Isolation of a transcriptive complex from Newcastle disease virions.

abstract：:Human immunodeficiency virus type 2 (HIV-2), like other lentiviruses, is capable of infecting nondividing T cells and macrophages. The present work shows that in HIV-2-infected cells, Vpx is necessary for efficient nuclear import of the preintegration complex. In agreement with this finding, the subcellular localizati...

journal_title：Journal of virology

authors： Pancio HA,Vander Heyden N,Ratner L

更新日期：2000-07-01 00:00:00

abstract：:The Epstein-Barr virus nuclear antigen 2 (EBNA-2) acidic domain is essential for B-lymphocyte growth transformation and can activate transcription when brought to a promoter by a sequence-specific DNA-binding domain. We now show that the EBNA-2 acidic domain has slightly less activity than the proteotypic acidic trans...

journal_title：Journal of virology

authors： Tong X,Wang F,Thut CJ,Kieff E

更新日期：1995-01-01 00:00:00

abstract：UNLABELLED:The RNA genome of respiratory syncytial virus (RSV) is constitutively encapsidated by the viral nucleoprotein N, thus forming a helical nucleocapsid. Polymerization of N along the genomic and antigenomic RNAs is concomitant to replication and requires the preservation of an unassembled monomeric nucleoprotei...

journal_title：Journal of virology

authors： Galloux M,Gabiane G,Sourimant J,Richard CA,England P,Moudjou M,Aumont-Nicaise M,Fix J,Rameix-Welti MA,Eléouët JF

更新日期：2015-04-01 00:00:00

abstract：:The retrovirus restriction factor TRIM5alpha targets the viral capsid soon after entry. Here we show that the TRIM5alpha protein oligomerizes into trimers. The TRIM5alpha coiled-coil and B30.2(SPRY) domains make important contributions to the formation and/or stability of the trimers. A functionally defective TRIM5alp...

journal_title：Journal of virology

authors： Mische CC,Javanbakht H,Song B,Diaz-Griffero F,Stremlau M,Strack B,Si Z,Sodroski J

更新日期：2005-11-01 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus (KSHV) is necessary but not sufficient for primary effusion lymphoma (PEL) development. Alterations in cellular signaling pathways are also a characteristic of PEL. Other B cell lymphomas have acquired an oncogenic mutation in the myeloid differentiation primary response 88 (MYD88...

journal_title：Journal of virology

authors： Seltzer J,Moorad R,Schifano JM,Landis JT,Dittmer DP

更新日期：2020-05-04 00:00:00

abstract：:Retinoid (vitamin A) is an essential diet constituent that governs a broad range of biological processes. Its biologically active metabolite, all-trans retinoic acid (ATRA), exhibits a potent antiviral property by enhancing both innate and adaptive antiviral immunity against a variety of viral pathogens, such as, but ...

journal_title：Journal of virology

authors： Bang BR,Li M,Tsai KN,Aoyagi H,Lee SA,Machida K,Aizaki H,Jung JU,Ou JJ,Saito T

更新日期：2019-04-03 00:00:00

abstract：:Viral myocarditis is an important human disease, and reovirus-induced murine myocarditis provides an excellent model system for study. Cardiac myocytes, like neurons in the central nervous system, are not replenished, yet there is no cardiac protective equivalent to the blood-brain barrier. Thus, cardiac myocytes may ...

journal_title：Journal of virology

authors： Zurney J,Howard KE,Sherry B

更新日期：2007-12-01 00:00:00

abstract：:Some retroviruses with an extended repeat (R) region encode the polyadenylation signal within the R region such that this signal is present at both the 5' and 3' ends of the viral transcript. This necessitates differential regulation to either repress recognition of the 5' polyadenylation signal or enhance usage of th...

journal_title：Journal of virology

authors： Das AT,Klaver B,Berkhout B

更新日期：1999-01-01 00:00:00

abstract：:Strategies were developed to insert the neo resistance marker into the junction between L DNA and the right terminal repetitive H DNA of herpesvirus saimiri. Recombinant viruses were selectable in permissive epithelioid cultures. The human T-cell line Jurkat could be infected persistently with the Neor virus; the cell...

journal_title：Journal of virology

authors： Grassmann R,Fleckenstein B

更新日期：1989-04-01 00:00:00

abstract：:We present data that retroviral gene expression in early hematopoietic cells is subjected to transcriptional controls similar to those previously described for embryonic stem cells. Transient transfection experiments revealed that both the viral enhancer region in the U3 region of the long terminal repeat as well as a...

journal_title：Journal of virology

authors： Baum C,Hegewisch-Becker S,Eckert HG,Stocking C,Ostertag W

更新日期：1995-12-01 00:00:00

abstract：:A lysate from hypotonically swollen polyoma-infected BALB/3T3 cells incorporated labeled deoxynucleotide triphosphates into both viral and cellular DNAs. The incorporation was stimulated by the presence of ATP, deoxynucleotide triphosphates, thiols, and magnesium ions. Strong inhibition of incorporation was observed w...

journal_title：Journal of virology

authors： Hunter T,Francke B

更新日期：1974-01-01 00:00:00

abstract：:We have identified nucleotide sequences that regulate transcription in both a cell-type-specific and general manner in the long terminal repeat of the MCF13 murine leukemia virus. Besides the enhancer element, we have observed that the region between the enhancer and promoter (DEN) has a profound effect on transcripti...

journal_title：Journal of virology

authors： Tupper JC,Chen H,Hays EF,Bristol GC,Yoshimura FK

更新日期：1992-12-01 00:00:00

abstract：:The emerging porcine epidemic diarrhea virus (PEDV) requires trypsin supplementation to activate its S protein for membrane fusion and virus propagation in cell culture. By substitution of a single amino acid in the S protein, we created a recombinant PEDV with an artificial furin protease cleavage site N terminal of ...

journal_title：Journal of virology

authors： Li W,Wicht O,van Kuppeveld FJ,He Q,Rottier PJ,Bosch BJ

更新日期：2015-08-01 00:00:00

abstract：UNLABELLED:A bat virus with high phylogenetic relatedness to human mumps virus (MuV) was identified recently at the nucleic acid level. We analyzed the functional activities of the hemagglutinin-neuraminidase (HN) and the fusion (F) proteins of the bat virus (batMuV) and compared them to the respective proteins of a hu...

journal_title：Journal of virology

authors： Krüger N,Hoffmann M,Drexler JF,Müller MA,Corman VM,Sauder C,Rubin S,He B,Örvell C,Drosten C,Herrler G

更新日期：2015-04-01 00:00:00

abstract：:CD4C/HIV(nef) transgenic (Tg) mice express Nef in CD4+ T cells and in the cells of the macrophage/monocyte/dendritic lineage, and they develop an AIDS-like disease similar to human AIDS. In these mice, Nef is constitutively expressed throughout life. To rule out the contribution of any developmental defects caused by ...

journal_title：Journal of virology

authors： Rahim MM,Chrobak P,Hu C,Hanna Z,Jolicoeur P

更新日期：2009-11-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (gammaHV68; also known as MHV-68) can establish a latent infection in both inbred and outbred strains of mice and, as such, provides a tractable small-animal model to address mechanisms and cell types involved in the establishment and maintenance of chronic gammaherpesvirus infection. Latenc...

journal_title：Journal of virology

authors： Willer DO,Speck SH

更新日期：2003-08-01 00:00:00

abstract：:For the identification of RNA-binding proteins that specifically interact with potato spindle tuber viroid (PSTVd), we subjected a tomato cDNA expression library prepared from viroid-infected leaves to an RNA ligand screening procedure. We repeatedly identified cDNA clones that expressed a protein of 602 amino acids. ...

journal_title：Journal of virology

authors： Martínez de Alba AE,Sägesser R,Tabler M,Tsagris M

更新日期：2003-09-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-specific T-cell lines generated by repeated stimulation with EBV-immortalized lymphoblastoid B-cell lines (LCL) have been successfully used to treat EBV-associated posttransplant lymphoproliferative disease (PTLD) in hematopoietic stem cell transplant recipients. However, PTLD in solid-organ t...

journal_title：Journal of virology

authors： Adhikary D,Behrends U,Feederle R,Delecluse HJ,Mautner J

更新日期：2008-04-01 00:00:00

abstract：:In wild aquatic birds and poultry around the world, influenza A viruses carrying 15 antigenic subtypes of hemagglutinin (HA) and 9 antigenic subtypes of neuraminidase (NA) have been described. Here we describe a previously unidentified antigenic subtype of HA (H16), detected in viruses circulating in black-headed gull...

journal_title：Journal of virology

authors： Fouchier RA,Munster V,Wallensten A,Bestebroer TM,Herfst S,Smith D,Rimmelzwaan GF,Olsen B,Osterhaus AD

更新日期：2005-03-01 00:00:00

abstract：:We report sequence hypervariability in the viral protein 1 (VP1) interaction domain of VP2 in the norovirus (NoV) genogroup II genotype 4 (GII.4) lineage on 3 levels: (i) the global evolution of pandemic/epidemic strains from the mid-1970s through post-2006, (ii) the local emergence of an epidemic strain, and (iii) an...

journal_title：Journal of virology

authors： Chan MC,Lee N,Ho WS,Law CO,Lau TC,Tsui SK,Sung JJ

更新日期：2012-01-01 00:00:00

abstract：:Several point mutations in the simian virus 40 (SV40) small-t antigen have been analyzed for their effects on protein stability, transformation, transactivation, and binding of two cellular proteins. All mutations which affected cysteine residues in two cysteine clusters produced highly unstable small-t antigens. Four...

journal_title：Journal of virology

authors： Jog P,Joshi B,Dhamankar V,Imperiale MJ,Rutila J,Rundell K

更新日期：1990-06-01 00:00:00

abstract：:Genetic studies with immunocompetent mice show the importance of both T cells and gamma interferon (IFN-γ) for survival of a measles virus (MV) challenge; however, the direct role of T cells and IFN-γ within the MV-infected brain has not been addressed. Organotypic brain explants represent a successful ex vivo system ...

journal_title：Journal of virology

authors： Stubblefield Park SR,Widness M,Levine AD,Patterson CE

更新日期：2011-04-01 00:00:00

abstract：:Accurate and sensitive quantitation of infectious human immunodeficiency virus (HIV) has been difficult to achieve. In this report, a quantitative focal immunoassay (FIA) for HIV was developed using human HeLa cells rendered susceptible to HIV infection by introduction of the CD4 gene via a retrovirus vector. Infected...

journal_title：Journal of virology

authors： Chesebro B,Wehrly K

更新日期：1988-10-01 00:00:00

abstract：:Coronavirus nonstructural protein 8 (nsp8) has been suggested to have diverse activities, including noncanonical template-dependent polymerase activities. Here, we characterized a recombinant form of the human coronavirus 229E (HCoV-229E) nsp8 and found that the protein has metal ion-dependent RNA 3'-terminal adenylyl...

journal_title：Journal of virology

authors： Tvarogová J,Madhugiri R,Bylapudi G,Ferguson LJ,Karl N,Ziebuhr J

更新日期：2019-05-29 00:00:00

abstract：:Rous sarcoma virus (RSV), a simple retrovirus, needs to export unspliced viral RNA from the nucleus to the cytoplasm, circumventing the host cell restriction on cytoplasmic expression of intron-containing RNA. The cytoplasmic accumulation of full-length viral RNA is promoted by two cis-acting direct repeat (DR) elemen...

journal_title：Journal of virology

authors： Paca RE,Ogert RA,Hibbert CS,Izaurralde E,Beemon KL

更新日期：2000-10-01 00:00:00

abstract：:Proteolytic processing of the picornaviral polyprotein mediated by the differential action of virus-encoded proteinase(s) is pivotal to both RNA genome replication and capsid formation. Possibly to enlarge the array of viral proteins, picornaviral polyprotein processing results in intermediate and mature products whic...

journal_title：Journal of virology

authors： Probst C,Jecht M,Gauss-Müller V

更新日期：1998-10-01 00:00:00

abstract：:The entire varicella-zoster virus (VZV) genome appears to be present in latently infected human ganglia, but the extent of virus DNA transcription is unknown. Conventional methods to study virus gene transcripts by Northern (RNA) blotting are not feasible, since ganglia are small and VZV DNA is not abundant. To circum...

journal_title：Journal of virology

authors： Cohrs RJ,Srock K,Barbour MB,Owens G,Mahalingam R,Devlin ME,Wellish M,Gilden DH

更新日期：1994-12-01 00:00:00

abstract：:Adenovirus types 5 and 3 (Ad5 and Ad3), two human adenovirus serotypes of evolutionarily divergent subgroups, show very different levels of E1A gene expression early after infection of permissive cells. Since adenovirus E1A gene expression is known to be transcriptionally autoregulated, we have investigated the differ...

journal_title：Journal of virology

authors： Jones SN,Tibbetts C

更新日期：1989-04-01 00:00:00

abstract：:Cottontail rabbit papillomavirus (CRPV)-induced papillomas progress at a high frequency to carcinomas and thus can serve as a model for high-cancer-risk human papillomavirus infection. Previously, we have shown that antibodies to nonstructural and structural proteins are detected in only a fraction of papilloma-bearin...

journal_title：Journal of virology

authors： Selvakumar R,Borenstein LA,Lin YL,Ahmed R,Wettstein FO

更新日期：1994-06-01 00:00:00

abstract：:PM2 DNA was prepared with different superhelical densities (sigma) in order to examine the relationship betweenn supercoiling and the occurrence of a region(s) of unpaired bases in this DNA. A previous study showed that CH3HgOH reacts with native superhelical PM2 DNA more rapidly than the nicked form II. This evaluati...

journal_title：Journal of virology

authors： Woodworth-Gutai M,Lebowitz J

更新日期：1976-04-01 00:00:00