Abstract:
:Valproic acid (VPA) is a short-chain fatty acid commonly used for treatment of neurological disorders. As VPA can interfere with cellular lipid metabolism, its effect on the infection of cultured cells by viruses of seven viral families relevant to human and animal health, including eight enveloped and four nonenveloped viruses, was analyzed. VPA drastically inhibited multiplication of all the enveloped viruses tested, including the zoonotic lymphocytic choriomeningitis virus and West Nile virus (WNV), while it did not affect infection by the nonenveloped viruses assayed. VPA reduced vesicular stomatitis virus infection yield without causing a major blockage of either viral RNA or protein synthesis. In contrast, VPA drastically abolished WNV RNA and protein synthesis, indicating that this drug can interfere the viral cycle at different steps of enveloped virus infection. Thus, VPA can contribute to an understanding of the crucial steps of viral maturation and to the development of future strategies against infections associated with enveloped viruses.
journal_name
J Viroljournal_title
Journal of virologyauthors
Vázquez-Calvo A,Saiz JC,Sobrino F,Martín-Acebes MAdoi
10.1128/JVI.01717-10subject
Has Abstractpub_date
2011-02-01 00:00:00pages
1267-74issue
3eissn
0022-538Xissn
1098-5514pii
JVI.01717-10journal_volume
85pub_type
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