Abstract:
:The role of the Autographa californica multiple nucleopolyhedrovirus (AcMNPV) immediate-early protein IE0 in the baculoviral infection is not clear. In this study, we constructed the recombinant virus vAcDeltaie0 null for ie0 expression by targeted mutagenesis replacing exon0 with the cat gene. We found that vAcDeltaie0 replicated efficiently in Spodoptera littoralis SL2 cells, which are poorly permissive for AcMNPV. In contrast, in Spodoptera frugiperda SF9 cells, which are fully permissive for AcMNPV, vAcDeltaie0 DNA replication and budded virus production were delayed. These results and recently published data (X. Dai et al., J. Virol. 78:9633-9644, 2004) indicate that ie0 is not essential for AcMNPV replication but enhances it in permissive SF9 cells.
journal_name
J Viroljournal_title
Journal of virologyauthors
Lu L,Rivkin H,Chejanovsky Ndoi
10.1128/JVI.79.15.10077-10082.2005subject
Has Abstractpub_date
2005-08-01 00:00:00pages
10077-82issue
15eissn
0022-538Xissn
1098-5514pii
79/15/10077journal_volume
79pub_type
杂志文章abstract::Diseases of the nasopharyngeal epithelium due to Epstein-Barr virus (EBV) infection typically occur in chronic virus carriers with preexisting virus-specific antibodies. In vitro studies have shown that EBV-specific immunoglobulin A (IgA) promotes infection of human epithelial cells, otherwise refractory to EBV, via t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.1.519-526.1997
更新日期:1997-01-01 00:00:00
abstract::Zika virus (ZIKV), a mosquito-transmitted flavivirus, is linked to microcephaly and other neurological defects in neonates and Guillain-Barré syndrome in adults. The molecular mechanisms regulating ZIKV infection and pathogenic outcomes are incompletely understood. Signaling by the mechanistic (mammalian) target of ra...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01575-20
更新日期:2020-10-27 00:00:00
abstract::Human cytomegalovirus (CMV) is the leading cause of prenatal viral infection. Affected infants may suffer intrauterine growth retardation and serious neurologic impairment. Analysis of spontaneously aborted conceptuses shows that CMV infects the placenta before the embryo or fetus. In the human hemochorial placenta, m...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.15.6808-6820.2000
更新日期:2000-08-01 00:00:00
abstract::Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (p...
journal_title:Journal of virology
pub_type: 历史文章,杂志文章
doi:10.1128/JVI.01292-15
更新日期:2015-12-01 00:00:00
abstract::Infectious bursal disease virus (IBDV) is a birnavirus causing immunosuppressive disease in chickens. Emergence of the very virulent form of IBDV (vvIBDV) in the late 1980s dramatically changed the epidemiology of the disease. In this study, we investigated the phylogenetic origins of its genome segments and estimated...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00585-06
更新日期:2006-09-01 00:00:00
abstract::An unusual human retrovirus was isolated from two patients with persistent generalized lymphadenopathy who originate from West-Central Africa and are currently residing in Belgium. Although the virus shared a number of the same biological and morphological properties as human immunodeficiency retrovirus type 1 (HIV-1)...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.3.1207-1216.1990
更新日期:1990-03-01 00:00:00
abstract::The intracellular and extracellular localization of pseudorabies virions and subvirion components was determined at various stages in the replicative cycle. It was discovered that infectious pseudorabies virus appears first in the nucleus of the infected cell early in the infectious cycle but later accumulates in the ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.6.3.280-285.1970
更新日期:1970-09-01 00:00:00
abstract::A number of options are available to modify and improve DNA vaccines. An interesting approach to improve DNA vaccines is to fuse bioactive domains, like cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4), to an antigen. Such fusion antigens are expressed in vivo and directed to immune cells by the specific bioactive...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.10.6368-6376.2005
更新日期:2005-05-01 00:00:00
abstract::Ebola virus (EBOV) continues to pose a significant threat to human health, as evidenced by the 2013-2016 epidemic in West Africa and the ongoing outbreak in the Democratic Republic of the Congo. EBOV causes hemorrhagic fever, organ damage, and shock culminating in death, with case fatality rates as high as 90%. This h...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00250-20
更新日期:2020-05-18 00:00:00
abstract::Although iridoviruses vary widely within and among genera with respect to their host range and virulence, variation within iridovirus species has been less extensively characterized. This study explores the nature and extent of intraspecific variation within an emerging iridovirus of North American warm-water fishes, ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.16.8812-8818.2003
更新日期:2003-08-01 00:00:00
abstract::The mechanism of regulation for the ribozyme activity of hepatitis delta virus (HDV) RNA in infected cells is unknown. Previously, we developed a direct assay capable of detecting the ribozyme activity of HDV dimer or trimer RNAs in vivo (K.-S. Jeng, A. Daniel, and M. M. C. Lai, J. Virol, 70:2403-2410, 1996). In this ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.7.4205-4209.1996
更新日期:1996-07-01 00:00:00
abstract::Influenza viruses resistant to the neuraminidase (NA) inhibitor oseltamivir arise under drug selection pressure both in vitro and in vivo. Several mutations in the active site of the viral NA are known to confer relative resistance to oseltamivir, and influenza viruses with certain oseltamivir resistance mutations hav...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01226-08
更新日期:2008-10-01 00:00:00
abstract::We demonstrate that the S4 genome segment of baboon reovirus (BRV) contains two sequential partially overlapping open reading frames (ORFs), both of which are functional in vitro and in virus-infected cells. The 15-kDa gene product (p15) of the 5"-proximal ORF induces efficient cell-cell fusion when expressed by itsel...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.5.2131-2140.2002
更新日期:2002-03-01 00:00:00
abstract::Human coronavirus NL63 (HCoV-NL63), a common human respiratory pathogen, is associated with both upper and lower respiratory tract disease in children and adults. Currently, no antiviral drugs are available to treat CoV infections; thus, potential drug targets need to be identified and characterized. Here, we identify...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02747-06
更新日期:2007-06-01 00:00:00
abstract::ICP0, one of the five immediate-early (IE) gene products of herpes simplex virus (HSV), is a potent activator of transcription. To assess the biological activities of ICP0 and to explore its mechanisms of action, two helper-independent recombinant adenoviruses were constructed. In each recombinant, the E1 region was s...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.12.4544-4553.1988
更新日期:1988-12-01 00:00:00
abstract::During Epstein-Barr virus (EBV) latent infection of B lymphocytes in vitro, six viral nuclear antigens (EBNAs) are expressed from one of two promoters, Cp or Wp, whose activities have previously been shown to be mutually exclusive in established lymphoblastoid cell lines. Initially after infection, the EBNA genes are ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.12.9134-9142.1997
更新日期:1997-12-01 00:00:00
abstract::Arthropod genomes contain sequences derived from integrations of DNA and nonretroviral RNA viruses. These sequences, known as endogenous viral elements (EVEs), have been acquired over the course of evolution and have been proposed to serve as a record of past viral infections. Recent evidence indicates that EVEs can f...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02124-18
更新日期:2019-03-05 00:00:00
abstract::Zinc finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses. There are two ZAP isoforms arising from alternative splicing, which differ only at the C termini. It was recently reported that the long isoform (ZAPL) promotes proteasomal degradation of influenza A vir...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01909-16
更新日期:2017-01-03 00:00:00
abstract::The arterivirus equine arteritis virus nonstructural protein 10 (nsp10) has previously been predicted to contain a Zn finger structure linked to a superfamily 1 (SF1) helicase domain. A recombinant form of nsp10, MBP-nsp10, was produced in Escherichia coli as a fusion protein with the maltose-binding protein. The prot...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.20.9586-9593.2000
更新日期:2000-10-01 00:00:00
abstract:UNLABELLED:During HIV-1 assembly, the Gag viral proteins are targeted and assemble at the inner leaflet of the cell plasma membrane. This process could modulate the cortical actin cytoskeleton, located underneath the plasma membrane, since actin dynamics are able to promote localized membrane reorganization. In additio...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00469-15
更新日期:2015-08-01 00:00:00
abstract::Rat (3Y1) and hamster embryo brain cells were transformed by wild-type adenovirus type 12 or the DNA-minus temperature-sensitive mutant ts401. The ts401-transformed 3Y1 cells, but not the wild-type transformants, displayed a temperature-sensitive response with respect to the following characteristics of the transforme...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.29.1.250-260.1979
更新日期:1979-01-01 00:00:00
abstract::Simian immunodeficiency virus (SIV) infection of rhesus macaques causes immune depletion and disease closely resembling human AIDS and is well recognized as the most relevant animal model for the human disease. Experimental investigations of viral pathogenesis and vaccine protection primarily involve a limited set of ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01862-12
更新日期:2012-12-01 00:00:00
abstract::It has been suggested that vaccination prior to infection may direct the mutational evolution of human immunodeficiency virus type 1 (HIV-1) to a less fit virus, resulting in an attenuated course of disease. The present study was initiated to explore whether prior immunization might prevent the reversion of the virus ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01193-10
更新日期:2010-12-01 00:00:00
abstract::The chimeric recombinant virus rHPIV3-N(B), a version of human parainfluenza virus type 3 (HPIV3) that is attenuated due to the presence of the bovine PIV3 nucleocapsid (N) protein open reading frame (ORF) in place of the HPIV3 ORF, was modified to encode the measles virus hemagglutinin (HA) inserted as an additional,...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.21.10498-10504.2001
更新日期:2001-11-01 00:00:00
abstract::Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing influenza A virus ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00576-15
更新日期:2015-10-14 00:00:00
abstract::HLA-B*57 is strongly associated with immune control of HIV and delayed AIDS progression. The closely related, but less protective, HLA-B*58:01 presents similar epitopes, but HLA-B*58:01(+) individuals do not generate CD8(+) T cells targeting the KF11-Gag epitope, which has been linked to low viremia. Here we show that...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01122-13
更新日期:2013-10-01 00:00:00
abstract::Phenol-extracted, infectious deoxyribonucleic acid (DNA) species from phi105 phage particles, from phi105 lysogenic bacteria, and from induced phi105 lysogenic bacteria were sedimented in sucrose gradients. Infectious DNA from phi105 particles sedimented like the bulk of mature phage DNA in neutral sucrose. Infectivit...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.5.5.604-608.1970
更新日期:1970-05-01 00:00:00
abstract::Most of the viral DNA extracted from simian virus 40 (SV40)-infected African green monkey kidney cells consists of circular molecules about 5.3 kilobases in contour length. However, about 1% of the viral DNA was found to occur as closed circular dimers that appeared to be formed, preferentially, late in infection. The...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.24.1.295-302.1977
更新日期:1977-10-01 00:00:00
abstract::The N termini of the capsid proteins VP1 and VP2 of adeno-associated virus (AAV) play important roles in subcellular steps of infection and contain motifs that are highly homologous to a phospholipase A(2) (PLA(2)) domain and nuclear localization signals (NLSs). To more clearly understand how virion components influen...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00687-10
更新日期:2010-09-01 00:00:00
abstract::Therapeutic strategies for the treatment of acute retroviral infections have relied mainly on antiviral drugs. In this study we used the Friend virus model system to demonstrate that enhancement of the immune system can also have dramatic therapeutic effects. Since resistance to Friend virus-induced leukemia in mice i...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.22.11397-11404.2002
更新日期:2002-11-01 00:00:00