Signaling through Toll-like receptors induces murine gammaherpesvirus 68 reactivation in vivo.

abstract：:Infection of normal rat fibroblasts (FR 3T3) with the early tsa mutant of polyoma virus may lead to either the A or the N phenotype, tsa-A transformants, originally derived by agar selection, are not temperature dependent for maintenance of the transformed phenotype, whereas tsa-N transormants revert at high temperatu...

journal_title：Journal of virology

authors： Rassoulzadegan M,Seif R,Cuzin F

更新日期：1978-11-01 00:00:00

abstract：:Sendai virus (SV) and human parainfluenza virus type 1 (hPIV1) have genomes consisting of nonsegmented negative-sense RNA in which the six genes are separated by well-conserved intergenic (IG) sequences and transcriptional start (S) and end signals. In hPIV1-infected cells, transcriptional termination at the M-F gene ...

journal_title：Journal of virology

authors： Bousse T,Matrosovich T,Portner A,Kato A,Nagai Y,Takimoto T

更新日期：2002-08-01 00:00:00

abstract：:Infection with the murine coronavirus strain JHM decreases cell surface expression of major histocompatibility complex class I antigens. Northern blots showed that JHM virus infection rapidly reduced the level of actin mRNA, whereas the levels of major histocompatibility complex class I and tubulin mRNAs were reduced ...

journal_title：Journal of virology

authors： Kyuwa S,Cohen M,Nelson G,Tahara SM,Stohlman SA

更新日期：1994-10-01 00:00:00

abstract：:Recently, we demonstrated that inverted repeat sequences inserted into first-generation adenovirus (Ad) vector genomes mediate precise genomic rearrangements resulting in vector genomes devoid of all viral genes that are efficiently packaged into functional Ad capsids. As a specific application of this finding, we gen...

journal_title：Journal of virology

authors： Lieber A,Steinwaerder DS,Carlson CA,Kay MA

更新日期：1999-11-01 00:00:00

abstract：:The activation of the human polyomavirus BK causes polyomavirus-associated nephropathy in immunocompromised humans. Studies of the virus have been restricted since the virus DNA replication is species specific. Cell-based and cell-free DNA replication systems, including the BK virus (BKV) monopolymerase DNA replicatio...

journal_title：Journal of virology

authors： Tikhanovich I,Nasheuer HP

更新日期：2010-07-01 00:00:00

abstract：UNLABELLED:STING has emerged in recent years as a key player in orchestrating innate immune responses to cytosolic DNA and RNA derived from pathogens. However, the regulation of STING still remains poorly defined. In the present study, we investigated the mechanism of the regulation of STING expression in relation to t...

journal_title：Journal of virology

authors： Liu Y,Goulet ML,Sze A,Hadj SB,Belgnaoui SM,Lababidi RR,Zheng C,Fritz JH,Olagnier D,Lin R

更新日期：2016-09-29 00:00:00

abstract：:The herpes simplex virus genome consists of two components, L and S, that invert relative to each other to yield four isomeric arrangements, prototype (P), inversion of the S component (Is), inversion of the L component (Il), and inversion of both components (Isl). Previous studies have shown that the 500-base-pair a ...

journal_title：Journal of virology

authors： Longnecker R,Roizman B

更新日期：1986-05-01 00:00:00

abstract：:Kinetic analysis showed that the Ki values and the Ki/Km ratios for mutated, recombinant M184V human immunodeficiency virus type 1 reverse transcriptase (RT) for (-)2'-dideoxy-3'-thiacytidine triphosphate (3TCTP) were 35-fold higher than the equivalent values for wild-type RT but only about twice as high as the equiva...

journal_title：Journal of virology

authors： Quan Y,Gu Z,Li X,Li Z,Morrow CD,Wainberg MA

更新日期：1996-08-01 00:00:00

abstract：:Panicum mosaic virus (PMV) is a recently molecularly characterized RNA virus with the unique feature of supporting the replication of two subviral RNAs in a few species of the family Gramineae. The subviral agents include a satellite RNA (satRNA) that is devoid of a coding region and the unrelated satellite panicum mo...

journal_title：Journal of virology

authors： Qiu W,Scholthof KB

更新日期：2001-06-01 00:00:00

abstract：:The hepadnavirus reverse transcriptase is a multifunction enzyme. In addition to its role in DNA synthesis, the polymerase is required for RNA packaging and also functions as the primer for minus-strand DNA synthesis. Previously, we demonstrated that the protein-priming activity of the polymerase requires a viral RNA ...

journal_title：Journal of virology

authors： Wang GH,Zoulim F,Leber EH,Kitson J,Seeger C

更新日期：1994-12-01 00:00:00

abstract：UNLABELLED:Baculovirus DNAs are synthesized and inserted into preformed capsids to form nucleocapsids at a site in the infected cell nucleus, termed the virogenic stroma. Nucleocapsid assembly ofAutographa californicamultiple nucleopolyhedrovirus (AcMNPV) requires the major capsid protein VP39 and nine minor capsid pro...

journal_title：Journal of virology

authors： Guan Z,Zhong L,Li C,Wu W,Yuan M,Yang K

更新日期：2016-03-28 00:00:00

abstract：:Epstein-Barr virus (EBV) efficiently drives proliferation of human primary B cells in vitro, a process relevant for human diseases such as infectious mononucleosis and posttransplant lymphoproliferative disease. Human B-cell proliferation is also driven by ligands of Toll-like receptors (TLRs), notably viral or bacter...

journal_title：Journal of virology

authors： Iskra S,Kalla M,Delecluse HJ,Hammerschmidt W,Moosmann A

更新日期：2010-04-01 00:00:00

abstract：:Enhancement of cell death is a distinguishing feature of H1N1 influenza virus A/Puerto Rico/8/34 protein PB1-F2. Comparing the sequences (amino acids [aa] 61 to 87 using PB1-F2 amino acid numbering) of the PB1-F2-derived C-terminal peptides from influenza A viruses inducing high or low levels of cell death, we identif...

journal_title：Journal of virology

authors： Alymova IV,Samarasinghe A,Vogel P,Green AM,Weinlich R,McCullers JA

更新日期：2014-01-01 00:00:00

abstract：:A hydrophilic region consisting of strikingly clustered charged amino acids is present at the center of human immunodeficiency virus type 1 (HIV-1) Vif. In this study, the role for this central hydrophilic region (E(88)WRKKR(93)) in the virus replication in nonpermissive H9 cells was investigated by extensive deletion...

journal_title：Journal of virology

authors： Fujita M,Sakurai A,Yoshida A,Miyaura M,Koyama AH,Sakai K,Adachi A

更新日期：2003-01-01 00:00:00

abstract：:We have used Northern blot hybridization to study the accumulation of specific cellular mRNAs in Vero cells infected with herpes simplex virus (HSV) type 1 or type 2. HSV-1 infection decreased the cytoplasmic levels of beta- and gamma-actin, beta-tubulin, and histone H3 and H4 mRNAs, though not all at the same rate. H...

journal_title：Journal of virology

authors： Schek N,Bachenheimer SL

更新日期：1985-09-01 00:00:00

abstract：:The global eradication of poliomyelitis will require substantial changes in immunization practices. One of the proposed scenarios includes cessation of vaccination with live oral poliovirus vaccine (OPV) and the creation of an OPV stockpile for emergency response in case of the reintroduction of poliovirus into circul...

journal_title：Journal of virology

authors： Korotkova EA,Park R,Cherkasova EA,Lipskaya GY,Chumakov KM,Feldman EV,Kew OM,Agol VI

更新日期：2003-12-01 00:00:00

abstract：:We report the use of a HeLa whole cell extract (WCE) runoff transcription system for the study of cis- and trans-acting elements, participating in the regulation of transcription initiation from the P38 promoter of the parvovirus minute virus of mice (MVM). Our initial studies with HeLa WCE indicated that transcriptio...

journal_title：Journal of virology

authors： Krauskopf A,Resnekov O,Aloni Y

更新日期：1990-01-01 00:00:00

abstract：UNLABELLED:Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella and herpes zoster. Membrane fusion is essential for VZV entry and the distinctive syncytium formation in VZV-infected skin and neuronal tissue. Herpesvirus fusion is mediated by a complex of glycoproteins gB and gH-gL, which are necess...

journal_title：Journal of virology

authors： Yang E,Arvin AM,Oliver SL

更新日期：2016-07-27 00:00:00

abstract：:The mechanisms mediating protective immunity to hepatitis C virus (HCV) infection are incompletely understood because early infection in humans is rarely identified, particularly in those individuals who subsequently demonstrate spontaneous virus eradication. We have established a large national network of patients wi...

journal_title：Journal of virology

authors： Smyk-Pearson S,Tester IA,Klarquist J,Palmer BE,Pawlotsky JM,Golden-Mason L,Rosen HR

更新日期：2008-02-01 00:00:00

abstract：:Herpesviruses are members of a diverse family of viruses that colonize all vertebrates from fish to mammals. Although more than one hundred herpesviruses exist, all are nearly identical architecturally, with a genome consisting of a linear double-stranded DNA molecule (100 to 225 kbp) protected by an icosahedral capsi...

journal_title：Journal of virology

authors： Morissette G,Flamand L

更新日期：2010-12-01 00:00:00

abstract：:The L1 and L2 capsid genes of human papillomavirus type 31 (HPV-31) are expressed upon keratinocyte differentiation from a promoter located in the E7 open reading frame (ORF) of the early region. Late transcripts must therefore pass through and ignore the early polyadenylation sequences to use the downstream late AAUA...

journal_title：Journal of virology

authors： Terhune SS,Hubert WG,Thomas JT,Laimins LA

更新日期：2001-09-01 00:00:00

abstract：:In this study, we investigated the expression levels of host restriction factors in six untreated HIV-1-positive patients over the course of infection. We found that the host restriction factor gene expression profile consistently increased over time and was significantly associated with CD4+ T cell activation and vir...

journal_title：Journal of virology

authors： Raposo RA,Abdel-Mohsen M,Deng X,Hecht FM,Pilcher CD,Pillai SK,Nixon DF

更新日期：2014-10-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) infection results in the disruption of ND10 (also called nuclear bodies, PODs, or PML-associated bodies), which are nuclear matrix domains of unknown function present in mammalian cells. After ND10 disruption, viral transcription and DNA replication occur in globular nuclear domains...

journal_title：Journal of virology

authors： Burkham J,Coen DM,Weller SK

更新日期：1998-12-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) Nef interferes with the endocytic machinery to modulate the cell surface expression of CD4. However, the basal trafficking of CD4 is governed by different rules in the target cells of HIV-1: whereas CD4 is rapidly internalized from the cell surface in myeloid cells, CD4 is s...

journal_title：Journal of virology

authors： Laguette N,Brégnard C,Bouchet J,Benmerah A,Benichou S,Basmaciogullari S

更新日期：2009-07-01 00:00:00

abstract：:T cells are central players in the immune response to infectious disease, with the specificity of their responses controlled by the T-cell receptor (TCR)/CD3 complex on the cell surface. Impairment of TCR/CD3-directed CD4(+) T-cell immune responses is frequently observed in individuals infected with human immunodefici...

journal_title：Journal of virology

authors： Segura I,Delmelle-Wibaut C,Janssens M,Cleuter Y,van den Broeke A,Kettmann R,Willard-Gallo KE

更新日期：1999-06-01 00:00:00

abstract：:The herpes simplex virus 1 (HSV-1) infected-cell protein 0 (ICP0) has the characteristics of a promiscuous transactivator of genes introduced into cells by infection or transfection. To identify cellular proteins interacting with ICP0, we used a domain of exon II of ICP0 that is known to be crucial for regulatory func...

journal_title：Journal of virology

authors： Kawaguchi Y,Van Sant C,Roizman B

更新日期：1997-10-01 00:00:00

abstract：:We describe respiratory syncytial virus (RSV)-specific cytotoxic T-cell (CTL) lines and clones developed from the spleens of C57BL/6 and BALB/c mice. Line 7 and clones derived from it were H-2Kb restricted, whereas line 12 had both Kb and Db components. Both lines, and all the clones except one, could lyse targets inf...

journal_title：Journal of virology

authors： Muñoz JL,McCarthy CA,Clark ME,Hall CB

更新日期：1991-08-01 00:00:00

abstract：:The RNA genomes from the cardioviruses, hepatoviruses, and aphthoviruses encode two to five tandem pseudoknots within their 5' untranslated regions. These pseudoknots lie adjacent to a pyrimidine-rich sequence, which in cardio- and aphthoviruses takes the form of a homopolymeric poly(C) tract. Seven deletion mutations...

journal_title：Journal of virology

authors： Martin LR,Palmenberg AC

更新日期：1996-11-01 00:00:00

abstract：:Infection of the chestnut blight fungus Cryphonectria parasitica with Cryphonectria hypovirus 1 (CHV1) causes disruption of virulence, pigmentation, and sporulation. Transcriptional downregulation of key developmentally regulated fungal genes occurs during infection, but vegetative growth is unaffected. Previous studi...

journal_title：Journal of virology

authors： Kazmierczak P,McCabe P,Turina M,Jacob-Wilk D,Van Alfen NK

更新日期：2012-06-01 00:00:00

abstract：:Tetherin/BST-2 is a host-encoded protein that restricts a wide diversity of viruses at the stage of virion release. However, viruses have evolved antagonists of Tetherin, including the Vpu and Nef proteins of primate lentiviruses. Like other host genes subject to viral antagonism, primate Tetherin genes have evolved u...

journal_title：Journal of virology

authors： Lim ES,Malik HS,Emerman M

更新日期：2010-07-01 00:00:00