Dengue virus- and hepatitis C virus-induced replication and assembly compartments: the enemy inside--caught in the web.

abstract：:The multifunctional simian and human immunodeficiency virus (SIV and HIV) Nef proteins are important for virulence. We studied the importance of selected Nef functions using an SIV Nef with mutations in two regions that are required for CD4 downregulation. This Nef mutant is defective for downregulating CD4 and, in ad...

journal_title：Journal of virology

authors： Iafrate AJ,Carl S,Bronson S,Stahl-Hennig C,Swigut T,Skowronski J,Kirchhoff F

更新日期：2000-11-01 00:00:00

abstract：:A method to study the function of individual African swine fever virus (ASFV) gene products utilizing the Escherichia coli lac repressor-operator system has been developed. Recombinant viruses containing both the lacI gene encoding the lac repressor and a strong virus late promoter modified by the insertion of one or ...

journal_title：Journal of virology

authors： García-Escudero R,Andrés G,Almazán F,Viñuela E

更新日期：1998-04-01 00:00:00

abstract：:In vivo decay rates for the individual T7 early mRNA species were determined. The physical half-lives, measured at 37 C, range from 1.1 min for gene 0.7 RNA to 4.5 min for gene 0.3 RNA. Physical half-lives, as observed after rifampin inhibition of RNA synthesis and polyacylamide electrophoresis of RNAs, are approximat...

journal_title：Journal of virology

authors： Hercules K,Jovanovich S,Sauerbrier W

更新日期：1976-02-01 00:00:00

abstract：:Second-site revertants from replication-incompetent molecular clones of human immunodeficiency virus (HIV) contain base substitutions adjacent to the TATA motif. The altered TATA box motifs were analyzed for their effect(s) on virus infectivity, long terminal repeat (LTR)-directed expression in transient transfection ...

journal_title：Journal of virology

authors： Kashanchi F,Shibata R,Ross EK,Brady JN,Martin MA

更新日期：1994-05-01 00:00:00

abstract：:Epstein-Barr virus (EBV) infection leads to lifelong viral persistence through its latency in B cells. EBV-specific T cells control reactivations and prevent the development of EBV-associated malignancies in most healthy carriers, but infection can sometimes cause chronic disease and malignant transformation. Epstein-...

journal_title：Journal of virology

authors： Leskowitz RM,Zhou XY,Villinger F,Fogg MH,Kaur A,Lieberman PM,Wang F,Ertl HC

更新日期：2013-08-01 00:00:00

abstract：:A panel of murine monoclonal antibodies (MAbs) to the human immunodeficiency virus type 1 trans-activator tat protein were characterized. The anti-tat MAbs were mapped to the different domains of the tat protein by Western blot (immunoblot) and Pepscan analyses. One-half of the MAbs tested mapped to the amino-terminal...

journal_title：Journal of virology

authors： Brake DA,Goudsmit J,Krone WJ,Schammel P,Appleby N,Meloen RH,Debouck C

更新日期：1990-02-01 00:00:00

abstract：:Murine cytomegalovirus propagated in mouse embryo fibroblasts was purified by the following procedures. (i) Extracellular virus was concentrated by centrifugation at 100,000 x g for 90 min. (ii) The concentrated virus was passed through a Bio-Rad Bio-Gel A-15m column to eliminate contaminating materials smaller than 1...

journal_title：Journal of virology

authors： Kim KS,Sapienza VJ,Carp RI,Moon HM

更新日期：1976-03-01 00:00:00

abstract：:The EICP0 protein of equine herpesvirus 1 (EHV-1) is an early, viral regulatory protein that independently trans-activates EHV-1 immediate-early (IE), early, gamma1 late, and gamma2 late promoters. To assess whether this powerful trans-activator functions in conjunction with three other EHV-1 regulatory proteins to ac...

journal_title：Journal of virology

authors： Bowles DE,Kim SK,O'Callaghan DJ

更新日期：2000-02-01 00:00:00

abstract：UNLABELLED:Human bocavirus 1 (HBoV1) is a single-stranded DNA parvovirus that causes lower respiratory tract infections in young children worldwide. In this study, we identified novel splice acceptor and donor sites, namely, A1' and D1', in the large nonstructural protein (NS1)-encoding region of the HBoV1 precursor mR...

journal_title：Journal of virology

authors： Shen W,Deng X,Zou W,Cheng F,Engelhardt JF,Yan Z,Qiu J

更新日期：2015-10-01 00:00:00

abstract：:As viruses are reliant upon their host cell to serve as proper environments for their replication, many have evolved mechanisms to alter intracellular conditions to suit their own needs. For example, human cytomegalovirus induces quiescent cells to enter the cell cycle and then arrests them in late G(1), before they e...

journal_title：Journal of virology

authors： Kalejta RF,Shenk T

更新日期：2003-03-01 00:00:00

abstract：:The retroviral restriction factor TRIMCyp, derived from the TRIM5 gene, blocks replication at a postentry step. TRIMCyp has so far been found in four species of Asian macaques, Macaca fascicularis, M. mulatta, M. nemestrina, and M. leonina. M. fascicularis is commonly used as a model for AIDS research, but TRIMCyp has...

journal_title：Journal of virology

authors： Dietrich EA,Brennan G,Ferguson B,Wiseman RW,O'Connor D,Hu SL

更新日期：2011-10-01 00:00:00

abstract：:Bluetongue virus (BTV), a member of the Reoviridae family, is an insect-borne animal pathogen. Virus release from infected cells is predominantly by cell lysis, but some BTV particles are also released from the plasma membrane. The nonstructural protein NS3 has been implicated in this process. Using alternate initiato...

journal_title：Journal of virology

authors： Celma CC,Roy P

更新日期：2011-05-01 00:00:00

abstract：UNLABELLED:The vaccinia virus (VACV) E3 protein has been shown to be important for blocking activation of the cellular innate immune system and allowing viral replication to occur unhindered. Mutation or deletion of E3L severely affects viral host range and pathogenesis. While the monkeypox virus (MPXV) genome encodes ...

journal_title：Journal of virology

authors： Arndt WD,Cotsmire S,Trainor K,Harrington H,Hauns K,Kibler KV,Huynh TP,Jacobs BL

更新日期：2015-10-01 00:00:00

abstract：:The ascomycete Botrytis porri causes clove rot and leaf blight of garlic worldwide. We report here the biological and molecular features of a novel bipartite double-stranded RNA (dsRNA) mycovirus named Botrytis porri RNA virus 1 (BpRV1) from the hypovirulent strain GarlicBc-72 of B. porri. The BpRV1 genome comprises t...

journal_title：Journal of virology

authors： Wu M,Jin F,Zhang J,Yang L,Jiang D,Li G

更新日期：2012-06-01 00:00:00

abstract：:Bovine leukemia virus (BLV) and human T-cell lymphotropic virus type 1 (HTLV-1) belong to the genus of deltaretroviruses. Their entry into the host cell is supposed to be mediated by interactions of the extracellular (SU) envelope glycoproteins with cellular receptors. To gain insight into the mechanisms governing thi...

journal_title：Journal of virology

authors： Gatot JS,Callebaut I,Van Lint C,Demonté D,Kerkhofs P,Portetelle D,Burny A,Willems L,Kettmann R

更新日期：2002-08-01 00:00:00

abstract：:Human group C adenoviruses cause an acute infection in respiratory epithelia and establish a long-term or persistent infection, possibly in lymphocytes. The mechanism by which this persistence is maintained is unknown; however, it would require that persistently infected lymphocytes not be deleted. The adenovirus geno...

journal_title：Journal of virology

authors： McNees AL,Garnett CT,Gooding LR

更新日期：2002-10-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) infection causes adult T-cell leukemia (ATL), which is frequently resistant to currently available therapies and has a very poor prognosis. To prevent the development of ATL among carriers, it is important to control HTLV-1-infected cells in infected individuals. Therefore, ...

journal_title：Journal of virology

authors： Tezuka K,Okuma K,Kuramitsu M,Matsuoka S,Tanaka R,Tanaka Y,Hamaguchi I

更新日期：2018-01-30 00:00:00

abstract：:Dengue virus (DENV) is a mosquito-borne virus that infects upward of 300 million people annually and has the potential to cause fatal hemorrhagic fever and shock. While the parameters contributing to dengue immunopathogenesis remain unclear, the collapse of redox homeostasis and the damage induced by oxidative stress ...

journal_title：Journal of virology

authors： Ferrari M,Zevini A,Palermo E,Muscolini M,Alexandridi M,Etna MP,Coccia EM,Fernandez-Sesma A,Coyne C,Zhang DD,Marques ETA,Olagnier D,Hiscott J

更新日期：2020-11-23 00:00:00

abstract：:Betapapillomavirus replication and transcription have not been studied in detail because of a lack of suitable cellular systems supporting human papillomavirus (HPV) genome replication. We have recently shown that the human osteosarcoma cell line U2OS provides a useful environment for the genome replication of many di...

journal_title：Journal of virology

authors： Sankovski E,Männik A,Geimanen J,Ustav E,Ustav M

更新日期：2014-01-01 00:00:00

abstract：:Antibodies present in two peritoneal exudates of rats bearing abdominal tumors induced by UR2-transformed rat cells were characterized. The ability to immunoprecipitate p68gag-ros and to inhibit the protein and phospholipid kinase activities of this protein was investigated. One of the exudates specifically inhibited ...

journal_title：Journal of virology

authors： Balduzzi PC,Chovav M,Christensen JR,Macara IG

更新日期：1986-11-01 00:00:00

abstract：:Luteoviruses and the luteovirus-like pea enation mosaic virus (PEMV; genus Enamovirus) are transmitted by aphids in a circulative, nonreplicative manner. Acquired virus particles persist for several weeks in the aphid hemolymph, in which a GroEL homolog, produced by the primary endosymbiont of the aphid, is abundantly...

journal_title：Journal of virology

authors： van den Heuvel JF,Bruyère A,Hogenhout SA,Ziegler-Graff V,Brault V,Verbeek M,van der Wilk F,Richards K

更新日期：1997-10-01 00:00:00

abstract：:We followed the dynamics of capsid amino acid replacement among 403 Nigerian outbreak isolates of type 2 circulating vaccine-derived poliovirus (cVDPV2) from 2005 through 2011. Four different functional domains were analyzed: (i) neutralizing antigenic (NAg) sites, (ii) residues binding the poliovirus receptor (PVR), ...

journal_title：Journal of virology

authors： Shaw J,Jorba J,Zhao K,Iber J,Chen Q,Adu F,Adeniji A,Bukbuk D,Baba M,Henderson E,Dybdahl-Sissoko N,McDonald S,Weldon WC,Gumede N,Oberste MS,Kew OM,Burns CC

更新日期：2018-04-13 00:00:00

abstract：:Human La protein has been implicated in facilitating internal ribosome entry site (IRES)-mediated translation of hepatitis C virus (HCV). Earlier, we demonstrated that the RNA recognition motif (RRM) encompassing residues 112 to 184 of La protein [La (112-184)] interacts with the HCV IRES near the initiator AUG codon....

journal_title：Journal of virology

authors： Mondal T,Ray U,Manna AK,Gupta R,Roy S,Das S

更新日期：2008-12-01 00:00:00

abstract：UNLABELLED:To date, the response of teleost B cells to specific pathogens has been only scarcely addressed. In this work, we have demonstrated that viral hemorrhagic septicemia virus (VHSV), a fish rhabdovirus, has the capacity to infect rainbow trout spleen IgM-positive (IgM(+)) cells, although the infection is not pr...

journal_title：Journal of virology

authors： Abós B,Castro R,González Granja A,Havixbeck JJ,Barreda DR,Tafalla C

更新日期：2015-02-01 00:00:00

abstract：:Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has been responsible for an epidemic outbreak of unprecedented magnitude in recent years. Since then, significant efforts have been made to better understand the biology of this virus, but we still have poor knowledge of CHIKV interactions with host c...

journal_title：Journal of virology

authors： Bouraï M,Lucas-Hourani M,Gad HH,Drosten C,Jacob Y,Tafforeau L,Cassonnet P,Jones LM,Judith D,Couderc T,Lecuit M,André P,Kümmerer BM,Lotteau V,Desprès P,Tangy F,Vidalain PO

更新日期：2012-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as key regulators in many biological processes, from development to defense, at almost all organismal levels. Recently, their role has been highlighted in pathogen-host interactions. Emerging evidence from a variety of virus-host systems indicates that cellular as well as virally encode...

journal_title：Journal of virology

authors： Hussain M,Asgari S

更新日期：2010-01-01 00:00:00

abstract：:The varicella-zoster virus major transactivator, IE62, contains a potent N-terminal acidic transcriptional activation domain (TAD). Our experiments revealed that the minimal IE62 TAD encompasses amino acids (aa) 19 to 67. We showed that the minimal TAD interacts with the human Mediator complex. Site-specific mutations...

journal_title：Journal of virology

authors： Yamamoto S,Eletsky A,Szyperski T,Hay J,Ruyechan WT

更新日期：2009-06-01 00:00:00

abstract：:Defective interfering (DI) RNAs of Tomato bushy stunt virus (TBSV), a plus-sense RNA virus, comprise four conserved noncontiguous regions (I through IV) derived from the viral genome. Region III, a 70-nucleotide-long sequence corresponding to a genomic segment located 378 nucleotides upstream of the 3' terminus of the...

journal_title：Journal of virology

authors： Ray D,White KA

更新日期：2003-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) undergoes latent and lytic replication cycles, and its reactivation from latency to lytic replication is initiated by expression of the two viral immediate-early transactivators, Zta and Rta. In vitro, reactivation of EBV can be induced by anti-immunoglobulin, tetradecanoyl phorbol acetate, an...

journal_title：Journal of virology

authors： Tsai PF,Lin SJ,Weng PL,Tsai SC,Lin JH,Chou YC,Tsai CH

更新日期：2011-03-01 00:00:00

abstract：:We have previously described the expression of the major nonstructural protein (NS-1) of Aleutian mink disease parvovirus (ADV) in insect cells by using a baculovirus vector (J. Christensen, T. Storgaard, B. Bloch, S. Alexandersen, and B. Aasted, J. Virol. 67:229-238, 1993). To study its biochemical properties, ADV NS...

journal_title：Journal of virology

authors： Christensen J,Pedersen M,Aasted B,Alexandersen S

更新日期：1995-03-01 00:00:00