Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras/PI3-K/Akt Pathway.

abstract：:In contrast to humans, several primate species are believed to have harbored simian immunodeficiency viruses (SIVs) since ancient times. In particular, the geographically dispersed species of African green monkeys (AGMs) are all infected with highly diversified SIVagm viruses at high prevalences (greater than 50% of s...

journal_title：Journal of virology

authors： Kuhmann SE,Madani N,Diop OM,Platt EJ,Morvan J,Müller-Trutwin MC,Barré-Sinoussi F,Kabat D

更新日期：2001-09-01 00:00:00

abstract：:The glycosylated Gag protein (gPr80) of murine leukemia viruses (MLVs) has been shown to exhibit multiple roles in facilitating retrovirus release, infection, and resistance to host-encoded retroviral restriction factors, such as APOBEC3, SERINC3, and SERINC5. One way in which gPr80 helps MLVs to escape host innate im...

journal_title：Journal of virology

authors： Renner TM,Bélanger K,Lam C,Gerpe MCR,McBane JE,Langlois MA

更新日期：2018-02-26 00:00:00

abstract：:During cell entry, native poliovirus (160S) converts to a cell-entry intermediate (135S) particle, resulting in the externalization of capsid proteins VP4 and the amino terminus of VP1 (residues 1 to 53). Externalization of these entities is followed by release of the RNA genome (uncoating), leaving an empty (80S) par...

journal_title：Journal of virology

authors： Lin J,Cheng N,Chow M,Filman DJ,Steven AC,Hogle JM,Belnap DM

更新日期：2011-10-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) has emerged as a clinically opportunistic pathogen that targets multiple types of ocular cells and tissues, including the iris region of the uveal tract during anterior uveitis. In this report, we used primary cultures of human iris stroma (HIS) cells derived from human eye donors to inves...

journal_title：Journal of virology

authors： Baldwin J,Maus E,Zanotti B,Volin MV,Tandon R,Shukla D,Tiwari V

更新日期：2015-05-01 00:00:00

abstract：:CD4C/HIV(nef) transgenic (Tg) mice express Nef in CD4+ T cells and in the cells of the macrophage/monocyte/dendritic lineage, and they develop an AIDS-like disease similar to human AIDS. In these mice, Nef is constitutively expressed throughout life. To rule out the contribution of any developmental defects caused by ...

journal_title：Journal of virology

authors： Rahim MM,Chrobak P,Hu C,Hanna Z,Jolicoeur P

更新日期：2009-11-01 00:00:00

abstract：:Mitochondrial DNA synthesis in adenovirus type 2-infected HeLa cells was measured at various times from 0 to 24 h postinfection. Although viral infection effectively turned off host chromosomal DNA synthesis, mitochondrial DNA synthesis was not inhibited. These findings indicate a dissociation between the regulation o...

journal_title：Journal of virology

authors： Fisher PB,Horwitz MS

更新日期：1977-05-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) mutants impaired in the activities of the structural protein VP16 and the immediate-early (IE) proteins ICP0 and ICP4 establish a quiescent infection in human fibroblasts, with most cells retaining an inactive, repressed viral genome for sustained periods in culture. To date, the qu...

journal_title：Journal of virology

authors： Preston CM,Nicholl MJ

更新日期：2008-12-01 00:00:00

abstract：:Temperature-sensitive COS cells, clone E540, have been stably transformed at a restrictive temperature with plasmid pVA1, which contains the adenovirus type 5 virus-associated (VA) genes in addition to the Neor marker. Transformed cell clones, named EVA cells, contained adenovirus DNA in an integrated form while grown...

journal_title：Journal of virology

authors： Martínez C,de la Luna S,Peláez F,Lopez-Turiso A,Valcárcel J,de Haro C,Ortín J

更新日期：1989-12-01 00:00:00

abstract：:Ebola viruses (EboV) are enveloped RNA viruses infecting cells by a pH-dependent process mediated by viral glycoproteins (GP) involving endocytosis of virions and their routing into acidic endosomes. As with well-characterized pH-dependent viral entry proteins, in particular influenza virus hemagglutinin, it is though...

journal_title：Journal of virology

authors： Bär S,Takada A,Kawaoka Y,Alizon M

更新日期：2006-03-01 00:00:00

abstract：:Human papillomavirus type 16 (HPV16) is the primary etiologic agent for cervical cancer. The infectious entry of HPV16 into cells occurs via a so-far poorly characterized clathrin- and caveolin-independent endocytic pathway, which involves tetraspanin proteins and actin. In this study, we investigated the specific rol...

journal_title：Journal of virology

authors： Scheffer KD,Gawlitza A,Spoden GA,Zhang XA,Lambert C,Berditchevski F,Florin L

更新日期：2013-03-01 00:00:00

abstract：:We investigated how the broadly neutralizing monoclonal antibody 2F5 affects the human immunodeficiency virus type 1 envelope glycoprotein as it undergoes receptor-induced conformational changes and show that 2F5 binds both native and fusion-intermediate conformations, suggesting inhibition of a late step in virus ent...

journal_title：Journal of virology

authors： de Rosny E,Vassell R,Jiang S,Kunert R,Weiss CD

更新日期：2004-03-01 00:00:00

abstract：:Cells expressing the low pH-triggered class II viral fusion protein E1 of Semliki Forest virus (SFV) were fused to target cells. Fusion was monitored by electrical capacitance and aqueous dye measurements. Electrical voltage-clamp measurements showed that SFV E1-induced cell-cell fusion occurred quickly after acidific...

journal_title：Journal of virology

authors： Markosyan RM,Kielian M,Cohen FS

更新日期：2007-10-01 00:00:00

abstract：:Viral infection triggers host innate immune responses through cellular sensor molecules which activate multiple signaling cascades that induce the production of interferons (IFN) and other cytokines. The recent identification of mammalian cytoplasmic viral RNA sensors, such as retinoic acid-inducible gene I (RIG-I)-li...

journal_title：Journal of virology

authors： Biacchesi S,LeBerre M,Lamoureux A,Louise Y,Lauret E,Boudinot P,Brémont M

更新日期：2009-08-01 00:00:00

abstract：:mRNA's homologous to the herpes simplex virus type 1 DNA restriction endonuclease fragment BamHI p, which contains the thymidine kinase gene, have been identified and mapped by hybrid-arrested translation and mRNA selection. Such mRNA's, when translated in vitro, directed the synthesis of polypeptides of apparent mole...

journal_title：Journal of virology

authors： Preston CM,McGeoch DJ

更新日期：1981-05-01 00:00:00

abstract：:Glycoprotein B (gB) is a conserved herpesvirus virion component implicated in membrane fusion. As with many-but not all-herpesviruses, the gB of murid herpesvirus 4 (MuHV-4) is cleaved into disulfide-linked subunits, apparently by furin. Preventing gB cleavage for some herpesviruses causes minor infection deficits in ...

journal_title：Journal of virology

authors： Glauser DL,Milho R,Frederico B,May JS,Kratz AS,Gillet L,Stevenson PG

更新日期：2013-10-01 00:00:00

abstract：:Data showing that an apoptotic reaction (the exit into the cytoplasm and nucleolytic internucleosomal degradation of chromosomal DNA, compaction and fragmentation of chromatin, cellular shrinkage, and cytoplasmic blebbing) developed in a subline of HeLa-S3 cells upon nonpermissive poliovirus infection with either a gu...

journal_title：Journal of virology

authors： Tolskaya EA,Romanova LI,Kolesnikova MS,Ivannikova TA,Smirnova EA,Raikhlin NT,Agol VI

更新日期：1995-02-01 00:00:00

abstract：:A receptor on YAC-1 cells, a mouse T-lymphoma cell line, bound all six serotypes of the group B coxsackieviruses (CVB). In addition, the cells produced infectious virus. Each of the CVB competed for the same receptor on YAC-1 cells. CVB3 bound relatively slowly to YAC-1 cells (k = 4 x 10(-11) min-1 cell-1), and there ...

journal_title：Journal of virology

authors： Hsu KH,Crowell RL

更新日期：1989-07-01 00:00:00

abstract：:Vaccines preventing HIV-1 infection will likely elicit antibodies that neutralize diverse strains. However, the capacity for lentiviruses to escape broadly neutralizing antibodies (NAbs) is not completely understood, nor is it known whether NAbs alone can control heterologous infection. Here, we determined that conval...

journal_title：Journal of virology

authors： Taylor SD,Leib SR,Carpenter S,Mealey RH

更新日期：2010-07-01 00:00:00

abstract：UNLABELLED:The noncovalent interactions that mediate trimerization of the influenza hemagglutinin (HA) are important determinants of its biological activities. Recent studies have demonstrated that mutations in the HA trimer interface affect the thermal and pH sensitivities of HA, suggesting a possible impact on vaccin...

journal_title：Journal of virology

authors： Yang H,Chang JC,Guo Z,Carney PJ,Shore DA,Donis RO,Cox NJ,Villanueva JM,Klimov AI,Stevens J

更新日期：2014-05-01 00:00:00

abstract：UNLABELLED:There are nine subtypes of influenza A virus neuraminidase (NA), N1 to N9. In addition, influenza B virus also contains NA, and there are two influenza virus NA-like molecules, N10 and N11, which were recently identified from bats. Crystal structures for all of these proteins have been solved, with the excep...

journal_title：Journal of virology

authors： Sun X,Li Q,Wu Y,Wang M,Liu Y,Qi J,Vavricka CJ,Gao GF

更新日期：2014-08-01 00:00:00

abstract：:We have previously described several human immunodeficiency virus type 1 (HIV-1) mutants that are characterized by an excessive-RNA-splicing phenotype and reduced virus particle production. In one of these mutants (NLD2up), the sequence of 5' splice site D2 was changed to a consensus splice donor site. This splice sit...

journal_title：Journal of virology

authors： Mandal D,Feng Z,Stoltzfus CM

更新日期：2008-02-01 00:00:00

abstract：:The entire measles virus (MV) hemagglutinin (HA)-coding region was reconstructed from cloned cDNAs and used as part of a hybrid transcription unit to replace a region of the adenovirus type 5 genome corresponding to the entire E1a transcription unit and most of the E1b transcription unit. The resulting recombinant vir...

journal_title：Journal of virology

authors： Alkhatib G,Briedis DJ

更新日期：1988-08-01 00:00:00

abstract：:We previously described a preleukemic state induced by Moloney murine leukemia virus (Mo-MuLV) characterized by hematopoietic hyperplasia in the spleen. Further experiments suggested that splenic hyperplasia results from inhibitory effects in the bone marrow, leading to compensatory extramedullary hematopoiesis. An en...

journal_title：Journal of virology

authors： Li QX,Fan H

更新日期：1991-08-01 00:00:00

abstract：:Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes resi...

journal_title：Journal of virology

authors： Wu J,Bera AK,Kuhn RJ,Smith JL

更新日期：2005-08-01 00:00:00

abstract：UNLABELLED:Aminoquinolines and piperazines, linked or not, have been used successfully to treat malaria, and some molecules of this family also exhibit antiviral properties. Here we tested several derivatives of 4-aminoquinolines and piperazines for their activity against hepatitis C virus (HCV). We screened 11 molecul...

journal_title：Journal of virology

authors： Vausselin T,Séron K,Lavie M,Mesalam AA,Lemasson M,Belouzard S,Fénéant L,Danneels A,Rouillé Y,Cocquerel L,Foquet L,Rosenberg AR,Wychowski C,Meuleman P,Melnyk P,Dubuisson J

更新日期：2016-09-12 00:00:00

abstract：:Hantaviruses replicate primarily in the vascular endothelium and cause two human diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). In this report, we demonstrate that the cellular entry of HFRS-associated hantaviruses is facilitated by specific integrins expressed on plate...

journal_title：Journal of virology

authors： Gavrilovskaya IN,Brown EJ,Ginsberg MH,Mackow ER

更新日期：1999-05-01 00:00:00

abstract：:We have developed idiotype-anti-idiotype monoclonal antibodies that provide evidence for rabies virus binding to the acetylcholine receptor (AChR). Hybridoma cell lines 7.12 and 7.25 resulted after fusion of NS-1 myeloma cells with spleen cells from a BALB/c mouse immunized with rabies virus strain CVS. Antibody 7.12 ...

journal_title：Journal of virology

authors： Hanham CA,Zhao F,Tignor GH

更新日期：1993-01-01 00:00:00

abstract：:Chimeric bovine respiratory syncytial viruses (BRSV) expressing glycoproteins of bovine parainfluenza virus type 3 (BPIV-3) instead of BRSV glycoproteins were generated from cDNA. In the BRSV antigenome cDNA, the open reading frames of the major BRSV glycoproteins, attachment protein G and fusion protein F, were repla...

journal_title：Journal of virology

authors： Stope MB,Karger A,Schmidt U,Buchholz UJ

更新日期：2001-10-01 00:00:00

abstract：:Retroviruses, as a result of the presence of two identical genomic RNA molecules in their virions, recombine at a high rate. When nonhomologous RNA is present in the dimer RNA molecules, nonhomologous recombination can occur, although the rate is very low, only 0.1% of the rate of essentially homologous recombination ...

journal_title：Journal of virology

authors： Zhang J,Temin HM

更新日期：1994-04-01 00:00:00

abstract：:Adeno-associated viruses (AAVs) are small single-stranded DNA viruses that can package and deliver nongenomic DNA for therapeutic gene delivery. AAV8, a liver-tropic vector, has shown great promise for the treatment of hemophilia A and B. However, as with other AAV vectors, host anti-capsid immune responses are a dete...

journal_title：Journal of virology

authors： Gurda BL,Raupp C,Popa-Wagner R,Naumer M,Olson NH,Ng R,McKenna R,Baker TS,Kleinschmidt JA,Agbandje-McKenna M

更新日期：2012-08-01 00:00:00