Capped nonviral sequences at the 5' end of the mRNAs of rice hoja blanca virus RNA4.

abstract：:Mice infected with myopathic coxsackievirus B1 Tucson (CVB1(T)) develop chronic inflammatory myopathy (CIM) consisting of hind limb weakness and inflammation. Amyopathic virus variants are infectious but attenuated for CIM. In this report, viral clones, chimeras, and sequencing were used to identify viral determinants...

journal_title：Journal of virology

authors： Tam PE,Weber-Sanders ML,Messner RP

更新日期：2003-11-01 00:00:00

abstract：:The prevailing hypothesis is that the intracellular site of budding of coronaviruses is determined by the localization of its membrane protein M (previously called E1). We tested this by analyzing the site of budding of four different coronaviruses in relation to the intracellular localization of their M proteins. Mou...

journal_title：Journal of virology

authors： Klumperman J,Locker JK,Meijer A,Horzinek MC,Geuze HJ,Rottier PJ

更新日期：1994-10-01 00:00:00

abstract：:Among the members of the paramyxovirus family, the transcription process and the components involved have been studied under in vitro conditions thus far. Here, we reexamined the function of the viral RNA-dependent RNA polymerase through infection studies with Sendai virus (SeV) N and P deletion (Delta) mutants. To el...

journal_title：Journal of virology

authors： Wiegand MA,Bossow S,Schlecht S,Neubert WJ

更新日期：2007-12-01 00:00:00

abstract：:Polyamine depletion produced by exogenous arginine in Escherichia coliK-12 cultures defective in agmatine ureohydrolase activity resulted in a marked inhibition of the rates of growth and nucleic acid synthesis. Addition of putrescine or spermidine to such depleted cultures restored the control rate of growth and nucl...

journal_title：Journal of virology

authors： Dion AS,Cohen SS

更新日期：1972-03-01 00:00:00

abstract：:Infectious vaccinia virus can be purified from whole cells by experimentally induced lysis (intracellular virus) or from supernatant growth medium (extracellular virus). Extracellular virus and intracellular virus differed by buoyant density (1.237 versus 1.272 g/cm3), phospholipid content and composition, and polypep...

journal_title：Journal of virology

authors： Hiller G,Eibl H,Weber K

更新日期：1981-09-01 00:00:00

abstract：:HIV-1 transmission occurs mainly through mucosal tissues. During mucosal transmission, HIV-1 preferentially infects α4β7+ gut-homing CCR7- CD4+ effector/effector memory T cells (TEM) and results in massive depletion of these cells and other subsets of TEM in gut-associated lymphoid tissues. However, besides being elim...

journal_title：Journal of virology

authors： Cheung KW,Wu T,Ho SF,Wong YC,Liu L,Wang H,Chen Z

更新日期：2018-03-28 00:00:00

abstract：:We have previously demonstrated that parainfluenza virus type 3 (PIV3), a significant respiratory pathogen, can markedly inhibit T-cell function in vitro. We now report that the virus potently induces interleukin-10 (IL-10) production by peripheral blood mononuclear cells. The IL-10 produced contributes to viral inhib...

journal_title：Journal of virology

authors： Sieg S,King C,Huang Y,Kaplan D

更新日期：1996-07-01 00:00:00

abstract：:Borna disease virus (BDV) is a nonsegmented negative-strand (NNS) RNA virus that is unusual because it replicates in the nucleus. The most abundant viral protein in infected cells is a 38/39-kDa doublet that is presumed to represent the nucleocapsid. Infectious particles also contain high levels of this protein, accou...

journal_title：Journal of virology

authors： Pyper JM,Gartner AE

更新日期：1997-07-01 00:00:00

abstract：:A sequence of polyadenylic acid, homogeneous in composition but heterogeneous in length, was isolated from complete pancreatic RNase digests of both middle and bottom RNAs of cowpea mosaic virus. The polyadenylic acid was 3'-terminal and occurred once per molecule. A fragment consisting of the polyadenylic acid and ap...

journal_title：Journal of virology

authors： Steele KP,Frist RH

更新日期：1978-05-01 00:00:00

abstract：:Viruses are considered to use vesicular trafficking in infected cells, but the details of assembly/release pathways of hepatitis B virus (HBV) are still unknown. To identify key regulators of HBV production, we performed short interfering RNA (siRNA) screening for Rab proteins, which are considered to act as molecular...

journal_title：Journal of virology

authors： Inoue J,Ninomiya M,Umetsu T,Nakamura T,Kogure T,Kakazu E,Iwata T,Takai S,Sano A,Fukuda M,Watashi K,Isogawa M,Tanaka Y,Shimosegawa T,McNiven MA,Masamune A

更新日期：2019-07-17 00:00:00

abstract：:Antisera were prepared against the amino acid sequences encoded within the N-terminal half of the adenovirus 12 (Ad12) early region 1A (E1A) gene. This was accomplished by construction of a plasmid vector which encoded the N-terminal 131 amino acids of Ad12 E1A joined in frame to the coding sequence of beta-galactosid...

journal_title：Journal of virology

authors： Scott MO,Kimelman D,Norris D,Ricciardi RP

更新日期：1984-06-01 00:00:00

abstract：:The ORF3 protein of hepatitis E virus (HEV) is a multifunctional protein important for virus replication. The ORF3 proteins from human, swine, and avian strains of HEV contain a conserved PXXP amino acid motif, resembling either Src homology 3 (SH3) cell signaling interaction motifs or "late domains" involved in host ...

journal_title：Journal of virology

authors： Kenney SP,Pudupakam RS,Huang YW,Pierson FW,LeRoith T,Meng XJ

更新日期：2012-05-01 00:00:00

abstract：:Envelope glycoprotein (Env) reactivity (ER) describes the propensity of human immunodeficiency virus type 1 (HIV-1) Env to change conformation from the metastable unliganded state in response to the binding of ligands (antibodies and soluble CD4 [sCD4]) or incubation in the cold. To investigate Env properties that fav...

journal_title：Journal of virology

authors： McGee K,Haim H,Korioth-Schmitz B,Espy N,Javanbakht H,Letvin N,Sodroski J

更新日期：2014-01-01 00:00:00

abstract：:We used 18 monoclonal antibodies against B19 parvovirus to identify neutralizing epitopes on the viral capsid. Of the 18 antibodies, 9 had in vitro neutralizing activity in a bone marrow colony culture assay. The overlapping polypeptide fragments spanning the B19 structural proteins were produced in a pMAL-c Escherich...

journal_title：Journal of virology

authors： Yoshimoto K,Rosenfeld S,Frickhofen N,Kennedy D,Hills R,Kajigaya S,Young NS

更新日期：1991-12-01 00:00:00

abstract：:The interaction of the mouse hepatitis virus (MHV) nucleocapsid protein (N) and viral RNA was examined. Monoclonal antibody specific for N protein coimmunoprecipitated MHV genomic RNA as well as all six MHV subgenomic mRNAs found in MHV-infected cells. In contrast, monoclonal antibodies to the MHV E2 or E1 envelope gl...

journal_title：Journal of virology

authors： Baric RS,Nelson GW,Fleming JO,Deans RJ,Keck JG,Casteel N,Stohlman SA

更新日期：1988-11-01 00:00:00

abstract：:We have examined EcoRI-restricted cellular DNA from BALB/c mouse-hamster somatic cell hybrids by blot hybridization for the presence of mouse mammary tumor virus-related sequences. Results of this analysis show that mouse mammary tumor virus-related proviral copies are located on chromosomes 16 (16-kilobase-pair fragm...

journal_title：Journal of virology

authors： Callahan R,Gallahan D,Kozak C

更新日期：1984-03-01 00:00:00

abstract：:To clarify hematological abnormalities following infection with human immunodeficiency virus (HIV), we examined the hematopoietic capability of bone marrow by using cynomolgus monkeys infected with pathogenic simian/human immunodeficiency virus (SHIV) strain C2/1, an animal model of HIV infection. The relationship bet...

journal_title：Journal of virology

authors： Yamakami K,Honda M,Takei M,Ami Y,Kitamura N,Nishinarita S,Sawada S,Horie T

更新日期：2004-10-01 00:00:00

abstract：:Mature dendritic cells (DCs) are potent antigen-presenting cells essential for initiating successful antiviral immune responses and would therefore serve as an ideal target for viruses seeking to evade or delay the immune response by disrupting their function. We have previously reported that VZV productively infects ...

journal_title：Journal of virology

authors： Morrow G,Slobedman B,Cunningham AL,Abendroth A

更新日期：2003-04-01 00:00:00

abstract：:We have selected neutralization escape mutants by using a monoclonal antibody (nt-MAb) against a sequential epitope between amino acids 93 through 104 (neutralization antigenic site I) of poliovirus type 1 Mahoney. The majority of mutants were also resistant against five strain-specific nt-MAbs which recognized confor...

journal_title：Journal of virology

authors： Wiegers K,Uhlig H,Dernick R

更新日期：1988-05-01 00:00:00

abstract：:The E2 gene products of papillomavirus play key roles in viral replication, both as regulators of viral transcription and as auxiliary factors that act with E1 in viral DNA replication. We have carried out a detailed structure-function analysis of conserved amino acids within the N-terminal domain of the human papillo...

journal_title：Journal of virology

authors： Sakai H,Yasugi T,Benson JD,Dowhanick JJ,Howley PM

更新日期：1996-03-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) envelope glycoprotein D (gD) plays an essential role in viral entry. The functional regions of gD responsible for viral entry have been mapped to its extracellular domain, whereas the gD cytoplasmic domain plays no obvious role in viral entry. Thus far, the role(s) of the gD cytoplasmic ...

journal_title：Journal of virology

authors： Arii J,Shindo K,Koyanagi N,Kato A,Kawaguchi Y

更新日期：2016-10-28 00:00:00

abstract：UNLABELLED:The latent HIV reservoir is a major impediment to curing HIV infection. The contribution of CD4(+) T cell activation status to the establishment and maintenance of the latent reservoir was investigated by enumerating viral DNA components in a cohort of 12 individuals commencing antiretroviral therapy (ART) c...

journal_title：Journal of virology

authors： Murray JM,Zaunders JJ,McBride KL,Xu Y,Bailey M,Suzuki K,Cooper DA,Emery S,Kelleher AD,Koelsch KK,PINT Study Team.

更新日期：2014-03-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) vpr inhibits the replication of tumor cell lines and peripheral blood mononuclear cells. Here it is demonstrated that expression of vpr, either in the context of a provirus or from an independent genetic element, induces a discrete cell cycle arrest, with cells containing 4N...

journal_title：Journal of virology

authors： Re F,Braaten D,Franke EK,Luban J

更新日期：1995-11-01 00:00:00

abstract：:African green monkeys can maintain long-term persistent infection with simian immunodeficiency viruses (SIVagm) without developing AIDS and thus provide an important model for understanding mechanisms of natural host resistance to disease. This study assessed the levels and anatomic distribution of SIVagm in healthy, ...

journal_title：Journal of virology

authors： Broussard SR,Staprans SI,White R,Whitehead EM,Feinberg MB,Allan JS

更新日期：2001-03-01 00:00:00

abstract：:Replication and transcription activator (RTA) (also referred to as ORF50), an immediate-early gene product of Kaposi's sarcoma-associated herpesvirus (KSHV)/(human herpesvirus 8), plays a critical role in balancing the viral life cycle between latency and lytic replication. RTA has been shown to act as a strong transc...

journal_title：Journal of virology

authors： Song MJ,Deng H,Sun R

更新日期：2003-09-01 00:00:00

abstract：:A number of herpes simplex virus (HSV) glycoproteins are found in oligomeric states: glycoprotein E (gE)-gI and gH-gL form heterodimers, and both gB and gC have been detected as homodimers. We have further explored the organization of glycoproteins in the virion envelope by using both purified virions to quantitate gl...

journal_title：Journal of virology

authors： Handler CG,Eisenberg RJ,Cohen GH

更新日期：1996-09-01 00:00:00

abstract：:Transfection of an Epstein-Barr virus (EBV)-encoded plasmid containing EBER caused a substantial decrease in the level of plasmid containing EBV in Akata and Mutu Burkitt's lymphoma (BL) lines, but failed to do so in other BL lines. The results suggest that EBER could replace the role of EBV, but other EBV products al...

journal_title：Journal of virology

authors： Maruo S,Nanbo A,Takada K

更新日期：2001-10-01 00:00:00

abstract：:West Nile virus (WNV) is a mosquito-borne Flavivirus that causes encephalitis in a subset of susceptible humans. Current treatment for WNV infections is supportive, and no specific therapy or vaccine is available. In this study, we directly tested the prophylactic and therapeutic efficacy of polyclonal antibodies agai...

journal_title：Journal of virology

authors： Engle MJ,Diamond MS

更新日期：2003-12-01 00:00:00

abstract：UNLABELLED:Increasing data suggest that NK cells can mediate antiviral activity in HIV-1-infected humans, and as such, novel approaches harnessing the anti-HIV-1 function of both T cells and NK cells represent attractive options to improve future HIV-1 immunotherapies. Chronic progressive HIV-1 infection has been assoc...

journal_title：Journal of virology

authors： Jost S,Tomezsko PJ,Rands K,Toth I,Lichterfeld M,Gandhi RT,Altfeld M

更新日期：2014-08-01 00:00:00

abstract：:A comparison has been made of the membrane glycoproteins and glycopeptides from two enveloped viruses, Sindbis virus and vesicular stomatitis virus (VSV). Glycopeptides isolated from Sindbis virus and VSV grown in the same host appear to differ principally in the number of sialic acid residues per glycopeptide; when s...

journal_title：Journal of virology

authors： Burge BW,Huang AS

更新日期：1970-08-01 00:00:00