Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease.

abstract：:In earlier studies, we have shown that superinfection of an interleukin-2 (IL-2)-dependent, Moloney murine leukemia virus (MoMuLV)-induced rat T-cell lymphoma line (4437A) with mink cell focus-forming (also called polytropic) murine retroviruses induces rapid progression to IL-2-independent growth. In this report, we ...

journal_title：Journal of virology

authors： Flubacher MM,Bear SE,Tsichlis PN

更新日期：1994-12-01 00:00:00

abstract：:Processing of the hepatitis C virus polyprotein is accomplished by a series of cotranslational and posttranslational cleavages mediated by host cell signalases and two virally encoded proteinases. Of these the NS3 proteinase is essential for processing at the NS3/4A, NS4A/4B, NS4B/5A, and NS5A/5B junctions. Processing...

journal_title：Journal of virology

authors： Bartenschlager R,Ahlborn-Laake L,Yasargil K,Mous J,Jacobsen H

更新日期：1995-01-01 00:00:00

abstract：:Productively infected bovine fibropapillomas were examined for bovine papillomavirus type 1 (BPV-1) E7 localization. BPV-1 E7 was observed in the cytoplasm of basal and lower spinous epithelial cells, coexpressed in the cytoplasm of basal cells with the E5 oncoprotein. E7 was also observed in nucleoli throughout the b...

journal_title：Journal of virology

authors： Bohl J,Hull B,Vande Pol SB

更新日期：2001-01-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1)-encoded RNA-binding protein Tat is known to play an essential role in viral gene expression. In the search for novel compounds to inhibit Tat transactivity, one coumarin derivative, BPRHIV001, was identified, with a 50% effective concentration (EC(50)) against HIV-1 at 1...

journal_title：Journal of virology

authors： Lin PH,Ke YY,Su CT,Shiao HY,Hsieh HP,Chao YK,Lee CN,Kao CL,Chao YS,Chang SY

更新日期：2011-09-01 00:00:00

abstract：:The late 19S RNAs of simian virus 40 (SV40) are functionally polycistronic, i.e., all encode both VP2 and VP3. The VP3-coding sequences are situated in the same reading frame as the VP2-coding sequences, within the carboxy-terminal two-thirds of the VP2-coding sequences. To test whether VP3 is produced by proteolytic ...

journal_title：Journal of virology

authors： Sedman SA,Mertz JE

更新日期：1988-03-01 00:00:00

abstract：:Dengue virus (DENV) is a major global pathogen that causes significant morbidity and mortality in tropical and subtropical areas worldwide. An improved understanding of the regions within the DENV genome and its encoded proteins that are required for the virus replication cycle will expedite the development of urgentl...

journal_title：Journal of virology

authors： Eyre NS,Johnson SM,Eltahla AA,Aloi M,Aloia AL,McDevitt CA,Bull RA,Beard MR

更新日期：2017-11-14 00:00:00

abstract：:The vaccinia virus A16L open reading frame encodes a 378-amino-acid protein with a predicted C-terminal transmembrane domain and 20 invariant cysteine residues that is conserved in all sequenced members of the poxvirus family. The A16 protein was expressed late in infection and incorporated into intracellular virus pa...

journal_title：Journal of virology

authors： Ojeda S,Senkevich TG,Moss B

更新日期：2006-01-01 00:00:00

abstract：:Infectious bursal disease virus (IBDV) is a double-stranded RNA (dsRNA) virus of the Birnaviridae family. Its two genome segments are encapsidated together with multiple copies of the viral RNA-dependent RNA polymerase, VP1, in a single-shell capsid that is composed of VP2 and VP3. In this study we identified the doma...

journal_title：Journal of virology

authors： Tacken MG,Peeters BP,Thomas AA,Rottier PJ,Boot HJ

更新日期：2002-11-01 00:00:00

abstract：UNLABELLED:Hepatitis C virus (HCV) requires proteins from the NS3-NS5B polyprotein to create a replicase unit for replication of its genome. The replicase proteins form membranous compartments in cells to facilitate replication, but little is known about their functional organization within these structures. We recentl...

journal_title：Journal of virology

authors： Gomes RG,Isken O,Tautz N,McLauchlan J,McCormick CJ

更新日期：2015-12-30 00:00:00

abstract：:Epstein-Barr virus (EBV)-encoded molecules have been detected in the tumor tissues of several cancers, including nasopharyngeal carcinoma (NPC), suggesting that EBV plays an important role in tumorigenesis. However, the nature of EBV with respect to genome width in vivo and whether EBV undergoes clonal expansion in th...

journal_title：Journal of virology

authors： Liu P,Fang X,Feng Z,Guo YM,Peng RJ,Liu T,Huang Z,Feng Y,Sun X,Xiong Z,Guo X,Pang SS,Wang B,Lv X,Feng FT,Li DJ,Chen LZ,Feng QS,Huang WL,Zeng MS,Bei JX,Zhang Y,Zeng YX

更新日期：2011-11-01 00:00:00

abstract：:A large percentage of the repetitive elements in mammalian genomes are retroelements, which have been moved primarily by LINE-1 retrotransposons and endogenous retroviruses. Although LINE-1 elements have remained active throughout the mammalian radiation, specific groups of endogenous retroviruses generally remain act...

journal_title：Journal of virology

authors： Cantrell MA,Ederer MM,Erickson IK,Swier VJ,Baker RJ,Wichman HA

更新日期：2005-12-01 00:00:00

abstract：:The Borna disease virus (BDV) is the prototype member of the Bornaviridae, and it replicates in the cell nucleus. The BDV p24P and p40N proteins carry nuclear localization signals (NLS) and are found in the nuclei of infected cells. The BDV p10 protein does not have an NLS, but it binds with P and/or N and is transloc...

journal_title：Journal of virology

authors： Malik TH,Kishi M,Lai PK

更新日期：2000-04-01 00:00:00

abstract：:To investigate the genetic stability of vaccinia virus DNA, we have tested whether alterations occurred in the polypeptide composition of this complex virus during persistent infections. We found that variants isolated at various passages in Friend erythroleukemia cells persistently infected with vaccinia virus contai...

journal_title：Journal of virology

authors： Paez E,Dallo S,Esteban M

更新日期：1987-08-01 00:00:00

abstract：:We generated a recombinant influenza A virus (Mmut) that produced low levels of matrix (M1) and M2 proteins in infected cells. Mmut virus propagated to significantly lower titers than did wild-type virus in cells infected at low multiplicity. By contrast, virion morphology and incorporation of viral proteins and vRNAs...

journal_title：Journal of virology

authors： Bourmakina SV,García-Sastre A

更新日期：2005-06-01 00:00:00

abstract：:Vesicular stomatitis virus (VSV) has served for several decades as the prototype rhabdovirus and a model RNA virus. Extensive studies upheld the original view of VSV genetics with simply five genes (N, P, M, G, and L), each encoding a single unique protein. We now report the first unambiguous demonstration of the exis...

journal_title：Journal of virology

authors： Spiropoulou CF,Nichol ST

更新日期：1993-06-01 00:00:00

abstract：:The phosphoprotein (P) of the nonsegmented negative-sense RNA viruses is a multimeric modular protein that is essential for RNA transcription and replication. Despite great variability in length and sequence, the architecture of this protein is conserved among the different viral families, with a long N-terminal intri...

journal_title：Journal of virology

authors： Gérard FCA,Jamin M,Blackledge M,Blondel D,Bourhis JM

更新日期：2020-02-28 00:00:00

abstract：:Hepatitis C virus (HCV) core protein forms the nucleocapsid of the HCV particle. Although many functions of core protein have been reported, how the HCV particle is assembled is not well understood. Here we show that the nucleocapsid-like particle of HCV is composed of a disulfide-bonded core protein complex (dbc-comp...

journal_title：Journal of virology

authors： Kushima Y,Wakita T,Hijikata M

更新日期：2010-09-01 00:00:00

abstract：UNLABELLED:Hepatitis C virus (HCV) infects 180 million people worldwide and is a leading cause of liver diseases such as fibrosis, cirrhosis, and hepatocellular carcinoma. It has been shown that HCV can spread to naive cells using two distinct entry mechanisms, "cell-free" entry of infectious extracellular virions that...

journal_title：Journal of virology

authors： Barretto N,Sainz B Jr,Hussain S,Uprichard SL

更新日期：2014-05-01 00:00:00

abstract：UNLABELLED:Although the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) epidemic was controlled by nonvaccine measures, coronaviruses remain a major threat to human health. The design of optimal coronavirus vaccines therefore remains a priority. Such vaccines present major challenges: coronavirus im...

journal_title：Journal of virology

authors： Honda-Okubo Y,Barnard D,Ong CH,Peng BH,Tseng CT,Petrovsky N

更新日期：2015-03-01 00:00:00

abstract：:The role of the Autographa californica multiple nucleopolyhedrovirus (AcMNPV) immediate-early protein IE0 in the baculoviral infection is not clear. In this study, we constructed the recombinant virus vAcDeltaie0 null for ie0 expression by targeted mutagenesis replacing exon0 with the cat gene. We found that vAcDeltai...

journal_title：Journal of virology

authors： Lu L,Rivkin H,Chejanovsky N

更新日期：2005-08-01 00:00:00

abstract：:The beginning of the second century of research in the field of virology (the first virus was discovered in 1898) was marked by its amalgamation with bioinformatics, resulting in the birth of a new domain--viroinformatics. The availability of more than 100 Web servers and databases embracing all or specific viruses (f...

journal_title：Journal of virology

authors： Sharma D,Priyadarshini P,Vrati S

更新日期：2015-02-01 00:00:00

abstract：:Characterizations of genetic variations among hepatitis delta virus (HDV) isolates have focused principally on phylogenetic analysis of sequences, which vary by 30 to 40% among three genotypes and about 10 to 15% among isolates of the same genotype. The significance of the sequence differences has been unclear but cou...

journal_title：Journal of virology

authors： Casey JL,Gerin JL

更新日期：1998-04-01 00:00:00

abstract：:In vitro mapping studies of the MD145 norovirus (Caliciviridae) ORF1 polyprotein identified two stable cleavage products containing the viral RNA-dependent RNA polymerase (RdRp) domains: ProPol (a precursor comprised of both the proteinase and polymerase) and Pol (the mature polymerase). The goal of this study was to ...

journal_title：Journal of virology

authors： Belliot G,Sosnovtsev SV,Chang KO,Babu V,Uche U,Arnold JJ,Cameron CE,Green KY

更新日期：2005-02-01 00:00:00

abstract：:Although xenotropic murine leukemia viruses cannot productively infect cells of laboratory mice, cells from various wild-derived mice can support replication of these viruses. Although the virus-sensitive wild mice generally lack all or most of the xenotropic proviral genes characteristic of inbred strains, susceptibi...

journal_title：Journal of virology

authors： Kozak CA

更新日期：1985-09-01 00:00:00

abstract：:The nucleotide sequence corresponding to the P3 region of the hepatitis A virus (HAV) polyprotein genome was determined from cloned cDNA and translated into an amino acid sequence. Comparison of the amino acid sequences of the genome-linked proteins (VPgs) of other picornaviruses with the predicted amino acid sequence...

journal_title：Journal of virology

authors： Weitz M,Baroudy BM,Maloy WL,Ticehurst JR,Purcell RH

更新日期：1986-10-01 00:00:00

abstract：:Norovirus (NoV) infections are a significant health burden to society, yet the lack of reliable tissue culture systems has hampered the development of appropriate antiviral therapies. Here we show that the NoV NS3 protein, derived from murine NoV (MNV), is intimately associated with the MNV replication complex and the...

journal_title：Journal of virology

authors： Cotton BT,Hyde JL,Sarvestani ST,Sosnovtsev SV,Green KY,White PA,Mackenzie JM

更新日期：2017-01-18 00:00:00

abstract：:The uncoating of adenovirus type 2 and a temperature-sensitive mutant, tsl, was studied. HEp-2 cells were infected with 32P- OR 125I-labeled purified virions for various lengths of time, and the nuclear and cytoplasmic fractions were analyzed by sucrose gradient velocity sedimentation and sodium dodecyl sulfate-polyac...

journal_title：Journal of virology

authors： Mirza MA,Weber J

更新日期：1979-05-01 00:00:00

abstract：:Coinfection with HIV-1 and Kaposi's sarcoma-associated herpesvirus (KSHV) often leads to AIDS-related malignancies, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). The interaction between HIV and KSHV plays a pivotal role in the progression of these malignancies. We have previously demonstrated th...

journal_title：Journal of virology

authors： Yan Q,Zhao R,Shen C,Wang F,Li W,Gao SJ,Lu C

更新日期：2018-08-29 00:00:00

abstract：:We previously reported that the adenovirus type 5 E3 14.5-kilodalton protein (14.5K) forms a complex with E3 10.4K and that both proteins are required to down-regulate the epidermal growth factor receptor in adenovirus-infected human cells. Both proteins are also required to prevent cytolysis by tumor necrosis factor ...

journal_title：Journal of virology

authors： Krajcsi P,Tollefson AE,Anderson CW,Wold WS

更新日期：1992-03-01 00:00:00

abstract：:The copy choice model for the generation of defective interfering (DI) particles of vesicular stomatitis virus suggests that during replication the polymerase prematurely terminates, moves with the nascent daughter strand to another site on the same or a different template molecule, and resumes elongation of the nasce...

journal_title：Journal of virology

authors： Meier E,Harmison GG,Keene JD,Schubert M

更新日期：1984-08-01 00:00:00