Reverse transcriptase activity in chicken embryo fibroblast culture supernatants is associated with particles containing endogenous avian retrovirus EAV-0 RNA.

abstract：:The protein kinase C (PKC) pathway has been considered to be essential for activation of latent Epstein-Barr virus (EBV) into the lytic cycle. The phorbol ester tetradecanoyl phorbol acetate (TPA), a PKC agonist, is one of the best understood activators of EBV lytic replication. Zp, the promoter of the EBV immediate-e...

journal_title：Journal of virology

authors： Gradoville L,Kwa D,El-Guindy A,Miller G

更新日期：2002-06-01 00:00:00

abstract：:We previously showed that the cellular proteins ZEB1 and ZEB2/SIP1 both play key roles in regulating the latent-lytic switch of Epstein-Barr Virus (EBV) by repressing BZLF1 gene expression. We investigated here the effects of cellular microRNA (miRNA) 200 (miR200) family members on the EBV infection status of cells. W...

journal_title：Journal of virology

authors： Ellis-Connell AL,Iempridee T,Xu I,Mertz JE

更新日期：2010-10-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) mutants with codon insertions and deletions in IE-0, the gene encoding ICP0, were constructed. The HSV-1 deletion mutant dl1403 (N. D. Stow and E. C. Stow, J. Gen. Virol. 67:2571-2585, 1986) and an IE-0:lacZ transplacement vector isolated in this study were used to facilitate the co...

journal_title：Journal of virology

authors： Chen J,Silverstein S

更新日期：1992-05-01 00:00:00

abstract：:Equine infectious anemia virus (EIAV) is a lentivirus with in vivo cell tropism primarily for tissue macrophages; however, in vitro the virus can be adapted to fibroblasts and other cell types. Tropism adaptation is associated with both envelope and long terminal repeat (LTR) changes, and findings strongly suggest tha...

journal_title：Journal of virology

authors： Maury W,Thompson RJ,Jones Q,Bradley S,Denke T,Baccam P,Smazik M,Oaks JL

更新日期：2005-05-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) against the rubella virion were used to locate epitopes involved in hemagglutination and neutralization. The MAbs exhibiting high-level hemagglutination-inhibiting activity were shown by Western blot analysis to be specific for the E1 polypeptide; this is consistent with the presence of th...

journal_title：Journal of virology

authors： Green KY,Dorsett PH

更新日期：1986-03-01 00:00:00

abstract：:Adenovirus (Ad) entry into cells is initiated by the binding of the fiber knob to a cell surface receptor. The coxsackie- and adenovirus receptor (CAR) functions as the attachment receptor for many, but not all, Ad serotypes. Ad type 37 (Ad37), a subgroup D virus that causes keratoconjunctivitis in humans, does not in...

journal_title：Journal of virology

authors： Chiu CY,Wu E,Brown SL,Von Seggern DJ,Nemerow GR,Stewart PL

更新日期：2001-06-01 00:00:00

abstract：:Kinetic curves for neutralization of adenovirus type 2 with anti-hexon serum revealed no lag periods even when the serum was highly diluted or when the temperature was lowered to 4 degrees C, thus indicating a single-hit mechanism. Multiplicity curves determined with anti-hexon serum displayed a linear correlation bet...

journal_title：Journal of virology

authors： Wohlfart C

更新日期：1988-07-01 00:00:00

abstract：:Analyses of prototype vesicular stomatitis (VSV, Indiana serotype) mRNA-32P-labeled viral RNA duplexes have established the assignments of 65 of the 72 large oligonucleotides that are recovered by two-dimensional electrophoresis of RNase T1 digests of the viral RNA. Fifty of the oligonucleotides are recovered in the L...

journal_title：Journal of virology

authors： Clewley JP,Bishop DH

更新日期：1979-04-01 00:00:00

abstract：:Cytomegalovirus (CMV) retinitis is an important ocular complication in human immunodeficiency virus-infected individuals and the leading cause of blindness in those not undergoing highly active antiretroviral therapy. Murine CMV (MCMV) infection of mice has been shown to be a useful small-animal model for the study of...

journal_title：Journal of virology

authors： Kercher L,Mitchell BM

更新日期：2002-09-01 00:00:00

abstract：:Viral transcription and replication of Ebola virus (EBOV) is balanced by transcription factor VP30, an RNA binding protein. An RNA hairpin at the transcription start site (TSS) of the first gene (NP hairpin) in the 3'-leader promoter is thought to mediate the VP30 dependency of transcription. Here, we investigated the...

journal_title：Journal of virology

authors： Bach S,Demper JC,Grünweller A,Becker S,Biedenkopf N,Hartmann RK

更新日期：2020-12-02 00:00:00

abstract：:JC polyomavirus (JCV) infection is highly prevalent and usually kept in a persistent state without clinical signs and symptoms. It is only during immunocompromise and especially impaired CD4(+) T cell function in the brain, as seen in AIDS patients or natalizumab-treated multiple sclerosis patients, that JCV may cause...

journal_title：Journal of virology

authors： Jelcic I,Aly L,Binder TM,Jelcic I,Bofill-Mas S,Planas R,Demina V,Eiermann TH,Weber T,Girones R,Sospedra M,Martin R

更新日期：2013-03-01 00:00:00

abstract：:Prior to the introduction of live-attenuated vaccines, mumps virus (MuV) was the leading cause of virus-induced meningitis. Although vaccination has been effective at controlling the disease, the use of insufficiently attenuated strains has been associated with high rates of aseptic meningitis in vaccinees. The molecu...

journal_title：Journal of virology

authors： Lemon K,Rima BK,McQuaid S,Allen IV,Duprex WP

更新日期：2007-08-01 00:00:00

abstract：:Gene expression of nonsegmented negative-sense RNA viruses involves sequential synthesis of monocistronic mRNAs and transcriptional attenuation at gene borders resulting in a transcript gradient. To address the role of the heterogeneous rabies virus (RV) intergenic regions (IGRs) in transcription attenuation, we const...

journal_title：Journal of virology

authors： Finke S,Cox JH,Conzelmann KK

更新日期：2000-08-01 00:00:00

abstract：:Naked DNA vaccines expressing the prM and E genes of two tick-borne flaviviruses, Russian spring summer encephalitis (RSSE) virus and Central European encephalitis (CEE) virus were evaluated in mice. The vaccines were administered by particle bombardment of DNA-coated gold beads by Accell gene gun inoculation. Two imm...

journal_title：Journal of virology

authors： Schmaljohn C,Vanderzanden L,Bray M,Custer D,Meyer B,Li D,Rossi C,Fuller D,Fuller J,Haynes J,Huggins J

更新日期：1997-12-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV-68) glycoprotein B (gB) was identified in purified virions by immunoblotting, immunoprecipitation, and immunoelectron microscopy. It was synthesized as a 120-kDa precursor in infected cells and cleaved into 65-kDa and 55-kDa disulfide-linked subunits close to the time of virion release....

journal_title：Journal of virology

authors： Lopes FB,Colaco S,May JS,Stevenson PG

更新日期：2004-12-01 00:00:00

abstract：:Infection with various human papillomaviruses (HPVs) induces cervical cancers. Cell surface heparan sulfates (HS) have been shown to serve as primary attachment receptors, and molecules with structural similarity to cell surface HS, like heparin, function as competitive inhibitors of HPV infection. Here we demonstrate...

journal_title：Journal of virology

authors： Selinka HC,Florin L,Patel HD,Freitag K,Schmidtke M,Makarov VA,Sapp M

更新日期：2007-10-01 00:00:00

abstract：:We assessed the prediction that access of the viral NS1 protein to cellular PDZ domain protein networks enhances the virulence of highly pathogenic avian influenza A viruses. The NS1 proteins of most avian influenza viruses bear the C-terminal ligand sequence Glu-Ser-Glu-Val (ESEV) for PDZ domains present in multiple ...

journal_title：Journal of virology

authors： Zielecki F,Semmler I,Kalthoff D,Voss D,Mauel S,Gruber AD,Beer M,Wolff T

更新日期：2010-10-01 00:00:00

abstract：:Major neutralization antigenic sites have been previously mapped by us on VP1, the largest capsid protein of poliovirus type 1. Here we report the first identification of the primary sequence of a neutralization antigenic site on capsid protein VP2. Inspection of the amino acid sequence of VP2 led to the selection and...

journal_title：Journal of virology

authors： Emini EA,Jameson BA,Wimmer E

更新日期：1984-11-01 00:00:00

abstract：:Serial passage at high multiplicity of pseudorabies virus generates defective interfering particles (DIPs) whose genomes consist at least in part of reiterations of segments of DNA in which sequences originating from different regions of the genome have become covalently linked (F. J. Rixon and T. Ben-Porat, Virology ...

journal_title：Journal of virology

authors： Wu CA,Harper L,Ben-Porat T

更新日期：1986-08-01 00:00:00

abstract：:Rift Valley fever virus (RVFV), a phlebovirus of the family Bunyaviridae, is a major public health threat in Egypt and sub-Saharan Africa. The viral and host cellular factors that contribute to RVFV virulence and pathogenicity are still poorly understood. All pathogenic RVFV strains direct the synthesis of a nonstruct...

journal_title：Journal of virology

authors： Bouloy M,Janzen C,Vialat P,Khun H,Pavlovic J,Huerre M,Haller O

更新日期：2001-02-01 00:00:00

abstract：:The RNA genome of human immunodeficiency virus type 1 (HIV-1) is converted into DNA after infection in order to integrate into the host cell DNA. However, a large number of these reverse-transcribed genomes remain unintegrated in the nucleus of infected cells. Currently, there are no data available about the intranucl...

journal_title：Journal of virology

authors： Bell P,Montaner LJ,Maul GG

更新日期：2001-08-01 00:00:00

abstract：UNLABELLED:Bluetongue is one of the major infectious diseases of ruminants and is caused by bluetongue virus (BTV), an arbovirus existing in nature in at least 26 distinct serotypes. Here, we describe the development of a vaccine platform for BTV. The advent of synthetic biology approaches and the development of revers...

journal_title：Journal of virology

authors： Nunes SF,Hamers C,Ratinier M,Shaw A,Brunet S,Hudelet P,Palmarini M

更新日期：2014-11-01 00:00:00

abstract：:The antibiotic tunicamycin, which blocks the synthesis of glycoproteins, inhibited the production of infectious herpes simplex virus. In the presence of this drug, [14C]glucosamine and [3H]mannose incorporation was reduced in infected cells, whereas total protein synthesis was not affected. Gel electrophoresis of [2-3...

journal_title：Journal of virology

authors： Pizer LI,Cohen GH,Eisenberg RJ

更新日期：1980-04-01 00:00:00

abstract：:Phage XP-12, which has complete substitution of the cytosine residues in its DNA with 5-methylcytosine residues, was shown to inhibit incorporation of uracil into host DNA and RNA during the latent period. This apparent inhibition of host macromolecular synthesis was not accompanied by extensive degradation of the hos...

journal_title：Journal of virology

authors： Ehrlich M,Lin FH,Ehrlich K,Brown SL,Mayo JA

更新日期：1977-09-01 00:00:00

abstract：:The human immunodeficiency virus type 1 Vpr protein is both packaged into virions and efficiently localized to the nucleus. In this report, we show that a significant fraction of Vpr also accumulates in the cytoplasm of virus-producing cells. Although Vpr shuttles between the nucleus and the cytoplasm, studies with an...

journal_title：Journal of virology

authors： Jenkins Y,Sanchez PV,Meyer BE,Malim MH

更新日期：2001-09-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is believed to begin with interactions between cell-free HCV and cell receptors that include CD81, scavenger receptor B1 (SR-B1), claudin-1 (CLDN1), and occludin (OCLN). In this study, we have demonstrated that HCV spreading from infected hepatocytes to uninfected hepatocytes leads to...

journal_title：Journal of virology

authors： Liu Z,He JJ

更新日期：2013-08-01 00:00:00

abstract：:The cellular transcription factors Sp1 and NF-kappaB were upregulated shortly after the binding of purified live or UV-inactivated human cytomegalovirus (HCMV) to the cell surface. The rapid time frame of transcription factor induction is similar to that seen in other systems in which cellular factors are induced foll...

journal_title：Journal of virology

authors： Yurochko AD,Hwang ES,Rasmussen L,Keay S,Pereira L,Huang ES

更新日期：1997-07-01 00:00:00

abstract：:The Rep78 and Rep68 proteins of adeno-associated virus type 2 (AAV) are multifunctional proteins which are required for viral replication, regulation of AAV promoters, and preferential integration of the AAV genome into a region of human chromosome 19. These proteins bind the hairpin structures formed by the AAV inver...

journal_title：Journal of virology

authors： Davis MD,Wonderling RS,Walker SL,Owens RA

更新日期：1999-03-01 00:00:00

abstract：:Five minority populations of aberrant, varicella-zoster virus (VZV)-derived genomes were identified among the encapsidated DNAs obtained from the nuclear and cytoplasmic fractions of an in vitro infection initiated with a lyophilized sample of the BIKEN VZV vaccine (strain Oka). These were (i) VZV genomes, present wit...

journal_title：Journal of virology

authors： Vlazny DA,Hyman RW

更新日期：1985-10-01 00:00:00

abstract：:Assembly and maturation of retroviral particles requires the aggregation and controlled proteolytic cleavage of polyprotein core precursors by a precursor-encoded protease (PR). Active, mature retroviral PR is a dimer, and the accumulation of precursors at sites of assembly may facilitate subunit interaction and subse...

journal_title：Journal of virology

authors： Burstein H,Bizub D,Skalka AM

更新日期：1991-11-01 00:00:00