Specificity analysis of human CD4+ T-cell clones directed against human herpesvirus 6 (HHV-6), HHV-7, and human cytomegalovirus.

abstract：:The herpes simplex virus type 1 (HSV-1) ICP34.5 gene is a neurovirulence gene in mice. In addition, some ICP34.5 mutants have been reported to have a reduced efficiency of induced reactivation as measured by in vitro explantation of latently infected mouse ganglia. However, since spontaneous reactivation is almost non...

journal_title：Journal of virology

authors： Perng GC,Thompson RL,Sawtell NM,Taylor WE,Slanina SM,Ghiasi H,Kaiwar R,Nesburn AB,Wechsler SL

更新日期：1995-05-01 00:00:00

abstract：:Restriction factors are intrinsic cellular defense proteins that have evolved to block microbial infections. Retroviruses such as HIV-1 are restricted by TRIM5 proteins, which recognize the viral capsid shell that surrounds, organizes, and protects the viral genome. TRIM5α uses a SPRY domain to bind capsids with low i...

journal_title：Journal of virology

authors： Wagner JM,Christensen DE,Bhattacharya A,Dawidziak DM,Roganowicz MD,Wan Y,Pumroy RA,Demeler B,Ivanov DN,Ganser-Pornillos BK,Sundquist WI,Pornillos O

更新日期：2018-01-30 00:00:00

abstract：:We generated a recombinant influenza A virus (Mmut) that produced low levels of matrix (M1) and M2 proteins in infected cells. Mmut virus propagated to significantly lower titers than did wild-type virus in cells infected at low multiplicity. By contrast, virion morphology and incorporation of viral proteins and vRNAs...

journal_title：Journal of virology

authors： Bourmakina SV,García-Sastre A

更新日期：2005-06-01 00:00:00

abstract：:E26 is a replication-defective avian retrovirus that causes an erythroblastic leukemia in vivo and transforms hematopoietic precursor cells of both the erythroid and the myeloid lineages in vitro. The E26 genome contains two sets of cell-derived sequences, ets and myb. myb sequences are also present in avian myeloblas...

journal_title：Journal of virology

authors： Nunn MF,Hunter T

更新日期：1989-01-01 00:00:00

abstract：:Long-acting antiretrovirals could provide a useful alternative to daily oral therapy for HIV-1-infected individuals. Building on a bi-specific molecule with adnectins targeting CD4 and gp41, a potential long-acting biologic, GSK3732394, was developed with three independent and synergistic modes of HIV entry inhibition...

journal_title：Journal of virology

authors： Wensel D,Sun Y,Davis J,Li Z,Zhang S,McDonagh T,Langley D,Mitchell T,Tabruyn S,Nef P,Cockett M,Krystal M

更新日期：2019-09-30 00:00:00

abstract：:The inactivation of type C retroviruses by human serum may be a considerable impediment to the use of retroviral vectors in vivo for gene therapy. Here we show that virus inactivation is dependent both on the virus and on the cell line used to produce the virus. All viruses produced from murine NIH 3T3 or dog Cf2ThS+L...

journal_title：Journal of virology

authors： Takeuchi Y,Cosset FL,Lachmann PJ,Okada H,Weiss RA,Collins MK

更新日期：1994-12-01 00:00:00

abstract：:A nucleotide phosphohydrolase is firmly associated with a purified polyhedral cytoplasmic deoxyvirus, frog virus 3. This adenosine triphosphatase is distinguishable from known mammalian cell adenosine triphosphatases and from adenosine triphosphatase of an unrelated cytoplasmic replicating virus grown in the same host...

journal_title：Journal of virology

authors： Vilagines R,McAuslan BR

更新日期：1971-05-01 00:00:00

abstract：:A distinctive feature of chronic human immunodeficiency virus type 1 (HIV-1) infection is the presence of multiple coexisting genetic variants, or subpopulations, that comprise the HIV-1 population detected in the peripheral blood. Analysis of HIV-1 RNA decay dynamics during the initiation of highly active antiretrovi...

journal_title：Journal of virology

authors： Ince WL,Harrington PR,Schnell GL,Patel-Chhabra M,Burch CL,Menezes P,Price RW,Eron JJ Jr,Swanstrom RI

更新日期：2009-05-01 00:00:00

abstract：:Respiratory syncytial (RS) virus infects the epithelium of the respiratory tract. We examined the replication and maturation of RS virus in two polarized epithelial cell lines, Vero C1008 and MDCK. Electron microscopy of RS virus-infected Vero C1008 cells revealed the presence of pleomorphic viral particles budding ex...

journal_title：Journal of virology

authors： Roberts SR,Compans RW,Wertz GW

更新日期：1995-04-01 00:00:00

abstract：:The E6 oncoprotein of high-risk human papillomavirus type 16 (HPV16) interacts with several nuclear transcription factors and coactivators in addition to cytoplasmic proteins, suggesting that nuclear import of HPV16 E6 plays a role in the cellular transformation process. In this study we have investigated the nuclear ...

journal_title：Journal of virology

authors： Le Roux LG,Moroianu J

更新日期：2003-02-01 00:00:00

abstract：:With the aid of three monoclonal antibodies (MAbs), a glycoprotein specifically localized to the outer envelope of vaccinia virus was shown to be encoded by the A33R gene. These MAbs reacted with a glycosylated protein that migrated as 23- to 28-kDa and 55-kDa species under reducing and nonreducing conditions, respect...

journal_title：Journal of virology

authors： Roper RL,Payne LG,Moss B

更新日期：1996-06-01 00:00:00

abstract：:GP64, the major envelope glycoprotein of the Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) budded virion, is important for host cell receptor binding and mediates low-pH-triggered membrane fusion during entry by endocytosis. In the current study, we examined the functional role of the AcMNPV GP64 tr...

journal_title：Journal of virology

authors： Li Z,Blissard GW

更新日期：2008-04-01 00:00:00

abstract：:Encephalomyocarditis (EMC) virus (K-2 strain) was separated into two distinct peaks of optical density by chromatography on calcium phosphate, eluting at 0.17 and 0.31 m, respectively. The virus in these peaks could not be distinguished by infectivity (plaque-forming units), hemagglutinin activity, electron microscopi...

journal_title：Journal of virology

authors： Burness AT

更新日期：1967-04-01 00:00:00

abstract：:Transgene expression after the administration of recombinant adenovirus with E1 deleted is constantly transient. It is admitted that E1A-substituting activities of cellular or viral origin allow viral antigen synthesis and trigger cytotoxic lymphocyte-mediated clearance of the recipient cells. Our approach to solving ...

journal_title：Journal of virology

authors： Yeh P,Dedieu JF,Orsini C,Vigne E,Denefle P,Perricaudet M

更新日期：1996-01-01 00:00:00

abstract：:For the identification of RNA-binding proteins that specifically interact with potato spindle tuber viroid (PSTVd), we subjected a tomato cDNA expression library prepared from viroid-infected leaves to an RNA ligand screening procedure. We repeatedly identified cDNA clones that expressed a protein of 602 amino acids. ...

journal_title：Journal of virology

authors： Martínez de Alba AE,Sägesser R,Tabler M,Tsagris M

更新日期：2003-09-01 00:00:00

abstract：:We report the identification of a functional nuclear localization signal (NLS) in the human cytomegalovirus (HCMV) large tegument protein pUL48 that is required for nuclear localization in transfected cells and is essential for viral growth. The NLS was mapped to pUL48 amino acid residues 284 to 302. This sequence con...

journal_title：Journal of virology

authors： Brock I,Krüger M,Mertens T,von Einem J

更新日期：2013-05-01 00:00:00

abstract：:Recombination is one of the driving forces of viral evolution. RNA recombination events among similar RNA viruses are frequent, although RNA recombination could also take place among unrelated viruses. In this paper, we have established efficient interviral recombination systems based on yeast and plants. We show that...

journal_title：Journal of virology

authors： Kovalev N,Pogany J,Nagy PD

更新日期：2019-12-12 00:00:00

abstract：:Data showing that an apoptotic reaction (the exit into the cytoplasm and nucleolytic internucleosomal degradation of chromosomal DNA, compaction and fragmentation of chromatin, cellular shrinkage, and cytoplasmic blebbing) developed in a subline of HeLa-S3 cells upon nonpermissive poliovirus infection with either a gu...

journal_title：Journal of virology

authors： Tolskaya EA,Romanova LI,Kolesnikova MS,Ivannikova TA,Smirnova EA,Raikhlin NT,Agol VI

更新日期：1995-02-01 00:00:00

abstract：:A radioimmunoassay (RIA) has been used to measure the quantity of protein P27 (mol wt 27,000; group specific-1 [gs-1]) of avian leukoviruses in different types of chicken embryos and tissues of adult chickens. The RIA used was 200- to 300-fold more sensitive than the complement fixation test and was able to detect as ...

journal_title：Journal of virology

authors： Chen JH,Hanafusa H

更新日期：1974-02-01 00:00:00

abstract：:Most retroviral packaging cell lines were established by a helper virus plasmid cotransfected with a separate plasmid encoding a selection marker. Since this selection marker coexisted in trans with the helper virus sequence, helper virus gene expression could be inactivated by host DNA methylation despite selection f...

journal_title：Journal of virology

authors： Young WB,Link CJ Jr

更新日期：2000-06-01 00:00:00

abstract：:The expression of a human immunodeficiency virus (HIV) type 1 provirus (F12-HIV) cloned from a nonproducer, chronically infected CD4 down-regulated Hut-78 cell clone (F12) does not lead to the formation of viral particles and, upon transfection in HeLa CD4+ cells, confers resistance to HIV superinfection without affec...

journal_title：Journal of virology

authors： Federico M,Nappi F,Ferrari G,Chelucci C,Mavilio F,Verani P

更新日期：1995-11-01 00:00:00

abstract：:Aichi virus, a member of the family Picornaviridae, encodes a leader (L) protein of 170 amino acids (aa). The Aichi virus L protein exhibits no significant sequence homology to those of other picornaviruses. In this study, we investigated the function of the Aichi virus L protein in virus growth. In vitro translation ...

journal_title：Journal of virology

authors： Sasaki J,Nagashima S,Taniguchi K

更新日期：2003-10-01 00:00:00

abstract：:Structural differences between human leukocyte virus-induced interferon and human fibroblast polyinosinic-polycytidylic acid (rIn-rCn)-induced interferon have been noted in previous studies. This study reports the behavior of human leukocyte and fibroblast interferon, induced by virus and by rIn-rCn, in several lectin...

journal_title：Journal of virology

authors： Jankowski WJ,Davey MW,O'Malley JA,Sulkowski E,Carter WA

更新日期：1975-11-01 00:00:00

abstract：UNLABELLED:Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella and herpes zoster. Membrane fusion is essential for VZV entry and the distinctive syncytium formation in VZV-infected skin and neuronal tissue. Herpesvirus fusion is mediated by a complex of glycoproteins gB and gH-gL, which are necess...

journal_title：Journal of virology

authors： Yang E,Arvin AM,Oliver SL

更新日期：2016-07-27 00:00:00

abstract：:Rhesus cytomegalovirus (RhCMV) infection of macaques exhibits strong similarities to human CMV (HCMV) persistence and pathogenesis. The immunogenicity of DNA vaccines encoding three RhCMV proteins (a truncated version of glycoprotein B lacking the transmembrane region and endodomain [gBDeltaTM], phosphoprotein 65-2 [p...

journal_title：Journal of virology

authors： Yue Y,Kaur A,Eberhardt MK,Kassis N,Zhou SS,Tarantal AF,Barry PA

更新日期：2007-02-01 00:00:00

abstract：:The phenomenon of prion strains with distinct biological characteristics has been hypothesized to be involved in the structural diversity of abnormal prion protein (PrP(Sc)). However, the molecular basis of the transmission of strain properties remains poorly understood. Real-time quaking-induced conversion (RT-QUIC) ...

journal_title：Journal of virology

authors： Sano K,Atarashi R,Ishibashi D,Nakagaki T,Satoh K,Nishida N

更新日期：2014-10-01 00:00:00

abstract：UNLABELLED:We have shown that glycoprotein K (gK) and its interacting partner, the UL20 protein, play crucial roles in virion envelopment. Specifically, virions lacking either gK or UL20 fail to acquire an envelope, thus causing accumulation of capsids in the cytoplasm of infected cells. The herpes simplex virus 1 (HSV...

journal_title：Journal of virology

authors： Jambunathan N,Chouljenko D,Desai P,Charles AS,Subramanian R,Chouljenko VN,Kousoulas KG

更新日期：2014-06-01 00:00:00

abstract：UNLABELLED:Inhibitor-of-apoptosis (IAP) proteins are key regulators of the innate antiviral response by virtue of their capacity to respond to signals affecting cell survival. In insects, wherein the host IAP provides a primary restriction to apoptosis, diverse viruses trigger rapid IAP depletion that initiates caspase...

journal_title：Journal of virology

authors： Vandergaast R,Mitchell JK,Byers NM,Friesen PD

更新日期：2015-04-01 00:00:00

abstract：:Neuraminidase (NA) inhibitors (NAIs) are widely used antiviral drugs for the treatment of humans with influenza virus infections. There have been widespread reports of NAI resistance among seasonal A(H1N1) viruses, and most have been identified in oseltamivir-exposed patients or those treated with other NAIs. Thus, mo...

journal_title：Journal of virology

authors： Lloren KKS,Kwon JJ,Choi WS,Jeong JH,Ahn SJ,Choi YK,Baek YH,Song MS

更新日期：2019-03-05 00:00:00

abstract：:Functions of viral proteins can be regulated through phosphorylation by serine/threonine kinases in plants, but little is known about the involvement of tyrosine kinases in plant virus infection. In this study, TGBp3, one of the three movement proteins encoded by a triple gene block (TGB) of Potato mop-top virus (PMTV...

journal_title：Journal of virology

authors： Samuilova O,Santala J,Valkonen JP

更新日期：2013-04-01 00:00:00