded form. We utilized Pseudomonas phage 6, a well-established virus assembly model, to probe the plasticity of the procapsid maturation pathway. The 6 packaging nucleosi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02285-13
更新日期:2013-12-01 00:00:00
abstract::CD8+ T cells are the key cellular effectors mediating the clearance of hepatitis B virus (HBV) infections. However, early immunological events surrounding the priming of HBV-specific CD8+ T cell responses remain poorly understood. This study examined the importance of priming location and the relative contribution of ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00920-18
更新日期:2018-10-12 00:00:00
abstract::In 2014 and 2015, the United States experienced an unprecedented outbreak of Eurasian clade 2.3.4.4 H5 highly pathogenic avian influenza (HPAI) virus. Initial cases affected mainly wild birds and mixed backyard poultry species, while later outbreaks affected mostly commercial chickens and turkeys. The pathogenesis, tr...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00960-17
更新日期:2017-10-13 00:00:00
abstract::The effects of human papillomavirus type 18 (HPV-18) E6 and E7 proteins on global patterns of host gene expression in primary human keratinocytes grown in organotypic raft culture system were assessed. Primary human keratinocytes were infected with retroviruses that express the wild-type HPV-18 E6 and E7 genes from th...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.17.9041-9050.2004
更新日期:2004-09-01 00:00:00
abstract::ZAM is an env-containing member of the gypsy family of retrotransposons that represents a possible retrovirus of invertebrates. In this paper, we traced ZAM mobilization to get information about a potential path a retroelement may take to reach the germ line of its host. In situ hybridization on whole-mount tissues an...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.22.10658-10669.2000
更新日期:2000-11-01 00:00:00
abstract::In adenovirus-infected cells, the epidermal growth factor receptor (EGF-R) is internalized from the cell surface via endosomes and is degraded, and the E3 10,400-dalton protein (10.4K protein) is required for this effect (C. R. Carlin, A. E. Tollefson, H. A. Brady, B. L. Hoffman, and W. S. M. Wold, Cell 57:135-144, 19...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.6.3095-3105.1991
更新日期:1991-06-01 00:00:00
abstract::Ten bacteriophages that attack and lyse saprophytic strains of Bdellovibrio bacteriovorus were isolated. Morphological, serological, and host-range studies revealed that there were four different bdellovibrio phages present among the isolates. One of the phages lysed a strain of B. bacteriovorus that requires the pres...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.10.3.516-523.1972
更新日期:1972-09-01 00:00:00
abstract::A ribonucleic acid (RNA)-dependent RNA polymerase was induced in chick embryo fibroblast cells after infection with Sendai virus (parainfluenza 1 virus). The enzyme was associated with the microsomal fraction of infected cells and reached maximum detectable activity at 18 hr after virus infection. The activity of the ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.5.6.663-671.1970
更新日期:1970-06-01 00:00:00
abstract::The relative antigenicity of the individual herpes simplex virus type 1 (KOS) glycoproteins gC and gB was analyzed in BALB/c mice by using KOS mutants altered in their ability to present these antigens on cell surface membranes during infection. The mutants employed were as follows: syn LD70 , a non-temperature-sensit...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.50.3.805-812.1984
更新日期:1984-06-01 00:00:00
abstract::Papillomaviruses (PVs) are a large family of small DNA viruses infecting mammals, reptiles, and birds. PV infection induces cell proliferation that may lead to the formation of orogenital or skin tumors. PV-induced cell proliferation has been related mainly to the expression of two small oncoproteins, E6 and E7. In ma...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01777-08
更新日期:2009-09-01 00:00:00
abstract::Activation of microglia and astroglia is seen in many neurodegenerative diseases including prion diseases. Activated glial cells produce cytokines as a protective response against certain pathogens and as part of the host inflammatory response to brain damage. In addition, cytokines might also exacerbate tissue damage...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01413-09
更新日期:2009-11-01 00:00:00