A novel human cytomegalovirus glycoprotein, gpUS9, which promotes cell-to-cell spread in polarized epithelial cells, colocalizes with the cytoskeletal proteins E-cadherin and F-actin.

abstract：:BCX 2798 (4-azido-5-isobutyrylamino-2,3-didehydro-2,3,4,5-tetradeoxy-d-glycero-d-galacto-2-nonulopyranosic acid) effectively inhibited the activities of the hemagglutinin-neuraminidase (HN) of human parainfluenza viruses (hPIV) in vitro and protected mice from lethal infection with a recombinant Sendai virus whose HN ...

journal_title：Journal of virology

authors： Alymova IV,Taylor G,Mishin VP,Watanabe M,Murti KG,Boyd K,Chand P,Babu YS,Portner A

更新日期：2008-09-01 00:00:00

abstract：:A specific endoribonucleolytic activity was detected when detergent-lysed vesicular stomatitis of Sendai virus was incubated with the precursor to Escherichia coli tRNA Tyr. The cleavage products produced and the characteristics of the reaction were similar to those previously reported for human KB cell RNase NU. Like...

journal_title：Journal of virology

authors： Kolakofsky D,Altman S

更新日期：1978-01-01 00:00:00

abstract：:Nonstructural protein 5A of the hepatitis C virus (HCV) is a highly phosphorylated molecule implicated in multiple interactions with the host cell and most likely involved in RNA replication. Two phosphorylated variants of NS5A have been described, designated according to their apparent molecular masses (in kilodalton...

journal_title：Journal of virology

authors： Appel N,Pietschmann T,Bartenschlager R

更新日期：2005-03-01 00:00:00

abstract：:The uncoating of adenovirus type 2 and a temperature-sensitive mutant, tsl, was studied. HEp-2 cells were infected with 32P- OR 125I-labeled purified virions for various lengths of time, and the nuclear and cytoplasmic fractions were analyzed by sucrose gradient velocity sedimentation and sodium dodecyl sulfate-polyac...

journal_title：Journal of virology

authors： Mirza MA,Weber J

更新日期：1979-05-01 00:00:00

abstract：:The mechanism whereby picornaviruses inhibit host protein synthesis while their own synthetic processes proceed unabated has remained elusive. One of our approaches to this problem was to study the ability of cell-free extracts derived from uninfected and mengovirus-infected Ehrlich ascites tumor cells to translate vi...

journal_title：Journal of virology

authors： Abreu SL,Lucas-Lenard J

更新日期：1976-04-01 00:00:00

abstract：:Human erythroid progenitor cells are the main target cells of the human parvovirus B19 (B19), and B19 infection induces a transient erythroid aplastic crisis. Several authors have reported that the nonstructural protein 1 (NS-1) encoded by this virus has a cytotoxic effect, but the underlying mechanism of NS-1-induced...

journal_title：Journal of virology

authors： Sol N,Le Junter J,Vassias I,Freyssinier JM,Thomas A,Prigent AF,Rudkin BB,Fichelson S,Morinet F

更新日期：1999-10-01 00:00:00

abstract：UNLABELLED:Protease is essential for retroviral replication, and protease inhibitors (PI) are important for treating HIV infection. HIV-2 exhibits intrinsic resistance to most FDA-approved HIV-1 PI, retaining clinically useful susceptibility only to lopinavir, darunavir, and saquinavir. The mechanisms for this resistan...

journal_title：Journal of virology

authors： Raugi DN,Smith RA,Gottlieb GS,University of Washington-Dakar HIV-2 Study Group.

更新日期：2015-11-11 00:00:00

abstract：:Misfolded alpha-synuclein (αS) may exhibit a number of characteristics similar to those of the prion protein, including the apparent ability to spread along neuroanatomical connections. The demonstration for this mechanism of spread is largely based on the intracerebral injections of preaggregated αS seeds in mice, in...

journal_title：Journal of virology

authors： Ayers JI,Riffe CJ,Sorrentino ZA,Diamond J,Fagerli E,Brooks M,Galaleldeen A,Hart PJ,Giasson BI

更新日期：2018-08-29 00:00:00

abstract：:Sonchus yellow net virus is a plant nucleorhabdovirus whose nucleocapsid (N), phosphoprotein (P), and polymerase (L) proteins form large viroplasms in the nuclei of infected plants (C. R. F. Martins, J. A. Johnson, D. M. Lawrence, T. J. Choi, A. Pisi, S. L. Tobin, D. Lapidus, J. D. O. Wagner, S. Ruzin, K. McDonald, an...

journal_title：Journal of virology

authors： Deng M,Bragg JN,Ruzin S,Schichnes D,King D,Goodin MM,Jackson AO

更新日期：2007-05-01 00:00:00

abstract：:The effect of guanidine on the replication of the group A arboviruses, Sindbis virus, and Semliki Forest virus (SFV) was studied. Guanidine rapidly, but reversibly, inhibited SFV ribonucleic acid (RNA) synthesis. The synthesis of all species of viral RNA was inhibited, but that of ribonuclease-resistant forms was leas...

journal_title：Journal of virology

authors： Friedman RM

更新日期：1970-11-01 00:00:00

abstract：:Vaccine-induced memory is necessary for protective immunity to pathogens, but many viruses induce a state of transient immune suppression that might contribute to the inability of a vaccine to elicit immunity. We evaluated here the fate of bystander T cells activated by third party cognate antigens during acute viral ...

journal_title：Journal of virology

authors： Marshall HD,Urban SL,Welsh RM

更新日期：2011-06-01 00:00:00

abstract：:Human adenoviruses typically cause mild infections in the upper or lower respiratory tract, gastrointestinal tract, or ocular epithelium. However, adenoviruses may be life-threatening in patients with impaired immunity and some serotypes cause epidemic outbreaks. Attachment to host cell receptors activates cell signal...

journal_title：Journal of virology

authors： Zeng X,Carlin CR

更新日期：2013-02-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (gammaHV68) provides an important experimental model for understanding mechanisms of immune control of the latent human gammaherpesviruses. Antiviral CD8 T cells play a key role throughout three separate phases of the infection: clearance of lytic virus, control of the latency amplification ...

journal_title：Journal of virology

authors： Freeman ML,Lanzer KG,Cookenham T,Peters B,Sidney J,Wu TT,Sun R,Woodland DL,Sette A,Blackman MA

更新日期：2010-03-01 00:00:00

abstract：:The DNA of lymphomas from 12 AKXD recombinant inbred mouse strains was analyzed to determine the presence of somatically acquired ecotropic and mink cell focus-forming proviruses. Mink cell focus-forming proviruses were associated primarily with T-cell lymphomas, whereas ecotropic proviruses were associated with lymph...

journal_title：Journal of virology

authors： Mucenski ML,Taylor BA,Copeland NG,Jenkins NA

更新日期：1987-09-01 00:00:00

abstract：:RNA recombination occurs frequently during replication of tombusviruses and carmoviruses, which are related small plus-sense RNA viruses of plants. The most common recombinants generated by these viruses are either defective interfering (DI) RNAs or chimeric satellite RNAs, which are thought to be generated by templat...

journal_title：Journal of virology

authors： Cheng CP,Nagy PD

更新日期：2003-11-01 00:00:00

abstract：:Two hundred forty pyridazinamine derivatives were tested for the ability to stabilize the antigenicity and infectivity of oral poliovirus vaccine subjected to 45 degrees C for 2 h. Seven compounds stabilized the antigenicity of all three vaccine strains and neutralized the viral particles in a way that is reversible b...

journal_title：Journal of virology

authors： Andries K,Rombaut B,Dewindt B,Boeyé A

更新日期：1994-05-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) Tat protein is essential for viral replication and stimulates transcription of the integrated provirus by recruiting the kinase complex TAK/P-TEFb, composed of cyclin T1 (CycT1) and Cdk9, to the viral TAR RNA element. TAK/P-TEFb phosphorylates the RNA polymerase II compl...

journal_title：Journal of virology

authors： Liou LY,Herrmann CH,Rice AP

更新日期：2002-11-01 00:00:00

abstract：:To examine the pathway of the coreceptor switching of CCR5-using (R5) virus to CXCR4-using (X4) virus in simian-human immunodeficiency virus SHIV(SF162P3N)-infected rhesus macaque BR24, analysis was performed on variants present at 20 weeks postinfection, the time when the signature gp120 V3 loop sequence of the X4 sw...

journal_title：Journal of virology

authors： Tasca S,Ho SH,Cheng-Mayer C

更新日期：2008-07-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) tegument is the least understood component of the virion, and the mechanism of tegument assembly and incorporation into virions during viral egress has not yet been elucidated. In the present study, the addition of tegument proteins (VP13/14, VP16, VP22, and US9) and envelope gl...

journal_title：Journal of virology

authors： Miranda-Saksena M,Boadle RA,Armati P,Cunningham AL

更新日期：2002-10-01 00:00:00

abstract：:The unique region of the capsid protein VP1 (VP1u) of human parvovirus B19 (B19) elicits a dominant immune response and has a phospholipase A(2) (PLA(2)) activity, which is necessary for the infection. In contrast to the rest of the parvoviruses, the VP1u of B19 is thought to occupy an external position in the virion,...

journal_title：Journal of virology

authors： Ros C,Gerber M,Kempf C

更新日期：2006-12-01 00:00:00

abstract：UNLABELLED:Barrier dysfunction of airway epithelium may increase the risk for acquiring secondary infections or allergen sensitization. Both rhinovirus (RV) and polyinosinic-polycytidilic acid [poly(I·C)], a double-stranded RNA (dsRNA) mimetic, cause airway epithelial barrier dysfunction, which is reactive oxygen speci...

journal_title：Journal of virology

authors： Unger BL,Ganesan S,Comstock AT,Faris AN,Hershenson MB,Sajjan US

更新日期：2014-04-01 00:00:00

abstract：:The expression of a human immunodeficiency virus (HIV) type 1 provirus (F12-HIV) cloned from a nonproducer, chronically infected CD4 down-regulated Hut-78 cell clone (F12) does not lead to the formation of viral particles and, upon transfection in HeLa CD4+ cells, confers resistance to HIV superinfection without affec...

journal_title：Journal of virology

authors： Federico M,Nappi F,Ferrari G,Chelucci C,Mavilio F,Verani P

更新日期：1995-11-01 00:00:00

abstract：:Previous studies with simian virus 40-transformed mouse 3T3 cells which are temperature sensitive for the expression of the transformed phenotype (ts SV3T3 cells) have shown that T-antigen expression and viral DNA transcription are under cell cycle control. Using these ts SV3T3 cells, we studied the expression of the ...

journal_title：Journal of virology

authors： Zouzias D,Basilico C

更新日期：1979-06-01 00:00:00

abstract：:We present data that retroviral gene expression in early hematopoietic cells is subjected to transcriptional controls similar to those previously described for embryonic stem cells. Transient transfection experiments revealed that both the viral enhancer region in the U3 region of the long terminal repeat as well as a...

journal_title：Journal of virology

authors： Baum C,Hegewisch-Becker S,Eckert HG,Stocking C,Ostertag W

更新日期：1995-12-01 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV) infection is required for the development of several AIDS-related malignancies, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). The high incidence of AIDS-KS has been ascribed to the interaction of KSHV and HIV-1. We have previously shown th...

journal_title：Journal of virology

authors： Yan Q,Shen C,Qin J,Li W,Hu M,Lu H,Qin D,Zhu J,Gao SJ,Lu C

更新日期：2016-09-12 00:00:00

abstract：:The effectiveness and potential immunosuppressive effects of anti-inflammatory glucocorticoids in the lungs of severe acute respiratory syndrome (SARS) patients are undefined. We treated porcine respiratory coronavirus (PRCV)-infected conventional pigs with the corticosteroid dexamethasone (DEX) as a model for SARS. I...

journal_title：Journal of virology

authors： Zhang X,Alekseev K,Jung K,Vlasova A,Hadya N,Saif LJ

更新日期：2008-05-01 00:00:00

abstract：:The cellular site of herpesvirus tegument assembly has yet to be defined. We have previously used a recombinant herpes simplex virus type 1 expressing a green fluorescent protein (GFP)-tagged tegument protein, namely VP22, to show that VP22 is localized exclusively to the cytoplasm during infection. Here we have const...

journal_title：Journal of virology

authors： Donnelly M,Elliott G

更新日期：2001-03-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) V3 loop is essential for coreceptor binding and principally determines tropism for the CCR5 and CXCR4 coreceptors. Using the dual-tropic virus HIV-1(R3A), we previously made an extensive panel of V3 deletions and identified subdomains within V3 that could differentially ...

journal_title：Journal of virology

authors： Nolan KM,Del Prete GQ,Jordan AP,Haggarty B,Romano J,Leslie GJ,Hoxie JA

更新日期：2009-04-01 00:00:00

abstract：:An active transcriptive complex was isolated from purified virions of Newcastle disease virus. After disruption with Triton X-100 and high salt, soluble and particulate fractions were separated by density gradient centrifugation. The transcriptive complex, recovered at a density of 1.275 g/cm3, appeared as a nucleocap...

journal_title：Journal of virology

authors： Colonno RJ,Stone HO

更新日期：1976-09-01 00:00:00

abstract：:The structure and replication of a cold-adapted, temperature-sensitive (TS) mutant of an Asian (H2N2) influenza virus was compared with that of its wild-type (WT) parent. Viruses were grown in a chicken kidney cell system, and at the nonpermissive temperature of 40 C, production of infectious TS virus was about 100,00...

journal_title：Journal of virology

authors： Kendal AP,Kiley MP,Maassab HF

更新日期：1973-12-01 00:00:00