Single-dose vaccination of a recombinant parainfluenza virus 5 expressing NP from H5N1 virus provides broad immunity against influenza A viruses.

abstract：:High concentrations of either trypsin or chymotrypsin caused nearly complete cleavage of capsid protein VP2 of hepatitis A virus but did not significantly reduce the infectivity, thermostability, or antigenicity of the virus. Chymotrypsin also had a lesser effect on VP1. These findings indicate the presence of a prote...

journal_title：Journal of virology

authors： Lemon SM,Amphlett E,Sangar D

更新日期：1991-10-01 00:00:00

abstract：:During infection, adenovirus-associated virus (AAV) undergoes microtubule-dependent retrograde transport as part of a program of vectorial transport of viral genome to the nucleus. A microtubule binding assay was used to evaluate the hypothesis that cytoplasmic dynein mediates AAV interaction with microtubules. Bindin...

journal_title：Journal of virology

authors： Kelkar S,De BP,Gao G,Wilson JM,Crystal RG,Leopold PL

更新日期：2006-08-01 00:00:00

abstract：UNLABELLED:During the chronic phase of HIV-1 infection, polyfunctional CD8+ T cell responses, which are characterized by a high frequency of cells able to secrete multiple cytokines simultaneously, are associated with lower virus loads and slower disease progression. This relationship may arise for different reasons. P...

journal_title：Journal of virology

authors： Graw F,Regoes RR

更新日期：2014-09-01 00:00:00

abstract：:Translation of early RNA specific for the leftmost early region 1 of adenovirus type 5 DNA in a rabbit reticulocyte cell-free system resulted in the synthesis of proteins with the following molecular weights: 65,000 (65K), 54K, 42 to 34K, 29K, 25K, 19K, and 18K. All of these proteins could be immunoprecipitated with h...

journal_title：Journal of virology

authors： Lupker JH,Davis A,Jochemsen H,van der Eb AJ

更新日期：1981-01-01 00:00:00

abstract：:It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity and led to in vivo attenuation. Pathogenicity was recovered in mutants that also regained E prot...

journal_title：Journal of virology

authors： To J,Surya W,Fung TS,Li Y,Verdià-Bàguena C,Queralt-Martin M,Aguilella VM,Liu DX,Torres J

更新日期：2017-02-14 00:00:00

abstract：:Murine leukemia viruses isolated from radiation-induced BALB/c leukemias were characterized with respect to viral proteins and RNA. Analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the viral structural proteins revealed that for p12, p15, p30, and gp70, three of four electrophoretic variants of...

journal_title：Journal of virology

authors： Ellis RW,Hopkins N,Fleissner E

更新日期：1980-02-01 00:00:00

abstract：:Hypervariable region 5 (HVR5) is a hydrophilic, serotypically nonconserved loop of the hexon monomer which extrudes from the adenovirus (Ad) capsid. We have replaced the HVR5 sequence of Ad5 with that of heterologous peptides and studied their effects on virus viability and peptide accessibility. A poliovirus model ep...

journal_title：Journal of virology

authors： Vigne E,Mahfouz I,Dedieu JF,Brie A,Perricaudet M,Yeh P

更新日期：1999-06-01 00:00:00

abstract：:We have investigated the ability of human immunodeficiency virus type 1 (HIV-1) and HIV-2 isolates to infect and replicate in primary human macrophages. Monocytes from blood donors were allowed to differentiate into macrophages by culture in the presence of autologous lymphocytes and human serum for 5 days before infe...

journal_title：Journal of virology

authors： Valentin A,Albert J,Fenyö EM,Asjö B

更新日期：1994-10-01 00:00:00

abstract：:Upon inoculation into AKR mice, mink cell focus-forming murine leukemia virus (MCF MLV) accelerates thymic lymphoma formation. During the preleukemic phase of disease, we observed the induction of apoptosis in thymic lymphocytes. A similar induction of apoptosis was observed for cultured mink epithelial cells after MC...

journal_title：Journal of virology

authors： Nanua S,Yoshimura FK

更新日期：2004-05-01 00:00:00

abstract：:Sequences of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) domain were determined by direct sequencing of HIV-1 RNA in successive plasma samples from eight seroconverting patients infected with virus bearing the T215Y/F amino acid substitution associated with zidovudine (ZDV) resistance. A...

journal_title：Journal of virology

authors： Yerly S,Rakik A,De Loes SK,Hirschel B,Descamps D,Brun-Vézinet F,Perrin L

更新日期：1998-05-01 00:00:00

abstract：:Utilization of internal ribosome entry segment (IRES) structures in the 5' noncoding region (5'NCR) of picornavirus RNAs for initiation of translation requires a number of host cell factors whose distribution may vary in different cells and whose requirement may vary for different picornaviruses. We have examined the ...

journal_title：Journal of virology

authors： Graff J,Cha J,Blyn LB,Ehrenfeld E

更新日期：1998-12-01 00:00:00

abstract：:The double-stranded-DNA bacteriophages employ powerful molecular motors to translocate genomic DNA into preformed capsids during the packaging step in phage assembly. Bacillus subtilis bacteriophage 29 has an oligomeric prohead RNA (pRNA) that is an essential component of its packaging motor. The crystal structure of ...

journal_title：Journal of virology

authors： Zhao W,Saha M,Ke A,Morais MC,Jardine PJ,Grimes S

更新日期：2012-11-01 00:00:00

abstract：:Interleukin-10 (IL-10) suppresses the maturation and cytokine production of dendritic cells (DCs), key regulators of adaptive immunity, and prevents the activation and polarization of naïve T cells towards protective gamma interferon-producing effectors. We hypothesized that human cytomegalovirus (HCMV) utilizes its v...

journal_title：Journal of virology

authors： Chang WL,Baumgarth N,Yu D,Barry PA

更新日期：2004-08-01 00:00:00

abstract：:Herpes simplex virus (HSV) strains HSV type 1 (HSV-1) KOS and HSV-2 186 are representative of delayed and early shutoff strains, respectively, with regard to their ability to inhibit protein synthesis in Friend erythroleukemia cells. When these cells were simultaneously infected with HSV-1 KOS and HSV-2 186, HSV-1 KOS...

journal_title：Journal of virology

authors： Hill TM,Sadler JR,Betz JL

更新日期：1985-10-01 00:00:00

abstract：:JC virus (JCV) is a DNA virus causing progressive multifocal leukoencephalopathy (PML) in immunodeficient patients. In the present study, 22 genetic quasispecies with more than 1.5% variant frequency were detected in JCV genomes from six clinical samples of PML by next-generation sequencing. A mutation from A to C at ...

journal_title：Journal of virology

authors： Takahashi K,Sekizuka T,Fukumoto H,Nakamichi K,Suzuki T,Sato Y,Hasegawa H,Kuroda M,Katano H

更新日期：2016-12-16 00:00:00

abstract：:The envelope glycoproteins of the human immunodeficiency virus (HIV) type 1 are synthesized as a precursor molecule, gp160, which is cleaved to generate the two mature envelope glycoproteins, gp120 and gp41. The cleavage reaction, which is mediated by a host protease, occurs at a sequence highly conserved in retrovira...

journal_title：Journal of virology

authors： Freed EO,Myers DJ,Risser R

更新日期：1989-11-01 00:00:00

abstract：:We have analyzed the mechanism by which the matrix (M1) protein associates with cellular membranes during influenza A virus assembly. Interaction of the M1 protein with the viral hemagglutinin (HA) or neuraminidase (NA) glycoprotein was extensively analyzed by using wild-type and transfectant influenza viruses as well...

journal_title：Journal of virology

authors： Enami M,Enami K

更新日期：1996-10-01 00:00:00

abstract：:The N terminus of the capsid protein (CA) undergoes a considerable conformational change when the human immunodeficiency virus (HIV) protease cleaves it free from the Pr55(Gag) polyprotein. This rearrangement is thought to facilitate the establishment of specific CA-CA interactions that are required for the formation ...

journal_title：Journal of virology

authors： Rue SM,Roos JW,Amzel LM,Clements JE,Barber SA

更新日期：2003-07-01 00:00:00

abstract：:The reovirus core particle is a molecular machine that mediates synthesis, capping, and export of the viral plus strand RNA transcripts. Its assembly and structure-function relationships remain to be well understood. Following the lead of previous studies with other Reoviridae family members, most notably orbiviruses ...

journal_title：Journal of virology

authors： Kim J,Zhang X,Centonze VE,Bowman VD,Noble S,Baker TS,Nibert ML

更新日期：2002-12-01 00:00:00

abstract：:Although adeno-associated virus type 2 (AAV) has gained attention as a potentially useful vector for human gene therapy, the transduction efficiencies of AAV vectors vary greatly in different cells and tissues in vitro and in vivo. We have documented that a cellular tyrosine phosphoprotein, designated the single-stran...

journal_title：Journal of virology

authors： Qing K,Hansen J,Weigel-Kelley KA,Tan M,Zhou S,Srivastava A

更新日期：2001-10-01 00:00:00

abstract：:In all retroviruses analyzed to date (except for the spumaretroviruses), the Zn(2+)-coordinating residues of nucleocapsid (NC) perform or assist in crucial reactions necessary to complete the retrovirus life cycle. Six replication-defective mutations have been engineered in the two NC Zn(2+) fingers (ZFs) of simian im...

journal_title：Journal of virology

authors： Yovandich JL,Chertova EN,Kane BP,Gagliardi TD,Bess JW Jr,Sowder RC 2nd,Henderson LE,Gorelick RJ

更新日期：2001-01-01 00:00:00

abstract：:Identifying protease cleavage sites contributes to our understanding of their specificity and biochemical properties and can help in designing specific inhibitors. One route to this end is the generation and screening of random libraries of cleavage sites. Both synthetic and phage-displayed libraries have been extensi...

journal_title：Journal of virology

authors： Pacini L,Vitelli A,Filocamo G,Bartholomew L,Brunetti M,Tramontano A,Steinkühler C,Migliaccio G

更新日期：2000-11-01 00:00:00

abstract：:The Tf1 retrotransposon of Schizosaccharomyces pombe represents a group of eukaryotic long terminal repeat (LTR) retroelements that, based on their sequences, were predicted to use an RNA self-primer for initiating reverse transcription while synthesizing the negative-sense DNA strand. This feature is substantially di...

journal_title：Journal of virology

authors： Hizi A

更新日期：2008-11-01 00:00:00

abstract：:The nature and theory of flow field-flow fractionation is described, and its potential applicability to virus-like particles is discussed. Different virus types are shown to be retained at different levels. Retention can be controlled by variation of the experimental parameters, in good agreement with theory. However,...

journal_title：Journal of virology

authors： Giddings JC,Yang FJ,Myers MN

更新日期：1977-01-01 00:00:00

abstract：:Polyamine depletion produced by exogenous arginine in Escherichia coliK-12 cultures defective in agmatine ureohydrolase activity resulted in a marked inhibition of the rates of growth and nucleic acid synthesis. Addition of putrescine or spermidine to such depleted cultures restored the control rate of growth and nucl...

journal_title：Journal of virology

authors： Dion AS,Cohen SS

更新日期：1972-03-01 00:00:00

abstract：:Many replication events are involved in the influenza A virus life cycle, and they are accomplished by different virus proteins with specific functions. However, because the size of the influenza virus genome is limited, the virus uses different mechanisms to express multiple viral proteins from a single gene segment....

journal_title：Journal of virology

authors： Muramoto Y,Noda T,Kawakami E,Akkina R,Kawaoka Y

更新日期：2013-03-01 00:00:00

abstract：:During the acute phase of infection with influenza A virus, the degree of lymphopenia correlates with severity of disease. Factors that contribute to T-cell activation during influenza virus infection may contribute to this observation. Since the immune response is initiated when dendritic cells (DC) interact with T c...

journal_title：Journal of virology

authors： Oh S,McCaffery JM,Eichelberger MC

更新日期：2000-06-01 00:00:00

abstract：:Bats are the second largest group of mammals on earth and act as reservoirs of many emerging viruses. In this study, a novel bat adenovirus (AdV) (BtAdV-TJM) was isolated from bat fecal samples by using a bat primary kidney cell line. Infection studies indicated that most animal and human cell lines are susceptible to...

journal_title：Journal of virology

authors： Li Y,Ge X,Zhang H,Zhou P,Zhu Y,Zhang Y,Yuan J,Wang LF,Shi Z

更新日期：2010-04-01 00:00:00

abstract：:Astrovirus is one of the major causes of infant and childhood diarrhea worldwide. Our understanding of astrovirus pathogenesis trails behind our knowledge of its molecular and epidemiologic properties. Using a recently developed small-animal model, we investigated the mechanisms by which astrovirus induces diarrhea an...

journal_title：Journal of virology

authors： Koci MD,Kelley LA,Larsen D,Schultz-Cherry S

更新日期：2004-02-01 00:00:00

abstract：:Transgenic mice expressing the simian virus 40 large T antigen (TAg) in enterocytes develop intestinal hyperplasia that progresses to dysplasia with age. This induction requires TAg action on the retinoblastoma (Rb) family of tumor suppressors and is independent of the p53 pathway. In cell culture systems, the inactiv...

journal_title：Journal of virology

authors： Rathi AV,Sáenz Robles MT,Pipas JM

更新日期：2007-09-01 00:00:00