Abstract:
:The beginning of the second century of research in the field of virology (the first virus was discovered in 1898) was marked by its amalgamation with bioinformatics, resulting in the birth of a new domain--viroinformatics. The availability of more than 100 Web servers and databases embracing all or specific viruses (for example, dengue virus, influenza virus, hepatitis virus, human immunodeficiency virus [HIV], hemorrhagic fever virus [HFV], human papillomavirus [HPV], West Nile virus, etc.) as well as distinct applications (comparative/diversity analysis, viral recombination, small interfering RNA [siRNA]/short hairpin RNA [shRNA]/microRNA [miRNA] studies, RNA folding, protein-protein interaction, structural analysis, and phylotyping and genotyping) will definitely aid the development of effective drugs and vaccines. However, information about their access and utility is not available at any single source or on any single platform. Therefore, a compendium of various computational tools and resources dedicated specifically to virology is presented in this article.
journal_name
J Viroljournal_title
Journal of virologyauthors
Sharma D,Priyadarshini P,Vrati Sdoi
10.1128/JVI.02027-14subject
Has Abstractpub_date
2015-02-01 00:00:00pages
1489-501issue
3eissn
0022-538Xissn
1098-5514pii
JVI.02027-14journal_volume
89pub_type
杂志文章,评审abstract::Of the numerous endogenous retroviral elements that are present in the human genome, the abundant HERV-K family is distinct because several members are transcriptionally active and coding for biologically active proteins. A detailed phylogeny of the HERV-K family based on the partial sequence of the reverse transcript...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.3.2365-2375.1999
更新日期:1999-03-01 00:00:00
abstract:UNLABELLED:PD-1 is an inhibitory receptor that has a major role in T cell dysfunction during chronic infections and cancer. While demethylation of the PD-1 promoter DNA is observed in exhausted T cells isolated from chronically infected individuals, little is known about when this stable demethylation of PD-1 promoter ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00798-16
更新日期:2016-09-12 00:00:00
abstract::Primate lentiviruses use chemokine coreceptors in addition to the CD4 receptor to initiate virus infection. Simian immunodeficiency virus (SIV) productively infects human cells expressing CD4 and the human allele of the chemokine coreceptor CCR-5 as efficiently as it infects macaque cells expressing human CD4, suggest...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.5.3932-3939.1997
更新日期:1997-05-01 00:00:00
abstract::West Nile virus (WNV) is a human pathogen that can cause neurological disorders, including meningoencephalitis. Experiments with mice and mammalian cell cultures revealed that WNV exhibited resistance to the innate immune program induced by alpha interferon (IFN-alpha). We have investigated the nature of this inhibiti...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.3.1343-1350.2005
更新日期:2005-02-01 00:00:00
abstract::Viruses display a wide range of genomic profiles and, consequently, a variety of gene expression strategies. Specific sequences associated with transcriptional processes have been described in viruses, and putative promoter motifs have been elucidated for some nucleocytoplasmic large DNA viruses (NCLDV). Among NCLDV, ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01088-17
更新日期:2017-10-13 00:00:00
abstract::Deletion mutants of bacteriphage T5 can be identified by analyzing the DNA content of single plaques, after alkaline denaturation, by agarose gel electrophoresis. Use of this procedure has resulted in the isolation of a new mutant, designated del2, that lacks a 1.6% segment located 68 to 70% from the left end of T5 DN...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.36.2.622-626.1980
更新日期:1980-11-01 00:00:00
abstract::The Epstein-Barr virus oriP, when examined with the use of in vitro nucleosome reconstitution, was found to exhibit a partial sparing of nucleosome assembly within the 3' dyad. Analysis of the homologous region containing the origin of replication of herpesvirus papio disclosed that sparing of nucleosome assembly was ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.12.5505-5508.1989
更新日期:1989-12-01 00:00:00
abstract::Respiratory syncytial virus (RSV) is the major cause of acute bronchiolitis in infancy, a syndrome characterized by wheezing, respiratory distress, and the pathologic findings of peribronchial mononuclear cell infiltration and release of inflammatory mediators by basophil and eosinophil leukocytes. Composition and act...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.6.4756-4764.1998
更新日期:1998-06-01 00:00:00
abstract::Rift Valley fever virus (RVFV) is an arbovirus that causes disease in livestock and humans in Africa and the Middle East. While human disease is typically mild and self-limiting, some individuals develop severe manifestations, such as hepatitis, hemorrhagic fever, or encephalitis. Encephalitis occurs 2 to 3 weeks afte...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01270-18
更新日期:2018-11-27 00:00:00
abstract::We investigated properties of the rotavirus genome segment 11 protein. A rotavirus SA11 genome segment 11 cDNA which contains the entire coding region was sequenced and inserted into the baculovirus transfer vector pVL941. Recombinants containing gene 11 cDNA were selected, and the gene 11 product expressed in Spodopt...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.9.3974-3982.1989
更新日期:1989-09-01 00:00:00
abstract::Reovirus serotype 1 Lang can be recovered in high titer from the intestines of neonatal mice up to day 8 after peroral inoculation. By contrast, reovirus serotype 3 Dearing cannot be recovered from intestinal tissue past day 4 after peroral inoculation. This difference between the two reoviruses was mapped by using re...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.3.1188-1193.1989
更新日期:1989-03-01 00:00:00
abstract::Mutants of polyomavirus with altered host specificities were isolated in undifferentiated C2 myoblast cells (L. Ricci, R. Maione, C. Passananti, A. Felsani, and P. Amati, J. Virol. 66:7153-7158, 1992). The mutations responsible for this phenotype belonged to either of the two classes: a large duplication of the enhanc...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.2.1196-1199.1994
更新日期:1994-02-01 00:00:00
abstract::A herpes simplex virus type 1 variant [C239(TK-)] harboring a deletion in the thymidine kinase (TK) gene was assessed for capacity to establish latent infections. Outbred Swiss Webster mice were inoculated on both hind footpads, and numbers of neurons expressing latency-associated transcript and amounts of viral DNA i...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.11.4976-4978.1989
更新日期:1989-11-01 00:00:00
abstract::The folded genome of Escherichia coli is converted to a slower-sedimenting form within 5 min after infection with bacteriophage T4 or T4nd28(den A)-amN82(44). Chloramphenicol sensitivity and response to UV-irradiation of the phage suggest participation of viral-induced functions. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.13.2.548-550.1974
更新日期:1974-02-01 00:00:00
abstract::Herpesviruses are important pathogens of humans and other animals. Herpesvirus infectious clones that can reconstitute phenotypically wild-type (wt) virus are extremely valuable tools for elucidating the roles of specific genes in virus pathophysiology as well as for making vaccines. Ictalurid herpesvirus 1 (channel c...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02152-07
更新日期:2008-04-01 00:00:00
abstract::Small-t antigen of simian virus 40 renders CV-1 cells resistant to growth arrest induced by theophylline and other methylxanthines. Elevated levels of cyclic AMP are not involved in growth arrest of CV-1 cells by methylxanthines, and small-t antigen does not alter cyclic AMP levels dramatically after infection. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.54.3.876-878.1985
更新日期:1985-06-01 00:00:00
abstract::The sodium dodecyl sulfate (SDS) complex of the major glycoprotein of avian myeloblastosis virus exhibited an anomalously low free electrophoretic mobility compared with those of non-glycosylated protein standards. The apparent molecular weight of the glycoprotein calculated from the relation between log molecular wei...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.26.3.825-827.1978
更新日期:1978-06-01 00:00:00
abstract::There are two types of infectious vaccinia virus particles: intracellular naked virions and extracellular enveloped virions (EEV). To determine the biological role of the enveloped form of vaccinia virus, we produced and characterized a mutant that is defective in EEV formation. The strategy involved replacement by ho...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.11.5910-5920.1991
更新日期:1991-11-01 00:00:00
abstract::Tobacco necrosis virus, strain D (TNV-D), is a positive-strand RNA virus in the genus Betanecrovirus and family Tombusviridae The production of its RNA-dependent RNA polymerase, p82, is achieved by translational readthrough. This process is stimulated by an RNA structure that is positioned immediately downstream of th...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02443-16
更新日期:2017-03-29 00:00:00
abstract::Parvovirus capsids are small but complex molecular machines responsible for undertaking many of the steps of cell infection, genome packing, and cell-to-cell as well as host-to-host transfer. The details of parvovirus infection of cells are still not fully understood, but the processes must involve small changes in th...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01871-16
更新日期:2017-01-03 00:00:00
abstract::We have recently described an intracellular protein, p21, in nonproducer cells transformed by either the Kirsten (Ki-MSV) or Harvey (Ha-MSV) strain of murine sarcoma virus (Shih et al., Virology, in press). The p21 is phosphorylated and has been shown to be coded for by either Ki-MSV or Ha-MSV. In this report, we comp...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.31.2.546-546.1979
更新日期:1979-08-01 00:00:00
abstract::The U(S)3 open reading frame of herpes simplex virus 1 (HSV-1) was reported to encode two mRNAs each directing the synthesis of the same protein. We report that the U(S)3 gene encodes two proteins. The predominant U(S)3 protein is made in wild-type HSV-1-infected cells. The truncated mRNA and a truncated protein desig...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.13.8470-8479.2005
更新日期:2005-07-01 00:00:00
abstract::The Roseobacter clade has been recognized as one of the abundant bacterial lineages in marine environments, which makes the characterization of bacteriophages infecting members of the clade important. Here we report the complete genome sequence of bacteriophage P12053L, which infects Celeribacter sp. strain IMCC12053,...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01153-12
更新日期:2012-08-01 00:00:00
abstract::Actively replicating endogenous retroviruses entered the human genome millions of years ago and became a stable part of the inherited genetic material. They subsequently acquired multiple mutations, leading to the assumption that these viruses no longer replicate. However, certain human tumor cell lines have been show...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00646-08
更新日期:2008-10-01 00:00:00
abstract::Mitochondrial DNA synthesis in adenovirus type 2-infected HeLa cells was measured at various times from 0 to 24 h postinfection. Although viral infection effectively turned off host chromosomal DNA synthesis, mitochondrial DNA synthesis was not inhibited. These findings indicate a dissociation between the regulation o...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.22.2.340-345.1977
更新日期:1977-05-01 00:00:00
abstract:UNLABELLED:Viruses that spread systemically from a peripheral site of infection cause morbidity and mortality in the human population. Innate myeloid cells, including monocytes, macrophages, monocyte-derived dendritic cells (mo-DC), and dendritic cells (DC), respond early during viral infection to control viral replica...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01024-15
更新日期:2015-10-01 00:00:00
abstract::The serological relationship of the ribonucleic acid (RNA)-containing coliphages MS-2, M-12, R-17, f(2), beta, fr, f(4), and Qbeta was determined. Antisera against MS-2, R-17, f(2), fr, and Qbeta neutralized the infectivity of all of these RNA phages to varying degrees. Although each phage was serologically distinct, ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.4.5.567-573.1969
更新日期:1969-11-01 00:00:00
abstract::Regulatory T (T(R)) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4(+) CD25(+) human T(R) cells suppress virus-specific T-cell responses. Depletion of T(R) cells from peripheral blood mononuclear cells enhances T-cell responses ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.5.2454-2459.2004
更新日期:2004-03-01 00:00:00
abstract::To investigate the genetic stability of vaccinia virus DNA, we have tested whether alterations occurred in the polypeptide composition of this complex virus during persistent infections. We found that variants isolated at various passages in Friend erythroleukemia cells persistently infected with vaccinia virus contai...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.8.2642-2647.1987
更新日期:1987-08-01 00:00:00
abstract::We previously demonstrated that human cytomegalovirus (HCMV) infection induced the activation of the cellular transcription factor NF-kappaB. Here, we investigate the mechanism for the HCMV-induced NF-kappaB activation and the role that the induced NF-kappaB plays in transactivation of the major immediate-early promot...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.9.4498-4507.2004
更新日期:2004-05-01 00:00:00