Covariation of major and minor viral capsid proteins in norovirus genogroup II genotype 4 strains.

abstract：:The NS3 protein of hepatitis C virus contains a bipartite structure consisting of an N-terminal serine protease and a C-terminal DEAD box helicase. We show that the C-terminal domain has ATPase and panhelicase activities. The integrity of the helicase function is dependent on the conserved DEAD motif and can be abolis...

journal_title：Journal of virology

authors： Heilek GM,Peterson MG

更新日期：1997-08-01 00:00:00

abstract：:Recently, significant numbers of individuals with primary human immunodeficiency virus (HIV) infection have been found to harbor viral strains with reduced susceptibility to antiretroviral drugs. In one study, HIV from 16% of such antiretroviral-naive individuals was shown to have a susceptibility to nonnucleoside rev...

journal_title：Journal of virology

authors： Brown AJ,Precious HM,Whitcomb JM,Wong JK,Quigg M,Huang W,Daar ES,D'Aquila RT,Keiser PH,Connick E,Hellmann NS,Petropoulos CJ,Richman DD,Little SJ

更新日期：2000-11-01 00:00:00

abstract：:The RNA genome of human immunodeficiency virus type 1 (HIV-1) is converted into DNA after infection in order to integrate into the host cell DNA. However, a large number of these reverse-transcribed genomes remain unintegrated in the nucleus of infected cells. Currently, there are no data available about the intranucl...

journal_title：Journal of virology

authors： Bell P,Montaner LJ,Maul GG

更新日期：2001-08-01 00:00:00

abstract：:The entry of the viral genomic DNA of cauliflower mosaic virus into the nucleus is a critical step of viral infection. We have shown by transient expression in plant protoplasts that the viral coat protein (CP), which is processed from the product of open reading frame IV, contains an N-terminal nuclear localization s...

journal_title：Journal of virology

authors： Leclerc D,Chapdelaine Y,Hohn T

更新日期：1999-01-01 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus (SARS-CoV) nsp1 protein has unique biological functions that have not been described in the viral proteins of any RNA viruses; expressed SARS-CoV nsp1 protein has been found to suppress host gene expression by promoting host mRNA degradation and inhibiting translation....

journal_title：Journal of virology

authors： Narayanan K,Huang C,Lokugamage K,Kamitani W,Ikegami T,Tseng CT,Makino S

更新日期：2008-05-01 00:00:00

abstract：:The structure of VRC01 in complex with the HIV-1 gp120 core reveals that this broadly neutralizing CD4 binding site (CD4bs) antibody partially mimics the interaction of the primary virus receptor, CD4, with gp120. Here, we extended the investigation of the VRC01-gp120 core interaction to the biologically relevant vira...

journal_title：Journal of virology

authors： Li Y,O'Dell S,Walker LM,Wu X,Guenaga J,Feng Y,Schmidt SD,McKee K,Louder MK,Ledgerwood JE,Graham BS,Haynes BF,Burton DR,Wyatt RT,Mascola JR

更新日期：2011-09-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) major envelope glycoprotein gp340 is the subject of current efforts to develop an EBV subunit vaccine. The importance of gp340-specific humoral immunity has been highlighted by studies of natural infection in humans and gp340 immunization of experimental animals. The former studies have de...

journal_title：Journal of virology

authors： Pither RJ,Zhang CX,Shiels C,Tarlton J,Finerty S,Morgan AJ

更新日期：1992-02-01 00:00:00

abstract：:Using real-time fluorescence PCR, we quantitated the numbers of copies of latent varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) genomes in 15 human trigeminal ganglia. Eight (53%) and 1 (7%) of 15 ganglia were PCR positive for HSV-1 or -2 glycoprotein G genes, with means of 2,9...

journal_title：Journal of virology

authors： Pevenstein SR,Williams RK,McChesney D,Mont EK,Smialek JE,Straus SE

更新日期：1999-12-01 00:00:00

abstract：:We have used immunofluorescence in parallel with transmission and scanning electron microscopy to characterize the unusual cytoplasmic and nucleolar accumulation of Simian virus 40 (SV40) virion protein (C antigen) at restrictive temperatures (39 to 41 C) in monkey cells infected with a temperature-sensitive mutant of...

journal_title：Journal of virology

authors： Widmer C,Robb JA

更新日期：1974-12-01 00:00:00

abstract：:Vaccinia virus (VACV) stimulates long-term immunity against highly pathogenic orthopoxvirus infection of humans (smallpox) and mice (mousepox [ectromelia virus {ECTV}]) despite the lack of a natural host-pathogen relationship with either of these species. Previous research revealed that VACV is able to induce polyfunc...

journal_title：Journal of virology

authors： Hersperger AR,Siciliano NA,Eisenlohr LC

更新日期：2012-07-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) were raised against human immunodeficiency virus type 1 gp120. One MAb, P4/D10, was found to mediate highly efficient antibody-dependent cellular cytotoxicity and virus neutralization. The reactivity was located to a major neutralizing region (amino acids 304 to 323) on gp120. Five other M...

journal_title：Journal of virology

authors： Broliden PA,Ljunggren K,Hinkula J,Norrby E,Akerblom L,Wahren B

更新日期：1990-02-01 00:00:00

abstract：:Replication and transcription activator (RTA) (also referred to as ORF50), an immediate-early gene product of Kaposi's sarcoma-associated herpesvirus (KSHV)/(human herpesvirus 8), plays a critical role in balancing the viral life cycle between latency and lytic replication. RTA has been shown to act as a strong transc...

journal_title：Journal of virology

authors： Song MJ,Deng H,Sun R

更新日期：2003-09-01 00:00:00

abstract：:The HIV-1 spike is composed of three protomeric units, each containing a peripheral gp120 and a transmembrane gp41 subunit. Binding to the CD4 and the chemokine receptors triggers them to mediate virus entry into cells by membrane fusion. The spikes also represent the major target for neutralizing antibodies (Abs) aga...

journal_title：Journal of virology

authors： Löving R,Sjöberg M,Wu SR,Binley JM,Garoff H

更新日期：2013-06-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) can infect nondividing cells productively because the nuclear import of viral nucleic acids occurs in the absence of cell division. A number of viral factors that are present in HIV-1 preintegration complexes (PICs) have been assigned functions in nuclear import, including a...

journal_title：Journal of virology

authors： Dvorin JD,Bell P,Maul GG,Yamashita M,Emerman M,Malim MH

更新日期：2002-12-01 00:00:00

abstract：:The poliovirus (PV) genome was manipulated by replacing its 2A-encoding sequence with the corresponding sequence of coxsackie B4 virus (CBV4) or human rhinovirus type 2 (HRV2). In vitro translation of the resulting chimeric PV genomes revealed a normal cis-cleavage activity for both heterologous 2A(pro) proteinases in...

journal_title：Journal of virology

authors： Lu HH,Li X,Cuconati A,Wimmer E

更新日期：1995-12-01 00:00:00

abstract：:A novel circular DNA virus sequence is reported from grapevine. The corresponding genomic organization, coding potential, and conserved origin of replication are similar to those of members of the family Geminiviridae, but the genome of 3,206 nucleotides is 4% larger than the largest reported geminiviral genome and sh...

journal_title：Journal of virology

authors： Krenz B,Thompson JR,Fuchs M,Perry KL

更新日期：2012-07-01 00:00:00

abstract：:Whole inactivated virus vaccines from the FL4 cell line protected against challenge with homologous feline immunodeficiency virus (Petaluma strain) but not against a heterologous FIV isolate (GL-8) which is distinct from the Petaluma strain in virus neutralization. Protection was associated with a type-specific neutra...

journal_title：Journal of virology

authors： Hosie MJ,Osborne R,Yamamoto JK,Neil JC,Jarrett O

更新日期：1995-02-01 00:00:00

abstract：:Bovine bone marrow-derived macrophages infected with the cytopathic biotype of bovine viral diarrhea virus released an antiviral activity into the supernatant which was tentatively characterized as type I interferon because of its physicochemical properties. Such supernatants primed both infected and uninfected macrop...

journal_title：Journal of virology

authors： Adler B,Adler H,Pfister H,Jungi TW,Peterhans E

更新日期：1997-04-01 00:00:00

abstract：:Mumps virus, like other paramyxoviruses in the Rubulavirus genus, encodes a V protein that can assemble a ubiquitin ligase complex from cellular components, leading to the destruction of cellular signal transducer and activator of transcription (STAT) proteins. While many V proteins target the interferon-activated STA...

journal_title：Journal of virology

authors： Puri M,Lemon K,Duprex WP,Rima BK,Horvath CM

更新日期：2009-07-01 00:00:00

abstract：:The complete genome sequences of the human coronavirus OC43 (HCoV-OC43) laboratory strain from the American Type Culture Collection (ATCC), and a HCoV-OC43 clinical isolate, designated Paris, were obtained. Both genomes are 30,713 nucleotides long, excluding the poly(A) tail, and only differ by 6 nucleotides. These si...

journal_title：Journal of virology

authors： St-Jean JR,Jacomy H,Desforges M,Vabret A,Freymuth F,Talbot PJ

更新日期：2004-08-01 00:00:00

abstract：:The antigenic binding sites of two monoclonal antibodies are located in the COOH-terminal region (clone 412) and probably in an internal region (clone 7) of simian virus 40 large T antigen. A third monoclonal antibody (clone 122), which has been shown to bind nonviral T antigen, does not react with HeLa cells infected...

journal_title：Journal of virology

authors： Deppert W,Gurney EG,Harrison RO

更新日期：1981-01-01 00:00:00

abstract：:Three mRNAs from the murine polyomavirus early region encode the three well-characterized tumor antigens. We report the existence of a fourth alternatively spliced mRNA which encodes a fourth tumor antigen, tiny T antigen, which comprises the amino-terminal domain common to all of the T antigens but is extended by six...

journal_title：Journal of virology

authors： Riley MI,Yoo W,Mda NY,Folk WR

更新日期：1997-08-01 00:00:00

abstract：:A protocol was designed to measure the forward mutation rate over an entire gene replicated as part of a Moloney murine leukemia virus-based vector. For these studies, the herpes simplex virus thymidine kinase (tk) gene under the control of the spleen necrosis virus U3 promoter was used as target sequence since it all...

journal_title：Journal of virology

authors： Varela-Echavarría A,Prorock CM,Ron Y,Dougherty JP

更新日期：1993-11-01 00:00:00

abstract：:The STP-C488 open reading frame of herpesvirus saimiri encodes an oncoprotein that has transforming and tumor-inducing activities independent of the rest of the herpesvirus genome. STP-C488 protein has an unusual, membrane-associated, fibrous structure and is located primarily in perinuclear compartments. We now repor...

journal_title：Journal of virology

authors： Jung JU,Desrosiers RC

更新日期：1992-03-01 00:00:00

abstract：:During EBV infection, lytic DNA replication activates late gene expression in trans via an uncharacterized pathway. In this study, we mapped the target of this regulatory cascade to a variant TATA box (TATTAAA) and the 3' flanking region within the core promoter of the BcLF1 gene. The inherent late activity of this co...

journal_title：Journal of virology

authors： Serio TR,Cahill N,Prout ME,Miller G

更新日期：1998-10-01 00:00:00

abstract：:Vif counteracts the host restriction factor APOBEC3G (A3G) and other APOBEC3s by preventing the incorporation of A3G into progeny virions. We previously identified Vif mutants with a dominant-negative (D/N) phenotype that interfered with the function of wild-type Vif, inhibited the degradation of A3G, and reduced the ...

journal_title：Journal of virology

authors： Miyagi E,Welbourn S,Sukegawa S,Fabryova H,Kao S,Strebel K

更新日期：2020-03-17 00:00:00

abstract：:The genetic evolution of human immunodeficiency virus type 1 (HIV-1) in the brain is distinct from that in lymphoid tissues, indicating tissue-specific compartmentalization of the virus. Few primary HIV-1 envelope glycoproteins (Envs) from uncultured brain tissues have been biologically well characterized. In this stu...

journal_title：Journal of virology

authors： Ohagen A,Devitt A,Kunstman KJ,Gorry PR,Rose PP,Korber B,Taylor J,Levy R,Murphy RL,Wolinsky SM,Gabuzda D

更新日期：2003-11-01 00:00:00

abstract：:Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has been responsible for an epidemic outbreak of unprecedented magnitude in recent years. Since then, significant efforts have been made to better understand the biology of this virus, but we still have poor knowledge of CHIKV interactions with host c...

journal_title：Journal of virology

authors： Bouraï M,Lucas-Hourani M,Gad HH,Drosten C,Jacob Y,Tafforeau L,Cassonnet P,Jones LM,Judith D,Couderc T,Lecuit M,André P,Kümmerer BM,Lotteau V,Desprès P,Tangy F,Vidalain PO

更新日期：2012-03-01 00:00:00

abstract：:We have shown previously that processing of the Sindbis virus envelope protein precursor PE2 to envelope protein E2 is not required for virus maturation in cultured vertebrate fibroblast cells and that unprocessed PE2 can be incorporated into infectious virus in place of E2 (J. F. Presley and D. T. Brown, J. Virol. 63...

journal_title：Journal of virology

authors： Presley JF,Polo JM,Johnston RE,Brown DT

更新日期：1991-04-01 00:00:00

abstract：:Cytomegalovirus (CMV) disease after bone marrow (BM) transplantation is often associated with BM graft failure. There are two possible reasons for such a correlation. First, a poor hematopoietic reconstitution of unrelated etiology could promote the progression of CMV infection by the lack of immune control. Alternati...

journal_title：Journal of virology

authors： Steffens HP,Podlech J,Kurz S,Angele P,Dreis D,Reddehase MJ

更新日期：1998-06-01 00:00:00