Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis.

abstract：:Formation of a six-helix bundle comprised of three C-terminal heptad repeat regions in antiparallel orientation in the grooves of an N-terminal coiled-coil is critical for promotion of membrane fusion by paramyxovirus fusion (F) proteins. We have examined the effect of mutations in four residues of the N-terminal hept...

journal_title：Journal of virology

authors： West DS,Sheehan MS,Segeleon PK,Dutch RE

更新日期：2005-02-01 00:00:00

abstract：:CCR5 serves as a requisite fusion coreceptor for clinically relevant strains of human immunodeficiency virus type 1 (HIV-1) and provides a promising target for antiviral therapy. However, no study to date has examined whether monoclonal antibodies, small molecules, or other nonchemokine agents possess broad-spectrum a...

journal_title：Journal of virology

authors： Trkola A,Ketas TJ,Nagashima KA,Zhao L,Cilliers T,Morris L,Moore JP,Maddon PJ,Olson WC

更新日期：2001-01-01 00:00:00

abstract：:Determinants of glycosylation site usage were explored by using the hemagglutinin-neuraminidase (HN) glycoprotein of the paramyxovirus Newcastle disease virus. The amino acid sequence of the HN protein, a type II glycoprotein, has six N-linked glycosylation addition sites, G1 to G6, two of which, G5 and G6, are not us...

journal_title：Journal of virology

authors： McGinnes LW,Morrison TG

更新日期：1997-04-01 00:00:00

abstract：:Infection with human papillomavirus (HPV) is a critical factor in the pathogenesis of most cervical cancers and some aerodigestive cancers. The HPV E6 oncoprotein from high-risk HPV types contributes to the immortalization and transformation of cells by multiple mechanisms, including degradation of p53, transcriptiona...

journal_title：Journal of virology

authors： James MA,Lee JH,Klingelhutz AJ

更新日期：2006-06-01 00:00:00

abstract：:Presumably due to the capability of the hepatitis C virus (HCV) to evade the antiviral effects of alpha interferon, treatment is ineffective in more than half of chronically genotype HCV type 1 (HCV-1)-infected patients. Previous approaches to correlate the number of amino acid mutations within regions of HCV nonstruc...

journal_title：Journal of virology

authors： Sarrazin C,Herrmann E,Bruch K,Zeuzem S

更新日期：2002-11-01 00:00:00

abstract：:Alphavirus infection of fibroblastic cell types in vitro inhibits host cell translation and transcription, leading to suppression of interferon alpha/beta (IFN-α/β) production. However, the effect of infection upon myeloid cells, which are often the first cells encountered by alphaviruses in vivo, is unclear. Previous...

journal_title：Journal of virology

authors： Bhalla N,Gardner CL,Downs SN,Dunn M,Sun C,Klimstra WB

更新日期：2019-11-26 00:00:00

abstract：:The minor glycoproteins from hepatitis B surface antigen, GP33 and GP36, contain at their carboxy-terminal part the sequence of the major protein P24. They have 55 additional amino acids at the amino-terminal part which are coded by the pre-S region of the viral DNA. ...

journal_title：Journal of virology

authors： Stibbe W,Gerlich WH

更新日期：1983-05-01 00:00:00

abstract：:Repeated passages of vaccinia virus in increasing concentrations of hydroxyurea followed by plaque purification resulted in the isolation of variants capable of growth in 5 mM hydroxyurea, a drug concentration which inhibited the reproduction of wild-type vaccinia virus 1,000-fold. Analyses of viral protein synthesis ...

journal_title：Journal of virology

authors： Slabaugh MB,Mathews CK

更新日期：1986-11-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV68) establishes a lifelong infection in mice and is used as a model pathogen to study the role of viral and host factors in chronic infection. The maintenance of chronic MHV68 infection, at least in some latency reservoirs, appears to be dependent on the capacity of the virus to reactiva...

journal_title：Journal of virology

authors： Gargano LM,Forrest JC,Speck SH

更新日期：2009-02-01 00:00:00

abstract：UNLABELLED:The vaccinia virus (VACV) E3 protein has been shown to be important for blocking activation of the cellular innate immune system and allowing viral replication to occur unhindered. Mutation or deletion of E3L severely affects viral host range and pathogenesis. While the monkeypox virus (MPXV) genome encodes ...

journal_title：Journal of virology

authors： Arndt WD,Cotsmire S,Trainor K,Harrington H,Hauns K,Kibler KV,Huynh TP,Jacobs BL

更新日期：2015-10-01 00:00:00

abstract：:For influenza virus, we developed an efficient, noncytotoxic, plasmid-based virus-like particle (VLP) system to reflect authentic virus particles. This system was characterized biochemically by analysis of VLP protein composition, morphologically by electron microscopy, and functionally with a VLP infectivity assay. T...

journal_title：Journal of virology

authors： Chen BJ,Leser GP,Morita E,Lamb RA

更新日期：2007-07-01 00:00:00

abstract：:Retroelements are important evolutionary forces but can be deleterious if left uncontrolled. Members of the human APOBEC3 family of cytidine deaminases can inhibit a wide range of endogenous, as well as exogenous, retroelements. These enzymes are structurally organized in one or two domains comprising a zinc-coordinat...

journal_title：Journal of virology

authors： Bulliard Y,Turelli P,Röhrig UF,Zoete V,Mangeat B,Michielin O,Trono D

更新日期：2009-12-01 00:00:00

abstract：:We report here the isolation by molecular cloning and the analysis by heteroduplex and restriction enzyme mapping of seven distinct DNA fragments containing hepatitis B virus (HBV) sequences from genomic DNA of the PLC/PRF/5 human liver carcinoma cell line (the Alexander cell). No intact full-length HBV genomes were p...

journal_title：Journal of virology

authors： Shaul Y,Ziemer M,Garcia PD,Crawford R,Hsu H,Valenzuela P,Rutter WJ

更新日期：1984-09-01 00:00:00

abstract：:We have constructed two point mutants of Rous sarcoma virus in which the amino-terminal glycine residue of the transforming protein, p60src, was changed to an alanine or a glutamic acid residue. Both mutant proteins failed to become myristylated and, more importantly, no longer transformed cells. The lack of transform...

journal_title：Journal of virology

authors： Buss JE,Kamps MP,Gould K,Sefton BM

更新日期：1986-05-01 00:00:00

abstract：:Some picornaviruses, for example, poliovirus, increase bidirectional permeability of the nuclear envelope and suppress active nucleocytoplasmic transport. These activities require the viral protease 2A(pro). Here, we studied nucleocytoplasmic traffic in cells infected with encephalomyocarditis virus (EMCV; a cardiovir...

journal_title：Journal of virology

authors： Lidsky PV,Hato S,Bardina MV,Aminev AG,Palmenberg AC,Sheval EV,Polyakov VY,van Kuppeveld FJ,Agol VI

更新日期：2006-03-01 00:00:00

abstract：:Viruses cause about 15% of the cancers that are still the leading causes of human mortality. The discovery of viral oncogenes has enhanced our understanding of viral oncogenesis. However, the underlying molecular mechanisms of virus-induced cancers are complex and require further investigation. The present study has a...

journal_title：Journal of virology

authors： Xu S,Xue C,Li J,Bi Y,Cao Y

更新日期：2011-01-01 00:00:00

abstract：:Infectious bursal disease virus (IBDV) is a double-stranded RNA (dsRNA) virus of the Birnaviridae family. Its two genome segments are encapsidated together with multiple copies of the viral RNA-dependent RNA polymerase, VP1, in a single-shell capsid that is composed of VP2 and VP3. In this study we identified the doma...

journal_title：Journal of virology

authors： Tacken MG,Peeters BP,Thomas AA,Rottier PJ,Boot HJ

更新日期：2002-11-01 00:00:00

abstract：UNLABELLED:Previous experiments carried out in a sheep scrapie model demonstrated that the transfusion of 200 μl of prion-infected whole blood has an apparent 100% efficacy for disease transmission. These experiments also indicated that, despite the apparent low infectious titer, the intravenous administration of white...

journal_title：Journal of virology

authors： Douet JY,Lacroux C,Litaise C,Lugan S,Corbière F,Arnold M,Simmons H,Aron N,Costes P,Tillier C,Cassard H,Andréoletti O

更新日期：2016-01-13 00:00:00

abstract：:The genome structure of a newly isolated sarcoma virus, Y73, was studied. Y73 is a defective, potent sarcomagenic virus and contains 4.8-kilobase (kb) RNA as its genome; in contrast, helper virus associated with Y73 had 8.5-kb RNA, similar to other avian leukemia viruses. Fingerprinting analysis these RNAs demonstrate...

journal_title：Journal of virology

authors： Yoshida M,Kawai S,Toyoshima K

更新日期：1981-05-01 00:00:00

abstract：:Coxsackievirus B3 (CB3) firmly attaches to HeLa cells, forming a specific complex between the virus and its receptor on the cell surface. We extracted this virus-receptor complex (VRC) with the detergents sodium deoxycholate and Triton X-100. The VRC was identified by its sedimentation coefficient (140S), which was le...

journal_title：Journal of virology

authors： Mapoles JE,Krah DL,Crowell RL

更新日期：1985-09-01 00:00:00

abstract：:The sensitivity of highly purified human fibroblast interferon and partially purified human leukocyte interferon to several proteolytic and glycolytic enzymes was determined with respect to antiviral activity, isoelectric point, molecular weight, and thermal stability. Leucine aminopeptidase altered the distribution o...

journal_title：Journal of virology

authors： Otto MJ,Sedmak JJ,Grossberg SE

更新日期：1980-08-01 00:00:00

abstract：:It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity and led to in vivo attenuation. Pathogenicity was recovered in mutants that also regained E prot...

journal_title：Journal of virology

authors： To J,Surya W,Fung TS,Li Y,Verdià-Bàguena C,Queralt-Martin M,Aguilella VM,Liu DX,Torres J

更新日期：2017-02-14 00:00:00

abstract：:We report the discovery and analysis of an endogenous foamy virus (PSFVaye) within the genome of the aye-aye (Daubentonia madagascariensis), a strepsirrhine primate from Madagascar. Phylogenetic analyses indicate that PSFVaye is divergent from all known simian foamy viruses, suggesting an association between foamy vir...

journal_title：Journal of virology

authors： Han GZ,Worobey M

更新日期：2012-07-01 00:00:00

abstract：:By using in situ hybridization, we localized three endogenous chicken retrovirus loci associated with the gs- chf- phenotype to distinct regions on chromosome 1. These three loci, ev4, ev5, and ev8, along with the two other known gs- chf--associated loci in White Leghorn chickens, ev1 and ev13, appear to be evenly dis...

journal_title：Journal of virology

authors： Tereba A,Astrin SM

更新日期：1982-08-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) requires that its genome be reverse transcribed into double-stranded DNA for productive infection of cells. This process requires not only reverse transcriptase but also the nucleocapsid protein (NC), which functions as a nucleic acid chaperone. Reverse transcription general...

journal_title：Journal of virology

authors： Thomas JA,Bosche WJ,Shatzer TL,Johnson DG,Gorelick RJ

更新日期：2008-10-01 00:00:00

abstract：:The effect of 5-bromodeoxyuridine (BrdU) on vaccinia virus-induced polypeptide synthesis in BSC-1 cells has been investigated. Most virus-induced pre- and post-replicative polypeptides were synthesized in concentrations of 5-bromodeoxyuridine that inhibited virus growth. The synthesis of a few post-replicative polypep...

journal_title：Journal of virology

authors： Pennington TH

更新日期：1976-06-01 00:00:00

abstract：:Animals immunized with the human immunodeficiency virus type 1 gp160 glycoprotein or certain recombinant envelope components develop potent virus-neutralizing activity. This activity is principally due to antibodies directed toward a hypervariable region of gp120 between cysteine residues 302 and 337 and is virus isol...

journal_title：Journal of virology

authors： Skinner MA,Langlois AJ,McDanal CB,McDougal JS,Bolognesi DP,Matthews TJ

更新日期：1988-11-01 00:00:00

abstract：:In earlier studies, we have shown that superinfection of an interleukin-2 (IL-2)-dependent, Moloney murine leukemia virus (MoMuLV)-induced rat T-cell lymphoma line (4437A) with mink cell focus-forming (also called polytropic) murine retroviruses induces rapid progression to IL-2-independent growth. In this report, we ...

journal_title：Journal of virology

authors： Flubacher MM,Bear SE,Tsichlis PN

更新日期：1994-12-01 00:00:00

abstract：:Diseases of the nasopharyngeal epithelium due to Epstein-Barr virus (EBV) infection typically occur in chronic virus carriers with preexisting virus-specific antibodies. In vitro studies have shown that EBV-specific immunoglobulin A (IgA) promotes infection of human epithelial cells, otherwise refractory to EBV, via t...

journal_title：Journal of virology

authors： Gan YJ,Chodosh J,Morgan A,Sixbey JW

更新日期：1997-01-01 00:00:00

abstract：:Viral protein genome-linked (VPg) plays a central role in several stages of potyvirus infection. This study sought to answer questions about the role of Potato virus A (PVA; genus Potyvirus) VPg in viral and host RNA expression. When expressed in Nicotiana benthamiana leaves in trans, a dual role of VPg in translation...

journal_title：Journal of virology

authors： Eskelin K,Hafrén A,Rantalainen KI,Mäkinen K

更新日期：2011-09-01 00:00:00