Switch to unusual amino acids at codon 215 of the human immunodeficiency virus type 1 reverse transcriptase gene in seroconvertors infected with zidovudine-resistant variants.

abstract：:Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is known to take an endosomal pathway for cell entry; however, it is thought to enter directly from the cell surface when a receptor-bound virion spike (S) protein is affected by trypsin, which induces cleavage of the S protein and activates its fusion po...

journal_title：Journal of virology

authors： Watanabe R,Matsuyama S,Shirato K,Maejima M,Fukushi S,Morikawa S,Taguchi F

更新日期：2008-12-01 00:00:00

abstract：:Immunity to human immunodeficiency virus virion-like structures or a polyprotein has been examined after DNA immunization with Rev-independent expression vectors. A Gag-Pol fusion protein stimulated cytotoxic T lymphocyte and antibody responses to Gag and Pol, while a Gag-Pol pseudoparticle did not elicit substantial ...

journal_title：Journal of virology

authors： Huang Y,Kong WP,Nabel GJ

更新日期：2001-05-01 00:00:00

abstract：:Herpes B virus (BV) naturally infects macaque monkeys and is genetically similar to herpes simplex virus (HSV). Zoonotic infection of humans can cause encephalitis and if untreated has a fatality rate of ∼80%. The frequent use of macaques in biomedical research emphasizes the need to understand the molecular basis of ...

journal_title：Journal of virology

authors： Amen MA,Griffiths A

更新日期：2011-07-01 00:00:00

abstract：:To determine mechanisms by which persistent viral infections are established and maintained, we initiated persistent infections of murine erythroleukemia (MEL) cells by using reovirus strains type 3 Abney and type 3 Dearing. Establishment of persistent reovirus infections of MEL cells was not associated with a signifi...

journal_title：Journal of virology

authors： Wetzel JD,Chappell JD,Fogo AB,Dermody TS

更新日期：1997-01-01 00:00:00

abstract：:Mouse cytomegalovirus (MCMV) encodes two potential seven-transmembrane-spanning proteins with homologies to cellular chemokine receptors, M33 and M78. While these virus-encoded chemokine receptors are necessary for the in vivo pathogenesis of MCMV, the function of these proteins is unknown. Since vascular smooth muscl...

journal_title：Journal of virology

authors： Melnychuk RM,Smith P,Kreklywich CN,Ruchti F,Vomaske J,Hall L,Loh L,Nelson JA,Orloff SL,Streblow DN

更新日期：2005-08-01 00:00:00

abstract：:Adenovirus E1B 55K protein cooperates with E1A gene products to induce cell transformation. E1B 55K mediates its effects by binding to and inhibiting the transcriptional activation and growth-suppression functions of the tumor suppressor p53. Previous studies in vivo have suggested that E1B 55K has an active role in r...

journal_title：Journal of virology

authors： Martin ME,Berk AJ

更新日期：1998-04-01 00:00:00

abstract：:Autographa californica nuclear polyhedrosis virus (AcMNPV) is a double-stranded DNA virus that expresses several immediate-early genes under the control of different promoters. The expression of one of these transcription units, IE-N, is shown here, by a transient expression assay, to be regulated by both cis- and tra...

journal_title：Journal of virology

authors： Carson DD,Summers MD,Guarino LA

更新日期：1991-02-01 00:00:00

abstract：:JC polyomavirus (JCV) infection is highly prevalent and usually kept in a persistent state without clinical signs and symptoms. It is only during immunocompromise and especially impaired CD4(+) T cell function in the brain, as seen in AIDS patients or natalizumab-treated multiple sclerosis patients, that JCV may cause...

journal_title：Journal of virology

authors： Jelcic I,Aly L,Binder TM,Jelcic I,Bofill-Mas S,Planas R,Demina V,Eiermann TH,Weber T,Girones R,Sospedra M,Martin R

更新日期：2013-03-01 00:00:00

abstract：:Divergent Toll-like receptor 7 (TLR7) and TLR9 signaling has been proposed to distinguish pathogenic from nonpathogenic simian immunodeficiency virus infection in primate models. We demonstrate here that increased expression of type I interferon in pathogenic rhesus macaques compared to nonpathogenic African green mon...

journal_title：Journal of virology

authors： Campillo-Gimenez L,Laforge M,Fay M,Brussel A,Cumont MC,Monceaux V,Diop O,Lévy Y,Hurtrel B,Zaunders J,Corbeil J,Elbim C,Estaquier J

更新日期：2010-02-01 00:00:00

abstract：:YY1 is a zinc finger transcription factor which acts as either a repressor or an activator dependent on the promoter context. YY1 is a potent activator of the genuine human papillomavirus type 18 (HPV-18) upstream regulatory region (URR) in HeLa cells, which are known for high-level expression of the HPV-18 early gene...

journal_title：Journal of virology

authors： Bauknecht T,Jundt F,Herr I,Oehler T,Delius H,Shi Y,Angel P,Zur Hausen H

更新日期：1995-01-01 00:00:00

abstract：:Primary telencephalic cultures derived from neonatal Wistar Furth rats were able to support the growth of coronavirus JHM if a viable neuronal population was maintained. This occurred under serum-free defined, but not serum-supplemented, growth conditions. The importance of neurons in establishing infections in mixed ...

journal_title：Journal of virology

authors： Pasick JM,Dales S

更新日期：1991-09-01 00:00:00

abstract：:Understanding how viral components collaborate to convert the human immunodeficiency virus type 1 genome from single-stranded RNA into double-stranded DNA is critical to the understanding of viral replication. Not only must the correct reactions be carried out, but unwanted side reactions must be avoided. After minus-...

journal_title：Journal of virology

authors： Driscoll MD,Hughes SH

更新日期：2000-10-01 00:00:00

abstract：:It has been previously shown that rotavirus maturation and stability of the outer capsid are calcium-dependent processes. More recently, it has been hypothesized that penetration of the cell membrane is also affected by conformational changes of the capsid induced by Ca2+. In this study, we determined quantitatively t...

journal_title：Journal of virology

authors： Ruiz MC,Charpilienne A,Liprandi F,Gajardo R,Michelangeli F,Cohen J

更新日期：1996-08-01 00:00:00

abstract：:Borna disease virus (BDV) uses a unique strategy of replication and transcription which takes place in the nucleus, unlike other known, nonsegmented, negative-stranded RNA viruses of animal origin. In this process, viral constituents necessary for replication must be transported to the nucleus from the cytoplasm. We r...

journal_title：Journal of virology

authors： Shoya Y,Kobayashi T,Koda T,Ikuta K,Kakinuma M,Kishi M

更新日期：1998-12-01 00:00:00

abstract：:Two forms of herpes simplex virus glycoprotein gD were recombined into Autographa californica nuclear polyhedrosis virus (baculovirus) and expressed in infected Spodoptera frugiperda (Sf9) cells. Each protein was truncated at residue 306 of mature gD. One form, gD-1(306t), contains the coding sequence of Patton strain...

journal_title：Journal of virology

authors： Sisk WP,Bradley JD,Leipold RJ,Stoltzfus AM,Ponce de Leon M,Hilf M,Peng C,Cohen GH,Eisenberg RJ

更新日期：1994-02-01 00:00:00

abstract：:The immune response to viral glycoproteins is often directed against conformation- and/or glycosylation-dependent structures; synthetic peptides and bacterially expressed proteins are inadequate probes for the mapping of such epitopes. This report describes a retroviral vector system that presents such native epitopes...

journal_title：Journal of virology

authors： Kayman SC,Wu Z,Revesz K,Chen H,Kopelman R,Pinter A

更新日期：1994-01-01 00:00:00

abstract：:TRIM5α is a natural resistance factor that binds retroviral capsid proteins and restricts virus replication. The B30.2/SPRY domain of TRIM5α is polymorphic in rhesus macaques, and some alleles are associated with reduced simian immunodeficiency virus (SIV) SIV(mac251) and SIV(smE543) replication in vivo. We determined...

journal_title：Journal of virology

authors： Fenizia C,Keele BF,Nichols D,Cornara S,Binello N,Vaccari M,Pegu P,Robert-Guroff M,Ma ZM,Miller CJ,Venzon D,Hirsch V,Franchini G

更新日期：2011-12-01 00:00:00

abstract：:The p24 protein, one of the three proteins implicated in local movement of potato virus X (PVX), was expressed in transgenic tobacco plants (Nicotiana tabacum Xanthi D8 NN). Plants with the highest level of p24 accumulation exhibited a stunted and slightly chlorotic phenotype. These transgenic plants facilitate the ce...

journal_title：Journal of virology

authors： Ares X,Calamante G,Cabral S,Lodge J,Hemenway P,Beachy RN,Mentaberry A

更新日期：1998-01-01 00:00:00

abstract：:Despite the long-standing observation that herpes simplex virus (HSV) latency-associated transcript (LAT) promoter deletion viruses show impaired recurrence phenotypes in relevant animal models, the mechanism by which these sequences exert this phenotypic effect is unknown. We constructed and evaluated four mutant HSV...

journal_title：Journal of virology

authors： Kawamura Y,Bosch-Marce M,Tang S,Patel A,Krause PR

更新日期：2018-06-29 00:00:00

abstract：:In vitro transcription by vesicular stomatitis virus nucleocapsids is inhibited by enzymatic dephosphorylation of the NS protein. We provide evidence that specific, partial dephosphorylation of NS molecules is the only detectable change in nucleocapsids treated with bacterial alkaline phosphatase under conditions that...

journal_title：Journal of virology

authors： Hsu CH,Morgan EM,Kingsbury DW

更新日期：1982-07-01 00:00:00

abstract：:Several aspects of the terminal stages of T4 head maturation were investigated using ts and am mutants blocked at single steps of the assembly pathway. We had previously found that cells infected with mutants of gene 13, e.g., tsN38 and amE609, accumulated both stable (10 to 20%)- and fragile (80%)-filled head precurs...

journal_title：Journal of virology

authors： Hamilton DL,Luftig RB

更新日期：1976-02-01 00:00:00

abstract：:The attachment of lymphocytic choriomeningitis virus (LCMV) to murine and primate cell lines was quantitated by a fluorescence-activated cell sorter assay in which binding of biotinylated virus was detected with streptavidin-fluorescein isothiocyanate. Cell lines that were readily infected by LCMV (e.g., MC57, Rin, BH...

journal_title：Journal of virology

authors： Borrow P,Oldstone MB

更新日期：1992-12-01 00:00:00

abstract：:The human T-cell leukemia virus type I (HTLV-I) envelope protein is synthesized as a gp61 precursor product cleaved into two mature proteins, a gp45 exterior protein and a gp20 anchoring the envelope at the cell membrane. Using N-glycosylation inhibitors and site-directed mutagenesis of the potential glycosylation sit...

journal_title：Journal of virology

authors： Pique C,Pham D,Tursz T,Dokhélar MC

更新日期：1992-02-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) infection causes adult T-cell leukemia (ATL), which is frequently resistant to currently available therapies and has a very poor prognosis. To prevent the development of ATL among carriers, it is important to control HTLV-1-infected cells in infected individuals. Therefore, ...

journal_title：Journal of virology

authors： Tezuka K,Okuma K,Kuramitsu M,Matsuoka S,Tanaka R,Tanaka Y,Hamaguchi I

更新日期：2018-01-30 00:00:00

abstract：:The adenovirus major late promoter (MLP) is active during both the early and late phases of infection. During the early phase the activity of the MLP is similar to those of the other early viral promoters, but during the late phase the rate of transcription from the MLP becomes much greater by comparison. We report he...

journal_title：Journal of virology

authors： Leong K,Lee W,Berk AJ

更新日期：1990-01-01 00:00:00

abstract：:RIG-I is a major cytoplasmic sensor of viral pathogen-associated molecular pattern (PAMP) RNA and induces type I interferon (IFN) production upon viral infection. A double-stranded RNA (dsRNA)-binding protein, PACT, plays an important role in potentiating RIG-I function. We have shown previously that arenaviral nucleo...

journal_title：Journal of virology

authors： Shao J,Huang Q,Liu X,Di D,Liang Y,Ly H

更新日期：2018-06-13 00:00:00

abstract：:Enteroviral persistence has been implicated in the pathogenesis of several chronic human diseases, including dilated cardiomyopathy, insulin-dependent diabetes mellitus, and chronic inflammatory myopathy. However, these viruses are considered highly cytolytic, and it is unclear what mechanisms might permit their long-...

journal_title：Journal of virology

authors： Feuer R,Mena I,Pagarigan R,Slifka MK,Whitton JL

更新日期：2002-05-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV/human herpesvirus 8 [HHV-8]) is a gamma-2-herpesvirus responsible for Kaposi's sarcoma as well as primary effusion lymphoma (PEL). KSHV is a lymphotropic virus that has pirated many mammalian genes involved in inflammation, cell cycle control, and angiogenesis. Among these...

journal_title：Journal of virology

authors： Cannon M,Philpott NJ,Cesarman E

更新日期：2003-01-01 00:00:00

abstract：:We have been studying defective interfering (DI) genomes of the RNA enveloped virus Sindbis virus. Deletion mapping of a DI cDNA demonstrated that only sequences at the 3' and 5' termini of the genome are required for the DI RNA to be biologically active. We constructed a series of cDNAs that transcribe DI RNAs differ...

journal_title：Journal of virology

authors： Tsiang M,Weiss BG,Schlesinger S

更新日期：1988-01-01 00:00:00

abstract：:West Nile virus (WNV) replicates in the skin; however, cell targets in the skin have not been identified. In the current studies, WNV infected the epidermis and adnexal glands of mouse skin, and the epidermal cells were identified as keratinocytes by double labeling for WNV antigen and keratin 10. Inoculation of mice ...

journal_title：Journal of virology

authors： Lim PY,Behr MJ,Chadwick CM,Shi PY,Bernard KA

更新日期：2011-05-01 00:00:00