Cleavage specificity of purified recombinant hepatitis A virus 3C proteinase on natural substrates.

abstract：:Callitrichid hepatitis is an infection of New World primates caused by an arenavirus, currently referred to as callitrichid hepatitis virus, that is closely related to lymphocytic choriomeningitis virus (LCMV). We have cloned and sequenced the GP-C gene of callitrichid hepatitis virus and found that the cDNA sequence ...

journal_title：Journal of virology

authors： Stephensen CB,Park JY,Blount SR

更新日期：1995-02-01 00:00:00

abstract：:ZEBRA is an Epstein-Barr virus (EBV) transcriptional activator that mediates a genetic switch between the latent and lytic states of the virus by binding to the promoters of genes involved in lytic DNA replication and activating their transcription. A computer survey revealed that 9 of 23 potential or known ZEBRA-resp...

journal_title：Journal of virology

authors： Carey M,Kolman J,Katz DA,Gradoville L,Barberis L,Miller G

更新日期：1992-08-01 00:00:00

abstract：:An extensive genetic map of coliphage P1 has been constructed for 113 amber mutants, using primarily a modification of the conventional complementation spot test. These spot tests failed to classify the mutants into cistrons, but when they were quantitated they permitted assignment of the mutants into 10 linkage clust...

journal_title：Journal of virology

authors： Walker DH Jr,Walker JT

更新日期：1976-10-01 00:00:00

abstract：:In immunocompromised patients, infection with Kaposi's sarcoma-associated herpesvirus (KSHV) can give rise to Kaposi's sarcoma and several lymphoproliferative disorders. In these tumors, KSHV establishes a latent infection in many of the rapidly proliferating and morphologically abnormal cells. Only a few viral gene p...

journal_title：Journal of virology

authors： Wong LY,Matchett GA,Wilson AC

更新日期：2004-09-01 00:00:00

abstract：:Two human papillomavirus type 16 (HPV 16)-immortalized human keratinocyte cell lines (HPK) were shown to have retained the ability for differentiation after subcutaneous injection into nude mice. These properties were maintained even at late passage. HPK cells gave rise to transiently growing cysts which exhibited an ...

journal_title：Journal of virology

authors： Dürst M,Bosch FX,Glitz D,Schneider A,zur Hausen H

更新日期：1991-02-01 00:00:00

abstract：:The papillomavirus (PV) E2 protein is a critical regulator of viral transcription and genome replication. We previously reported that tyrosine (Y) 138 of HPV-31 E2 is phosphorylated by the fibroblast growth factor receptor 3 (FGFR3) kinase. In this study, we generated quasiviruses containing G418-selectable HPV-31 gen...

journal_title：Journal of virology

authors： Jose L,Androphy EJ,DeSmet M

更新日期：2020-07-01 00:00:00

abstract：:The required activities of CD4(+) T cells and antibody against the virally encoded oncoprotein simian virus 40 (SV40) Tag have previously been demonstrated by our laboratory to be mediators in achieving antitumor responses and tumor protection through antibody-dependent cell-mediated cytotoxicity (ADCC). In this study...

journal_title：Journal of virology

authors： Lowe DB,Shearer MH,Jumper CA,Bright RK,Kennedy RC

更新日期：2010-01-01 00:00:00

abstract：:Coronavirus subgenomic mRNA possesses a 5'-end leader sequence which is derived from the 5' end of genomic RNA and is linked to the mRNA body sequence. This study examined whether coronavirus transcription involves a discontinuous transcription step; the possibility that a leader sequence from mouse hepatitis virus (M...

journal_title：Journal of virology

authors： Jeong YS,Makino S

更新日期：1994-04-01 00:00:00

abstract：:The genomes of influenza A viruses consist of eight negative-strand RNA segments. Recent studies suggest that influenza viruses are able to specifically package their segmented genomes into the progeny virions. Segment-specific packaging signals of influenza virus RNAs (vRNAs) are located in the 5' and 3' noncoding re...

journal_title：Journal of virology

authors： Gao Q,Chou YY,Doğanay S,Vafabakhsh R,Ha T,Palese P

更新日期：2012-07-01 00:00:00

abstract：:Initial studies determined whether intraperitoneal (i.p.) injection of BALB/c mice with 0.1, 1.0, and 10 mg of adriamycin (a cardiotoxic anthracycline antibiotic) for times ranging between 1 and 9 weeks prior to i.p. injection of 10(5) PFU of coxsackievirus B3 (CVB3) would alter the severity of virus-induced myocardit...

journal_title：Journal of virology

authors： Huber SA,Moraska A,Choate M

更新日期：1992-11-01 00:00:00

abstract：:N6-adenosine methylation (m6A) is the most common posttranscriptional RNA modification in mammalian cells. We found that most transcripts encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome undergo m6A modification. The levels of m6A-modified mRNAs increased substantially upon stimulation for lytic re...

journal_title：Journal of virology

authors： Ye F,Chen ER,Nilsen TW

更新日期：2017-07-27 00:00:00

abstract：:Simian varicella virus (SVV) and varicella-zoster virus (VZV) are closely related alphaherpesviruses that cause varicella (chickenpox) in nonhuman primates and humans, respectively. After resolution of the primary disease, SVV and VZV establish latent infection of neural ganglia and may later reactivate to cause a sec...

journal_title：Journal of virology

authors： Ou Y,Davis KA,Traina-Dorge V,Gray WL

更新日期：2007-08-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV/human herpesvirus 8 [HHV-8]) is a gamma-2-herpesvirus responsible for Kaposi's sarcoma as well as primary effusion lymphoma (PEL). KSHV is a lymphotropic virus that has pirated many mammalian genes involved in inflammation, cell cycle control, and angiogenesis. Among these...

journal_title：Journal of virology

authors： Cannon M,Philpott NJ,Cesarman E

更新日期：2003-01-01 00:00:00

abstract：:The major envelope glycoprotein of bovine leukemia virus was isolated by lectin-bound Sepharose and DEAE-cellulose column chromatography. This protein was shown to have a molecular weight of about 41,000 and to lack detectable immunological cross-reactivity with glycoproteins of other oncornaviruses. Sera obtained fro...

journal_title：Journal of virology

authors： Devare SG,Stephenson JR

更新日期：1977-08-01 00:00:00

abstract：:The protein kinase (PK) encoded by the Epstein-Barr Virus (EBV) BGLF4 gene is the only EBV protein kinase. The expression pattern of EBV PK during the reactivation of the viral lytic cycle and the subcellular localization of the protein were analyzed with a polyclonal antiserum raised against a peptide corresponding t...

journal_title：Journal of virology

authors： Gershburg E,Marschall M,Hong K,Pagano JS

更新日期：2004-11-01 00:00:00

abstract：:The nonstructural 4B (NS4B) protein of hepatitis C virus (HCV) plays a central role in the formation of the HCV replication complex. To gain insight into the role of charged residues for NS4B function in HCV RNA replication, alanine substitutions were engineered in place of 28 charged residues residing in the N- and C...

journal_title：Journal of virology

authors： Blight KJ

更新日期：2011-08-01 00:00:00

abstract：UNLABELLED:The majority of currently circulating influenza A(H1N1) viruses are antigenically similar to the virus that caused the 2009 influenza pandemic. However, antigenic variants are expected to emerge as population immunity increases. Amino acid substitutions in the hemagglutinin protein can result in escape from ...

journal_title：Journal of virology

authors： Koel BF,Mögling R,Chutinimitkul S,Fraaij PL,Burke DF,van der Vliet S,de Wit E,Bestebroer TM,Rimmelzwaan GF,Osterhaus AD,Smith DJ,Fouchier RA,de Graaf M

更新日期：2015-04-01 00:00:00

abstract：:Paramyxoviruses initiate entry through the concerted action of the tetrameric attachment glycoprotein (HN, H, or G) and the trimeric fusion glycoprotein (F). The ectodomains of HN/H/G contain a stalk region important for oligomeric stability and for the F triggering resulting in membrane fusion. Paramyxovirus HN, H, a...

journal_title：Journal of virology

authors： Maar D,Harmon B,Chu D,Schulz B,Aguilar HC,Lee B,Negrete OA

更新日期：2012-06-01 00:00:00

abstract：:Viral myocarditis is an important human disease, and reovirus-induced murine myocarditis provides an excellent model system for study. Cardiac myocytes, like neurons in the central nervous system, are not replenished, yet there is no cardiac protective equivalent to the blood-brain barrier. Thus, cardiac myocytes may ...

journal_title：Journal of virology

authors： Zurney J,Howard KE,Sherry B

更新日期：2007-12-01 00:00:00

abstract：:The synthesis of viral RNA by wild-type vesicular stomatitis virus (L(1)VSV) and a small, plaque-size mutant (S(2)VSV) was studied in vitro and in chicken embryo (CE) and mouse L-cell cultures. Virus-specific RNA synthesized in CE or L cells infected with either L(1) or S(2)VSV at low multiplicity was of the same size...

journal_title：Journal of virology

authors： Wertz GW,Levine M

更新日期：1973-08-01 00:00:00

abstract：:The mechanism of regulation for the ribozyme activity of hepatitis delta virus (HDV) RNA in infected cells is unknown. Previously, we developed a direct assay capable of detecting the ribozyme activity of HDV dimer or trimer RNAs in vivo (K.-S. Jeng, A. Daniel, and M. M. C. Lai, J. Virol, 70:2403-2410, 1996). In this ...

journal_title：Journal of virology

authors： Jeng KS,Su PY,Lai MM

更新日期：1996-07-01 00:00:00

abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV) (or human herpesvirus 8) open reading frame (ORF) K15 encodes a putative integral transmembrane protein in the same genomic location as latent membrane protein 2A of Epstein-Barr virus. Ectopic expression of K15 in cell lines revealed the presence of several different...

journal_title：Journal of virology

authors： Sharp TV,Wang HW,Koumi A,Hollyman D,Endo Y,Ye H,Du MQ,Boshoff C

更新日期：2002-01-01 00:00:00

abstract：:Techniques are described for the growth and rapid purification of the avian coronavirus infectious bronchitis virus (IBV). Purified IBV has a sedimentation coefficient of 320S and a buoyant density of 1.22 g/ml in sucrose-deuterium oxide equilibrium gradients. IBV RNA extracted by proteinase K in the presence of sodiu...

journal_title：Journal of virology

authors： Lomniczi B,Kennedy I

更新日期：1977-10-01 00:00:00

abstract：:Candidate foot-and-mouth disease (FMD) DNA vaccines designed to produce viral capsids lacking infectious viral nucleic acid were evaluated. Plasmid DNAs containing a portion of the FMDV genome coding for the capsid precursor protein (P1-2A) and wild-type or mutant viral proteinase 3C (plasmids P12X3C or P12X3C-mut, re...

journal_title：Journal of virology

authors： Chinsangaram J,Beard C,Mason PW,Zellner MK,Ward G,Grubman MJ

更新日期：1998-05-01 00:00:00

abstract：:CD8(+) cytotoxic T lymphocytes (CTL) play a key role in the control of many virus infections, and the need for vaccines to elicit strong CD8(+) T-cell responses in order to provide optimal protection in such infections is increasingly apparent. However, the mechanisms involved in the induction and maintenance of CD8(+...

journal_title：Journal of virology

authors： Borrow P,Tough DF,Eto D,Tishon A,Grewal IS,Sprent J,Flavell RA,Oldstone MB

更新日期：1998-09-01 00:00:00

abstract：:Treatment of influenza virus and its purified hemagglutining with glycosidases from Diplococcus pneumoniae, which included beta-galactosidase, beta-N-acetylglucosminidase, and endoglycosidase D, released amino and neutral sugars from the virus and these as well as large oligosaccharides from the purified hemagglutinin...

journal_title：Journal of virology

authors： Collins JK,Knight CA

更新日期：1978-07-01 00:00:00

abstract：:Hemorrhage is a common clinical manifestation in dengue patients. However, the pathogenic mechanism of dengue virus (DV)-induced hemorrhage awaits clarification. We established a mouse model of DV hemorrhage using immunocompetent C57BL/6 mice by injecting DV serotype 2 strain 16681 intradermally. While inoculation of ...

journal_title：Journal of virology

authors： Chen HC,Hofman FM,Kung JT,Lin YD,Wu-Hsieh BA

更新日期：2007-06-01 00:00:00

abstract：:The presence or absence of the receptor CD4 and the coreceptors CCR5 and CXCR4 restrict the cell tropism of human immunodeficiency virus type 1 (HIV-1). Despite the importance of thymic infection by HIV-1, conflicting reports regarding the expression of HIV-1 coreceptors on human thymocytes have not been resolved. We ...

journal_title：Journal of virology

authors： Taylor JR Jr,Kimbrell KC,Scoggins R,Delaney M,Wu L,Camerini D

更新日期：2001-09-01 00:00:00

abstract：:The stability of an Epstein-Barr virus (EBV)-simian virus 40 (SV40) hybrid shuttle vector, the p205-GTI plasmid, was analyzed in human cells during EBV- or SV40-type replication mode. When the p205-GTI plasmid was maintained as an episomal EBV vector in the human 293 cell line, no rearrangement was detected. To induce...

journal_title：Journal of virology

authors： Stary A,James MR,Sarasin A

更新日期：1989-09-01 00:00:00

abstract：:The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is a potent activator of viral transcription. Tax also activates the expression of specific cellular genes involved in the control of T-lymphocyte growth via effects on cellular transcription factors, including members of the NF-kappaB/cRel family. Immunoc...

journal_title：Journal of virology

authors： Bex F,McDowall A,Burny A,Gaynor R

更新日期：1997-05-01 00:00:00