Monoclonal antibodies against simian virus 40 tumor antigens: analysis of antigenic binding sites, using adenovirus type 2-simian virus 40 hybrid viruses.

abstract：:We have previously identified a functionally essential bulged stem-loop in the 3' untranslated region of the positive-stranded RNA genome of mouse hepatitis virus. This 68-nucleotide structure is composed of six stem segments interrupted by five bulges, and its structure, but not its primary sequence, is entirely cons...

journal_title：Journal of virology

authors： Hsue B,Hartshorne T,Masters PS

更新日期：2000-08-01 00:00:00

abstract：:Complexes of f2 phage RNA and its A protein, or maturation protein, transfect Escherichia coli cells much better than does protein-free RNA. We used these complexes to introduce the bacteriophage f2 lysis gene into cells. The A protein-RNA complex was found to kill cells, probably by causing them to leak large macromo...

journal_title：Journal of virology

authors： Cody JD,Conway TW

更新日期：1981-07-01 00:00:00

abstract：:Although hepatitis A virus (HAV) is typically transmitted by the fecal-oral route, little is known of its interactions with cells of the gastrointestinal tract. We studied the replication of HAV in polarized cultures of Caco-2 cells, a human cell line which retains many differentiated functions of small intestinal epi...

journal_title：Journal of virology

authors： Blank CA,Anderson DA,Beard M,Lemon SM

更新日期：2000-07-01 00:00:00

abstract：:Previous studies with the herpes simplex virus type 1 X type 2 intertypic recombinant RS6 suggested that the genomic region from 0.11 to 0.14 map units is involved in neurovirulence (R. T. Javier, R. L. Thompson, and J. G. Stevens, J. Virol. 61:1978-1984, 1987). To study this further, we isolated an RS6-derived herpes...

journal_title：Journal of virology

authors： Javier RT,Izumi KM,Stevens JG

更新日期：1988-04-01 00:00:00

abstract：:Minute virus of canines (MVC) is a member of the genus Bocavirus in the family Parvoviridae. We have molecularly cloned and sequenced the 5'- and 3'-terminal palindromes of MVC. The MVC genome, 5,404 nucleotides (nt) in length, shared an identity of 52.6% and 52.1% with that of human bocavirus and bovine parvovirus, r...

journal_title：Journal of virology

authors： Sun Y,Chen AY,Cheng F,Guan W,Johnson FB,Qiu J

更新日期：2009-04-01 00:00:00

abstract：:Subgenomic RNAs of both polarities corresponding to rice hoja blanca virus (RHBV) ambisense RNA4 were detected in RHBV-infected rice tissues. Total RNA extracted from RHBV-infected and noninfected rice tissues and RNA4 purified from RHBV ribonucleoprotein particles were used as templates for primer extension studies. ...

journal_title：Journal of virology

authors： Ramirez BC,Garcin D,Calvert LA,Kolakofsky D,Haenni AL

更新日期：1995-03-01 00:00:00

abstract：:Previous studies showed that the amino-terminal domain of Rous sarcoma virus p60v-src involved in myristylation and membrane association of the protein is required for morphological transformation and anchorage independence. Analysis of src delection mutants revealed that the amino-terminal one-third of p60v-src, incl...

journal_title：Journal of virology

authors： Calothy G,Laugier D,Cross FR,Jove R,Hanafusa T,Hanafusa H

更新日期：1987-05-01 00:00:00

abstract：:Enveloped viruses often require cleavage of a surface glycoprotein by a cellular endoprotease such as furin for infectivity and virulence. Previously, we showed that Ebola virus glycoprotein does not require the furin cleavage motif for virus replication in cell culture. Here, we show that there are no appreciable dif...

journal_title：Journal of virology

authors： Neumann G,Geisbert TW,Ebihara H,Geisbert JB,Daddario-DiCaprio KM,Feldmann H,Kawaoka Y

更新日期：2007-03-01 00:00:00

abstract：:We report here that sex hormones modulate susceptibility to a sexually transmitted viral agent, herpes simplex virus type 2 (HSV-2), in a mouse model. Ovariectomized mice were administered either saline (control), estradiol (E(2)), progesterone (P(4)), or a combination of both estradiol and progesterone (E+P) and infe...

journal_title：Journal of virology

authors： Gillgrass AE,Fernandez SA,Rosenthal KL,Kaushic C

更新日期：2005-03-01 00:00:00

abstract：:The major human tRNA(Lys) isoacceptors, and, are selectively packaged into human immunodeficiency virus type 1 (HIV-1) during assembly, where acts as a primer for reverse transcription. Lysyl-tRNA synthetase (LysRS) is also incorporated into HIV-1, independently of tRNA(Lys), via its interaction with Gag, and is a str...

journal_title：Journal of virology

authors： Guo F,Cen S,Niu M,Javanbakht H,Kleiman L

更新日期：2003-09-01 00:00:00

abstract：:The mechanism of lysis by in vivo-induced cytotoxic T lymphocytes (CTL) was examined with virus-specific CTL from mice infected with lymphocytic choriomeningitis virus (LCMV). LCMV-induced T cells were shown to have greater than 10 times the serine esterase activity of T cells from normal mice, and high levels of seri...

journal_title：Journal of virology

authors： Welsh RM,Nishioka WK,Antia R,Dundon PL

更新日期：1990-08-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) entry inhibitor eCD4-Ig is a fusion of CD4-Ig and a coreceptor-mimetic peptide. eCD4-Ig is markedly more potent than CD4-Ig, with neutralization efficiencies approaching those of HIV-1 broadly neutralizing antibodies (bNAbs). However, unlike bNAbs, eCD4-Ig neutralized al...

journal_title：Journal of virology

authors： Fetzer I,Gardner MR,Davis-Gardner ME,Prasad NR,Alfant B,Weber JA,Farzan M

更新日期：2018-05-29 00:00:00

abstract：:Endogenous retroviruses (ERV) are found throughout vertebrate genomes, and failure to silence their activation can have deleterious consequences on the host. Mutation and subsequent disruption of ERV loci is therefore an indispensable component of the cell-intrinsic defenses that maintain the integrity of the host gen...

journal_title：Journal of virology

authors： Treger RS,Tokuyama M,Dong H,Salas-Briceno K,Ross SR,Kong Y,Iwasaki A

更新日期：2019-09-30 00:00:00

abstract：:We have established a genetic assay for the multimerization of retroviral gag polyproteins. This assay is based on the GAL4 two-hybrid system for studying protein-protein interactions (S. Fields and O. Song, Nature (London) 340:245-246, 1989). In our initial experiments, we generated Saccharomyces cerevisiae plasmids ...

journal_title：Journal of virology

authors： Luban J,Alin KB,Bossolt KL,Humaran T,Goff SP

更新日期：1992-08-01 00:00:00

abstract：:The catalytic core domain (CCD) of human immunodeficiency virus type 1 (HIV-1) integrase (IN) harbors the enzyme active site and binds viral and chromosomal DNA during integration. Thirty-five CCD mutant viruses were constructed, paying particular attention to conserved residues in the Phe(139)-Gln(146) flexible loop ...

journal_title：Journal of virology

authors： Lu R,Limón A,Ghory HZ,Engelman A

更新日期：2005-02-01 00:00:00

abstract：:The tegument of herpesviruses is a highly complex structural layer between the nucleocapsid and the envelope of virions. Tegument proteins play both structural and regulatory functions during replication and spread, but the interactions and functions of many of these proteins are poorly understood. Here we focus on tw...

journal_title：Journal of virology

authors： Albecka A,Owen DJ,Ivanova L,Brun J,Liman R,Davies L,Ahmed MF,Colaco S,Hollinshead M,Graham SC,Crump CM

更新日期：2017-01-03 00:00:00

abstract：:Two of 25 healthy pet sooty mangabey (SM) monkeys (Cercocebus atys) living in West Africa were seropositive by immunoblot when surveyed for antibody to simian immunodeficiency virus of macaques (SIVmac). SIVsmLIB1 was isolated from one of the pet sooty mangabeys. Nucleotide sequence data showed that this isolate is a ...

journal_title：Journal of virology

authors： Marx PA,Li Y,Lerche NW,Sutjipto S,Gettie A,Yee JA,Brotman BH,Prince AM,Hanson A,Webster RG

更新日期：1991-08-01 00:00:00

abstract：:Herpesviruses encode a set of core proteins essential for lytic replication of their genomes. Three of these proteins form a tripartite helix-primase complex that, in the case of Epstein-Barr virus (EBV), consists of the helicase BBLF4, the primase BSLF1, and the linker protein BBLF2/3. BBLF2/3 and its homologs in the...

journal_title：Journal of virology

authors： Liao G,Huang J,Fixman ED,Hayward SD

更新日期：2005-01-01 00:00:00

abstract：:Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mic...

journal_title：Journal of virology

authors： Yoshikai Y,Kidokoro H,Kimura K,Aoki Y,Makino M,Hiromatsu K

更新日期：1997-01-01 00:00:00

abstract：:Poliovirus proteinase 2A (2Apro) is autocatalytically released from the viral polyprotein by cleavage in cis of a Tyr-Gly dipeptide at its own amino terminus, resulting in separation of the P1 structural and P2-P3 nonstructural protein precursors. A second Ty-Gly dipeptide within 3D polymerase is cleaved by 2Apro in t...

journal_title：Journal of virology

authors： Hellen CU,Lee CK,Wimmer E

更新日期：1992-06-01 00:00:00

abstract：:The cytoplasmic assembly of vaccinia virus is reversibly blocked by the antibiotic rifampin, leading to the accumulation of partially membrane-delineated rifampin bodies in infected cells. Rifampin-resistant vaccinia virus mutants have point mutations in the D13L gene, which is controlled by a late promoter and expres...

journal_title：Journal of virology

authors： Sodeik B,Griffiths G,Ericsson M,Moss B,Doms RW

更新日期：1994-02-01 00:00:00

abstract：:In a previous study (S. Zheng, G. N. Woode, D. R. Melendy, and R. F. Ramig, J. Clin. Microbiol. 27:1939-1945, 1989), it was predicted that the VP7 serotype 6 bovine rotavirus strains NCDV and B641 do not share antigenically similar VP4s. In this study, gene 4 and the VP7 gene of B641 were sequenced, and the amino acid...

journal_title：Journal of virology

authors： Hardy ME,Woode GN,Xu ZC,Gorziglia M

更新日期：1991-10-01 00:00:00

abstract：UNLABELLED:Human metapneumovirus (HMPV), a recently discovered paramyxovirus, infects nearly 100% of the world population and causes severe respiratory disease in infants, the elderly, and immunocompromised patients. We previously showed that HMPV binds heparan sulfate proteoglycans (HSPGs) and that HMPV binding requir...

journal_title：Journal of virology

authors： Klimyte EM,Smith SE,Oreste P,Lembo D,Dutch RE

更新日期：2016-09-29 00:00:00

abstract：:The entry of enveloped viruses into cells is normally mediated by fusion between viral and cellular membranes, in which the fusion peptide plays a crucial role. The fusion peptides of group II nucleopolyhedrovirus (NPV) F proteins are quite conserved, with a hydrophobic region located at the N terminal of the F(1) fra...

journal_title：Journal of virology

authors： Tan Y,Jiang L,Wang M,Yin F,Deng F,Liu M,Hu Z,Wang H

更新日期：2008-08-01 00:00:00

abstract：:BK polyomavirus (BKV) establishes persistent, low-level, and asymptomatic infections in most humans and causes polyomavirus-associated nephropathy (PVAN) and other pathologies in some individuals. The activation of BKV replication following kidney transplantation, leading to viruria, viremia, and, ultimately, PVAN, is...

journal_title：Journal of virology

authors： Liang B,Tikhanovich I,Nasheuer HP,Folk WR

更新日期：2012-03-01 00:00:00

abstract：:The conversion of simian virus 40 (SV40) component II deoxyribonucleic acid to component I has been used to assay polynucleotide ligase in extracts of tissue culture cells. All cell types examined, including chicken, hamster, mouse, monkey, and human cells, contained adenosine triphosphate-dependent ligase. After infe...

journal_title：Journal of virology

authors： Sambrook J,Shatkin AJ

更新日期：1969-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A) is widely expressed in EBV-infected cells within the infected human host and EBV-associated malignancies, suggesting that LMP2A is important for EBV latency, persistence, and EBV-associated tumorigenesis. Previously, we demonstrated that LMP2A provides an ant...

journal_title：Journal of virology

authors： Fukuda M,Longnecker R

更新日期：2007-09-01 00:00:00

abstract：:Enveloped virus vectors are used in a wide variety of applications. We have discovered that treatment of cultured cells with phosphatidylserine (PS) liposomes can increase virus vector infection by up to 20-fold. This effect does not abrogate virus receptor requirements, is specific to PS compared to other phospholipi...

journal_title：Journal of virology

authors： Coil DA,Miller AD

更新日期：2005-09-01 00:00:00

abstract：:Phosphorylation of viral proteins plays important roles in the influenza A virus (IAV) life cycle. By using mass spectrometry, we identified tyrosine 132 (Y132) as a phosphorylation site of the matrix protein (M1) of the influenza virus A/WSN/1933(H1N1). Phosphorylation at this site is essential to the process of viru...

journal_title：Journal of virology

authors： Wang S,Zhao Z,Bi Y,Sun L,Liu X,Liu W

更新日期：2013-06-01 00:00:00

abstract：:With the rationale that the neuropathological similarities between scrapie and Alzheimer's disease reflect convergent pathological mechanisms involving altered gene expression, we set out to identify molecular events involved in both processes, using scrapie as a model to study the time course of these changes. We dif...

journal_title：Journal of virology

authors： Diedrich JF,Minnigan H,Carp RI,Whitaker JN,Race R,Frey W 2nd,Haase AT

更新日期：1991-09-01 00:00:00