Abstract:
:The mechanisms mediating protective immunity to hepatitis C virus (HCV) infection are incompletely understood because early infection in humans is rarely identified, particularly in those individuals who subsequently demonstrate spontaneous virus eradication. We have established a large national network of patients with acute HCV infection. Here, we comprehensively examined total HCV-specific CD4(+) and CD8(+) T-cell responses and identified functional T-cell thresholds that predict recovery. Interestingly, we found that the presence of HCV-specific cytotoxic T lymphocytes (CTLs) that can proliferate, exhibit cytotoxicity, and produce gamma interferon does not ensure recovery, but whether these CTLs were primed in the presence or absence of CD4(+) T-cell help (HCV-specific interleukin-2 production) is a critical determinant. These results have important implications for early prediction of the virologic outcome following acute HCV and for the development of novel immunotherapeutic approaches.
journal_name
J Viroljournal_title
Journal of virologyauthors
Smyk-Pearson S,Tester IA,Klarquist J,Palmer BE,Pawlotsky JM,Golden-Mason L,Rosen HRdoi
10.1128/JVI.01581-07subject
Has Abstractpub_date
2008-02-01 00:00:00pages
1827-37issue
4eissn
0022-538Xissn
1098-5514pii
JVI.01581-07journal_volume
82pub_type
杂志文章abstract::The kinetics of retroviral DNA and RNA synthesis are parameters vital to understanding viral growth, especially for human immunodeficiency virus (HIV), which encodes several of its own regulatory genes. We have established a single-cycle growth condition for HIV in H9 cells, a human CD4+ lymphocyte line. The full-leng...
journal_title:Journal of virology
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doi:10.1128/JVI.63.9.3708-3713.1989
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journal_title:Journal of virology
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doi:10.1128/JVI.60.2.363-368.1986
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.12.5037-5045.1989
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pub_type: 杂志文章
doi:10.1128/JVI.79.1.637-643.2005
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pub_type: 杂志文章
doi:10.1128/JVI.4.6.872-878.1969
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01263-15
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.3.1886-1893.1998
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03052-14
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.3.1340-1354.1996
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.18.1.182-194.1976
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.10.5114-5122.1990
更新日期:1990-10-01 00:00:00
abstract::Chikungunya virus (CHIKV), a mosquito-borne alphavirus, has traditionally circulated in Africa and Asia, causing human febrile illness accompanied by severe, chronic joint pain. In Africa, epidemic emergence of CHIKV involves the transition from an enzootic, sylvatic cycle involving arboreal mosquito vectors and nonhu...
journal_title:Journal of virology
pub_type: 杂志文章
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