Naked DNA vaccines expressing the prM and E genes of Russian spring summer encephalitis virus and Central European encephalitis virus protect mice from homologous and heterologous challenge.

abstract：:Viral particles infecting some stocks of the protozoan parasite Leishmania braziliensis subsp. guyanensis contain a double-stranded RNA genome of ca. 5 kbp and are associated with an RNA-dependent RNA polymerase which synthesizes in vitro double-stranded and single-stranded, genome-length transcripts. The majority of ...

journal_title：Journal of virology

authors： Widmer G,Patterson JL

更新日期：1991-08-01 00:00:00

abstract：UNLABELLED:Avian metapneumovirus (aMPV), also known as avian pneumovirus or turkey rhinotracheitis virus, is the causative agent of turkey rhinotracheitis and is associated with swollen head syndrome in chickens. Since its discovery in the 1970s, aMPV has been recognized as an economically important pathogen in the pou...

journal_title：Journal of virology

authors： Sun J,Wei Y,Rauf A,Zhang Y,Ma Y,Zhang X,Shilo K,Yu Q,Saif YM,Lu X,Yu L,Li J

更新日期：2014-11-01 00:00:00

abstract：:Members of the Geminiviridae have single-stranded DNA genomes that replicate in nuclei of infected plant cells. All geminiviruses encode a conserved protein (Rep) that catalyzes initiation of rolling-circle replication. Earlier studies showed that three conserved motifs-motifs I, II, and III-in the N termini of gemini...

journal_title：Journal of virology

authors： Nash TE,Dallas MB,Reyes MI,Buhrman GK,Ascencio-Ibañez JT,Hanley-Bowdoin L

更新日期：2011-02-01 00:00:00

abstract：:The RNA polymerase in the nucleocapsid of Pseudomonas phaseolicola bacteriophage phi 6 transcribed large, medium, and small single-stranded RNA from the viral double-stranded RNA genome by a semiconservative (displacement) mechanism. Approximately 23%, 63%, and 65% of the nucleocapsid particles in the assay mixture sy...

journal_title：Journal of virology

authors： Van Etten JL,Burbank DE,Cuppels DA,Lane LC,Vidaver AK

更新日期：1980-02-01 00:00:00

abstract：:Nef is a regulatory gene product of human immunodeficiency virus type 1 (HIV-1) and other primate lentiviruses which enhances virion infectivity by an unknown mechanism. We report here that Nef is detectable at moderate levels in preparations of HIV-1 virions which lack active viral protease (PR). Significantly smalle...

journal_title：Journal of virology

authors： Bukovsky AA,Dorfman T,Weimann A,Göttlinger HG

更新日期：1997-02-01 00:00:00

abstract：:We analyzed the susceptibility of 10 AKXD recombinant inbred (RI) mouse strains to lymphomas. These strains were derived from crosses of AKR/J, a highly lymphomatous strain, and DBA/2J, a weakly lymphomatous strain. Of the 10 strains analyzed, nine showed a high incidence of lymphoma development. As with the other 13 ...

journal_title：Journal of virology

authors： Gilbert DJ,Neumann PE,Taylor BA,Jenkins NA,Copeland NG

更新日期：1993-04-01 00:00:00

abstract：:Recent evidence suggests that the type II feline coronavirus (FCoV) strains 79-1146 and 79-1683 have arisen from a homologous RNA recombination event between FCoV type I and canine coronavirus (CCV). In both cases, the template switch apparently took place between the S and M genes, giving rise to recombinant viruses ...

journal_title：Journal of virology

authors： Herrewegh AA,Smeenk I,Horzinek MC,Rottier PJ,de Groot RJ

更新日期：1998-05-01 00:00:00

abstract：:Phosphorylation of the murine mammary tumor virus (MuMTV) structural proteins was studied in an MuMTV-infected epithelial cell line derived from a BALB/cf C3H mouse mammary tumor. Immunoprecipitation of 32P-labeled cell extracts with monospecific anti-p27 serum revealed that phosphorylation occurred at the stage of th...

journal_title：Journal of virology

authors： Racevskis J,Sarkar NH

更新日期：1979-04-01 00:00:00

abstract：:Nearly 50 years ago, the discovery of interferon prompted the notion that host cells innately respond to viral invasion. Since that time, technological advances have allowed this response to be extensively characterized and dissected in vitro. However, these advances have only recently been applied to highly complex, ...

journal_title：Journal of virology

authors： Hartman ZC,Kiang A,Everett RS,Serra D,Yang XY,Clay TM,Amalfitano A

更新日期：2007-02-01 00:00:00

abstract：:Growth of phage phi105 and its deoxyribonucleic acid (DNA) was studied in radiation-sensitive mutants of Bacillus subtilis. The recA gene is required for optimal prophage induction with mitomycin C and for infectivity of prophage DNA. rec B gene is required for marker rescue from mature DNA. The importance of bacteria...

journal_title：Journal of virology

authors： Rutberg B,Rutberg L

更新日期：1971-12-01 00:00:00

abstract：:Following infection by pairs of reovirus isolates consisting of combinations of reovirus T1 Lang, T2 Jones, or T3 Dearing, we found that one of the isolates interfered with the yield of progeny RNA derived from the other parents. The most significant interference was produced by T2 Jones or T3 Dearing, when mixed with...

journal_title：Journal of virology

authors： Rozinov MN,Fields BN

更新日期：1994-10-01 00:00:00

abstract：:The filoviruses Ebola Zaire virus and Marburg virus are believed to infect target cells through endocytic vesicles, but the details of this pathway are unknown. We used a pseudotyping strategy to investigate the cell biology of filovirus entry. We observed that specific inhibitors of the caveola system, including chol...

journal_title：Journal of virology

authors： Empig CJ,Goldsmith MA

更新日期：2002-05-01 00:00:00

abstract：:Mononuclear phagocytes (MP) and T lymphocytes play a pivotal role in the host immune response to human immunodeficiency virus type 1 (HIV-1) infection. Regulation of such immune responses can be mediated, in part, through the interaction of the T-lymphocyte-expressed molecule CD40 ligand (CD40L) with its receptor on M...

journal_title：Journal of virology

authors： Cotter RL,Zheng J,Che M,Niemann D,Liu Y,He J,Thomas E,Gendelman HE

更新日期：2001-05-01 00:00:00

abstract：:In-frame stop codons were introduced into the coding region of human immunodeficiency virus type 1 (HIV-1) transmembrane protein (gp41). Truncation of 147 amino acids from the carboxyl terminus of gp41 (TM709) significantly decreased the stability and cell surface expression of the viral Env proteins, while truncation...

journal_title：Journal of virology

authors： Yu X,Yuan X,McLane MF,Lee TH,Essex M

更新日期：1993-01-01 00:00:00

abstract：:In 2014 and 2015, the United States experienced an unprecedented outbreak of Eurasian clade 2.3.4.4 H5 highly pathogenic avian influenza (HPAI) virus. Initial cases affected mainly wild birds and mixed backyard poultry species, while later outbreaks affected mostly commercial chickens and turkeys. The pathogenesis, tr...

journal_title：Journal of virology

authors： Bertran K,Lee DH,Pantin-Jackwood MJ,Spackman E,Balzli C,Suarez DL,Swayne DE

更新日期：2017-10-13 00:00:00

abstract：:Viruses with spindle-shaped virions are abundant in diverse environments. Over the years, such viruses have been isolated from a wide range of archaeal hosts. Evolutionary relationships between them remained enigmatic, however. Here, using structural proteins as markers, we define familial ties among these "dark horse...

journal_title：Journal of virology

authors： Krupovic M,Quemin ER,Bamford DH,Forterre P,Prangishvili D

更新日期：2014-02-01 00:00:00

abstract：:Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is indispensable for viral DNA replication and episome maintenance in latency. Four promoters, Cp, Wp, Qp, and Fp, are known to drive EBNA1 expression. Here we show that the TATA-less Qp is constitutively active in a variety of EBV-positive [EBV(+)] tumors and cell li...

journal_title：Journal of virology

authors： Tao Q,Robertson KD,Manns A,Hildesheim A,Ambinder RF

更新日期：1998-09-01 00:00:00

abstract：UNLABELLED:Influenza virus hemagglutinin (HA) mediates virus entry by binding to cell surface receptors and fusing the viral and endosomal membranes following uptake by endocytosis. The acidic environment of endosomes triggers a large-scale conformational change in the transmembrane subunit of HA (HA2) involving a loop...

journal_title：Journal of virology

authors： Wang W,DeFeo CJ,Alvarado-Facundo E,Vassell R,Weiss CD

更新日期：2015-10-01 00:00:00

abstract：:Vaccines preventing HIV-1 infection will likely elicit antibodies that neutralize diverse strains. However, the capacity for lentiviruses to escape broadly neutralizing antibodies (NAbs) is not completely understood, nor is it known whether NAbs alone can control heterologous infection. Here, we determined that conval...

journal_title：Journal of virology

authors： Taylor SD,Leib SR,Carpenter S,Mealey RH

更新日期：2010-07-01 00:00:00

abstract：:Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus that has a worldwide distribution in the population of cattle. Many factors make human contamination by BoHV-4 likely to occur. In this study, we performed in vitro experiments to assess the risk and the consequences of human infection by BoHV-4. First, by using a re...

journal_title：Journal of virology

authors： Gillet L,Minner F,Detry B,Farnir F,Willems L,Lambot M,Thiry E,Pastoret PP,Schynts F,Vanderplasschen A

更新日期：2004-03-01 00:00:00

abstract：:Tegument is a unique structure of herpesvirus, which surrounds the capsid and interacts with the envelope. Morphogenesis of gammaherpesvirus is poorly understood due to lack of efficient lytic replication for Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8, which are etiologically as...

journal_title：Journal of virology

authors： Guo H,Wang L,Peng L,Zhou ZH,Deng H

更新日期：2009-10-01 00:00:00

abstract：:Infection with the murine coronavirus strain JHM decreases cell surface expression of major histocompatibility complex class I antigens. Northern blots showed that JHM virus infection rapidly reduced the level of actin mRNA, whereas the levels of major histocompatibility complex class I and tubulin mRNAs were reduced ...

journal_title：Journal of virology

authors： Kyuwa S,Cohen M,Nelson G,Tahara SM,Stohlman SA

更新日期：1994-10-01 00:00:00

abstract：:Characterization of immune responses induced by live attenuated simian immunodeficiency virus (SIV) strains may yield clues to the nature of protective immunity induced by this vaccine approach. We investigated the ability of CD8(+) T lymphocytes from rhesus macaques immunized with the live, attenuated SIV strain SIVm...

journal_title：Journal of virology

authors： Gauduin MC,Glickman RL,Means R,Johnson RP

更新日期：1998-08-01 00:00:00

abstract：:Single-envelope human immunodeficiency virus (HIV) vaccines have been studied for more than a decade, with some successes in homologous challenge experiments in nonhuman primates but with no clear successes in clinical trials. To gain insight into the breadth of the immunity elicited by such vaccines, we have dissecte...

journal_title：Journal of virology

authors： Zhan X,Slobod KS,Surman S,Brown SA,Lockey TD,Coleclough C,Doherty PC,Hurwitz JL

更新日期：2003-04-01 00:00:00

abstract：:Epstein-Barr (EBV) is a powerful immortalizing virus for human B lymphocytes in vitro and is associated with several human neoplasias in vivo. Previously, we have shown that the majority of EBV-infected cells in the peripheral blood of healthy, persistently infected individuals do not express the activated phenotype, ...

journal_title：Journal of virology

authors： Miyashita EM,Yang B,Babcock GJ,Thorley-Lawson DA

更新日期：1997-07-01 00:00:00

abstract：:Polyomavirus large T antigen is phosphorylated on both serine and threonine residues at a ratio of approximately 6 to 1. This phosphorylation could be resolved into a series of nine Staphylococcus aureus V8 phosphopeptides. All of these were found in an N-terminal chymotryptic fragment with a molecular weight of 57,00...

journal_title：Journal of virology

authors： Bockus BJ,Schaffhausen B

更新日期：1987-04-01 00:00:00

abstract：UNLABELLED:Bovine papillomavirus 1 E6 interacts with two similar proteins that regulate cell attachment and cell migration called paxillin (PXN) and HIC-5 (also known as HIC5, ARA55, HIC-5, TSC-5, and TGFB1I1). Despite the similarity between HIC-5 and paxillin, paxillin is required for E6 to transform mouse embryo fibr...

journal_title：Journal of virology

authors： Brimer N,Wade R,Vande Pol S

更新日期：2014-09-01 00:00:00

abstract：UNLABELLED:Cell culture systems reproducing virus replication can serve as unique models for the discovery of novel bioactive molecules. Here, using a hepatitis C virus (HCV) cell culture system, we identified neoechinulin B (NeoB), a fungus-derived compound, as an inhibitor of the liver X receptor (LXR). NeoB was init...

journal_title：Journal of virology

authors： Nakajima S,Watashi K,Ohashi H,Kamisuki S,Izaguirre-Carbonell J,Kwon AT,Suzuki H,Kataoka M,Tsukuda S,Okada M,Moi ML,Takeuchi T,Arita M,Suzuki R,Aizaki H,Kato T,Suzuki T,Hasegawa H,Takasaki T,Sugawara F,Wakita T

更新日期：2016-09-29 00:00:00

abstract：:A virus recovered from the saliva of a child with chronic active Epstein-Barr virus (EBV) infection for 8 years was shown to induce EBV early antigen (EBV-EA) in Raji cells and to be expressed into EBV-EA in fresh EBV-negative peripheral blood leukocytes. However, it did not replicate its DNA. Oropharyngeal epithelial...

journal_title：Journal of virology

authors： Alfieri C,Joncas JH

更新日期：1987-10-01 00:00:00

abstract：:Given the current difficulties generating vaccine-induced neutralizing antibodies to human immunodeficiency virus (HIV), the focus of the vaccine community has shifted toward creating cytotoxic-T-lymphocyte (CTL)-based vaccines. Recent reports of CTL-based vaccine trials in macaques challenged with simian/human immuno...

journal_title：Journal of virology

authors： Vogel TU,Reynolds MR,Fuller DH,Vielhuber K,Shipley T,Fuller JT,Kunstman KJ,Sutter G,Marthas ML,Erfle V,Wolinsky SM,Wang C,Allison DB,Rud EW,Wilson N,Montefiori D,Altman JD,Watkins DI

更新日期：2003-12-01 00:00:00