Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens.

abstract：:ISG15, a 15-kDa interferon-induced protein that participates in antiviral defenses of mammals, is highly conserved among vertebrates. In fish, as in mammals, viral infection and interferon treatment induce isg15 expression. The two ubiquitin-like domains of ISG15 and the presence of a consensus LRLRGG sequence in the ...

journal_title：Journal of virology

authors： Langevin C,van der Aa LM,Houel A,Torhy C,Briolat V,Lunazzi A,Harmache A,Bremont M,Levraud JP,Boudinot P

更新日期：2013-09-01 00:00:00

abstract：:The vif gene of human immunodeficiency virus type 1 (HIV-1) encodes a basic Mr 23,000 protein that is necessary for production of infectious virions by nonpermissive cells (human lymphocytes and macrophages) but not by permissive cells such as HeLa-CD4. It had been proposed that permissive cells may contain an unident...

journal_title：Journal of virology

authors： Madani N,Kabat D

更新日期：1998-12-01 00:00:00

abstract：:The effects of human papillomavirus type 18 (HPV-18) E6 and E7 proteins on global patterns of host gene expression in primary human keratinocytes grown in organotypic raft culture system were assessed. Primary human keratinocytes were infected with retroviruses that express the wild-type HPV-18 E6 and E7 genes from th...

journal_title：Journal of virology

authors： Garner-Hamrick PA,Fostel JM,Chien WM,Banerjee NS,Chow LT,Broker TR,Fisher C

更新日期：2004-09-01 00:00:00

abstract：:A number of naturally occurring hepatitis B virus mutants that cannot synthesize the virus precore protein have been identified. Such mutants have been associated with more severe forms of hepatitis, including fulminant hepatitis. The most common mutation observed is a substitution of G to A in the distal precore gene...

journal_title：Journal of virology

authors： Chen HS,Kew MC,Hornbuckle WE,Tennant BC,Cote PJ,Gerin JL,Purcell RH,Miller RH

更新日期：1992-09-01 00:00:00

abstract：:Restriction factors are intrinsic cellular defense proteins that have evolved to block microbial infections. Retroviruses such as HIV-1 are restricted by TRIM5 proteins, which recognize the viral capsid shell that surrounds, organizes, and protects the viral genome. TRIM5α uses a SPRY domain to bind capsids with low i...

journal_title：Journal of virology

authors： Wagner JM,Christensen DE,Bhattacharya A,Dawidziak DM,Roganowicz MD,Wan Y,Pumroy RA,Demeler B,Ivanov DN,Ganser-Pornillos BK,Sundquist WI,Pornillos O

更新日期：2018-01-30 00:00:00

abstract：:The humoral immune response of cats that were naturally infected with the feline leukemia virus (FeLV) was examined after antigenic stimulation with the synthetic antigen poly(L-Tyr, L-Glu)-poly(DL-Ala)-poly(L-Lys). The primary humoral antibody response in FeLV-infected cats was both delayed and greatly reduced, compa...

journal_title：Journal of virology

authors： Wernicke D,Trainin Z,Ungar-Waron H,Essex M

更新日期：1986-11-01 00:00:00

abstract：:Valproic acid (VPA) is a short-chain fatty acid commonly used for treatment of neurological disorders. As VPA can interfere with cellular lipid metabolism, its effect on the infection of cultured cells by viruses of seven viral families relevant to human and animal health, including eight enveloped and four nonenvelop...

journal_title：Journal of virology

authors： Vázquez-Calvo A,Saiz JC,Sobrino F,Martín-Acebes MA

更新日期：2011-02-01 00:00:00

abstract：:It is well established that chronic viral infections can cause immune suppression, resulting in increased susceptibility to other infectious diseases. However, the effects of chronic viral infection on T-cell responses and vaccination against highly pathogenic viruses are not well understood. We have recently shown th...

journal_title：Journal of virology

authors： Alves-Peixoto P,Férez M,Knudson CJ,Melo-Silva CR,Stotesbury C,Wong EB,Correia-Neves M,Sigal LJ

更新日期：2020-02-14 00:00:00

abstract：:Evidence is presented that, in frog virus 3-infected BHK cells, inhibition of ribonucleic acid (RNA) synthesis is paralleled by a decreased activity of host cell RNA polymerase II, while the template ability of host cell nuclei and chromatin is unaffected. ...

journal_title：Journal of virology

authors： Campadelli-Fiume G,Costanzo F,Mannini-Palenzona A,La Placa M

更新日期：1972-04-01 00:00:00

abstract：:Picornavirus RNAs are uncapped messengers and have unusually long 5' nontranslated regions (5'NTRs) which contain many noninitiating AUG triplets. The translational efficiency of different picornavirus RNAs varies between different cell-free extracts and even in the same extract, such as micrococcal nuclease-treated r...

journal_title：Journal of virology

authors： Jang SK,Kräusslich HG,Nicklin MJ,Duke GM,Palmenberg AC,Wimmer E

更新日期：1988-08-01 00:00:00

abstract：:The herpes simplex virus 1 (HSV-1) multifunctional regulatory protein ICP27 shuttles between the nucleus and cytoplasm in its role as a viral mRNA export factor. Arginine methylation on glycine- and arginine-rich motifs has been shown to regulate protein export. ICP27 contains an RGG box and has been shown to be methy...

journal_title：Journal of virology

authors： Souki SK,Gershon PD,Sandri-Goldin RM

更新日期：2009-06-01 00:00:00

abstract：:Avian leukosis virus subgroup J (ALV-J), an exogenous avian retrovirus, is thought to have evolved by recombination with the highly identical env gene of the endogenous avian retrovirus EAV-HP. Embryonic expression of EAV-HP env has been suggested to be associated with the induction of immunological tolerance, a featu...

journal_title：Journal of virology

authors： Sacco MA,Venugopal K

更新日期：2001-12-01 00:00:00

abstract：:While the cytoplasmic phase of the hepadnavirus replication cycle is well understood, very little is known about the nuclear phase. In contrast to retroviruses, proviral integration is not required for hepadnavirus replication; however, some of the viral DNAs in the nucleus are diverted into an integration pathway. Un...

journal_title：Journal of virology

authors： Gong SS,Jensen AD,Wang H,Rogler CE

更新日期：1995-12-01 00:00:00

abstract：:RIG-I is a major cytoplasmic sensor of viral pathogen-associated molecular pattern (PAMP) RNA and induces type I interferon (IFN) production upon viral infection. A double-stranded RNA (dsRNA)-binding protein, PACT, plays an important role in potentiating RIG-I function. We have shown previously that arenaviral nucleo...

journal_title：Journal of virology

authors： Shao J,Huang Q,Liu X,Di D,Liang Y,Ly H

更新日期：2018-06-13 00:00:00

abstract：:Serial passage of reovirus temperature-sensitive (ts) mutant C(447) produced by passage 9 (P9) a heavily defective population of virus from which the double-stranded RNA genomic segments L(1), L(3), and M(1) were largely missing. Viral cores obtained from this P9 population were heterogeneous with respect to buoyant d...

journal_title：Journal of virology

authors： Ahmed R,Graham AF

更新日期：1977-08-01 00:00:00

abstract：:Purified retrovirus Gag proteins can assemble in vitro into virus-like particles (VLPs) in the presence of RNA. It was shown previously that a Rous sarcoma virus Gag protein missing only the protease domain forms spherical particles resembling immature virions lacking a membrane but that a similar protein missing the ...

journal_title：Journal of virology

authors： Joshi SM,Vogt VM

更新日期：2000-11-01 00:00:00

abstract：:We examined cellular components which associate with p40tax, the viral transactivation molecule of human T-cell leukemia virus type I. Such molecules were searched by immunoprecipitation with polyclonal and monoclonal antibodies specific for p40tax. Two cellular proteins with molecular masses of 95 kDa (p95) and 60 kD...

journal_title：Journal of virology

authors： Nagata K,Ide Y,Takagi T,Ohtani K,Aoshima M,Tozawa H,Nakamura M,Sugamura K

更新日期：1992-02-01 00:00:00

abstract：:Cells infected by Rous-associated virus 61 (RAV-61) contained a precursor-like protein, pr90, that was specifically precipitated by antiserum directed against envelope glycoproteins, gp85 and gp35. Tryptic peptide mapping showed that pr90 contained tryptic sequences of both gp85 and gp35. Pactamycin mapping experiment...

journal_title：Journal of virology

authors： Shealy DJ,Rueckert RR

更新日期：1978-05-01 00:00:00

abstract：:Organotypic cultures support the stratification and differentiation of keratinocytes and the human papillomavirus (HPV) life cycle. We report transcription from four novel promoters in the HPV31b upstream regulatory region during the viral life cycle in organotypic cultures. Promoter initiation was not differentiation...

journal_title：Journal of virology

authors： Ozbun MA,Meyers C

更新日期：1999-04-01 00:00:00

abstract：:The initial virus strains from as many as 12% of individuals with primary human immunodeficiency virus (HIV) infection have a 50% inhibitory concentration

journal_title：Journal of virology

authors： Leigh Brown AJ,Frost SD,Good B,Daar ES,Simon V,Markowitz M,Collier AC,Connick E,Conway B,Margolick JB,Routy JP,Corbeil J,Hellmann NS,Richman DD,Little SJ

更新日期：2004-03-01 00:00:00

abstract：:A cloned DNA copy of simian rotavirus SA11 genomic segment 10 was used to confirm the assignment of the nonstructural glycoprotein NCVP5 to this gene. Determination of the nucleotide sequence for gene 10 indicated that NCVP5 is 175 amino acids in length and has an N-terminal hydrophobic region with the characteristics...

journal_title：Journal of virology

authors： Both GW,Siegman LJ,Bellamy AR,Atkinson PH

更新日期：1983-11-01 00:00:00

abstract：:We have previously demonstrated that two mouse cell lines that are poorly infectible by reovirus become highly susceptible upon transfection with the gene encoding the epidermal growth factor receptor (EGFR) (J. E. Strong, D. Tang, and P. W. K. Lee, Virology 197:405-411, 1993). This enhancement of infection efficiency...

journal_title：Journal of virology

authors： Strong JE,Lee PW

更新日期：1996-01-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pcDC) and myeloid dendritic cells (myDC) are shown to express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both DC types were more susceptible to infection with a macrophage t...

journal_title：Journal of virology

authors： Patterson S,Rae A,Hockey N,Gilmour J,Gotch F

更新日期：2001-07-01 00:00:00

abstract：:Replication of the human herpesvirus Epstein-Barr virus drastically impairs cellular protein synthesis. This shutoff phenotype results from mRNA degradation upon expression of the early lytic-phase protein BGLF5. Interestingly, BGLF5 is the viral DNase, or alkaline exonuclease, homologues of which are present througho...

journal_title：Journal of virology

authors： Horst D,Burmeister WP,Boer IG,van Leeuwen D,Buisson M,Gorbalenya AE,Wiertz EJ,Ressing ME

更新日期：2012-09-01 00:00:00

abstract：:Adeno-associated virus (AAV) is a member of the Parvoviridae, belonging to the Dependovirus genus. Currently, several distinct isolates of AAV are in development for use in human gene therapy applications due to their ability to transduce different target cells. The need to manipulate AAV capsids for specific tissue d...

journal_title：Journal of virology

authors： Padron E,Bowman V,Kaludov N,Govindasamy L,Levy H,Nick P,McKenna R,Muzyczka N,Chiorini JA,Baker TS,Agbandje-McKenna M

更新日期：2005-04-01 00:00:00

abstract：:Merkel cell polyomavirus (MCV) is a recently discovered human polyomavirus causing the majority of human Merkel cell carcinomas. We mapped a 71-bp minimal MCV replication core origin sufficient for initiating eukaryotic DNA replication in the presence of wild-type MCV large T protein (LT). The origin includes a poly(T...

journal_title：Journal of virology

authors： Kwun HJ,Guastafierro A,Shuda M,Meinke G,Bohm A,Moore PS,Chang Y

更新日期：2009-12-01 00:00:00

abstract：UNLABELLED:Tetherin (BST2, CD317, or HM1.24) is a host cellular restriction factor that prevents the release of enveloped viruses by mechanically linking virions to the plasma membrane. The precise arrangement of tetherin molecules at the plasma membrane site of HIV-1 assembly, budding, and restriction is not well unde...

journal_title：Journal of virology

authors： Strauss JD,Hammonds JE,Yi H,Ding L,Spearman P,Wright ER

更新日期：2015-11-18 00:00:00

abstract：UNLABELLED:The antiviral role of TRIM E3 ligases in vivo is not fully understood. To test the hypothesis that TRIM5α and TRIM22 have differential transcriptional regulation and distinct anti-HIV roles according to infection phase and compartment, we measured TRIM5α, TRIM22, and type I interferon (IFN-I)-inducible myxov...

journal_title：Journal of virology

authors： Singh R,Patel V,Mureithi MW,Naranbhai V,Ramsuran D,Tulsi S,Hiramen K,Werner L,Mlisana K,Altfeld M,Luban J,Kasprowicz V,Dheda K,Abdool Karim SS,Ndung'u T

更新日期：2014-04-01 00:00:00

abstract：:Previous findings of low levels of reverse transcriptase (RT) activity in chick cell-derived measles and mumps vaccines showed this activity to be associated with virus particles containing RNA of both subgroup E endogenous avian leukosis viruses (ALV-E) and endogenous avian viruses (EAV). These particles originate fr...

journal_title：Journal of virology

authors： Johnson JA,Heneine W

更新日期：2001-04-01 00:00:00

abstract：:An alternatively spliced form of c-myb exists that encodes an additional 120 amino acids in chicken and 121 amino acids in human and mouse. These amino acids are encoded by an additional exon, termed exon 9A. This exon is not present in v-myb, and proteins containing these amino acids have never been tested for oncoge...

journal_title：Journal of virology

authors： Woo CH,Sopchak L,Lipsick JS

更新日期：1998-08-01 00:00:00