Analysis of structural proteins of purified murine cytomegalovirus.

abstract：:Mus dunni endogenous virus (MDEV) is activated from cells of the Asian wild mouse M. dunni (also known as Mus terricolor) in response to treatment with either 5-iodo-2'-deoxyuridine or hydrocortisone. MDEV represents a new murine retrovirus interference group and thus appears to use a different receptor for entry into...

journal_title：Journal of virology

authors： Bonham L,Wolgamot G,Miller AD

更新日期：1997-06-01 00:00:00

abstract：:We have previously shown that two inhibitors specific for cellular cyclin-dependent kinases (cdks), Roscovitine (Rosco) and Olomoucine (Olo), block the replication of herpes simplex virus (HSV). Based on these results, we demonstrated that HSV replication requires cellular cdks that are sensitive to these drugs (L. M....

journal_title：Journal of virology

authors： Schang LM,Rosenberg A,Schaffer PA

更新日期：2000-03-01 00:00:00

abstract：:In response to viral infection, reactive oxygen species (ROS) mediate innate immune signaling or generate danger signals to activate immune cells. The mechanisms of virally induced ROS are poorly defined, however. We demonstrate that ROS are produced within minutes of adenovirus type 5 (Ad5) infection of macrophages a...

journal_title：Journal of virology

authors： McGuire KA,Barlan AU,Griffin TM,Wiethoff CM

更新日期：2011-10-01 00:00:00

abstract：:Assembly of hepatitis delta virus (HDV) in infected human hepatocytes involves association of the 1,679- nucleotide single-stranded genomic RNA (deltaRNA) with multiple copies of both small and large forms of the delta protein (deltaAg) to form a ribonucleoprotein particle which in turn interacts with envelope protein...

journal_title：Journal of virology

authors： Gudima S,Chang J,Moraleda G,Azvolinsky A,Taylor J

更新日期：2002-04-01 00:00:00

abstract：:Adeno-associated virus (AAV) integrates very efficiently into a specific site (AAVS1) of human chromosome 19. Two elements of the AAV genome are sufficient: the inverted terminal repeats (ITRs) and the Rep78 or Rep68 protein. The incorporation of the AAV integration machinery in nonviral delivery systems is of great i...

journal_title：Journal of virology

authors： Lamartina S,Roscilli G,Rinaudo D,Delmastro P,Toniatti C

更新日期：1998-09-01 00:00:00

abstract：:The temperature-sensitive defects of virus mutants isolated from L cells persistently infected with Newcastle disease virus (NDV) were analyzed. Genetic grouping of the mutants by complementation tests was attempted by using several different methods, including yield analysis, RNA synthesis, and heterozygote formation...

journal_title：Journal of virology

authors： Preble OT,Youngner JS

更新日期：1973-09-01 00:00:00

abstract：UNLABELLED:In a previous screen of putative interferon-stimulated genes, SUN2 was shown to inhibit HIV-1 infection in an uncharacterized manner. SUN2 is an inner nuclear membrane protein belonging to the linker of nucleoskeleton and cytoskeleton complex. We have analyzed here the role of SUN2 in HIV infection. We repor...

journal_title：Journal of virology

authors： Donahue DA,Amraoui S,di Nunzio F,Kieffer C,Porrot F,Opp S,Diaz-Griffero F,Casartelli N,Schwartz O

更新日期：2016-03-28 00:00:00

abstract：:Herpes simplex virus 2 (HSV-2) infection is still one of the common causes of sexually transmitted diseases worldwide. The prevalence of HSV strains resistant to traditional nucleoside antiviral agents has led to the development of novel antiviral drugs. Human alpha-defensin 5 (HD5), a kind of endogenous antimicrobial...

journal_title：Journal of virology

authors： Wang A,Chen F,Wang Y,Shen M,Xu Y,Hu J,Wang S,Geng F,Wang C,Ran X,Su Y,Cheng T,Wang J

更新日期：2013-03-01 00:00:00

abstract：:Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL) cells are predominantly infected with latent Kaposi's sarcoma-associated herpesvirus (KSHV), presenting a barrier to the destruction of tumor cells. Latent KSHV can be reactivated to undergo lytic replication. Here we report that in PEL cells, oxidative stress ...

journal_title：Journal of virology

authors： Li X,Feng J,Sun R

更新日期：2011-01-01 00:00:00

abstract：:The mechanisms mediating protective immunity to hepatitis C virus (HCV) infection are incompletely understood because early infection in humans is rarely identified, particularly in those individuals who subsequently demonstrate spontaneous virus eradication. We have established a large national network of patients wi...

journal_title：Journal of virology

authors： Smyk-Pearson S,Tester IA,Klarquist J,Palmer BE,Pawlotsky JM,Golden-Mason L,Rosen HR

更新日期：2008-02-01 00:00:00

abstract：:Infection of cells with enveloped viruses is accomplished through membrane fusion. The binding and fusion processes are mediated by the spike proteins in the envelope of the virus particle and usually involve a series of conformational changes in these proteins. We have studied the low-pH-mediated fusion process of th...

journal_title：Journal of virology

authors： Wahlberg JM,Bron R,Wilschut J,Garoff H

更新日期：1992-12-01 00:00:00

abstract：:To replicate its segmented, double-stranded RNA (dsRNA) genome, the rotavirus RNA-dependent RNA polymerase, VP1, must recognize viral plus-strand RNAs (+RNAs) and guide them into the catalytic center. VP1 binds to the conserved 3' end of rotavirus +RNAs via both sequence-dependent and sequence-independent contacts. Se...

journal_title：Journal of virology

authors： Ogden KM,Ramanathan HN,Patton JT

更新日期：2011-03-01 00:00:00

abstract：:We have recently shown that live attenuated virus vaccines produced on chicken-derived cells contain low levels of particle-associated reverse transcriptase (RT). In both virus and corresponding control harvests produced on chicken embryo fibroblasts, these activities were present at significantly higher concentration...

journal_title：Journal of virology

authors： Weissmahr RN,Schüpbach J,Böni J

更新日期：1997-04-01 00:00:00

abstract：:The J-F intercistronic region of the genomes of bacteriophages phi X174 and G4 is transcribed but not translated. It contains the potential for a perfectly base-paired hairpin structure, which has been proposed to act as a terminator of transcription or as a regulatory region for mRNA turnover (or both). We measured p...

journal_title：Journal of virology

authors： Romantschuk ML,Müller UR

更新日期：1983-10-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection has been shown to activate the mTORC1 signaling pathway. However, the phosphorylation of mTORC1 targets is differentially sensitive to the mTORC1 inhibitor rapamycin, and the drug inhibits HCMV replication to a modest extent. Using Torin1, a newly developed inhibitor that targets...

journal_title：Journal of virology

authors： Moorman NJ,Shenk T

更新日期：2010-05-01 00:00:00

abstract：:We examined the 5' ends of Hantaan virus (HTN) genomes and mRNAs to gain insight into the manner in which these chains were initiated. Like those of all members of the family Bunyaviridae described so far, the HTN mRNAs contained 5' terminal extensions that were heterogeneous in both length and sequence, presumably be...

journal_title：Journal of virology

authors： Garcin D,Lezzi M,Dobbs M,Elliott RM,Schmaljohn C,Kang CY,Kolakofsky D

更新日期：1995-09-01 00:00:00

abstract：:Purified replicative form (RF) and replicative intermediate (RI) prepared from Escherichia coli cells infected with the ribonucleic acid (RNA) bacteriophage R17 were denatured with dimethyl sulfoxide at 37 C or in aqueous solvents of low ionic strength at 97 C. Denaturation was demonstrated for RF and RI by an increas...

journal_title：Journal of virology

authors： Franklin RM

更新日期：1967-06-01 00:00:00

abstract：:The morphogenesis of vesicular stomatitis virus was examined using freeze-fracture techniques, and the results obtained were compared with those from previously published experiments carried out with influenza viruses and togaviruses. The process of conversion of the host cell plasma membrane into the vesicular stomat...

journal_title：Journal of virology

authors： Brown DT,Riedel B

更新日期：1977-02-01 00:00:00

abstract：:Work in this laboratory previously demonstrated that the tropism of different human immunodeficiency type 1 isolates for infection of human CD4+ continuous cell lines (e.g., T-cell lines and HeLa-CD4 transformants) versus primary macrophages is associated with parallel intrinsic fusogenic specificities of the correspo...

journal_title：Journal of virology

authors： Alkhatib G,Broder CC,Berger EA

更新日期：1996-08-01 00:00:00

abstract：:Latency is an integral feature of the pathogenesis of cytomegalovirus infection and disease. Using in situ hybridization, we detected viral DNA in the splenic stroma of mice with acute murine cytomegalovirus (MCMV) infection but could not detect latent infection. By using enzymatic amplification of a 700-bp region of ...

journal_title：Journal of virology

authors： Pomeroy C,Hilleren PJ,Jordan MC

更新日期：1991-06-01 00:00:00

abstract：UNLABELLED:The HIV-1 virion infectivity factor (Vif) targets the cellular cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) for degradation via the host ubiquitin-proteasome pathway. Vif recruits a cellular E3 ubiquitin ligase to polyubiquitinate A3G/F. The activity of Vif critically depends on the cellular core bi...

journal_title：Journal of virology

authors： Fribourgh JL,Nguyen HC,Wolfe LS,Dewitt DC,Zhang W,Yu XF,Rhoades E,Xiong Y

更新日期：2014-03-01 00:00:00

abstract：:Both CD4(+) and CD8(+) T cells are required for clearance of the murine coronavirus mouse hepatitis virus (MHV) during acute infection. We investigated the effects of an epitope-specific CD8(+) T-cell response on acute infection of MHV, strain A59, in the murine CNS. Mice with CD8(+) T cells specific for gp33-41 (an H...

journal_title：Journal of virology

authors： Chua MM,MacNamara KC,San Mateo L,Shen H,Weiss SR

更新日期：2004-02-01 00:00:00

abstract：:Here, we report a novel porcine circovirus type 2a (PCV2a) strain with 11 nucleotides (nt) inserted in the origin of genome replication (Ori). This is the first report of a PCV2a strain with nucleotide insertion in Ori. Our study will help further epidemiological studies and extend our knowledge of evolutionary charac...

journal_title：Journal of virology

authors： Cai L,Han X,Hu D,Li X,Wang B,Ni J,Zhou Z,Yu X,Zhai X,Tian K

更新日期：2012-06-01 00:00:00

abstract：:Incorporation of human immunodeficiency virus type 1 (HIV-1) envelope proteins into vesicular stomatitis virus (VSV) particles was studied in a system that allows expressed envelope proteins to rescue phenotypically a temperature-sensitive mutant of VSV (tsO45). This mutant exhibits defective transport of its own enve...

journal_title：Journal of virology

authors： Owens RJ,Rose JK

更新日期：1993-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) infection of children previously immunized with a nonlive, formalin-inactivated (FI)-RSV vaccine has been associated with serious enhanced respiratory disease (ERD). Consequently, detailed studies of potential ERD are a critical step in the development of nonlive RSV vaccines targetin...

journal_title：Journal of virology

authors： Schneider-Ohrum K,Cayatte C,Bennett AS,Rajani GM,McTamney P,Nacel K,Hostetler L,Cheng L,Ren K,O'Day T,Prince GA,McCarthy MP

更新日期：2017-03-29 00:00:00

abstract：:Domains required late in the virus budding process (L domains) have been identified in the Gag proteins of a number of retroviruses. Here we show that the human T-cell leukemia virus type 1 candidate L domain motif PPPY is indeed required for virus production. Strikingly, however, mutation of this motif arrested virus...

journal_title：Journal of virology

authors： Le Blanc I,Prévost MC,Dokhélar MC,Rosenberg AR

更新日期：2002-10-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope (Env) proteins are extensively decorated with N-glycans, predominantly of the high-mannose type. However, it is unclear how high-mannose N-glycans on Env impact viral spread. We show that exclusive modification of SIV Env with these N-...

journal_title：Journal of virology

authors： Karsten CB,Buettner FF,Cajic S,Nehlmeier I,Neumann B,Klippert A,Sauermann U,Reichl U,Gerardy-Schahn R,Rapp E,Stahl-Hennig C,Pöhlmann S

更新日期：2015-11-01 00:00:00

abstract：:A fresh inoculum of human adenovirus type 12 (Ad12) was obtained from the American Type Culture Collection and passaged once on human embryonic kidney cells, and Ad12 DNA was prepared from the first-passage yield to avoid higher passages which might have generated host-virus DNA recombinants. The 18 PstI fragments of ...

journal_title：Journal of virology

authors： Sprengel J,Schmitz B,Heuss-Neitzel D,Zock C,Doerfler W

更新日期：1994-01-01 00:00:00

abstract：:West Nile virus (WNV), currently the cause of a serious U.S. epidemic, is a mosquito-borne flavivirus and member of the Japanese encephalitis (JE) serocomplex. There is currently no approved human WNV vaccine, and treatment options remain limited, resulting in significant mortality and morbidity from human infection. ...

journal_title：Journal of virology

authors： Petrovsky N,Larena M,Siddharthan V,Prow NA,Hall RA,Lobigs M,Morrey J

更新日期：2013-09-01 00:00:00

abstract：:Precore and core proteins are two related co-carboxy-terminal proteins of hepatitis B virus. Precore protein contains the entire sequence of core protein plus an amino-terminal extension of 29 amino acid residues. Both proteins can display a common antigenic determinant known as core antigen (HBcAg). Clinically, HBcAg...

journal_title：Journal of virology

authors： Yeh CT,Liaw YF,Ou JH

更新日期：1990-12-01 00:00:00